TRIM52-AS1

Summary

TRIM52-AS1 (TRIM52 antisense RNA 1, HGNC:49006) is a long non-coding RNA gene on chromosome 5q35.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49006
Approved symbol	TRIM52-AS1
Name	TRIM52 antisense RNA 1
Location	5q35.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248275
Ensembl biotype	lncRNA
OMIM	619266
Entrez	100507602
RNAcentral	URS000075B7E7 — lncRNA, 1113 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000433265, ENST00000507434, ENST00000509252, ENST00000514146, ENST00000657194, ENST00000715342, ENST00000715343, ENST00000715344, ENST00000715345, ENST00000715346, ENST00000715347, ENST00000840385, ENST00000840386, ENST00000840387, ENST00000840388, ENST00000840389, ENST00000840390, ENST00000840391, ENST00000840392, ENST00000840393, ENST00000840394, ENST00000840395, ENST00000840396, ENST00000840397, ENST00000840398, ENST00000840399, ENST00000840400, ENST00000840401, ENST00000840402, ENST00000840403, ENST00000840404, ENST00000840405, ENST00000840406, ENST00000840407, ENST00000840408

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433265 — 3 exons

Exon	Start	End
ENSE00002046033	181263628	181263766
ENSE00002074801	181264052	181264581
ENSE00004263723	181261198	181261384

Expression profiles

Bgee: expression breadth ubiquitous, 202 present calls, max score 96.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.8885 / max 57.9624, expressed in 1764 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60693	5.7322	1724
60694	2.6918	1332
60695	0.4646	153

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	96.04	gold quality
muscle of leg	UBERON:0001383	95.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.08	gold quality
apex of heart	UBERON:0002098	91.33	gold quality
right lung	UBERON:0002167	90.89	gold quality
tibialis anterior	UBERON:0001385	90.61	silver quality
skeletal muscle tissue	UBERON:0001134	89.79	gold quality
right atrium auricular region	UBERON:0006631	89.54	gold quality
popliteal artery	UBERON:0002250	89.41	gold quality
tibial artery	UBERON:0007610	89.40	gold quality
left uterine tube	UBERON:0001303	89.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.19	gold quality
lower esophagus	UBERON:0013473	89.13	gold quality
heart left ventricle	UBERON:0002084	89.07	gold quality
left ovary	UBERON:0002119	89.06	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.75	gold quality
cardiac ventricle	UBERON:0002082	88.54	gold quality
granulocyte	CL:0000094	88.46	gold quality
body of pancreas	UBERON:0001150	88.31	gold quality
aorta	UBERON:0000947	88.28	gold quality
cardiac atrium	UBERON:0002081	88.28	gold quality
biceps brachii	UBERON:0001507	88.09	gold quality
ganglionic eminence	UBERON:0004023	88.00	gold quality
muscle tissue	UBERON:0002385	87.97	gold quality
body of uterus	UBERON:0009853	87.93	gold quality
adenohypophysis	UBERON:0002196	87.88	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	87.73	gold quality
right ovary	UBERON:0002118	87.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A. (PMID:32391716)
• Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression. (PMID:35676608)
• miR-96-5p regulates cervical cancer cell resistance to cisplatin by inhibiting lncRNA TRIM52-AS1 and promoting IGF2BP2. (PMID:36354205)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.