TRMT1L

Summary

TRMT1L (tRNA methyltransferase 1L, HGNC:16782) is a protein-coding gene on chromosome 1q25.3, encoding tRNA (guanine(27)-N(2))-dimethyltransferase (Q7Z2T5). Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups.

This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene.

Source: NCBI Gene 81627 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 94 total
• Druggable target: yes
• MANE Select transcript: NM_030934

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16782
Approved symbol	TRMT1L
Name	tRNA methyltransferase 1L
Location	1q25.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000121486
Ensembl biotype	protein_coding
OMIM	611673
Entrez	81627

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000367506, ENST00000458395, ENST00000465827, ENST00000487028, ENST00000860206, ENST00000860207, ENST00000860208, ENST00000860209, ENST00000913481, ENST00000913482, ENST00000942796

RefSeq mRNA: 2 — MANE Select: NM_030934 NM_001202423, NM_030934

CCDS: CCDS1366

Canonical transcript exons

ENST00000367506 — 15 exons

Exon	Start	End
ENSE00000822938	185137606	185137796
ENSE00000822939	185139367	185139579
ENSE00000822940	185139973	185140222
ENSE00000922197	185143357	185143436
ENSE00000922198	185143906	185144029
ENSE00001597691	185118101	185120271
ENSE00001814009	185156478	185156953
ENSE00003462891	185128669	185128747
ENSE00003540966	185124944	185125110
ENSE00003553794	185147182	185147246
ENSE00003562080	185151825	185151935
ENSE00003617390	185120383	185120509
ENSE00003625965	185150379	185150492
ENSE00003645260	185123857	185123919
ENSE00003686644	185145439	185145568

Expression profiles

Bgee: expression breadth ubiquitous, 279 present calls, max score 93.51.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.5218 / max 100.4753, expressed in 1782 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16291	9.3801	1780
16290	0.1417	46

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	93.51	gold quality
buccal mucosa cell	CL:0002336	92.70	gold quality
epithelium of bronchus	UBERON:0002031	91.33	gold quality
germinal epithelium of ovary	UBERON:0001304	90.96	gold quality
bronchus	UBERON:0002185	90.73	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	90.67	gold quality
biceps brachii	UBERON:0001507	90.64	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	89.70	gold quality
trabecular bone tissue	UBERON:0002483	89.45	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.18	gold quality
testis	UBERON:0000473	88.76	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.76	gold quality
left testis	UBERON:0004533	88.76	gold quality
caput epididymis	UBERON:0004358	88.68	gold quality
right testis	UBERON:0004534	88.59	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.08	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.53	gold quality
gastrocnemius	UBERON:0001388	87.44	gold quality
muscle of leg	UBERON:0001383	87.38	gold quality
muscle organ	UBERON:0001630	87.23	gold quality
vastus lateralis	UBERON:0001379	87.16	gold quality
endothelial cell	CL:0000115	87.06	gold quality
secondary oocyte	CL:0000655	86.71	gold quality
quadriceps femoris	UBERON:0001377	86.68	gold quality
skeletal muscle tissue	UBERON:0001134	86.61	gold quality
islet of Langerhans	UBERON:0000006	86.53	gold quality
stromal cell of endometrium	CL:0002255	86.23	gold quality
calcaneal tendon	UBERON:0003701	85.98	gold quality
amniotic fluid	UBERON:0000173	85.92	gold quality
corpus epididymis	UBERON:0004359	85.59	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.30
E-GEOD-100618	no	89.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

91 targeting TRMT1L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-3671	99.90	73.04	3897

Literature-anchored findings (GeneRIF, showing 2)

• Includes the identification of the C1orf25 gene. (PMID:11318611)
• Functional characterization of the mouse C1orf25 ortholog and comparison to the human protein. (PMID:17198746)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	trmt1l	ENSDARG00000042057
mus_musculus	Trmt1l	ENSMUSG00000053286
rattus_norvegicus	Trmt1l	ENSRNOG00000002580

Paralogs (1): TRMT1 (ENSG00000104907)

Protein

Protein identifiers

tRNA (guanine(27)-N(2))-dimethyltransferase — Q7Z2T5 (reviewed: Q7Z2T5)

Alternative names: tRNA methyltransferase 1-like protein

All UniProt accessions (2): Q7Z2T5, X6RK96

UniProt curated annotations — full annotation on UniProt →

Function. Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups. Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons. Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs.

Subcellular location. Nucleus. Nucleolus.

Tissue specificity. Widely expressed.

Similarity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7Z2T5-1	1	yes
Q7Z2T5-2	2

RefSeq proteins (2): NP_001189352, NP_112196* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002905	Trm1	Family
IPR013087	Znf_C2H2_type	Domain
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily
IPR042296	tRNA_met_Trm1_C	Homologous_superfamily

Pfam: PF02005

Catalyzed reactions (Rhea), 1 shown:

• guanosine(27) in tRNA(Tyr) + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(27) in tRNA(Tyr) + 2 S-adenosyl-L-homocysteine + 2 H(+) (RHEA:83895)

UniProt features (28 total): binding site 8, modified residue 4, compositionally biased region 3, splice variant 2, mutagenesis site 2, sequence conflict 2, chain 1, domain 1, zinc finger region 1, cross-link 1, sequence variant 1, region of interest 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z2T5-F1	73.62	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 357; 358; 488; 491; 513; 515; 260; 307

Post-translational modifications (5): 26, 66, 612, 707, 585

Mutagenesis-validated functional residues (2):

Position	Phenotype
135–139	abolished nucleolar localization.
373	abolished trna guanine-dimethyltransferase activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 128 (showing top): TGCGCANK_UNKNOWN, GOBP_TRNA_METABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, RACCACAR_AML_Q6, GOBP_RNA_METHYLATION, PATIL_LIVER_CANCER, TCF4_Q5, GOBP_RNA_MODIFICATION, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_TRNA_METHYLATION, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP, AML1_01, RGAGGAARY_PU1_Q6, ACEVEDO_LIVER_CANCER_UP

GO Biological Process (3): tRNA N2-guanine methylation (GO:0002940), tRNA processing (GO:0008033), methylation (GO:0032259)

GO Molecular Function (9): tRNA binding (GO:0000049), RNA binding (GO:0003723), zinc ion binding (GO:0008270), tRNA (guanine(27)-N2)-dimethyltransferase activity (GO:0160248), protein binding (GO:0005515), methyltransferase activity (GO:0008168), tRNA (guanine) methyltransferase activity (GO:0016423), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleolus (GO:0005730)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
tRNA methylation	1
RNA processing	1
tRNA metabolic process	1
metabolic process	1
RNA binding	1
nucleic acid binding	1
transition metal ion binding	1
N-methyltransferase activity	1
tRNA (guanine) methyltransferase activity	1
binding	1
transferase activity, transferring one-carbon groups	1
tRNA methyltransferase activity	1
S-adenosylmethionine-dependent methyltransferase activity	1
catalytic activity	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1826 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRMT1L	CCDC90B	Q9GZT6	557
TRMT1L	THUMPD2	Q9BTF0	539
TRMT1L	SWT1	Q5T5J6	520
TRMT1L	METTL1	Q9UBP6	509
TRMT1L	FTSJ1	Q9UET6	495
TRMT1L	MRM3	Q9HC36	464
TRMT1L	IVNS1ABP	Q9Y6Y0	459
TRMT1L	ZNF574	Q6ZN55	451
TRMT1L	NSUN2	Q08J23	448
TRMT1L	TPK1	Q9H3S4	447
TRMT1L	TRMT1	Q9NXH9	443
TRMT1L	TRMT11	Q7Z4G4	441
TRMT1L	FTCD	O95954	441
TRMT1L	TRMT2B	Q96GJ1	441
TRMT1L	TMX1	Q9H3N1	430

IntAct

156 interactions, top by confidence:

A	B	Type	Score
POLR3GL	POLR3A	psi-mi:“MI:0914”(association)	0.730
HSPD1	NUDT19	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MAPK7	PFDN6	psi-mi:“MI:0914”(association)	0.640
POLR3K	POLR3A	psi-mi:“MI:0914”(association)	0.640
TRMT1L	GTF2B	psi-mi:“MI:0915”(physical association)	0.560
PLEKHO1	UBA6	psi-mi:“MI:0914”(association)	0.530
MECP2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
HEATR3	SLC27A2	psi-mi:“MI:0914”(association)	0.530
ZSCAN31	DHX57	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
FOXM1	PES1	psi-mi:“MI:0914”(association)	0.500
TRMT1L	HNRNPK	psi-mi:“MI:0915”(physical association)	0.400
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
Srp72		psi-mi:“MI:0914”(association)	0.350
Rrbp1	PIPSL	psi-mi:“MI:0914”(association)	0.350
PKN2	TMUB1	psi-mi:“MI:0914”(association)	0.350
HNRNPU		psi-mi:“MI:0914”(association)	0.350

BioGRID (241): TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), NTPCR (Co-fractionation), TCEA1 (Co-fractionation), TRMT1L (Co-fractionation), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS), TRMT1L (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IXF6, A0A1L8HU22, A0JMD0, A0JMU5, A2RSY6, A5D7S3, A5WW08, A6NNW6, A9LLI8, E9PUQ8, F1LW30, F4HS99, O75460, P0C218, P26374, P79457, Q12789, Q16760, Q1LWH4, Q2I6J1, Q2T9V5, Q3B7T1, Q3KR54, Q496Z9, Q4R6C7, Q5FWP4, Q5R5T0, Q5ZLG9, Q64398, Q6GQV7, Q6NVF4, Q6NZP1, Q6P2P2, Q6P5D8, Q6PJI9, Q6UXZ4, Q7Z2T5, Q7ZXF1, Q8C0M0, Q8C5W4

Diamond homologs: A1RV26, A2SRK9, A3CW75, A3MTQ5, A4FZY5, A4WMB7, A4YHH9, A5D7S3, A5UM08, A6UUN6, A6VIL5, A7I9E9, A9A871, B0R713, B1YCV9, B6YUU9, B8GF12, B9LSI7, C3MPR5, C3MYQ9, C3N5E1, C3NDZ5, C3NHQ8, C4KH07, C5A6N2, O27258, O29443, O59493, O67010, P0CW64, P0CW65, P15565, P20300, P57705, P57706, P81554, Q12Y46, Q18EA0, Q2FN43, Q2NI56

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 190 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RNA Polymerase III Chain Elongation	12	53.2×	1e-16
RNA Polymerase III Transcription Termination	12	41.7×	1e-15
RNA Polymerase III Transcription Initiation From Type 2 Promoter	13	38.5×	6e-16
RNA Polymerase III Transcription Initiation From Type 1 Promoter	13	37.1×	6e-16
RNA Polymerase III Transcription Initiation From Type 3 Promoter	13	37.1×	6e-16
RNA Polymerase III Transcription Initiation	13	30.5×	9e-15
RNA Polymerase III Transcription	13	29.7×	1e-14
Cytosolic sensors of pathogen-associated DNA	13	25.9×	7e-14

GO biological processes:

GO term	Partners	Fold	FDR
transcription by RNA polymerase III	5	21.8×	5e-04
negative regulation of mRNA splicing, via spliceosome	5	21.8×	5e-04
ribosomal large subunit biogenesis	8	20.2×	1e-06
cytoplasmic translation	18	18.9×	3e-15
DNA damage checkpoint signaling	5	11.1×	7e-03
translation	18	10.5×	6e-11
ribosomal small subunit biogenesis	8	10.3×	2e-04
rRNA processing	12	9.7×	1e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

94 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	76
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2366 predictions. Top by Δscore:

Variant	Effect	Δscore
1:185120267:TTAAC:T	acceptor_gain	1.0000
1:185120268:TAAC:T	acceptor_gain	1.0000
1:185120270:ACCT:A	acceptor_loss	1.0000
1:185120271:CCT:C	acceptor_loss	1.0000
1:185120272:C:CC	acceptor_gain	1.0000
1:185120272:C:T	acceptor_loss	1.0000
1:185120381:A:AC	donor_gain	1.0000
1:185120382:C:CC	donor_gain	1.0000
1:185123853:ATACC:A	donor_loss	1.0000
1:185123854:TA:T	donor_loss	1.0000
1:185123855:A:C	donor_loss	1.0000
1:185123856:C:G	donor_loss	1.0000
1:185123917:CTT:C	acceptor_gain	1.0000
1:185123920:C:CC	acceptor_gain	1.0000
1:185123927:A:AC	acceptor_gain	1.0000
1:185123927:A:C	acceptor_gain	1.0000
1:185123933:C:CT	acceptor_gain	1.0000
1:185123934:A:T	acceptor_gain	1.0000
1:185124197:G:C	donor_gain	1.0000
1:185124202:A:AC	donor_gain	1.0000
1:185124203:C:CC	donor_gain	1.0000
1:185124939:GTCAC:G	donor_loss	1.0000
1:185124942:A:AC	donor_loss	1.0000
1:185124943:C:CT	donor_loss	1.0000
1:185124943:CCTTG:C	donor_gain	1.0000
1:185124984:A:AC	donor_gain	1.0000
1:185124985:C:CC	donor_gain	1.0000
1:185124997:CACT:C	donor_gain	1.0000
1:185125106:TTGAC:T	acceptor_gain	1.0000
1:185125109:ACCT:A	acceptor_loss	1.0000

AlphaMissense

4825 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:185120194:C:G	R676P	1.000
1:185120195:G:T	R676S	1.000
1:185120201:C:G	G674R	1.000
1:185128678:C:T	G528E	1.000
1:185128679:C:G	G528R	1.000
1:185128679:C:T	G528R	1.000
1:185128718:A:G	C515R	1.000
1:185128722:A:C	C513W	1.000
1:185128723:C:T	C513Y	1.000
1:185128724:A:G	C513R	1.000
1:185137637:T:A	R494S	1.000
1:185137637:T:G	R494S	1.000
1:185137646:A:C	C491W	1.000
1:185137647:C:A	C491F	1.000
1:185137647:C:G	C491S	1.000
1:185137647:C:T	C491Y	1.000
1:185137648:A:G	C491R	1.000
1:185137648:A:T	C491S	1.000
1:185137655:A:C	C488W	1.000
1:185137656:C:A	C488F	1.000
1:185137656:C:G	C488S	1.000
1:185137656:C:T	C488Y	1.000
1:185137657:A:G	C488R	1.000
1:185137657:A:T	C488S	1.000
1:185139487:T:A	D401V	1.000
1:185120158:A:G	L688P	0.999
1:185120170:A:G	F684S	0.999
1:185120185:G:T	A679E	0.999
1:185120195:G:C	R676G	0.999
1:185120200:C:T	G674D	0.999

dbSNP variants (sampled 300 via entrez): RS1000010247 (1:185131643 C>A), RS1000038501 (1:185157720 T>C), RS1000112858 (1:185158068 A>G), RS1000138030 (1:185157436 C>T), RS1000291428 (1:185119045 T>C), RS1000347798 (1:185152171 T>C), RS1000425304 (1:185145669 T>C), RS1000426905 (1:185139661 A>C,G), RS1000540831 (1:185133710 G>A), RS1000741394 (1:185118723 T>C), RS1000770141 (1:185126697 C>T), RS1000772306 (1:185118467 A>C), RS1000831688 (1:185132434 G>A), RS1000849668 (1:185147654 C>T), RS1000971544 (1:185140359 C>A,T)

Disease associations

OMIM: gene MIM:611673 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005830_34	Hand grip strength	3.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006941	grip strength measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066260 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.81	Kd	15.36	nM	CHEMBL5653589
7.81	ED50	15.36	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149661: Binding affinity to human TRMT1L incubated for 45 mins by Kinobead based pull down assay	kd	0.0154	uM

CTD chemical–gene interactions

54 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	decreases expression, affects cotreatment	2
mercuric bromide	decreases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Valproic Acid	decreases methylation, increases expression	2
Cyclosporine	decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
methylmercuric chloride	decreases expression	1
deoxynivalenol	increases expression	1
decabromobiphenyl ether	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
tetrabromobisphenol A	decreases expression	1
perfluorooctanoic acid	increases expression	1
coumarin	increases phosphorylation	1
nivalenol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
ICG 001	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
hexabrominated diphenyl ether 153	decreases expression	1
jinfukang	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652703	Binding	Binding affinity to human TRMT1L incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.