TRG-AS1

Summary

TRG-AS1 (TRG antisense RNA 1, HGNC:48974) is a long non-coding RNA gene on chromosome 7p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48974
Approved symbol	TRG-AS1
Name	TRG antisense RNA 1
Location	7p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000281103
Ensembl biotype	lncRNA
Entrez	100506776
RNAcentral	URS000075B7A7 — lncRNA, 3516 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000629357, ENST00000629576, ENST00000661780, ENST00000668633, ENST00000669822, ENST00000685384, ENST00000685545, ENST00000685679, ENST00000686045, ENST00000687175, ENST00000687516, ENST00000687941, ENST00000688614, ENST00000689140, ENST00000689202, ENST00000690659, ENST00000690797, ENST00000691500, ENST00000692347, ENST00000693344, ENST00000700818, ENST00000700835, ENST00000701984, ENST00000702133, ENST00000702282, ENST00000702486, ENST00000702643, ENST00000702673, ENST00000702682, ENST00000702790, ENST00000702793, ENST00000723494, ENST00000824409

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000629357 — 4 exons

Exon	Start	End
ENSE00003760564	38350346	38350450
ENSE00003767999	38346021	38346127
ENSE00003774929	38375557	38378804
ENSE00003986243	38341615	38341799

Expression profiles

Bgee: expression breadth ubiquitous, 180 present calls, max score 95.90.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4772 / max 40.2441, expressed in 321 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
78231	0.5224	164
78232	0.5136	175
78230	0.4412	189

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	95.90	gold quality
granulocyte	CL:0000094	91.62	gold quality
spleen	UBERON:0002106	90.30	gold quality
thymus	UBERON:0002370	86.20	gold quality
blood	UBERON:0000178	84.59	gold quality
lymph node	UBERON:0000029	82.97	gold quality
leukocyte	CL:0000738	82.50	gold quality
monocyte	CL:0000576	81.76	gold quality
trabecular bone tissue	UBERON:0002483	79.65	gold quality
jejunal mucosa	UBERON:0000399	79.52	gold quality
colonic epithelium	UBERON:0000397	78.30	gold quality
epithelium of nasopharynx	UBERON:0001951	77.12	gold quality
visceral pleura	UBERON:0002401	77.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.02	gold quality
prostate gland	UBERON:0002367	76.51	gold quality
ileal mucosa	UBERON:0000331	76.27	gold quality
vermiform appendix	UBERON:0001154	76.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.99	gold quality
bone marrow cell	CL:0002092	75.89	gold quality
bone marrow	UBERON:0002371	75.14	gold quality
superficial temporal artery	UBERON:0001614	74.76	gold quality
tonsil	UBERON:0002372	74.07	gold quality
secondary oocyte	CL:0000655	72.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.41	gold quality
palpebral conjunctiva	UBERON:0001812	72.02	gold quality
rectum	UBERON:0001052	71.97	gold quality
gall bladder	UBERON:0002110	71.50	gold quality
amniotic fluid	UBERON:0000173	71.47	gold quality
small intestine	UBERON:0002108	71.45	gold quality
caecum	UBERON:0001153	70.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• TRG-AS1 promotes glioblastoma cell proliferation by acting as a ceRNA of miR-877-5p to regulate SUZ12 expression (PMID:31196742)
• LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis. (PMID:36801505)
• The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13. (PMID:38357893)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.