TRIM15

Summary

TRIM15 (tripartite motif containing 15, HGNC:16284) is a protein-coding gene on chromosome 6p22.1, encoding E3 ubiquitin-protein ligase TRIM15 (Q9C019). E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Source: NCBI Gene 89870 — RefSeq curated summary.

At a glance

• GWAS associations: 23
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_033229

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16284
Approved symbol	TRIM15
Name	tripartite motif containing 15
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	ZNFB7, RNF93
Ensembl gene	ENSG00000204610
Ensembl biotype	protein_coding
Entrez	89870

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 retained_intron

ENST00000376694, ENST00000433744, ENST00000477944, ENST00000619857, ENST00000854373, ENST00000854374, ENST00000854375, ENST00000854376

RefSeq mRNA: 1 — MANE Select: NM_033229 NM_033229

CCDS: CCDS4677

Canonical transcript exons

ENST00000259930 — 0 exons

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 95.31.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2215 / max 34.8889, expressed in 66 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66706	0.1454	41
66704	0.0481	30
66705	0.0280	19

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	95.31	gold quality
mucosa of transverse colon	UBERON:0004991	93.64	gold quality
rectum	UBERON:0001052	93.56	gold quality
right lobe of liver	UBERON:0001114	83.41	gold quality
transverse colon	UBERON:0001157	83.11	gold quality
liver	UBERON:0002107	82.31	gold quality
small intestine	UBERON:0002108	82.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	81.98	gold quality
gall bladder	UBERON:0002110	81.78	gold quality
adult mammalian kidney	UBERON:0000082	76.30	gold quality
vermiform appendix	UBERON:0001154	74.44	gold quality
intestine	UBERON:0000160	72.92	gold quality
kidney	UBERON:0002113	69.37	gold quality
colon	UBERON:0001155	69.20	gold quality
colonic epithelium	UBERON:0000397	63.03	gold quality
smooth muscle tissue	UBERON:0001135	61.28	gold quality
islet of Langerhans	UBERON:0000006	60.12	gold quality
cortex of kidney	UBERON:0001225	59.50	gold quality
metanephros cortex	UBERON:0010533	55.74	gold quality
skin of leg	UBERON:0001511	54.13	gold quality
zone of skin	UBERON:0000014	51.80	gold quality
bone marrow	UBERON:0002371	51.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	50.45	gold quality
leukocyte	CL:0000738	49.38	gold quality
monocyte	CL:0000576	49.15	gold quality
skin of abdomen	UBERON:0001416	48.24	gold quality
bone marrow cell	CL:0002092	47.42	gold quality
pancreas	UBERON:0001264	46.53	gold quality
granulocyte	CL:0000094	43.43	silver quality
lower esophagus mucosa	UBERON:0035834	43.35	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10018	yes	6.33
E-ANND-3	no	1.37

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
JUN	Activation

miRNA regulators (miRDB)

33 targeting TRIM15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489
HSA-MIR-548O-5P	99.94	71.24	3488
HSA-MIR-548W	99.94	71.24	3488
HSA-MIR-548Y	99.94	71.28	3514
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-142-5P	99.48	70.92	2416
HSA-MIR-5590-3P	99.48	70.91	2429
HSA-MIR-4270	99.02	66.26	1987

Literature-anchored findings (GeneRIF, showing 8)

• Downregulation of TRIM11 and TRIM15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells. (PMID:18248090)
• TRIM15-depleted cells display impaired cell migration and reduced focal adhesion disassembly rates. (PMID:25015296)
• TRIM15 may function as a tumor suppressor of colon cancer. (PMID:25450970)
• TCGA database showed that higher TRIM15 RNA transcription indicates poorer overall survival of gastric cancer patients. Besides, low expression of TRIM15 was significantly associated with advanced tumor invasion depth and advanced TNM stage. (PMID:30412518)
• Knockdown of TRIM15 inhibits the proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inactivation of the Wnt/beta-catenin signaling pathway. (PMID:33515345)
• TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. (PMID:34497368)
• E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway. (PMID:35534896)
• TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs. (PMID:36670097)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Trim15	ENSMUSG00000050747
rattus_norvegicus	Trim15	ENSRNOG00000031689

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

E3 ubiquitin-protein ligase TRIM15 — Q9C019 (reviewed: Q9C019)

Alternative names: RING finger protein 93, Zinc finger protein 178, Zinc finger protein B7

All UniProt accessions (4): Q9C019, A0A087X199, H0Y5R0, Q5SRL0

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a ‘Lys-63’-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of ‘Lys-63’-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated ‘Lys-63’-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm. Also plays an important regulatory effect on the activation of hepatic stellate cells (HSCs).

Subunit / interactions. Interacts with paxillin/PXN; this interaction recruits TRIM15 to focal adhesions. Interacts with TRIM8; this interaction prevents TRIM8 cytoplasmic translocation.

Subcellular location. Cytoplasm. Nucleus. Cell junction. Focal adhesion.

Induction. By TNF.

Similarity. Belongs to the TRIM/RBCC family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9C019-1	1, Alpha	yes
Q9C019-2	2, Beta

RefSeq proteins (1): NP_150232* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR006574	PRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR018957	Znf_C3HC4_RING-type	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00097, PF00622, PF00643, PF13765

UniProt features (35 total): strand 15, sequence variant 5, binding site 4, turn 3, splice variant 2, zinc finger region 2, chain 1, domain 1, helix 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7QS2	X-RAY DIFFRACTION	1.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9C019-F1	84.52	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 83; 86; 105; 111

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 175 (showing top): GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION, GOBP_FORMATION_OF_PRIMARY_GERM_LAYER, ENK_UV_RESPONSE_KERATINOCYTE_UP, GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GATA3_01, GOBP_CELL_FATE_COMMITMENT_INVOLVED_IN_FORMATION_OF_PRIMARY_GERM_LAYER, MODULE_379, GOBP_REGULATION_OF_BIOLOGICAL_PROCESS_INVOLVED_IN_SYMBIOTIC_INTERACTION, GOBP_CYTOKINE_PRODUCTION, GOBP_REGULATION_OF_RESPONSE_TO_STRESS

GO Biological Process (10): mesodermal cell fate determination (GO:0007500), positive regulation of type I interferon production (GO:0032481), suppression of viral release by host (GO:0044790), innate immune response (GO:0045087), positive regulation of RIG-I signaling pathway (GO:1900246), negative regulation of non-canonical NF-kappaB signal transduction (GO:1901223), negative regulation of intracellular transport of viral material (GO:1901253), canonical NF-kappaB signal transduction (GO:0007249), positive regulation of DNA-templated transcription (GO:0045893), protein K63-linked ubiquitination (GO:0070534)

GO Molecular Function (7): transcription coactivator activity (GO:0003713), zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), molecular sequestering activity (GO:0140313), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), focal adhesion (GO:0005925), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell fate determination	1
mesodermal cell fate commitment	1
positive regulation of cytokine production	1
regulation of type I interferon production	1
type I interferon production	1
defense response to virus	1
immune response	1
defense response to symbiont	1
RIG-I signaling pathway	1
regulation of RIG-I signaling pathway	1
positive regulation of pattern recognition receptor signaling pathway	1
positive regulation of intracellular signal transduction	1
non-canonical NF-kappaB signal transduction	1
regulation of non-canonical NF-kappaB signal transduction	1
negative regulation of intracellular signal transduction	1
intracellular transport of virus	1
regulation of intracellular transport of viral material	1
negative regulation of viral life cycle	1
intracellular signaling cassette	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
protein polyubiquitination	1
transcription coregulator activity	1
positive regulation of DNA-templated transcription	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
molecular_function	1
binding	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
cell-substrate junction	1
cell junction	1

Protein interactions and networks

STRING

772 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM15	TRAT1	Q6PIZ9	594
TRIM15	GPC5	P78333	517
TRIM15	PRY	O14603	506
TRIM15	PXN	P49023	495
TRIM15	METTL1	Q9UBP6	492
TRIM15	CD6	P30203	491
TRIM15	MAVS	Q7Z434	476
TRIM15	AKAP17A	Q02040	470
TRIM15	BBOX1	O75936	462
TRIM15	TRIM66	O15016	456
TRIM15	HLA-DRB5	Q30154	436
TRIM15	TRIM29	Q14134	433
TRIM15	OR12D3	Q9UGF7	433
TRIM15	HLA-DPB1	P01916	425
TRIM15	CLEC16A	Q2KHT3	425

IntAct

34 interactions, top by confidence:

A	B	Type	Score
TRIM15	FAM161A	psi-mi:“MI:0915”(physical association)	0.560
FAM151B	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
RABGEF1	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
FAM161A	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
TRIM15	FAM151B	psi-mi:“MI:0915”(physical association)	0.560
TRIM15	RABGEF1	psi-mi:“MI:0915”(physical association)	0.560
AXIN1	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
YJU2	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
CDK6	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
FAM161B	TRIM15	psi-mi:“MI:0915”(physical association)	0.560
TRIM15	TINF2	psi-mi:“MI:0915”(physical association)	0.370
ACD	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
UBE2U	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
SNW1	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
GTF2E1	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
IRF5	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
MYBL2	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
TAF9B	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
EHMT1	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
TRIM15	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
MED7	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
TRIM8	TRIM15	psi-mi:“MI:0915”(physical association)	0.370
YJU2	TRIM15	psi-mi:“MI:0915”(physical association)	0.000
CDK6	TRIM15	psi-mi:“MI:0915”(physical association)	0.000
FAM161B	TRIM15	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (115): TRIM15 (Two-hybrid), TRIM15 (Two-hybrid), FAM151B (Two-hybrid), PXN (Affinity Capture-Western), TRIM15 (Affinity Capture-Western), PXN (Reconstituted Complex), TRIM15 (Synthetic Growth Defect), TRIM15 (Synthetic Growth Defect), TRIM15 (PCA), TRIM15 (Affinity Capture-Western), CORO1B (Affinity Capture-Western), CTTN (Affinity Capture-Western), FBLIM1 (Affinity Capture-Western), VASP (Affinity Capture-Western), AKT1 (PCA)

ESM2 similar proteins: A0JN74, A6NCK2, A6NGJ6, A6NI03, B1H278, K7N6K2, O00478, O00481, P14373, P19474, Q13410, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q1XHU0, Q2YEM8, Q2YEM9, Q3ZEE5, Q587N6, Q5C8T6, Q5C8T8, Q5C8U1, Q5D7I9, Q5D7J0, Q5D7J1, Q5NCC9, Q5R996, Q62158, Q6MFZ5, Q7YR33, Q7YRV4, Q80V85, Q8BGE7, Q8NG06, Q923T7, Q96BQ3, Q96F44, Q99PP6, Q99PQ2

Diamond homologs: A0A0E4BZH1, A0JN74, A4QPC6, A6NGJ6, A6NI03, A6NK02, A6NLU0, A7TZE6, A7TZF0, A7TZF3, A7XUX6, A7XUY5, A7XUZ6, A7XV04, A7XV07, A8MVZ5, B1H278, D4ABM4, F8S122, F8VTS6, O00478, O00481, O00635, O15553, O70355, O75677, O75678, O75679, P14373, P18892, P19474, P55803, P78410, Q02084, Q13410, Q1XHU0, Q27J48, Q2T9Z0, Q3UWZ0, Q495X7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM15	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1032 predictions. Top by Δscore:

Variant	Effect	Δscore
6:30164064:GG:G	donor_gain	1.0000
6:30164064:GGGTA:G	donor_loss	1.0000
6:30164065:GG:G	donor_gain	1.0000
6:30164066:G:GC	donor_loss	1.0000
6:30164066:G:GG	donor_gain	1.0000
6:30164067:T:A	donor_loss	1.0000
6:30167230:G:GT	donor_gain	1.0000
6:30168290:T:G	acceptor_gain	1.0000
6:30168295:T:A	acceptor_gain	1.0000
6:30168298:A:AC	acceptor_loss	1.0000
6:30168298:A:AG	acceptor_gain	1.0000
6:30168299:G:GA	acceptor_gain	1.0000
6:30168299:GA:G	acceptor_gain	1.0000
6:30168299:GACTC:G	acceptor_gain	1.0000
6:30168456:G:GT	donor_gain	1.0000
6:30168513:GCAA:G	donor_gain	1.0000
6:30168517:G:GG	donor_gain	1.0000
6:30168531:G:GG	donor_gain	1.0000
6:30168557:GA:G	donor_gain	1.0000
6:30169259:AGCAG:A	donor_loss	1.0000
6:30169260:GCAGG:G	donor_loss	1.0000
6:30169261:CAGGT:C	donor_loss	1.0000
6:30169262:AG:A	donor_loss	1.0000
6:30169263:GGT:G	donor_loss	1.0000
6:30170495:CTGCA:C	acceptor_loss	1.0000
6:30170496:TGCA:T	acceptor_loss	1.0000
6:30170497:GCAGG:G	acceptor_loss	1.0000
6:30170498:CA:C	acceptor_loss	1.0000
6:30170499:AGGTG:A	acceptor_loss	1.0000
6:30170500:G:T	acceptor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000193870 (6:30166777 C>A,T), RS1000368816 (6:30173109 G>A), RS1000439832 (6:30169245 T>A,C), RS1000698966 (6:30171701 C>A), RS1000806121 (6:30164911 C>T), RS1000924326 (6:30165308 G>A), RS1000978550 (6:30171366 G>T), RS1001481965 (6:30167967 G>A), RS1001514069 (6:30162116 A>C), RS1001947236 (6:30168896 G>T), RS1002106446 (6:30163939 G>C,T), RS1002358106 (6:30170070 G>GT), RS1002983063 (6:30164847 A>T), RS1003319967 (6:30163718 G>C), RS1003743956 (6:30172950 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

23 associations (top):

Study	Trait	p-value
GCST002324_6	Anger	8.000000e-07
GCST004521_121	Autism spectrum disorder or schizophrenia	3.000000e-13
GCST004521_171	Autism spectrum disorder or schizophrenia	4.000000e-14
GCST004521_2	Autism spectrum disorder or schizophrenia	2.000000e-16
GCST004521_210	Autism spectrum disorder or schizophrenia	5.000000e-15
GCST004521_263	Autism spectrum disorder or schizophrenia	7.000000e-17
GCST004521_268	Autism spectrum disorder or schizophrenia	7.000000e-12
GCST004521_269	Autism spectrum disorder or schizophrenia	7.000000e-11
GCST004521_295	Autism spectrum disorder or schizophrenia	6.000000e-18
GCST004521_3	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_44	Autism spectrum disorder or schizophrenia	2.000000e-17
GCST004521_56	Autism spectrum disorder or schizophrenia	1.000000e-22
GCST004521_70	Autism spectrum disorder or schizophrenia	8.000000e-20
GCST004521_79	Autism spectrum disorder or schizophrenia	1.000000e-16
GCST005232_23	Neuroticism	8.000000e-09
GCST006940_178	Neurociticism	2.000000e-08
GCST007993_27	Asthma (adult onset)	7.000000e-07
GCST007995_23	Asthma (childhood onset)	3.000000e-08
GCST011766_16	Chronic obstructive pulmonary disease	8.000000e-08
GCST012576_2	Tonsillitis	5.000000e-06
GCST90002384_83	Hemoglobin	4.000000e-11
GCST90002390_571	Mean corpuscular hemoglobin	4.000000e-18
GCST90002404_251	Red cell distribution width	4.000000e-25

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0003015	aggressive behavior
EFO:0007660	neuroticism measurement
EFO:1002011	adult onset asthma
EFO:0004509	hemoglobin measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, affects response to substance	3
Tetrachlorodibenzodioxin	increases expression	3
Benzo(a)pyrene	affects methylation, increases methylation, increases mutagenesis	2
dicrotophos	decreases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	increases expression	1
tobacco tar	increases expression, decreases reaction	1
diallyl disulfide	increases expression, decreases reaction	1
CGP 52608	affects binding, increases reaction	1
Capecitabine	increases response to substance	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic Trioxide	decreases response to substance	1
Air Pollutants	decreases methylation, increases abundance	1
Arsenic	affects methylation	1
Hydrogen Peroxide	affects expression	1
Nitrogen Oxides	decreases methylation, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Zinc	decreases expression	1
Cyclosporine	decreases expression	1
Okadaic Acid	increases expression	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8XQ	Ubigene HCT 116 TRIM15 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.