TRIM77

Summary

TRIM77 (tripartite motif containing 77, HGNC:34228) is a protein-coding gene on chromosome 11q14.3, encoding Tripartite motif-containing protein 77 (I1YAP6).

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm.

Source: NCBI Gene 390231 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 80 total
• MANE Select transcript: NM_001146162

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34228
Approved symbol	TRIM77
Name	tripartite motif containing 77
Location	11q14.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000214414
Ensembl biotype	protein_coding
Entrez	390231

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000398290, ENST00000534392

RefSeq mRNA: 2 — MANE Select: NM_001146162 NM_001146162, NM_001271942

CCDS: CCDS60929

Canonical transcript exons

ENST00000398290 — 6 exons

Exon	Start	End
ENSE00001532516	89711410	89711505
ENSE00001532518	89710299	89710709
ENSE00003684119	89717379	89717872
ENSE00003757720	89715158	89715180
ENSE00003760169	89715890	89715987
ENSE00003760260	89714192	89714422

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 57.57.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.57	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	37.14	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
liver	UBERON:0002107	30.30	gold quality
prefrontal cortex	UBERON:0000451	29.89	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
corpus callosum	UBERON:0002336	28.99	gold quality
monocyte	CL:0000576	28.40	gold quality
leukocyte	CL:0000738	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.50	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.04	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
right lobe of liver	UBERON:0001114	24.84	gold quality
muscle of leg	UBERON:0001383	24.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (80): MID2 (ENSG00000080561), TRIM9 (ENSG00000100505), MID1 (ENSG00000101871), MEFV (ENSG00000103313), TRIM35 (ENSG00000104228), TRIM14 (ENSG00000106785), TRIM37 (ENSG00000108395), TRIM2 (ENSG00000109654), TRIM3 (ENSG00000110171), TRIM38 (ENSG00000112343), TRIM62 (ENSG00000116525), TRIM67 (ENSG00000119283), TRIM32 (ENSG00000119401), BSPRY (ENSG00000119411), TRIM25 (ENSG00000121060), TRIM6 (ENSG00000121236), TRIM24 (ENSG00000122779), TRIM51 (ENSG00000124900), TRIM28 (ENSG00000130726), TRIM21 (ENSG00000132109), TRIM5 (ENSG00000132256), TRIM22 (ENSG00000132274), TRIM47 (ENSG00000132481), TRIM45 (ENSG00000134253), TRIM29 (ENSG00000137699), TRIM54 (ENSG00000138100), PML (ENSG00000140464), TRIM65 (ENSG00000141569), TRIM43B (ENSG00000144010), TRIM43 (ENSG00000144015), TRIM7 (ENSG00000146054), TRIM41 (ENSG00000146063), TRIM50 (ENSG00000146755), TRIM4 (ENSG00000146833), TRIM55 (ENSG00000147573), TRIM48 (ENSG00000150244), TRIM36 (ENSG00000152503), TRIM11 (ENSG00000154370), TRIM74 (ENSG00000155428), TRIM42 (ENSG00000155890)

Protein

Protein identifiers

Tripartite motif-containing protein 77 — I1YAP6 (reviewed: I1YAP6)

All UniProt accessions (2): I1YAP6, S4R3H6

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the TRIM/RBCC family.

RefSeq proteins (2): NP_001139634, NP_001258871 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000315	Znf_B-box	Domain
IPR001841	Znf_RING	Domain
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR003879	Butyrophylin_SPRY	Domain
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017907	Znf_RING_CS	Conserved_site
IPR018957	Znf_C3HC4_RING-type	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050143	TRIM/RBCC	Family

Pfam: PF00097, PF00622

UniProt features (8 total): binding site 4, zinc finger region 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-I1YAP6-F1	82.10	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 93; 96; 115; 121

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 6 (showing top): GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOMF_ACYLTRANSFERASE_ACTIVITY, GOMF_AMINOACYLTRANSFERASE_ACTIVITY, GOMF_UBIQUITIN_LIKE_PROTEIN_LIGASE_ACTIVITY, chr11q14, GOBP_BIOLOGICAL_PROCESS_INVOLVED_IN_INTERSPECIES_INTERACTION_BETWEEN_ORGANISMS

GO Biological Process (2): regulation of gene expression (GO:0010468), innate immune response (GO:0045087)

GO Molecular Function (4): zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
gene expression	1
regulation of macromolecule biosynthetic process	1
immune response	1
defense response to symbiont	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
cation binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

202 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIM77	TRIM42	Q8IWZ5	502
TRIM77	FAM153A	Q9UHL3	480
TRIM77	ZNF396	Q96N95	473
TRIM77	TRIM52	Q96A61	421
TRIM77	TRIM55	Q9BYV6	419
TRIM77	TRIM59	Q8IWR1	404
TRIM77	TRIM14	Q14142	370
TRIM77	ANKRD20A4P	Q4UJ75	353
TRIM77	TRIM23	P36406	348
TRIM77	TRIM67	Q6ZTA4	324
TRIM77	TRIM47	Q96LD4	322
TRIM77	FRG1	Q14331	311
TRIM77	TRIM54	Q9BYV2	293
TRIM77	TRIM56	Q9BRZ2	293
TRIM77	TRIM74	Q86UV6	278

IntAct

2 interactions, top by confidence:

A	B	Type	Score
TRIM77	H2BC5	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): HIST1H2BD (Proximity Label-MS)

ESM2 similar proteins: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, C9J1S8, I1YAP6, K7N6K2, P0CI25, P0CI26, P15533, Q0PF16, Q1ACD5, Q1ACD6, Q1ACD7, Q1ACD8, Q2YEM8, Q2YEM9, Q2YEN0, Q2YEN2, Q3ZEE5, Q587N6, Q587N7, Q5BN31, Q5C8T6, Q5C8T8, Q5C8U1, Q5C8U3, Q5C8U4, Q5D7H7, Q5D7H8, Q5D7I0, Q5D7I1, Q5D7I2, Q5D7I3, Q5D7I5, Q5D7I6, Q5D7I9, Q5D7J0

Diamond homologs: A0A3B3IT33, A6NCK2, A6NDI0, A6NGJ6, A6NI03, A6NLI5, B0BLU1, C9J1S8, I1YAP6, O00478, O00481, O15344, O75677, O75678, O75679, O76064, P0CI25, P0CI26, P18892, P19474, P62603, P86448, P86449, Q13410, Q2HJ46, Q3C1V9, Q3TL54, Q4KLN8, Q5EBN2, Q5PQN2, Q5R4I2, Q5R996, Q61510, Q62556, Q6INS5, Q6MFY8, Q6UX41, Q6UXE8, Q6ZWI9, Q7T308

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	TRIM77	ubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

920 predictions. Top by Δscore:

Variant	Effect	Δscore
11:89711501:GGGAA:G	donor_gain	1.0000
11:89711502:GGAAG:G	donor_gain	1.0000
11:89711503:G:GT	donor_gain	1.0000
11:89711503:G:T	donor_gain	1.0000
11:89711506:G:GG	donor_gain	1.0000
11:89711510:GCA:G	donor_gain	1.0000
11:89711513:G:GG	donor_gain	1.0000
11:89715884:TTGCA:T	acceptor_loss	1.0000
11:89715885:TGCA:T	acceptor_loss	1.0000
11:89715888:A:AG	acceptor_gain	1.0000
11:89715888:A:G	acceptor_loss	1.0000
11:89715888:AG:A	acceptor_gain	1.0000
11:89715889:G:GG	acceptor_gain	1.0000
11:89715889:G:GT	acceptor_loss	1.0000
11:89715889:GG:G	acceptor_gain	1.0000
11:89715889:GGA:G	acceptor_gain	1.0000
11:89715889:GGAAT:G	acceptor_gain	1.0000
11:89715985:GAG:G	donor_gain	1.0000
11:89715986:AGG:A	donor_loss	1.0000
11:89711502:GGAA:G	donor_gain	0.9900
11:89711503:GAA:G	donor_gain	0.9900
11:89715889:GGAA:G	acceptor_gain	0.9900
11:89717137:G:GG	donor_gain	0.9900
11:89717377:A:AG	acceptor_gain	0.9900
11:89717378:G:GG	acceptor_gain	0.9900
11:89717378:GT:G	acceptor_gain	0.9900
11:89717378:GTGT:G	acceptor_gain	0.9900
11:89711408:A:AG	acceptor_gain	0.9800
11:89711409:G:GG	acceptor_gain	0.9800
11:89717136:A:AG	donor_gain	0.9800

AlphaMissense

3018 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:89717777:T:C	F420L	0.975
11:89717779:T:A	F420L	0.975
11:89717779:T:G	F420L	0.975
11:89717747:T:C	F410L	0.970
11:89717749:C:A	F410L	0.970
11:89717749:C:G	F410L	0.970
11:89717548:G:C	W343C	0.964
11:89717548:G:T	W343C	0.964
11:89717546:T:A	W343R	0.959
11:89717546:T:C	W343R	0.959
11:89717576:T:A	W353R	0.957
11:89717576:T:C	W353R	0.957
11:89717849:T:C	F444L	0.947
11:89717851:C:A	F444L	0.947
11:89717851:C:G	F444L	0.947
11:89717586:G:A	G356E	0.941
11:89717774:A:C	S419R	0.936
11:89717776:C:A	S419R	0.936
11:89717776:C:G	S419R	0.936
11:89717645:T:C	F376L	0.933
11:89717647:T:A	F376L	0.933
11:89717647:T:G	F376L	0.933
11:89717778:T:C	F420S	0.929
11:89717547:G:C	W343S	0.917
11:89717543:T:G	Y342D	0.916
11:89710398:T:C	F34L	0.912
11:89710400:T:A	F34L	0.912
11:89710400:T:G	F34L	0.912
11:89717578:G:C	W353C	0.912
11:89717578:G:T	W353C	0.912

dbSNP variants (sampled 300 via entrez): RS1000428182 (11:89717023 T>C), RS1000574934 (11:89712321 C>T), RS1001033665 (11:89718235 G>A,C,T), RS1001147514 (11:89717274 T>C), RS1001374289 (11:89717601 C>G), RS1001416271 (11:89711327 C>G), RS1002363746 (11:89712403 A>G), RS1002823162 (11:89712719 T>G), RS1003415426 (11:89714131 C>T), RS1004547371 (11:89717935 T>G), RS1004654719 (11:89711651 T>C), RS1004770625 (11:89711363 A>G), RS1005654692 (11:89713127 C>A), RS1005770807 (11:89712777 G>A), RS1007988683 (11:89708631 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST007998_24	Intraocular pressure	3.000000e-07
GCST012020_222	Serum metabolite levels	6.000000e-20

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.