TRIM73

Summary

TRIM73 (tripartite motif containing 73, HGNC:18162) is a protein-coding gene on chromosome 7q11.23, encoding Tripartite motif-containing protein 73 (Q86UV7).

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Located in cytosol.

Source: NCBI Gene 375593 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 5 total
• MANE Select transcript: NM_198924

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18162
Approved symbol	TRIM73
Name	tripartite motif containing 73
Location	7q11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000178809
Ensembl biotype	protein_coding
OMIM	612549
Entrez	375593

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000323819, ENST00000430211, ENST00000447409, ENST00000450434, ENST00000463766, ENST00000483979, ENST00000862514

RefSeq mRNA: 1 — MANE Select: NM_198924 NM_198924

CCDS: CCDS34665

Canonical transcript exons

ENST00000323819 — 5 exons

Exon	Start	End
ENSE00002438342	75403645	75403740
ENSE00002439922	75395629	75395810
ENSE00002507097	75398916	75399332
ENSE00002514412	75404839	75405069
ENSE00003573105	75405182	75405605

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 86.19.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	86.19	gold quality
body of stomach	UBERON:0001161	86.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.16	gold quality
cerebellar hemisphere	UBERON:0002245	83.79	gold quality
cerebellar cortex	UBERON:0002129	83.69	gold quality
cerebellum	UBERON:0002037	83.68	gold quality
right uterine tube	UBERON:0001302	83.47	gold quality
right testis	UBERON:0004534	83.34	gold quality
left testis	UBERON:0004533	83.15	gold quality
stomach	UBERON:0000945	83.11	gold quality
mucosa of stomach	UBERON:0001199	82.56	gold quality
testis	UBERON:0000473	81.90	gold quality
body of pancreas	UBERON:0001150	78.96	gold quality
left uterine tube	UBERON:0001303	78.76	gold quality
endocervix	UBERON:0000458	77.97	gold quality
left ovary	UBERON:0002119	76.97	gold quality
right ovary	UBERON:0002118	76.88	gold quality
body of uterus	UBERON:0009853	76.77	gold quality
cortex of kidney	UBERON:0001225	76.60	gold quality
tibial nerve	UBERON:0001323	76.49	gold quality
right lobe of liver	UBERON:0001114	76.48	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.32	gold quality
ovary	UBERON:0000992	75.94	gold quality
right adrenal gland cortex	UBERON:0035827	75.92	gold quality
stromal cell of endometrium	CL:0002255	75.87	gold quality
spleen	UBERON:0002106	75.42	gold quality
uterine cervix	UBERON:0000002	75.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.13	gold quality
skin of leg	UBERON:0001511	75.00	gold quality
left adrenal gland cortex	UBERON:0035825	75.00	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-111727	no	282.17
E-GEOD-124858	no	10.70
E-ANND-3	no	2.04

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting TRIM73, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-3059-5P	99.70	69.93	2491
HSA-MIR-6832-5P	99.58	64.82	1132
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-484	98.16	66.92	1074
HSA-MIR-6511B-5P	97.98	65.64	823
HSA-MIR-6811-5P	97.98	64.96	848
HSA-MIR-3137	97.26	66.78	761
HSA-MIR-6858-3P	96.37	64.41	771

Literature-anchored findings (GeneRIF, showing 1)

• Maps within the critical region of Williams-Beuren syndrome. (PMID:18398435)

Cross-species orthologs

0 orthologs

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

Tripartite motif-containing protein 73 — Q86UV7 (reviewed: Q86UV7)

Alternative names: Tripartite motif-containing protein 50B

All UniProt accessions (4): Q86UV7, C9JQH3, I3L0H3, J3KQW6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the TRIM/RBCC family.

RefSeq proteins (1): NP_944606* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR027370	Znf-RING_euk	Domain
IPR050143	TRIM/RBCC	Family

Pfam: PF00643, PF13445

UniProt features (9 total): binding site 4, zinc finger region 2, coiled-coil region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UV7-F1	88.56	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 89; 92; 111; 117

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 26 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, chr7q11, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, ZWANG_EGF_INTERVAL_UP, SRC_UP.V1_DN, PAF1_TARGET_GENES, GSE12366_GC_VS_MEMORY_BCELL_DN, MIR6811_5P, MIR6511B_5P, MIR3137, KANNAN_BLOOD_2012_2013_TIV_AGE_65PLS_REVACCINATED_IN_6_9_MO_VS_REVACCINATED_IN_12_13_MO_UP

GO Biological Process (1): innate immune response (GO:0045087)

GO Molecular Function (3): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), metal ion binding (GO:0046872)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
immune response	1
defense response to symbiont	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
cation binding	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

342 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM73	BBOX1	O75936	777
TRIM73	ALKAL1	Q6UXT8	540
TRIM73	TRIM56	Q9BRZ2	459
TRIM73	TRIM52	Q96A61	435
TRIM73	F5GXT2	F5GXT2	431
TRIM73	FAM86C1P	Q9NVL1	419
TRIM73	TMEM270	Q6UE05	418
TRIM73	TRIM40	Q6P9F5	418
TRIM73	RNF113B	Q8IZP6	417
TRIM73	SPANXN5	Q5MJ07	404
TRIM73	RNF207	Q6ZRF8	382
TRIM73	LRRC41	Q15345	377
TRIM73	TRIM3	O75382	372
TRIM73	RFPL4A	A6NLU0	357
TRIM73	TRIML1	Q8N9V2	357

IntAct

3 interactions, top by confidence:

A	B	Type	Score
TRIM73	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.400
ECE1	TRIM73	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (21): TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid), TRIM73 (Two-hybrid)

ESM2 similar proteins: A0JPQ4, E1BD59, O15197, P0C0K6, P62603, Q14142, Q1XH17, Q1XH18, Q3UWZ0, Q5BK82, Q5JZY3, Q5M929, Q5NCC3, Q5RBG2, Q5RKG6, Q5TM55, Q5W0U4, Q640S6, Q6P6S3, Q6PGR9, Q6PJ69, Q6ZMU5, Q7TPM3, Q7YR32, Q80VI1, Q80X56, Q80YW5, Q810I1, Q810I2, Q865W2, Q86UV6, Q86UV7, Q86XT4, Q8BFW4, Q8BVW3, Q8BYG9, Q8C006, Q8C0E3, Q8IUD6, Q8K243

Diamond homologs: A0A3B3IT33, A0JN74, A4QPC6, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, A6NLU0, B1H278, B6VQ60, C9J1S8, D4ABM4, F6ZQ54, F8VTS6, I1YAP6, O00478, O00481, O15344, O70583, O75677, O75678, O75679, O76064, P0CI25, P0CI26, P18892, P19474, P82458, P86448, P86449, Q02398, Q03605, Q13410, Q14258, Q1L5Z9, Q1XHT8, Q2HJ46, Q2T9Z0, Q3TL54

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM73	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

1641 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:75399228:T:C	F99L	0.977
7:75399230:C:A	F99L	0.977
7:75399230:C:G	F99L	0.977
7:75404878:T:C	F179L	0.957
7:75404880:C:A	F179L	0.957
7:75404880:C:G	F179L	0.957
7:75405061:T:C	F240L	0.953
7:75405063:C:A	F240L	0.953
7:75405063:C:G	F240L	0.953
7:75405185:T:C	F244L	0.940
7:75405187:C:A	F244L	0.940
7:75405187:C:G	F244L	0.940
7:75399000:T:C	F23L	0.906
7:75399002:C:A	F23L	0.906
7:75399002:C:G	F23L	0.906
7:75403727:G:C	R161P	0.897
7:75399255:T:C	C108R	0.884
7:75399209:C:A	H92Q	0.878
7:75399209:C:G	H92Q	0.878
7:75399229:T:C	F99S	0.871
7:75399293:C:A	H120Q	0.863
7:75399293:C:G	H120Q	0.863
7:75403733:G:C	R163P	0.859
7:75399332:G:C	K133N	0.858
7:75399332:G:T	K133N	0.858
7:75399264:T:A	C111S	0.856
7:75399265:G:C	C111S	0.856
7:75399256:G:A	C108Y	0.853
7:75399284:C:A	H117Q	0.851
7:75399284:C:G	H117Q	0.851

dbSNP variants (sampled 300 via entrez): RS111656303 (7:75402415 G>A,T), RS111923502 (7:75401667 T>C), RS112340704 (7:75399739 T>C), RS112493146 (7:75398245 T>C), RS112728736 (7:75396500 G>A), RS113249493 (7:75397849 A>C,G), RS113406400 (7:75398282 T>C), RS1156312055 (7:75396419 G>A,T), RS1156445621 (7:75401119 A>G), RS1156746632 (7:75405619 G>A), RS1156849793 (7:75402632 C>A,T), RS1157357336 (7:75394706 C>T), RS1157629921 (7:75395668 T>A), RS1158231926 (7:75397679 G>A,C), RS1158475184 (7:75396099 C>T)

Disease associations

OMIM: gene MIM:612549 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation, affects cotreatment	5
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
3,4-dichloroaniline	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, decreases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, increases expression, decreases expression	1
licochalcone B	increases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases expression	1
Diuron	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.