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TRIM67

gene
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Also known as TNL

Summary

TRIM67 (tripartite motif containing 67, HGNC:31859) is a protein-coding gene on chromosome 1q42.2, encoding Tripartite motif-containing protein 67 (Q6ZTA4).

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm.

Source: NCBI Gene 440730 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 113 total
  • MANE Select transcript: NM_001004342

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:31859
Approved symbolTRIM67
Nametripartite motif containing 67
Location1q42.2
Locus typegene with protein product
StatusApproved
AliasesTNL
Ensembl geneENSG00000119283
Ensembl biotypeprotein_coding
OMIM610584
Entrez440730

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000366653, ENST00000444294, ENST00000449018

RefSeq mRNA: 3 — MANE Select: NM_001004342 NM_001004342, NM_001300889, NM_001410937

CCDS: CCDS44333, CCDS73048, CCDS91173

Canonical transcript exons

ENST00000366653 — 10 exons

ExonStartEnd
ENSE00000793195231206652231206790
ENSE00001007663231197371231197466
ENSE00001070051231208947231209250
ENSE00001259088231200148231200258
ENSE00001291220231203867231204012
ENSE00001319216231199047231199169
ENSE00001323399231201358231201517
ENSE00001335848231213815231213977
ENSE00002091218231162058231164013
ENSE00002136608231215375231221565

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 93.39.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2123 / max 39.4772, expressed in 51 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
90430.165344
90440.047019

Top tissues by expression

222 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
cortical plateUBERON:000534393.39gold quality
parotid glandUBERON:000183184.40gold quality
nasal cavity epitheliumUBERON:000538476.65gold quality
right hemisphere of cerebellumUBERON:001489075.79gold quality
cerebellar hemisphereUBERON:000224575.72gold quality
cerebellar cortexUBERON:000212975.69gold quality
cerebellumUBERON:000203774.70gold quality
biceps brachiiUBERON:000150773.64gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450269.76gold quality
esophagus squamous epitheliumUBERON:000692067.42gold quality
ganglionic eminenceUBERON:000402366.58gold quality
postcentral gyrusUBERON:000258166.28gold quality
entorhinal cortexUBERON:000272865.48gold quality
bronchial epithelial cellCL:000232864.57gold quality
superior frontal gyrusUBERON:000266163.59gold quality
bronchusUBERON:000218563.47gold quality
mammary ductUBERON:000176563.36gold quality
cerebellar vermisUBERON:000472062.62gold quality
parietal lobeUBERON:000187262.08gold quality
ventricular zoneUBERON:000305361.17gold quality
corpus epididymisUBERON:000435960.88gold quality
prefrontal cortexUBERON:000045160.79gold quality
cauda epididymisUBERON:000436060.73gold quality
caput epididymisUBERON:000435860.32gold quality
neocortexUBERON:000195059.22gold quality
myocardiumUBERON:000234959.12gold quality
vastus lateralisUBERON:000137959.09gold quality
temporal lobeUBERON:000187158.96gold quality
frontal cortexUBERON:000187058.89gold quality
quadriceps femorisUBERON:000137758.86gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes3.92

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

246 targeting TRIM67, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-12118100.0065.881270
HSA-MIR-4510100.0066.602050
HSA-MIR-6127100.0066.762188
HSA-MIR-6129100.0066.462080
HSA-MIR-6130100.0066.692012
HSA-MIR-6133100.0066.482064
HSA-MIR-4283100.0066.422097
HSA-MIR-1252-5P100.0069.802774
HSA-MIR-4747-5P100.0067.902681
HSA-MIR-5196-5P100.0067.982761
HSA-MIR-4776-3P100.0068.731340
HSA-MIR-3689D100.0066.141181
HSA-MIR-6851-5P100.0065.631294
HSA-MIR-4476100.0068.182030
HSA-MIR-6876-5P100.0067.682126
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-450099.9972.722367
HSA-MIR-34A-5P99.9971.211784
HSA-MIR-449A99.9971.051776
HSA-MIR-607799.9968.042299
HSA-MIR-33A-5P99.9968.621055
HSA-MIR-33B-5P99.9968.581062
HSA-MIR-6759-5P99.9966.54785
HSA-MIR-186-5P99.9970.833707
HSA-MIR-453499.9966.581907
HSA-MIR-548C-3P99.9974.017587
HSA-LET-7A-5P99.9872.291790
HSA-LET-7B-5P99.9872.311790

Literature-anchored findings (GeneRIF, showing 3)

  • TRIM67 functions as a pivotal tumor suppressor in colorectal cancer.Epigenetic silencing of TRIM67 correlates with poor survival in patients with colorectal cancer.TRIM67 stabilizes p53 and activates p53 signaling pathway.TRIM67 is a direct target gene of p53. (PMID:31239268)
  • Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease. (PMID:35806477)
  • TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells. (PMID:38477606)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_rerioTRIM67ENSDARG00000108787
mus_musculusTrim67ENSMUSG00000036913
rattus_norvegicusTrim67ENSRNOG00000019024

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890), TRIM63 (ENSG00000158022)

Protein

Protein identifiers

Tripartite motif-containing protein 67 — Q6ZTA4 (reviewed: Q6ZTA4)

Alternative names: TRIM9-like protein

All UniProt accessions (2): Q6ZTA4, F8W8C1

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cytoplasm. Cytoskeleton.

Similarity. Belongs to the TRIM/RBCC family.

Isoforms (2)

UniProt IDNamesCanonical?
Q6ZTA4-31yes
Q6ZTA4-22

RefSeq proteins (3): NP_001004342, NP_001287818, NP_001397866 (=MANE)

Domains & families (InterPro)

IDNameType
IPR000315Znf_B-boxDomain
IPR001841Znf_RINGDomain
IPR001870B30.2/SPRYDomain
IPR003649Bbox_CDomain
IPR003877SPRY_domDomain
IPR003961FN3_domDomain
IPR013083Znf_RING/FYVE/PHDHomologous_superfamily
IPR013320ConA-like_dom_sfHomologous_superfamily
IPR013783Ig-like_foldHomologous_superfamily
IPR017903COS_domainDomain
IPR017907Znf_RING_CSConserved_site
IPR036116FN3_sfHomologous_superfamily
IPR043136B30.2/SPRY_sfHomologous_superfamily
IPR050617E3_ligase_FN3/SPRYFamily

Pfam: PF00041, PF00622, PF00643, PF22586

UniProt features (36 total): strand 14, binding site 4, domain 3, turn 3, zinc finger region 3, compositionally biased region 2, splice variant 2, sequence conflict 2, chain 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
7QS5X-RAY DIFFRACTION1.65

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6ZTA4-F178.780.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 303; 306; 326; 332

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 138 (showing top): BENPORATH_ES_WITH_H3K27ME3, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEUROGENESIS, GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_CELL_PROJECTION_ORGANIZATION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, ATTCTTT_MIR186, GOBP_REGULATION_OF_NEURON_PROJECTION_DEVELOPMENT, GOBP_POSITIVE_REGULATION_OF_PROTEOLYSIS, GOBP_CELL_PROJECTION_ORGANIZATION, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION

GO Biological Process (4): positive regulation of neuron projection development (GO:0010976), regulation of protein localization (GO:0032880), negative regulation of Ras protein signal transduction (GO:0046580), positive regulation of ubiquitin-dependent protein catabolic process (GO:2000060)

GO Molecular Function (3): zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
regulation of neuron projection development1
neuron projection development1
positive regulation of cell projection organization1
intracellular protein localization1
regulation of localization1
Ras protein signal transduction1
regulation of Ras protein signal transduction1
negative regulation of small GTPase mediated signal transduction1
ubiquitin-dependent protein catabolic process1
positive regulation of protein catabolic process1
regulation of ubiquitin-dependent protein catabolic process1
transition metal ion binding1
binding1
cation binding1
intracellular anatomical structure1
cellular anatomical structure1
intracellular membraneless organelle1

Protein interactions and networks

STRING

910 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
TRIM67TRIM17Q9Y577755
TRIM67BBOX1O75936744
TRIM67TRAT1Q6PIZ9591
TRIM67SNAP47Q5SQN1522
TRIM67TMEM247A6NEH6507
TRIM67TRIM59Q8IWR1450
TRIM67TRIM66O15016442
TRIM67CRIPTQ9P021437
TRIM67ATP6V1E2Q96A05431
TRIM67RCOR3Q9P2K3430
TRIM67UNC13AQ9UPW8428
TRIM67FAM89AQ96GI7424
TRIM67VASPP50552420
TRIM67RCOR2Q8IZ40414
TRIM67TSNAXQ99598410

IntAct

3 interactions, top by confidence:

ABTypeScore
DISC1TRIM67psi-mi:“MI:0915”(physical association)0.000
EXOC1TRIM67psi-mi:“MI:0915”(physical association)0.000

BioGRID (4996): DCC (Affinity Capture-Western), TP53 (Affinity Capture-Western), MDM2 (Affinity Capture-Western), TP53 (Reconstituted Complex), TRIM67 (Affinity Capture-Western), CORO1A (Affinity Capture-Western), MYO16 (Affinity Capture-Western), SIPA1L1 (Affinity Capture-Western), GRIP1 (Affinity Capture-Western), KIF1A (Affinity Capture-Western), EXOC1 (Affinity Capture-Western), VCP (Affinity Capture-Western), TRIM67 (Affinity Capture-Western), Tanc2 (Affinity Capture-MS), Pex5 (Affinity Capture-MS)

ESM2 similar proteins: A4I9M7, A8HNV0, A8ICS9, A8ID74, A8IF44, A8IRK7, A8ITV9, A8J1V4, A8JAF2, A8JAN3, A8JBB2, A8JFU2, C4YBE4, D3ZX63, D4P3R7, P04292, P04293, P07917, P07918, P09854, P36702, P46870, P52824, P89453, Q3V1N1, Q4Q3F0, Q505D9, Q53JI9, Q5Z6X0, Q6T5K3, Q6Z690, Q6ZTA4, Q750K9, Q755E4, Q756C3, Q758T2, Q759I2, Q75AH9, Q7F239, Q8GSP8

Diamond homologs: A0A0G2JXN2, A0JN74, A0JPQ4, A5D7F8, A5D8S5, A6NGJ6, A6NI03, B6VQ60, E1BD59, F6ZQ54, G3X8Y1, O60858, P15533, P86449, Q03601, Q1ACD6, Q1ACD7, Q28E95, Q29RQ5, Q2KHN1, Q2YEM8, Q2YEM9, Q32L60, Q38HM4, Q3TL54, Q3ZEE5, Q503I2, Q505D9, Q5C8T6, Q5C8T8, Q5C8U3, Q5D7H7, Q5D7I2, Q5D7I3, Q5EBN2, Q5M7V1, Q5M929, Q5PQN5, Q5RBR0, Q5RKG6

SIGNOR signaling

1 interactions.

AEffectBMechanism
Ub:E2“up-regulates activity”TRIM67ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance108
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1752 predictions. Top by Δscore:

VariantEffectΔscore
1:231197366:TTCA:Tacceptor_loss1.0000
1:231197368:CA:Cacceptor_loss1.0000
1:231197369:A:ACacceptor_loss1.0000
1:231197369:A:AGacceptor_gain1.0000
1:231197370:G:GGacceptor_gain1.0000
1:231197370:GGCAC:Gacceptor_gain1.0000
1:231199024:A:AGacceptor_gain1.0000
1:231199025:A:Gacceptor_gain1.0000
1:231199028:A:AGacceptor_gain1.0000
1:231199029:A:Gacceptor_gain1.0000
1:231199035:A:AGacceptor_gain1.0000
1:231199168:AGGT:Adonor_loss1.0000
1:231199170:G:GCdonor_loss1.0000
1:231199171:T:Adonor_loss1.0000
1:231200145:CAGAT:Cacceptor_loss1.0000
1:231200146:A:AGacceptor_gain1.0000
1:231200146:AGAT:Aacceptor_gain1.0000
1:231200146:AGATG:Aacceptor_gain1.0000
1:231200147:G:GTacceptor_gain1.0000
1:231200147:GA:Gacceptor_gain1.0000
1:231200147:GAT:Gacceptor_gain1.0000
1:231200147:GATG:Gacceptor_gain1.0000
1:231200147:GATGG:Gacceptor_gain1.0000
1:231200255:ACAG:Adonor_loss1.0000
1:231200257:AGGTG:Adonor_loss1.0000
1:231200259:G:Tdonor_loss1.0000
1:231203862:C:Aacceptor_gain1.0000
1:231203865:A:AGacceptor_gain1.0000
1:231203865:AGT:Aacceptor_gain1.0000
1:231203866:G:GTacceptor_gain1.0000

AlphaMissense

5091 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
1:231162983:T:CL5P1.000
1:231162988:T:AC7S1.000
1:231162988:T:CC7R1.000
1:231162989:G:AC7Y1.000
1:231162989:G:CC7S1.000
1:231162990:T:GC7W1.000
1:231162997:T:AC10S1.000
1:231162997:T:CC10R1.000
1:231162998:G:AC10Y1.000
1:231162998:G:CC10S1.000
1:231162998:G:TC10F1.000
1:231162999:C:GC10W1.000
1:231163019:C:AP17H1.000
1:231163028:T:CL20P1.000
1:231163033:T:AC22S1.000
1:231163033:T:CC22R1.000
1:231163034:G:AC22Y1.000
1:231163034:G:CC22S1.000
1:231163035:T:GC22W1.000
1:231163039:C:GH24D1.000
1:231163046:T:AV26D1.000
1:231163048:T:AC27S1.000
1:231163048:T:CC27R1.000
1:231163049:G:AC27Y1.000
1:231163049:G:CC27S1.000
1:231163050:C:GC27W1.000
1:231163057:T:AC30S1.000
1:231163057:T:CC30R1.000
1:231163058:G:AC30Y1.000
1:231163058:G:CC30S1.000

dbSNP variants (sampled 300 via entrez): RS1000004184 (1:231179577 A>C), RS1000004698 (1:231212471 T>C,G), RS1000014726 (1:231215393 T>C), RS1000026850 (1:231174504 T>A,G), RS1000063461 (1:231204854 A>G), RS1000100261 (1:231179880 G>A,C), RS1000128462 (1:231167634 T>C), RS1000163427 (1:231161615 T>C), RS1000174337 (1:231190603 C>T), RS1000185166 (1:231200838 A>C,T), RS1000251376 (1:231195393 G>A), RS1000348062 (1:231185076 G>A), RS1000488725 (1:231210856 T>A), RS1000650617 (1:231169523 C>T), RS1000681623 (1:231169303 C>T)

Disease associations

OMIM: gene MIM:610584 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST001762_143Obesity-related traits4.000000e-07
GCST007622_3Impulsivity1.000000e-06
GCST007637_55Diffusing capacity of carbon monoxide8.000000e-06
GCST012048_22Triglyceride levels3.000000e-08

EFO canonical traits (4, from GWAS)

EFO IDTrait name
EFO:0004810interleukin-6 measurement
EFO:0006946behavioural disinhibition measurement
EFO:0009369diffusing capacity of the lung for carbon monoxide
EFO:0004530triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Aincreases expression2
arseniteaffects binding, decreases reaction, increases methylation2
aristolochic acid Iincreases expression1
butyraldehydedecreases expression1
nutlin 3affects cotreatment, increases expression1
abrineincreases expression1
Resveratrolaffects cotreatment, decreases expression1
Benzo(a)pyreneincreases methylation1
Camptothecinincreases expression1
Cisplatinincreases expression1
Dactinomycinaffects cotreatment, increases expression1
Niclosamideincreases expression1
Plant Extractsaffects cotreatment, decreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 74

This page pulls from 74 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot