TRIM75

Summary

TRIM75 (tripartite motif containing 75, HGNC:32686) is a protein-coding gene on chromosome 4q32.3, encoding Tripartite motif-containing protein 75 (A6NK02). May play a role in female meiosis.

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in female meiosis I; innate immune response; and regulation of gene expression. Located in extracellular space.

Source: NCBI Gene 391714 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001396070

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32686
Approved symbol	TRIM75
Name	tripartite motif containing 75
Location	4q32.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000250374
Ensembl biotype	protein_coding
Entrez	391714

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000503032

RefSeq mRNA: 1 — MANE Select: NM_001396070 NM_001396070

CCDS: CCDS47160

Canonical transcript exons

ENST00000503032 — 2 exons

Exon	Start	End
ENSE00002050460	165058800	165060554
ENSE00003840661	165053866	165053948

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 81.30.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.30	gold quality
placenta	UBERON:0001987	43.57	gold quality
bone marrow cell	CL:0002092	40.38	gold quality
cortical plate	UBERON:0005343	40.10	gold quality
ganglionic eminence	UBERON:0004023	37.24	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	37.16	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
mucosa of stomach	UBERON:0001199	35.23	gold quality
bone marrow	UBERON:0002371	35.02	gold quality
islet of Langerhans	UBERON:0000006	34.28	silver quality
right uterine tube	UBERON:0001302	34.23	gold quality
liver	UBERON:0002107	33.53	gold quality
primary visual cortex	UBERON:0002436	33.18	gold quality
monocyte	CL:0000576	32.81	gold quality
duodenum	UBERON:0002114	32.59	gold quality
superior frontal gyrus	UBERON:0002661	32.49	gold quality
calcaneal tendon	UBERON:0003701	32.38	gold quality
leukocyte	CL:0000738	32.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	32.07	gold quality
right lobe of liver	UBERON:0001114	31.37	gold quality
prefrontal cortex	UBERON:0000451	30.99	gold quality
right ovary	UBERON:0002118	30.86	gold quality
left uterine tube	UBERON:0001303	30.56	silver quality
ovary	UBERON:0000992	30.38	gold quality
rectum	UBERON:0001052	30.33	gold quality
lymph node	UBERON:0000029	30.32	gold quality
blood	UBERON:0000178	30.30	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

Tripartite motif-containing protein 75 — A6NK02 (reviewed: A6NK02)

All UniProt accessions (1): A6NK02

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in female meiosis.

Subcellular location. Cytoplasm. Cytoskeleton. Spindle.

Similarity. Belongs to the TRIM/RBCC family.

RefSeq proteins (1): NP_001382999* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR006574	PRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR035785	SPRY/PRY_TRIM75	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00622, PF00643, PF13765, PF15227

UniProt features (9 total): binding site 4, zinc finger region 2, chain 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NK02-F1	86.08	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 97; 100; 119; 125

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 26 (showing top): chr4q32, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_ORGANELLE_FISSION, GOBP_FEMALE_GAMETE_GENERATION, GOBP_MEIOTIC_CELL_CYCLE_PROCESS, GOCC_SPINDLE, GOBP_MEIOTIC_CELL_CYCLE, GOBP_CELL_CYCLE_PROCESS, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_DN, GOBP_FEMALE_MEIOTIC_NUCLEAR_DIVISION, GOBP_FEMALE_MEIOSIS_I, GOBP_MEIOSIS_I_CELL_CYCLE_PROCESS

GO Biological Process (3): female meiosis I (GO:0007144), regulation of gene expression (GO:0010468), innate immune response (GO:0045087)

GO Molecular Function (4): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (5): obsolete extracellular space (GO:0005615), nucleus (GO:0005634), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membraneless organelle	2
meiosis I	1
female meiotic nuclear division	1
female gamete generation	1
meiotic cell cycle	1
gene expression	1
regulation of macromolecule biosynthetic process	1
immune response	1
defense response to symbiont	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
microtubule cytoskeleton	1

Protein interactions and networks

STRING

228 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM75	AMN1	Q8IY45	627
TRIM75	FBXO33	Q7Z6M2	611
TRIM75	ZFAND5	O76080	569
TRIM75	TRIM42	Q8IWZ5	447
TRIM75	TRIM36	Q9NQ86	435
TRIM75	TRIM47	Q96LD4	303
TRIM75	CMYA5	Q8N3K9	293
TRIM75	PRY	O14603	289
TRIM75	TRIM24	O15164	284
TRIM75	BBOX1	O75936	281
TRIM75	GPATCH11	Q8N954	275
TRIM75	UBA5	Q9GZZ9	272
TRIM75	TRIM37	O94972	268
TRIM75	TRIM33	Q9UPN9	263
TRIM75	KIAA1328	Q86T90	252

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A0G2JMD5, A0A0J9YX57, A2A368, A2A9R3, A6NCF6, A6NK02, A8MXT2, D9I2F9, D9I2G3, D9I2H0, O15479, O15480, O15481, O60809, O95521, P14373, P25233, P43355, P43356, P43357, P43358, P43360, P43361, P43362, P43363, P43364, P43365, P43366, Q2LKU9, Q2LKW6, Q4R998, Q5PPP4, Q5SWL7, Q62191, Q6AY37, Q6AZZ1, Q8BQR7, Q8BVP1, Q8K243, Q8N7X4

Diamond homologs: A0A0R4I9Y1, A0A0R4IBK5, A6NK02, B6VQ60, E9Q555, F4I443, Q63HN8, A0JN74, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, B1H278, C9J1S8, K7N6K2, O00635, O15553, O19085, O77666, P0CI25, P0CI26, P14373, P15533, P18892, P19474, Q02084, Q0PF16, Q12899, Q13410, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q1XHU0, Q2T9Z0, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM75	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

3103 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:165060067:T:C	L307P	0.977
4:165060228:T:A	W361R	0.973
4:165060228:T:C	W361R	0.973
4:165060198:T:A	W351R	0.969
4:165060198:T:C	W351R	0.969
4:165060195:T:C	F350L	0.968
4:165060197:C:A	F350L	0.968
4:165060197:C:G	F350L	0.968
4:165060160:T:A	V338D	0.965
4:165060021:T:C	F292L	0.961
4:165060023:T:A	F292L	0.961
4:165060023:T:G	F292L	0.961
4:165060231:G:C	A362P	0.960
4:165059250:T:C	F35L	0.955
4:165059252:C:A	F35L	0.955
4:165059252:C:G	F35L	0.955
4:165060141:T:C	F332L	0.949
4:165060143:T:A	F332L	0.949
4:165060143:T:G	F332L	0.949
4:165059466:T:C	F107L	0.948
4:165059468:C:A	F107L	0.948
4:165059468:C:G	F107L	0.948
4:165060423:T:C	F426L	0.948
4:165060425:C:A	F426L	0.948
4:165060425:C:G	F426L	0.948
4:165060471:T:C	F442L	0.944
4:165060473:T:A	F442L	0.944
4:165060473:T:G	F442L	0.944
4:165060393:T:C	F416L	0.942
4:165060395:C:A	F416L	0.942

dbSNP variants (sampled 300 via entrez): RS1000030799 (4:165058618 T>C), RS1000640004 (4:165060185 T>G), RS1000754329 (4:165054386 G>C), RS1000981478 (4:165058961 G>A,T), RS1001488269 (4:165053243 T>C,G), RS1001769891 (4:165055525 C>T), RS1002385631 (4:165057462 G>A), RS1002819064 (4:165056715 A>T), RS1002990598 (4:165055943 T>C), RS10030636 (4:165057616 C>T), RS1003662305 (4:165052206 T>C), RS1004005695 (4:165060862 G>A), RS1004048071 (4:165054664 T>C), RS1004218812 (4:165058091 T>C), RS1004284273 (4:165053912 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	1
Cadmium	increases expression, increases abundance	1
Cadmium Chloride	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.