TRINGS

Summary

TRINGS (TP53 regulated inhibitor of necrosis under glucose starvation, HGNC:53614) is a long non-coding RNA gene on chromosome 4q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53614
Approved symbol	TRINGS
Name	TP53 regulated inhibitor of necrosis under glucose starvation
Location	4q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251095
Ensembl biotype	lncRNA
Entrez	144093370

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 48 lncRNA

ENST00000506864, ENST00000507916, ENST00000508021, ENST00000509723, ENST00000512077, ENST00000513572, ENST00000612706, ENST00000621944, ENST00000659714, ENST00000659878, ENST00000689416, ENST00000691837, ENST00000776682, ENST00000776683, ENST00000776684, ENST00000776685, ENST00000776686, ENST00000776687, ENST00000776688, ENST00000776689, ENST00000776690, ENST00000776691, ENST00000776692, ENST00000776693, ENST00000776694, ENST00000776695, ENST00000776696, ENST00000776697, ENST00000776698, ENST00000776699, ENST00000776700, ENST00000776701, ENST00000776702, ENST00000776703, ENST00000776704, ENST00000776705, ENST00000776706, ENST00000776707, ENST00000776708, ENST00000776709, ENST00000776710, ENST00000776711, ENST00000776712, ENST00000776713, ENST00000776714, ENST00000776715, ENST00000776716, ENST00000776717

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000506864 — 4 exons

Exon	Start	End
ENSE00002034930	89627782	89627917
ENSE00002037728	89691285	89691373
ENSE00002062646	89587821	89587940
ENSE00002081314	89551356	89551570

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 98.19.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	98.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.08	gold quality
placenta	UBERON:0001987	80.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.69	gold quality
skin of abdomen	UBERON:0001416	76.80	gold quality
prostate gland	UBERON:0002367	75.75	gold quality
zone of skin	UBERON:0000014	74.43	gold quality
ganglionic eminence	UBERON:0004023	74.00	gold quality
testis	UBERON:0000473	73.69	gold quality
left testis	UBERON:0004533	73.30	gold quality
skin of leg	UBERON:0001511	72.95	gold quality
right testis	UBERON:0004534	72.91	gold quality
adenohypophysis	UBERON:0002196	71.81	gold quality
bone marrow	UBERON:0002371	70.91	gold quality
sural nerve	UBERON:0015488	70.33	gold quality
skeletal muscle tissue	UBERON:0001134	69.62	gold quality
pituitary gland	UBERON:0000007	68.79	gold quality
colonic epithelium	UBERON:0000397	68.79	silver quality
tibial nerve	UBERON:0001323	66.34	gold quality
blood	UBERON:0000178	65.31	gold quality
monocyte	CL:0000576	64.45	gold quality
islet of Langerhans	UBERON:0000006	64.18	gold quality
ventricular zone	UBERON:0003053	63.27	gold quality
corpus callosum	UBERON:0002336	61.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.42	gold quality
lower esophagus mucosa	UBERON:0035834	61.13	gold quality
prefrontal cortex	UBERON:0000451	59.78	gold quality
vagina	UBERON:0000996	59.78	gold quality
myometrium	UBERON:0001296	59.43	gold quality
endocervix	UBERON:0000458	59.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	7.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.