TRIM51

Summary

TRIM51 (tripartite motif-containing 51, HGNC:19023) is a protein-coding gene on chromosome 11q12.1, encoding Tripartite motif-containing protein 51 (Q9BSJ1).

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm.

Source: NCBI Gene 84767 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_032681

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19023
Approved symbol	TRIM51
Name	tripartite motif-containing 51
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	TRIM51A
Ensembl gene	ENSG00000124900
Ensembl biotype	protein_coding
Entrez	84767

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000244891, ENST00000449290

RefSeq mRNA: 1 — MANE Select: NM_032681 NM_032681

Canonical transcript exons

ENST00000449290 — 7 exons

Exon	Start	End
ENSE00001667539	55891133	55891810
ENSE00002471399	55883297	55883384
ENSE00002497611	55888032	55888262
ENSE00002506282	55888979	55889001
ENSE00002528192	55885425	55885839
ENSE00002528791	55889942	55890039
ENSE00002528930	55886123	55886218

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 82.45.

Top tissues by expression

224 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.45	gold quality
oocyte	CL:0000023	63.00	gold quality
endothelial cell	CL:0000115	61.28	gold quality
secondary oocyte	CL:0000655	60.13	gold quality
Brodmann (1909) area 46	UBERON:0006483	55.02	gold quality
buccal mucosa cell	CL:0002336	53.20	gold quality
sperm	CL:0000019	52.50	gold quality
middle temporal gyrus	UBERON:0002771	51.92	gold quality
lower lobe of lung	UBERON:0008949	51.61	silver quality
vastus lateralis	UBERON:0001379	51.33	gold quality
quadriceps femoris	UBERON:0001377	51.08	gold quality
deltoid	UBERON:0001476	46.68	gold quality
tendon of biceps brachii	UBERON:0008188	45.50	gold quality
upper leg skin	UBERON:0004262	44.77	silver quality
saphenous vein	UBERON:0007318	44.74	gold quality
biceps brachii	UBERON:0001507	43.58	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
gingival epithelium	UBERON:0001949	42.52	gold quality
epithelium of nasopharynx	UBERON:0001951	42.01	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
entorhinal cortex	UBERON:0002728	41.28	gold quality
gingiva	UBERON:0001828	41.23	gold quality
oviduct epithelium	UBERON:0004804	41.16	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
parotid gland	UBERON:0001831	40.86	gold quality
medulla oblongata	UBERON:0001896	40.78	gold quality
medial globus pallidus	UBERON:0002477	40.77	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.77

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

15 targeting TRIM51, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3617-5P	99.75	69.41	1968
HSA-MIR-641	99.75	69.35	1975
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-4677-5P	99.70	70.09	1940
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-7156-5P	99.64	68.81	1369
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-4721	99.26	66.05	818
HSA-MIR-6739-3P	99.22	68.84	1843
HSA-MIR-6506-5P	99.04	65.66	1386
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-619-5P	98.57	64.97	1988
HSA-MIR-197-3P	98.09	69.23	1004
HSA-MIR-4314	97.50	67.30	1369

Cross-species orthologs

0 orthologs

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890), TRIM63 (ENSG00000158022)

Protein

Protein identifiers

Tripartite motif-containing protein 51 — Q9BSJ1 (reviewed: Q9BSJ1)

Alternative names: SPRY domain-containing protein 5

All UniProt accessions (1): Q9BSJ1

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the TRIM/RBCC family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BSJ1-1	1	yes
Q9BSJ1-2	2

RefSeq proteins (1): NP_116070* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00622, PF15227

UniProt features (9 total): binding site 4, zinc finger region 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BSJ1-F1	86.80	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 93; 96; 115; 121

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 15 (showing top): GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, SOX10_TARGET_GENES, MIR1252_3P, MIR6739_3P, MIR619_5P, GSE17974_IL4_AND_ANTI_IL12_VS_UNTREATED_72H_ACT_CD4_TCELL_UP, GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS, GSE34205_RSV_VS_FLU_INF_INFANT_PBMC_UP, chr11q12, GSE19772_CTRL_VS_HCMV_INF_MONOCYTES_AND_PI3K_INHIBITION_UP, GSE32034_UNTREATED_VS_ROSIGLIZATONE_TREATED_LY6C_LOW_MONOCYTE_DN, JIANG_CORE_DUPLICON_GENES

GO Biological Process (2): regulation of gene expression (GO:0010468), innate immune response (GO:0045087)

GO Molecular Function (4): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gene expression	1
regulation of macromolecule biosynthetic process	1
immune response	1
defense response to symbiont	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

432 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM51	SLC45A3	Q96JT2	588
TRIM51	TRIM56	Q9BRZ2	478
TRIM51	PRAMEF13	Q5VWM6	477
TRIM51	OR8J3	Q8NGG0	476
TRIM51	PRAMEF1	O95521	474
TRIM51	PRAMEF11	O60813	474
TRIM51	MS4A2	Q01362	471
TRIM51	GATA2	P23769	467
TRIM51	TRIM52	Q96A61	459
TRIM51	TRIM54	Q9BYV2	453
TRIM51	MS4A1	P08984	451
TRIM51	KHDC1L	Q5JSQ8	448
TRIM51	OR5F1	O95221	447
TRIM51	OR5D16	Q8NGK9	446
TRIM51	OR4A15	Q8NGL6	445

IntAct

5 interactions, top by confidence:

A	B	Type	Score
TRIM51		psi-mi:“MI:0915”(physical association)	0.370
SPRY2	TRIM51	psi-mi:“MI:0915”(physical association)	0.370
RNF40	TRIM51	psi-mi:“MI:0915”(physical association)	0.370
MAGEA11	TRIM51	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (6): TRIM51 (Two-hybrid), TRIM51 (Two-hybrid), TRIM51 (Two-hybrid), TRIM51 (Two-hybrid), TRIM51 (Two-hybrid), TRIM51 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, C9J1S8, I1YAP6, K7N6K2, P0CI25, P0CI26, P15533, Q0PF16, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2, Q3ZEE5, Q587N6, Q587N7, Q5BN31, Q5C8T6, Q5C8T8, Q5C8U1, Q5C8U3, Q5C8U4, Q5D7H7, Q5D7H8, Q5D7I0, Q5D7I1, Q5D7I2, Q5D7I3, Q5D7I5, Q5D7I6, Q5D7I9, Q5D7J0

Diamond homologs: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, B0BLU1, C9J1S8, I1YAP6, O00478, O00481, O15344, O75677, O75678, O75679, O76064, P0CI25, P0CI26, P18892, P19474, P62603, P86448, P86449, Q13410, Q2HJ46, Q3C1V9, Q3TL54, Q4KLN8, Q5EBN2, Q5PQN2, Q5R4I2, Q5R996, Q61510, Q62556, Q6INS5, Q6MFY8, Q6UX41, Q6UXE8, Q6ZWI9, Q7T308

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM51	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

617 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55888025:A:AG	acceptor_gain	1.0000
11:55888029:CAG:C	acceptor_loss	1.0000
11:55888030:A:AG	acceptor_gain	1.0000
11:55888030:AGGAT:A	acceptor_loss	1.0000
11:55888031:G:GT	acceptor_gain	1.0000
11:55888031:GGA:G	acceptor_gain	1.0000
11:55888031:GGAT:G	acceptor_gain	1.0000
11:55888031:GGATT:G	acceptor_gain	1.0000
11:55888208:A:T	donor_gain	1.0000
11:55888259:CCAG:C	donor_loss	1.0000
11:55888260:CAGG:C	donor_loss	1.0000
11:55888261:AGG:A	donor_loss	1.0000
11:55888262:GGTAT:G	donor_loss	1.0000
11:55888263:GTATG:G	donor_loss	1.0000
11:55889937:TGCA:T	acceptor_loss	1.0000
11:55889938:GCA:G	acceptor_loss	1.0000
11:55889939:CAGGT:C	acceptor_loss	1.0000
11:55889940:A:AC	acceptor_loss	1.0000
11:55889940:A:AG	acceptor_gain	1.0000
11:55889940:AG:A	acceptor_gain	1.0000
11:55889941:G:GC	acceptor_gain	1.0000
11:55889941:G:T	acceptor_loss	1.0000
11:55889941:GG:G	acceptor_gain	1.0000
11:55889941:GGT:G	acceptor_gain	1.0000
11:55889941:GGTA:G	acceptor_gain	1.0000
11:55889941:GGTAT:G	acceptor_gain	1.0000
11:55890037:GAG:G	donor_gain	1.0000
11:55890037:GAGGT:G	donor_loss	1.0000
11:55890038:AG:A	donor_gain	1.0000
11:55890038:AGG:A	donor_loss	1.0000

AlphaMissense

3036 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55891537:T:C	F422L	0.951
11:55891539:T:A	F422L	0.951
11:55891539:T:G	F422L	0.951
11:55885735:T:C	F103L	0.929
11:55885737:C:A	F103L	0.929
11:55885737:C:G	F103L	0.929
11:55891507:T:C	F412L	0.923
11:55891509:C:A	F412L	0.923
11:55891509:C:G	F412L	0.923
11:55890033:T:C	F285L	0.906
11:55890035:C:A	F285L	0.906
11:55890035:C:G	F285L	0.906
11:55891405:T:C	F378L	0.903
11:55891407:T:A	F378L	0.903
11:55891407:T:G	F378L	0.903
11:55885528:T:C	F34L	0.901
11:55885530:T:A	F34L	0.901
11:55885530:T:G	F34L	0.901
11:55891279:T:C	F336L	0.893
11:55891281:C:A	F336L	0.893
11:55891281:C:G	F336L	0.893
11:55886213:T:A	W168R	0.892
11:55886213:T:C	W168R	0.892
11:55891330:T:A	W353R	0.890
11:55891330:T:C	W353R	0.890
11:55891300:T:A	W343R	0.888
11:55891300:T:C	W343R	0.888
11:55891447:T:C	F392L	0.888
11:55891449:T:A	F392L	0.888
11:55891449:T:G	F392L	0.888

dbSNP variants (sampled 300 via entrez): RS1000275832 (11:55883237 AGAG>A), RS1000644677 (11:55882247 A>C), RS1000710829 (11:55883368 A>T), RS1001004660 (11:55887366 A>G), RS1001015383 (11:55882004 T>C), RS1001099089 (11:55887077 G>A), RS1001233696 (11:55892035 GTC>G), RS1001674651 (11:55889575 C>A), RS1001771010 (11:55889346 A>G), RS1002100038 (11:55888243 C>G,T), RS1002683892 (11:55890667 A>G), RS1003127121 (11:55885321 A>G), RS1004066743 (11:55885817 A>C,G), RS1004616734 (11:55884095 C>T), RS1005145652 (11:55886352 AC>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003225_8	Pelvic organ prolapse (moderate/severe)	5.000000e-06
GCST006916_3	Attention deficit hyperactivity disorder	4.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	2
Acetaminophen	decreases expression	1
Arsenic	affects methylation	1
Cadmium	decreases expression	1
Rifampin	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.