TRIQK

Summary

TRIQK (triple QxxK/R motif containing, HGNC:27828) is a protein-coding gene on chromosome 8q22.1, encoding Triple QxxK/R motif-containing protein (Q629K1). May play a role in cell growth and maintenance of cell morphology.

Predicted to be located in endoplasmic reticulum membrane.

Source: NCBI Gene 286144 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 22 total
• MANE Select transcript: NM_001171797

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27828
Approved symbol	TRIQK
Name	triple QxxK/R motif containing
Location	8q22.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp779L1068, PRO0845, LOC286144
Ensembl gene	ENSG00000205133
Ensembl biotype	protein_coding
Entrez	286144

Gene structure

Transcript identifiers

Ensembl transcripts: 53 — 46 protein_coding, 5 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000378861, ENST00000517540, ENST00000517751, ENST00000517858, ENST00000518400, ENST00000518748, ENST00000519069, ENST00000519792, ENST00000519969, ENST00000520384, ENST00000520430, ENST00000520686, ENST00000521617, ENST00000521988, ENST00000522903, ENST00000522925, ENST00000523060, ENST00000523375, ENST00000523580, ENST00000524037, ENST00000524107, ENST00000524260, ENST00000537541, ENST00000884571, ENST00000884572, ENST00000884573, ENST00000884574, ENST00000884575, ENST00000884576, ENST00000884577, ENST00000884578, ENST00000884579, ENST00000884580, ENST00000884581, ENST00000884582, ENST00000884583, ENST00000884584, ENST00000884585, ENST00000884586, ENST00000884587, ENST00000884588, ENST00000884589, ENST00000923118, ENST00000923119, ENST00000923120, ENST00000923121, ENST00000971347, ENST00000971348, ENST00000971349, ENST00000971350, ENST00000971351, ENST00000971352, ENST00000971353

RefSeq mRNA: 7 — MANE Select: NM_001171797 NM_001171795, NM_001171796, NM_001171797, NM_001171798, NM_001171799, NM_001191035, NM_001191036

CCDS: CCDS55261

Canonical transcript exons

ENST00000521988 — 5 exons

Exon	Start	End
ENSE00001479063	92954406	92954564
ENSE00002093361	92916929	92917010
ENSE00002113664	92883534	92886735
ENSE00002122882	92966007	92966144
ENSE00003524421	92891989	92892074

Expression profiles

Bgee: expression breadth ubiquitous, 247 present calls, max score 95.02.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.3892 / max 302.5516, expressed in 1728 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93957	9.9899	1653
93954	6.5521	1556
93953	3.8585	1375
93955	2.0128	1080
93956	0.9108	589
93952	0.6556	375
93951	0.3393	140
93959	0.0636	16
93960	0.0066	5

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epithelial cell of pancreas	CL:0000083	95.02	gold quality
islet of Langerhans	UBERON:0000006	94.73	gold quality
cortical plate	UBERON:0005343	94.31	gold quality
adrenal tissue	UBERON:0018303	93.79	gold quality
left ventricle myocardium	UBERON:0006566	93.37	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.30	gold quality
calcaneal tendon	UBERON:0003701	92.68	gold quality
germinal epithelium of ovary	UBERON:0001304	92.51	gold quality
Brodmann (1909) area 23	UBERON:0013554	91.83	gold quality
tibia	UBERON:0000979	91.72	gold quality
gall bladder	UBERON:0002110	91.17	gold quality
monocyte	CL:0000576	91.15	gold quality
middle temporal gyrus	UBERON:0002771	90.68	gold quality
leukocyte	CL:0000738	90.59	gold quality
myocardium	UBERON:0002349	89.98	gold quality
parietal pleura	UBERON:0002400	89.74	gold quality
kidney epithelium	UBERON:0004819	89.52	silver quality
rectum	UBERON:0001052	89.15	gold quality
ganglionic eminence	UBERON:0004023	89.09	gold quality
bronchial epithelial cell	CL:0002328	88.95	gold quality
palpebral conjunctiva	UBERON:0001812	88.89	gold quality
medial globus pallidus	UBERON:0002477	88.82	gold quality
Brodmann (1909) area 46	UBERON:0006483	88.79	gold quality
bronchus	UBERON:0002185	88.55	gold quality
endothelial cell	CL:0000115	88.53	gold quality
ileal mucosa	UBERON:0000331	88.46	gold quality
globus pallidus	UBERON:0001875	88.33	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.89	gold quality
primary visual cortex	UBERON:0002436	87.79	gold quality
corpus callosum	UBERON:0002336	87.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

180 targeting TRIQK, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AA	99.96	70.64	3753

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	triqk	ENSDARG00000076296
mus_musculus	Triqk	ENSMUSG00000055963
rattus_norvegicus	Triqk	ENSRNOG00000039924

Protein

Protein identifiers

Triple QxxK/R motif-containing protein — Q629K1 (reviewed: Q629K1)

Alternative names: Triple repetitive-sequence of QXXK/R protein homolog

All UniProt accessions (5): A0A1Y8EM41, E5RG44, E5RGJ1, E5RIT1, Q629K1

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in cell growth and maintenance of cell morphology.

Subcellular location. Endoplasmic reticulum membrane.

Similarity. Belongs to the TRIQK family.

RefSeq proteins (7): NP_001165266, NP_001165267, NP_001165268, NP_001165269, NP_001165270, NP_001177964, NP_001177965 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024842	TRIQK	Family

Pfam: PF15168

UniProt features (2 total): chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q629K1-F1	74.72	0.13

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 102 (showing top): GOZGIT_ESR1_TARGETS_DN, chr8q22, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP, MEISSNER_ES_ICP_WITH_H3K4ME3, MEISSNER_NPC_ICP_WITH_H3K4ME3, MEISSNER_BRAIN_ICP_WITH_H3K4ME3, KOYAMA_SEMA3B_TARGETS_DN, GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN, FORTSCHEGGER_PHF8_TARGETS_DN, NKX2_2_TARGET_GENES, ZNF407_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

220 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRIQK	OR5AU1	Q8NGC0	570
TRIQK	FBLL1	A6NHQ2	452
TRIQK	MFSD2B	A6NFX1	445
TRIQK	RTL8B	Q17RB0	441
TRIQK	RNASEK	Q6P5S7	433
TRIQK	THSD1	Q9NS62	425
TRIQK	TMEM51	Q9NW97	410
TRIQK	C9JE84	C9JE84	400
TRIQK	SERTM1	A2A2V5	380
TRIQK	CDC42EP5	Q6NZY7	374
TRIQK	NPTXR	O95502	374
TRIQK	FEZ2	Q9UHY8	374
TRIQK	CFAP44	Q96MT7	370
TRIQK	PCDHGA9	Q9Y5G4	366
TRIQK	PPEF2	O14830	350

IntAct

2 interactions, top by confidence:

A	B	Type	Score
SLC30A10	GOLIM4	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): TRIQK (Affinity Capture-RNA), TRIQK (Positive Genetic), TRIQK (Cross-Linking-MS (XL-MS)), TRIQK (Cross-Linking-MS (XL-MS)), TRIQK (Affinity Capture-MS), TRIQK (Proximity Label-MS), TRIQK (Proximity Label-MS), TRIQK (Proximity Label-MS)

ESM2 similar proteins: A2VDA9, A4IG59, A5WVU9, B0BN56, B0WN94, B2B9D9, B2B9E1, B3DHH5, C5DIL2, F4HVZ5, O22912, P52870, P52871, P82925, P92204, Q09JL7, Q0IFA9, Q22472, Q28DN4, Q42841, Q53HL2, Q553P6, Q56JY4, Q5EB66, Q5I030, Q5RBS5, Q5RDR6, Q5U4A3, Q5ZKA6, Q60ZR7, Q61733, Q629K1, Q68EU0, Q6AXW0, Q6AZH0, Q6CJX5, Q7PH91, Q8J2P4, Q8SY72, Q8VY39

Diamond homologs: A5WVU9, B2B9D9, B2B9E1, Q5EB66, Q5RDR6, Q629K1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

22 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	15
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2709 predictions. Top by Δscore:

Variant	Effect	Δscore
8:92892308:C:CT	acceptor_gain	1.0000
8:92916923:GCTTA:G	donor_loss	1.0000
8:92916924:CTTA:C	donor_loss	1.0000
8:92916925:TT:T	donor_loss	1.0000
8:92916926:TA:T	donor_loss	1.0000
8:92916927:A:AC	donor_gain	1.0000
8:92916927:A:T	donor_loss	1.0000
8:92916928:C:CA	donor_loss	1.0000
8:92916928:C:CC	donor_gain	1.0000
8:92954561:CTTA:C	acceptor_gain	1.0000
8:92891983:GTTTA:G	donor_loss	0.9900
8:92891984:TTTA:T	donor_loss	0.9900
8:92891985:TTACC:T	donor_loss	0.9900
8:92891986:TACCT:T	donor_loss	0.9900
8:92891987:A:C	donor_loss	0.9900
8:92891988:C:CA	donor_loss	0.9900
8:92892074:CCTAG:C	acceptor_loss	0.9900
8:92892075:C:CC	acceptor_gain	0.9900
8:92892076:T:A	acceptor_loss	0.9900
8:92892161:A:AC	donor_gain	0.9900
8:92892162:C:CC	donor_gain	0.9900
8:92892219:TGTC:T	donor_gain	0.9900
8:92916928:CCAA:C	donor_gain	0.9900
8:92916928:CCAAT:C	donor_gain	0.9900
8:92917006:GCCTG:G	acceptor_gain	0.9900
8:92917007:CCTGC:C	acceptor_gain	0.9900
8:92917008:CTG:C	acceptor_gain	0.9900
8:92917009:TG:T	acceptor_gain	0.9900
8:92930628:G:C	donor_gain	0.9900
8:92954528:C:CT	acceptor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000024676 (8:92943832 T>C), RS1000025671 (8:92987904 A>G), RS1000032715 (8:92900726 C>A), RS1000037489 (8:93018214 T>C), RS1000091729 (8:92997803 T>C,G), RS1000094811 (8:92945189 C>A), RS1000104421 (8:92929575 C>T), RS1000133063 (8:92908125 A>C), RS1000133408 (8:92953604 G>A), RS1000141007 (8:92950032 A>G), RS1000194285 (8:92981841 A>C,G), RS1000214688 (8:92950384 A>C), RS1000226831 (8:93014433 A>G), RS1000262970 (8:92891642 C>A), RS1000284090 (8:92925948 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST006994_2	Logical memory (immediate recall) in Alzheimer’s disease dementia	4.000000e-07
GCST007576_259	Chronotype	9.000000e-12
GCST007626_6	Lack of perseverance	7.000000e-07
GCST010307_8	Urinary albumin excretion	2.000000e-08
GCST010550_2	Acute ischemic stroke x type 2 diabetes interaction	3.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004874	memory performance
EFO:0008328	chronotype measurement
EFO:0006946	behavioural disinhibition measurement
EFO:0004285	albuminuria

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
bisphenol A	affects cotreatment, increases expression	1
sodium arsenite	decreases expression	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
jinfukang	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Zoledronic Acid	increases expression	1
Leflunomide	increases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	decreases expression	1
Catechin	affects cotreatment, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Gallic Acid	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Methyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.