TRIM34

Summary

TRIM34 (tripartite motif containing 34, HGNC:10063) is a protein-coding gene on chromosome 11p15.4, encoding E3 ubiquitin-protein ligase TRIM34 (Q9BYJ4). Functions as antiviral protein and contributes to the defense against retroviral infections.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.

Source: NCBI Gene 53840 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_021616

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:10063
Approved symbol	TRIM34
Name	tripartite motif containing 34
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000258659
Ensembl biotype	protein_coding
OMIM	605684
Entrez	53840

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000429814, ENST00000491385, ENST00000495668, ENST00000514226, ENST00000870811, ENST00000870812, ENST00000870813, ENST00000870814, ENST00000930054, ENST00000970166

RefSeq mRNA: 3 — MANE Select: NM_021616 NM_001003827, NM_021616, NM_130390

CCDS: CCDS31391

Canonical transcript exons

ENST00000429814 — 8 exons

Exon	Start	End
ENSE00002102799	5625001	5625060
ENSE00003465295	5643144	5644398
ENSE00003466434	5632255	5632754
ENSE00003479821	5634631	5634861
ENSE00003492074	5633804	5633899
ENSE00003540762	5642406	5642506
ENSE00003556062	5642817	5642843
ENSE00003681796	5641167	5641189

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 90.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.8291 / max 145.4754, expressed in 1386 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112819	4.7321	1383
112820	0.0971	45

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	90.38	gold quality
leukocyte	CL:0000738	90.04	gold quality
lymph node	UBERON:0000029	84.93	gold quality
blood	UBERON:0000178	84.51	gold quality
spleen	UBERON:0002106	84.44	gold quality
placenta	UBERON:0001987	84.05	gold quality
granulocyte	CL:0000094	83.73	gold quality
vermiform appendix	UBERON:0001154	83.48	gold quality
right adrenal gland	UBERON:0001233	83.41	gold quality
right adrenal gland cortex	UBERON:0035827	83.38	gold quality
rectum	UBERON:0001052	82.19	gold quality
left adrenal gland	UBERON:0001234	82.10	gold quality
left adrenal gland cortex	UBERON:0035825	81.54	gold quality
adrenal gland	UBERON:0002369	81.52	gold quality
right uterine tube	UBERON:0001302	81.43	gold quality
calcaneal tendon	UBERON:0003701	81.19	gold quality
smooth muscle tissue	UBERON:0001135	80.93	gold quality
duodenum	UBERON:0002114	80.70	gold quality
endometrium	UBERON:0001295	80.60	gold quality
gall bladder	UBERON:0002110	79.85	gold quality
left ovary	UBERON:0002119	79.66	gold quality
ovary	UBERON:0000992	79.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.36	gold quality
right ovary	UBERON:0002118	79.22	gold quality
small intestine	UBERON:0002108	78.92	gold quality
mucosa of transverse colon	UBERON:0004991	78.90	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.85	gold quality
adrenal tissue	UBERON:0018303	78.62	gold quality
colonic epithelium	UBERON:0000397	78.59	gold quality
right lung	UBERON:0002167	78.11	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-4850	no	280.04
E-ANND-3	no	2.17

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

55 targeting TRIM34, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-12130	99.75	65.47	452
HSA-MIR-1255A	99.74	68.09	744
HSA-MIR-1255B-5P	99.74	68.16	741
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-145-3P	99.33	67.66	764
HSA-MIR-6828-5P	99.31	69.21	1433
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-3191-5P	99.24	66.52	1722
HSA-MIR-296-3P	99.21	66.56	474
HSA-MIR-146A-3P	99.13	68.99	1881

Literature-anchored findings (GeneRIF, showing 5)

• Data show there was no distinguished colocalization relationship between the complex of tripartite motif-containing protein 34 (TRIM34)-micronulei and mitochondria. (PMID:27371841)
• TRIM34 proteins contribute to the formation of MGCs. (PMID:31487507)
• TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. (PMID:32282853)
• TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. (PMID:35065966)
• TRIM34 suppresses non-small-cell lung carcinoma via inducing mTORC1-dependent glucose utilization and promoting cellular death. (PMID:38336254)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Trim34a	ENSMUSG00000056144
mus_musculus	Trim34b	ENSMUSG00000090215
rattus_norvegicus	Trim34	ENSRNOG00000042686

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

E3 ubiquitin-protein ligase TRIM34 — Q9BYJ4 (reviewed: Q9BYJ4)

Alternative names: Interferon-responsive finger protein 1, RING finger protein 21

All UniProt accessions (1): Q9BYJ4

UniProt curated annotations — full annotation on UniProt →

Function. Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for ‘Lys-63’-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells.

Subunit / interactions. Homotrimer. Interacts (via B-box and SPRY domain) with TRIM5. (Microbial infection) Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes.

Subcellular location. Cytoplasm. Mitochondrion.

Tissue specificity. Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.

Induction. Up-regulated by interferons.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the TRIM/RBCC family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BYJ4-1	1, Medium	yes
Q9BYJ4-2	2, Short

RefSeq proteins (2): NP_001003827, NP_067629* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR035826	TRIM34_PRY/SPRY	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00622, PF00643, PF15227

UniProt features (23 total): strand 4, binding site 4, sequence variant 3, splice variant 2, helix 2, zinc finger region 2, chain 1, domain 1, mutagenesis site 1, sequence conflict 1, turn 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2EGP	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BYJ4-F1	86.62	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 97; 100; 119; 125

Mutagenesis-validated functional residues (1):

Position	Phenotype
121	reduced association with trim5.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-877300	Interferon gamma signaling

MSigDB gene sets: 125 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_DEFENSE_RESPONSE_TO_VIRUS, CHEN_HOXA5_TARGETS_9HR_DN, GOBP_RESPONSE_TO_VIRUS, HOWLIN_CITED1_TARGETS_1_DN, HOWLIN_CITED1_TARGETS_2_DN, ZHENG_FOXP3_TARGETS_IN_THYMUS_UP, ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN, BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_DN

GO Biological Process (5): regulation of gene expression (GO:0010468), protein ubiquitination (GO:0016567), innate immune response (GO:0045087), defense response to virus (GO:0051607), regulation of primary metabolic process (GO:0080090)

GO Molecular Function (6): zinc ion binding (GO:0008270), identical protein binding (GO:0042802), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): cytoplasm (GO:0005737), mitochondrion (GO:0005739), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Interferon Signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoplasm	2
gene expression	1
regulation of macromolecule biosynthetic process	1
protein modification by small protein conjugation	1
immune response	1
defense response to symbiont	1
defense response	1
response to virus	1
regulation of metabolic process	1
primary metabolic process	1
transition metal ion binding	1
protein binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

588 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM34	TRAT1	Q6PIZ9	923
TRIM34	BBOX1	O75936	829
TRIM34	TNPO3	Q9Y5L0	581
TRIM34	TNPO1	Q92973	533
TRIM34	BTBD2	Q9BX70	494
TRIM34	BTBD1	Q9H0C5	494
TRIM34	TRIM56	Q9BRZ2	487
TRIM34	OR52B6	Q8NGF0	476
TRIM34	MYC	P01106	474
TRIM34	TRIM23	P36406	469
TRIM34	IKBKE	Q14164	467
TRIM34	TRIM66	O15016	448
TRIM34	PRY	O14603	447
TRIM34	TRIM28	Q13263	423
TRIM34	TRIM24	O15164	418

IntAct

8 interactions, top by confidence:

A	B	Type	Score
TRIM5	TRIM34	psi-mi:“MI:0915”(physical association)	0.550
UBE2U	TRIM34	psi-mi:“MI:0915”(physical association)	0.370
HIP2	TRIM34	psi-mi:“MI:0915”(physical association)	0.370
TRIM34	BIRC2	psi-mi:“MI:0915”(physical association)	0.370
MNAT1	TRIM34	psi-mi:“MI:0915”(physical association)	0.370
TRIM34	MKRN3	psi-mi:“MI:0915”(physical association)	0.370
TRIM34	TRIM6-TRIM34	psi-mi:“MI:0914”(association)	0.350

BioGRID (37): TRIM34 (Affinity Capture-Western), TRIM6-TRIM34 (Affinity Capture-MS), ZWINT (Affinity Capture-MS), TRIM5 (Affinity Capture-MS), TRIM6 (Affinity Capture-MS), ZBP1 (Biochemical Activity), UBE2N (Reconstituted Complex), UBE2D2 (Reconstituted Complex), TRIM34 (Affinity Capture-MS), TRIM34 (Affinity Capture-Western), ZBP1 (Affinity Capture-Western), ZBP1 (Reconstituted Complex), RIPK3 (Affinity Capture-Western), TRIM34 (Affinity Capture-MS), FASN (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, C9J1S8, I1YAP6, K7N6K2, P0CI25, P0CI26, P15533, Q0PF16, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2, Q3ZEE5, Q587N6, Q587N7, Q5BN31, Q5C8T6, Q5C8T8, Q5C8U1, Q5C8U3, Q5C8U4, Q5D7H7, Q5D7H8, Q5D7I0, Q5D7I1, Q5D7I2, Q5D7I3, Q5D7I5, Q5D7I6, Q5D7I9, Q5D7J0

Diamond homologs: A0JN74, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NK02, A6NLI5, B1H278, C9J1S8, K7N6K2, O00635, O15553, O19085, O77666, P0CI25, P0CI26, P14373, P15533, P18892, P19474, Q02084, Q0PF16, Q12899, Q13410, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q1XHU0, Q2T9Z0, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2, Q3UWZ0, Q3ZEE5, Q495X7, Q587N6, Q587N7, Q58DK8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM34	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1614 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5632734:G:GT	donor_gain	1.0000
11:5633896:G:GT	donor_gain	1.0000
11:5633933:G:GT	donor_gain	1.0000
11:5633934:A:T	donor_gain	1.0000
11:5633945:GACCT:G	donor_gain	1.0000
11:5634629:A:AG	acceptor_gain	1.0000
11:5634630:G:GG	acceptor_gain	1.0000
11:5634859:CAG:C	donor_loss	1.0000
11:5634860:AGGTA:A	donor_loss	1.0000
11:5634861:GG:G	donor_loss	1.0000
11:5634862:G:GC	donor_loss	1.0000
11:5634862:GT:G	donor_loss	1.0000
11:5620021:CAGGT:C	donor_loss	0.9900
11:5620023:GGTA:G	donor_loss	0.9900
11:5620024:G:C	donor_loss	0.9900
11:5620025:T:A	donor_loss	0.9900
11:5633897:A:T	donor_gain	0.9900
11:5633907:G:GT	donor_gain	0.9900
11:5633958:G:GT	donor_gain	0.9900
11:5633959:G:GT	donor_gain	0.9900
11:5633959:G:T	donor_gain	0.9900
11:5634629:AGTAT:A	acceptor_gain	0.9900
11:5634630:GT:G	acceptor_gain	0.9900
11:5634630:GTAT:G	acceptor_gain	0.9900
11:5634630:GTATC:G	acceptor_gain	0.9900
11:5634858:GCAG:G	donor_gain	0.9900
11:5643142:A:AG	acceptor_gain	0.9900
11:5643143:G:GG	acceptor_gain	0.9900
11:5621611:T:TA	donor_gain	0.9800
11:5621612:A:AA	donor_gain	0.9800

AlphaMissense

3229 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5643323:T:A	W361R	0.985
11:5643323:T:C	W361R	0.985
11:5643293:T:A	W351R	0.981
11:5643293:T:C	W351R	0.981
11:5643578:T:C	F446L	0.971
11:5643580:T:A	F446L	0.971
11:5643580:T:G	F446L	0.971
11:5634670:T:C	F187L	0.970
11:5634672:T:A	F187L	0.970
11:5634672:T:G	F187L	0.970
11:5643295:G:C	W351C	0.968
11:5643295:G:T	W351C	0.968
11:5643617:T:C	F459L	0.966
11:5643619:C:A	F459L	0.966
11:5643619:C:G	F459L	0.966
11:5643332:G:T	G364W	0.965
11:5643573:T:A	V444D	0.959
11:5643333:G:A	G364E	0.958
11:5643332:G:A	G364R	0.951
11:5643332:G:C	G364R	0.951
11:5643548:T:C	F436L	0.946
11:5643550:C:A	F436L	0.946
11:5643550:C:G	F436L	0.946
11:5632650:T:C	F107L	0.945
11:5632652:C:A	F107L	0.945
11:5632652:C:G	F107L	0.945
11:5643579:T:C	F446S	0.945
11:5643546:T:A	V435D	0.943
11:5643294:G:C	W351S	0.941
11:5643542:G:T	G434W	0.938

dbSNP variants (sampled 300 via entrez): RS1000011327 (11:5630522 G>T), RS1000043628 (11:5630215 A>T), RS1000139707 (11:5629996 G>A), RS1000165634 (11:5627135 T>G), RS1000205321 (11:5636909 G>A), RS1000218152 (11:5642596 C>A,T), RS1000246603 (11:5624869 T>C,G), RS1000409803 (11:5621343 TTC>T), RS1000514974 (11:5637042 G>A,T), RS1000575774 (11:5636708 A>G), RS1000622586 (11:5620359 A>G), RS1000685025 (11:5634115 A>G), RS1000725197 (11:5619801 C>G), RS1001029880 (11:5621605 T>C), RS1001045452 (11:5631636 G>C)

Disease associations

OMIM: gene MIM:605684 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55
GCST90002391_237	Mean corpuscular hemoglobin concentration	1.000000e-12
GCST90002403_238	Red blood cell count	2.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	2
Doxorubicin	decreases expression, increases expression	2
Silicon Dioxide	decreases expression	2
methylmercuric chloride	decreases expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol S	affects cotreatment, decreases expression	1
jinfukang	increases expression	1
Acetaminophen	decreases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Cisplatin	increases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, decreases expression	1
Oxygen	increases expression	1
Tretinoin	increases expression	1
Valproic Acid	increases methylation	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Aflatoxin B1	increases methylation	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1IC	Abcam A-549 TRIM34 KO 1	Cancer cell line	Male
CVCL_B2QW	Abcam A-549 TRIM34 KO 2	Cancer cell line	Male
CVCL_TU12	HAP1 TRIM34 (-) 1	Cancer cell line	Male
CVCL_TU13	HAP1 TRIM34 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.