TRHDE-AS1

Summary

TRHDE-AS1 (TRHDE antisense RNA 1, HGNC:27471) is a long non-coding RNA gene on chromosome 12q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27471
Approved symbol	TRHDE-AS1
Name	TRHDE antisense RNA 1
Location	12q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236333
Ensembl biotype	lncRNA
Entrez	283392
RNAcentral	URS000075E8D2 — lncRNA, 3175 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 25 lncRNA, 1 retained_intron

ENST00000426250, ENST00000435350, ENST00000549957, ENST00000550334, ENST00000653894, ENST00000655350, ENST00000655489, ENST00000656147, ENST00000658779, ENST00000659498, ENST00000661366, ENST00000662127, ENST00000663532, ENST00000663541, ENST00000663575, ENST00000663912, ENST00000663992, ENST00000665830, ENST00000667144, ENST00000667301, ENST00000667465, ENST00000668395, ENST00000668786, ENST00000671462, ENST00000796619, ENST00000796620

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426250 — 5 exons

Exon	Start	End
ENSE00001779229	72272765	72273945
ENSE00001785037	72261198	72264621
ENSE00001788483	72271823	72272162
ENSE00002353069	72274820	72274907
ENSE00003863173	72253538	72255774

Expression profiles

Bgee: expression breadth ubiquitous, 176 present calls, max score 91.49.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7206 / max 145.9742, expressed in 449 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132126	0.5985	204
132123	0.2535	95
132125	0.2331	89
132127	0.2047	81
132128	0.1897	93
132130	0.0807	38
132131	0.0598	22
132124	0.0584	19
132129	0.0366	18
132132	0.0055	4

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	91.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.43	gold quality
cerebellar cortex	UBERON:0002129	91.31	gold quality
cerebellum	UBERON:0002037	90.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	87.87	gold quality
adipose tissue	UBERON:0001013	86.89	gold quality
body of pancreas	UBERON:0001150	85.97	gold quality
adipose tissue of abdominal region	UBERON:0007808	82.83	gold quality
omental fat pad	UBERON:0010414	82.23	gold quality
peritoneum	UBERON:0002358	82.12	gold quality
endocervix	UBERON:0000458	81.09	gold quality
ectocervix	UBERON:0012249	79.32	gold quality
right lung	UBERON:0002167	78.79	gold quality
left ovary	UBERON:0002119	78.70	gold quality
right ovary	UBERON:0002118	78.63	gold quality
stromal cell of endometrium	CL:0002255	78.46	gold quality
metanephros cortex	UBERON:0010533	78.05	gold quality
adult mammalian kidney	UBERON:0000082	77.74	gold quality
primary visual cortex	UBERON:0002436	77.39	gold quality
uterine cervix	UBERON:0000002	76.28	gold quality
cortex of kidney	UBERON:0001225	75.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.62	silver quality
Brodmann (1909) area 9	UBERON:0013540	75.16	gold quality
kidney	UBERON:0002113	75.10	gold quality
right frontal lobe	UBERON:0002810	74.88	gold quality
pancreas	UBERON:0001264	74.76	gold quality
vagina	UBERON:0000996	74.48	gold quality
colonic epithelium	UBERON:0000397	73.85	gold quality
ovary	UBERON:0000992	73.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of the long noncoding RNA TRHDE-AS1 inhibits the progression of lung cancer via the miRNA-103/KLF4 axis. (PMID:31119790)
• lncRNA TRHDE-AS1 Correlated with Genomic Landscape and Clinical Outcome in Glioma. (PMID:37239411)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.