TRIM51G

Summary

TRIM51G (tripartite motif-containing 51G, HGNC:43972) is a protein-coding gene on chromosome 11p11.12, encoding Tripartite motif-containing protein 51G (A0A3B3IT33).

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm.

Source: NCBI Gene 120824 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• MANE Select transcript: NM_001396075

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43972
Approved symbol	TRIM51G
Name	tripartite motif-containing 51G
Location	11p11.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000220948
Ensembl biotype	protein_coding
Entrez	120824

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000534741

RefSeq mRNA: 1 — MANE Select: NM_001396075 NM_001396075

CCDS: CCDS91472

Canonical transcript exons

ENST00000534741 — 7 exons

Exon	Start	End
ENSE00002144630	48975498	48975997
ENSE00002152937	48980906	48981001
ENSE00002157045	48978872	48979102
ENSE00002165835	48978138	48978160
ENSE00002180412	48977085	48977182
ENSE00002199133	48981285	48981699
ENSE00003972279	48983739	48983885

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0075 / max 13.5061, expressed in 1 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119681	0.0075	1

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
sural nerve	UBERON:0015488	35.76	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
muscle tissue	UBERON:0002385	32.62	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
superior frontal gyrus	UBERON:0002661	29.99	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	28.34	gold quality
duodenum	UBERON:0002114	28.14	gold quality
right coronary artery	UBERON:0001625	28.00	gold quality
urinary bladder	UBERON:0001255	27.71	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.98	gold quality
monocyte	CL:0000576	26.92	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.38	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.29	gold quality
uterine cervix	UBERON:0000002	24.81	gold quality
ectocervix	UBERON:0012249	24.68	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

Tripartite motif-containing protein 51G — A0A3B3IT33 (reviewed: A0A3B3IT33)

All UniProt accessions (1): A0A3B3IT33

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the TRIM/RBCC family.

RefSeq proteins (1): NP_001383004* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00622, PF00643, PF15227

UniProt features (8 total): binding site 4, zinc finger region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A3B3IT33-F1	87.11	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 93; 96; 115; 121

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 6 (showing top): GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS, chr11p11

GO Biological Process (2): regulation of gene expression (GO:0010468), innate immune response (GO:0045087)

GO Molecular Function (4): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gene expression	1
regulation of macromolecule biosynthetic process	1
immune response	1
defense response to symbiont	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM51G	OR4A47	Q6IF82	697
TRIM51G	GAREM1	Q9H706	593
TRIM51G	GALNT18	Q6P9A2	479
TRIM51G	SLC9A9	Q8IVB4	432
TRIM51G	KALRN	O60229	370
TRIM51G	CHFR	Q96EP1	370
TRIM51G	EBF2	Q9HAK2	366
TRIM51G	TRIM56	Q9BRZ2	352
TRIM51G	TRIM52	Q96A61	349
TRIM51G	TRIM54	Q9BYV2	347
TRIM51G	VIPR2	P41587	336
TRIM51G	DAPK2	Q9UIK4	323
TRIM51G	FOLH1	Q04609	228
TRIM51G	TRIM74	Q86UV6	223
TRIM51G	TRIM73	Q86UV7	223
TRIM51G	TRIM50	Q86XT4	223

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, C9J1S8, I1YAP6, K7N6K2, P0CI25, P0CI26, P15533, Q0PF16, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2, Q3ZEE5, Q587N6, Q587N7, Q5BN31, Q5C8T6, Q5C8T8, Q5C8U1, Q5C8U3, Q5C8U4, Q5D7H7, Q5D7H8, Q5D7I0, Q5D7I1, Q5D7I2, Q5D7I3, Q5D7I5, Q5D7I6, Q5D7I9, Q5D7J0

Diamond homologs: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, B0BLU1, C9J1S8, I1YAP6, O00478, O00481, O15344, O75677, O75678, O75679, O76064, P0CI25, P0CI26, P18892, P19474, P62603, P86448, P86449, Q13410, Q2HJ46, Q3C1V9, Q3TL54, Q4KLN8, Q5EBN2, Q5PQN2, Q5R4I2, Q5R996, Q61510, Q62556, Q6INS5, Q6MFY8, Q6UX41, Q6UXE8, Q6ZWI9, Q7T308

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

3061 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:48975591:A:C	F422L	0.980
11:48975591:A:T	F422L	0.980
11:48975593:A:G	F422L	0.980
11:48975800:A:G	W353R	0.968
11:48975800:A:T	W353R	0.968
11:48975592:A:G	F422S	0.965
11:48975723:A:C	F378L	0.959
11:48975723:A:T	F378L	0.959
11:48975725:A:G	F378L	0.959
11:48975790:C:T	G356D	0.958
11:48975621:G:C	F412L	0.957
11:48975621:G:T	F412L	0.957
11:48975623:A:G	F412L	0.957
11:48975594:G:C	S421R	0.952
11:48975594:G:T	S421R	0.952
11:48975596:T:G	S421R	0.952
11:48977089:G:C	F285L	0.951
11:48977089:G:T	F285L	0.951
11:48977091:A:G	F285L	0.951
11:48981387:G:C	F103L	0.950
11:48981387:G:T	F103L	0.950
11:48981389:A:G	F103L	0.950
11:48975681:A:C	F392L	0.948
11:48975681:A:T	F392L	0.948
11:48975683:A:G	F392L	0.948
11:48975797:C:G	A354P	0.946
11:48975830:A:G	W343R	0.945
11:48975830:A:T	W343R	0.945
11:48975628:C:T	G410E	0.940
11:48978975:A:G	L212P	0.939

dbSNP variants (sampled 300 via entrez): RS1000227452 (11:48982619 C>G,T), RS1000258616 (11:48983270 T>C), RS1000857151 (11:48985109 T>C), RS1001296824 (11:48976656 A>C), RS1001811788 (11:48976884 T>C,G), RS1002233965 (11:48980616 C>G,T), RS1002263569 (11:48980806 T>A), RS1002464237 (11:48985584 T>C,G), RS1003043066 (11:48984569 A>G,T), RS1003266333 (11:48979702 A>C), RS1003644769 (11:48979424 A>C), RS1003983144 (11:48985826 G>A), RS1004206852 (11:48980830 A>T), RS1004301217 (11:48976066 G>A), RS1004496140 (11:48980681 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007094_236	Diastolic blood pressure	3.000000e-06
GCST007095_88	Systolic blood pressure	2.000000e-07
GCST007095_89	Systolic blood pressure	3.000000e-07
GCST007099_195	Systolic blood pressure	4.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.