TRMT61B

Summary

TRMT61B (tRNA methyltransferase 61B, HGNC:26070) is a protein-coding gene on chromosome 2p23.2, encoding tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (Q9BVS5). Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC).

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine(58)-N1)-methyltransferase activity. Involved in mRNA processing and mitochondrial tRNA processing. Located in mitochondrial matrix.

Source: NCBI Gene 55006 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 97 total
• MANE Select transcript: NM_017910

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26070
Approved symbol	TRMT61B
Name	tRNA methyltransferase 61B
Location	2p23.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20628
Ensembl gene	ENSG00000171103
Ensembl biotype	protein_coding
OMIM	619404
Entrez	55006

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000306108, ENST00000419999, ENST00000439947, ENST00000484060, ENST00000490390, ENST00000873366, ENST00000873367, ENST00000873368, ENST00000873369, ENST00000922653, ENST00000922654, ENST00000949006

RefSeq mRNA: 1 — MANE Select: NM_017910 NM_017910

CCDS: CCDS1768

Canonical transcript exons

ENST00000306108 — 7 exons

Exon	Start	End
ENSE00001155029	28851072	28851298
ENSE00001155047	28865017	28865119
ENSE00001660532	28849821	28850242
ENSE00001751691	28869579	28870309
ENSE00003568206	28850328	28850405
ENSE00003576038	28852408	28852499
ENSE00003616980	28861118	28861308

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 91.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.1548 / max 99.6345, expressed in 1789 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27572	15.1548	1789

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	91.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.77	gold quality
oocyte	CL:0000023	89.15	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.25	gold quality
heart right ventricle	UBERON:0002080	88.17	gold quality
cerebellar hemisphere	UBERON:0002245	86.28	gold quality
cerebellar cortex	UBERON:0002129	86.27	gold quality
heart left ventricle	UBERON:0002084	86.06	gold quality
cardiac ventricle	UBERON:0002082	85.97	gold quality
cortical plate	UBERON:0005343	85.80	gold quality
ventricular zone	UBERON:0003053	85.73	gold quality
jejunal mucosa	UBERON:0000399	85.70	gold quality
left adrenal gland cortex	UBERON:0035825	85.59	gold quality
left adrenal gland	UBERON:0001234	85.50	gold quality
cerebellum	UBERON:0002037	85.44	gold quality
right adrenal gland	UBERON:0001233	85.32	gold quality
ganglionic eminence	UBERON:0004023	85.30	gold quality
right adrenal gland cortex	UBERON:0035827	85.17	gold quality
duodenum	UBERON:0002114	85.11	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.11	gold quality
nephron tubule	UBERON:0001231	85.07	gold quality
adrenal cortex	UBERON:0001235	84.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.97	gold quality
adrenal gland	UBERON:0002369	84.87	gold quality
mammary duct	UBERON:0001765	84.85	gold quality
gastrocnemius	UBERON:0001388	84.77	gold quality
renal glomerulus	UBERON:0000074	84.72	gold quality
muscle of leg	UBERON:0001383	84.59	gold quality
biceps brachii	UBERON:0001507	84.59	gold quality
metanephric glomerulus	UBERON:0004736	84.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

44 targeting TRMT61B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-6079	99.84	68.54	1170
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-199A-3P	99.75	70.48	929
HSA-MIR-199B-3P	99.75	70.48	929
HSA-MIR-3129-5P	99.75	70.46	914
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4762-5P	99.57	68.54	1424
HSA-MIR-4519	99.48	66.10	859
HSA-MIR-4696	99.48	67.48	1040
HSA-MIR-140-5P	99.44	67.20	792
HSA-MIR-19A-5P	99.36	66.93	1675
HSA-MIR-19B-1-5P	99.36	67.07	1669
HSA-MIR-19B-2-5P	99.36	67.07	1669
HSA-MIR-6828-5P	99.31	69.21	1433

Literature-anchored findings (GeneRIF, showing 3)

• Unlike the cytoplasmic tRNA m(1)A58 methyltransferase that consists of an alpha2beta2 heterotetramer formed by Trmt61A and Trmt6, Trmt61B formed a homo-oligomer (presumably a homotetramer) that resembled the bacterial homotetrameric m(1)A58 methyltransferase. (PMID:23097428)
• 16S rRNA RNA-DNA differences result from a 1-methyladenosine (m1A) modification introduced by TRMT61B. (PMID:27631568)
• TRMT61B rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers. (PMID:37531210)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	trmt61b	ENSDARG00000097465
drosophila_melanogaster	Trmt61	FBGN0039407
caenorhabditis_elegans	W02A11.1	WBGENE00012192

Paralogs (1): TRMT61A (ENSG00000166166)

Protein

Protein identifiers

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial — Q9BVS5 (reviewed: Q9BVS5)

Alternative names: mRNA methyladenosine-N(1)-methyltransferase

All UniProt accessions (3): Q9BVS5, F8WDR2, H7C2E8

UniProt curated annotations — full annotation on UniProt →

Function. Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation.

Subunit / interactions. Homooligomer; in contrast to TRMT61A, does not form a heterotetramer.

Subcellular location. Mitochondrion matrix.

Similarity. Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

RefSeq proteins (1): NP_060380* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR014816	tRNA_MeTrfase_Gcd14	Family
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily
IPR049470	TRM61_C	Domain
IPR054151	TR61B_FKBP-like	Domain

Pfam: PF08704, PF21985

Enzyme classification (BRENDA):

• EC 2.1.1.220 — tRNA (adenine58-N1)-methyltransferase (BRENDA: 8 organisms, 17 substrates, 2 inhibitors, 5 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

3 substrates with measured Km, best-characterized 3. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
ADENINE58 IN INITIATOR TRNAMET	—	1
ADENINE58 IN TRNAPHE	0.0001	1
S-ADENOSYL-L-METHIONINE	0.005	1

Catalyzed reactions (Rhea), 2 shown:

• adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:43152)
• an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:55392)

UniProt features (45 total): strand 14, region of interest 9, helix 8, binding site 5, compositionally biased region 2, sequence conflict 2, turn 2, transit peptide 1, chain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2B25	X-RAY DIFFRACTION	2.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BVS5-F1	72.30	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (5): 259; 278–279; 317; 335; 463

Mutagenesis-validated functional residues (1):

Position	Phenotype
335	loss of ability to catalyze the formation of 1-methyladenosine at position 947 of mitochondrial 16s ribosomal rna.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6787450	tRNA modification in the mitochondrion
R-HSA-9937008	Mitochondrial mRNA modification

MSigDB gene sets: 118 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_TRNA_METABOLIC_PROCESS, GOBP_RNA_METHYLATION, GOBP_RNA_MODIFICATION, GOBP_MITOCHONDRIAL_RNA_PROCESSING, E4F1_Q6, GOBP_TRNA_METHYLATION, GOBP_MITOCHONDRIAL_RNA_METABOLIC_PROCESS, LASTOWSKA_COAMPLIFIED_WITH_MYCN, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, TIEN_INTESTINE_PROBIOTICS_24HR_UP, ACEVEDO_LIVER_CANCER_UP, GOBP_RRNA_MODIFICATION, GOBP_METHYLATION

GO Biological Process (6): mRNA processing (GO:0006397), tRNA methylation (GO:0030488), mitochondrial tRNA processing (GO:0090646), tRNA processing (GO:0008033), rRNA methylation (GO:0031167), methylation (GO:0032259)

GO Molecular Function (7): rRNA (adenine) methyltransferase activity (GO:0016433), mRNA (adenine-N1-)-methyltransferase activity (GO:0061953), tRNA (adenine(58)-N1)-methyltransferase activity (GO:0160107), protein binding (GO:0005515), methyltransferase activity (GO:0008168), tRNA (adenine) methyltransferase activity (GO:0016426), transferase activity (GO:0016740)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), tRNA (m1A) methyltransferase complex (GO:0031515)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
tRNA processing	1
Metabolism of RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
RNA methylation	2
mRNA metabolic process	1
tRNA modification	1
mitochondrial RNA metabolic process	1
mitochondrial RNA processing	1
tRNA processing	1
tRNA metabolic process	1
rRNA modification	1
metabolic process	1
rRNA methyltransferase activity	1
mRNA methyltransferase activity	1
tRNA (adenine) methyltransferase activity	1
binding	1
transferase activity, transferring one-carbon groups	1
tRNA methyltransferase activity	1
S-adenosylmethionine-dependent methyltransferase activity	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1
tRNA methyltransferase complex	1

Protein interactions and networks

STRING

1744 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRMT61B	TRMT6	Q9UJA5	918
TRMT61B	TRMT10C	Q7L0Y3	917
TRMT61B	TRMT61A	Q96FX7	893
TRMT61B	ALKBH1	Q13686	711
TRMT61B	MRM2	Q9UI43	668
TRMT61B	ALKBH3	Q96Q83	667
TRMT61B	NSUN4	Q96CB9	647
TRMT61B	MRM3	Q9HC36	626
TRMT61B	RPUSD4	Q96CM3	624
TRMT61B	TRMT2B	Q96GJ1	621
TRMT61B	RRP8	O43159	596
TRMT61B	METTL1	Q9UBP6	572
TRMT61B	TRUB2	O95900	568
TRMT61B	PUS1	Q9Y606	568
TRMT61B	TRMT5	Q32P41	567

IntAct

73 interactions, top by confidence:

A	B	Type	Score
DFFB	DFFA	psi-mi:“MI:0914”(association)	0.940
TRMT61B	PPTC7	psi-mi:“MI:0914”(association)	0.710
TRMT61B	FAM9B	psi-mi:“MI:0915”(physical association)	0.670
FAM9B	TRMT61B	psi-mi:“MI:0915”(physical association)	0.670
RHOD	PLXNB2	psi-mi:“MI:0914”(association)	0.640
IRF7	TRMT61B	psi-mi:“MI:0915”(physical association)	0.620
TRMT61B	MTIF2	psi-mi:“MI:0914”(association)	0.610
GRN	TRMT61B	psi-mi:“MI:0915”(physical association)	0.560
TRMT61B	WFS1	psi-mi:“MI:0915”(physical association)	0.560
HIKESHI	CLEC3A	psi-mi:“MI:0914”(association)	0.530
POLR1C	POLR3A	psi-mi:“MI:0914”(association)	0.530
VTN	HAT1	psi-mi:“MI:0914”(association)	0.530
MRM3	NDUFS6	psi-mi:“MI:0914”(association)	0.530
PPTC7	UBB	psi-mi:“MI:0914”(association)	0.530
KCTD17	CBX4	psi-mi:“MI:0914”(association)	0.530
NOTCH2	ZNF316	psi-mi:“MI:0914”(association)	0.530
NXT1	GLE1	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
TRIM10	WIZ	psi-mi:“MI:0914”(association)	0.530
IRF7	AIP	psi-mi:“MI:0914”(association)	0.500

BioGRID (342): FAM9B (Two-hybrid), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), TRMT61B (Affinity Capture-MS), CARS2 (Affinity Capture-MS)

ESM2 similar proteins: A4D126, A4II32, A6NDL7, A6QP81, B0K012, E1B8U2, E1BCH6, O55055, O95568, P50747, Q149N8, Q28IN4, Q2KIJ2, Q2T9W2, Q3U2J5, Q498D5, Q4AC99, Q4KM84, Q58DC7, Q5RE14, Q5VZV1, Q6DJF8, Q6GQ33, Q6GR37, Q6ZMV9, Q7SY78, Q7TPQ3, Q80WC9, Q8BLU2, Q8BSE0, Q8C436, Q8CDZ2, Q8K2I9, Q8NE18, Q8NFZ0, Q8WXB1, Q95LL7, Q96EN8, Q96LZ7, Q9BTF0

Diamond homologs: A6H791, O14307, P0CS08, P0CS09, P46959, P9WFZ0, P9WFZ1, Q2U3W4, Q2YY85, Q4WUT7, Q57598, Q5A416, Q5SKN4, Q6AY46, Q6BX32, Q6C0P9, Q6CN53, Q6FL77, Q755M8, Q80XC2, Q86JJ0, Q8GBB2, Q96FX7, Q9BVS5, Q9V1J7, A1AI22, A1SRS4, A4WFY5, A6TGL3, A6UWM1, A7MQL7, A7ZU40, A8A6U0, A8AAV7, A8ACY2, A9MIY3, A9MY97, B1IW72, B1LM21, B1XAJ7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

97 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1484 predictions. Top by Δscore:

Variant	Effect	Δscore
2:28850401:TTCTT:T	acceptor_gain	1.0000
2:28850403:CTT:C	acceptor_gain	1.0000
2:28850406:C:CC	acceptor_gain	1.0000
2:28850409:T:TC	acceptor_gain	1.0000
2:28852406:A:AC	donor_gain	1.0000
2:28852407:C:CC	donor_gain	1.0000
2:28861116:A:AC	donor_gain	1.0000
2:28861116:ACTG:A	donor_gain	1.0000
2:28861117:C:CC	donor_gain	1.0000
2:28861117:CTG:C	donor_gain	1.0000
2:28861117:CTGC:C	donor_gain	1.0000
2:28861310:T:C	acceptor_gain	1.0000
2:28849849:GTA:G	acceptor_gain	0.9900
2:28850324:TCA:T	donor_loss	0.9900
2:28850325:CACCT:C	donor_loss	0.9900
2:28850326:A:AT	donor_loss	0.9900
2:28850404:TT:T	acceptor_gain	0.9900
2:28850406:C:T	acceptor_loss	0.9900
2:28850407:T:A	acceptor_loss	0.9900
2:28850409:T:C	acceptor_gain	0.9900
2:28852407:CTTTA:C	donor_gain	0.9900
2:28861117:CT:C	donor_gain	0.9900
2:28861306:CAA:C	acceptor_gain	0.9900
2:28861306:CAACT:C	acceptor_gain	0.9900
2:28861309:C:CC	acceptor_gain	0.9900
2:28861314:G:GC	acceptor_gain	0.9900
2:28850243:C:CC	acceptor_gain	0.9800
2:28850411:G:C	acceptor_gain	0.9800
2:28850411:G:GC	acceptor_gain	0.9800
2:28861109:AAAAC:A	donor_loss	0.9800

AlphaMissense

3094 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:28861283:A:C	S276R	0.983
2:28861283:A:T	S276R	0.983
2:28861285:T:G	S276R	0.983
2:28861195:A:G	W306R	0.981
2:28861195:A:T	W306R	0.981
2:28865036:G:C	S261R	0.980
2:28865036:G:T	S261R	0.980
2:28865038:T:G	S261R	0.980
2:28865070:A:T	V250D	0.974
2:28850238:A:C	F465L	0.972
2:28850238:A:T	F465L	0.972
2:28850240:A:G	F465L	0.972
2:28861175:A:C	F312L	0.954
2:28861175:A:T	F312L	0.954
2:28861177:A:G	F312L	0.954
2:28851207:A:G	W393R	0.948
2:28851207:A:T	W393R	0.948
2:28861193:C:A	W306C	0.945
2:28861193:C:G	W306C	0.945
2:28852427:A:G	C356R	0.944
2:28861120:C:G	A331P	0.944
2:28861176:A:G	F312S	0.944
2:28861308:A:T	V268D	0.943
2:28865025:G:A	S265F	0.939
2:28861290:A:T	V274D	0.938
2:28861231:A:G	W294R	0.937
2:28861231:A:T	W294R	0.937
2:28865046:C:T	G258D	0.927
2:28861251:G:T	A287D	0.925
2:28851278:A:G	L369P	0.924

dbSNP variants (sampled 300 via entrez): RS1000176198 (2:28853427 C>T), RS1000176860 (2:28857453 T>C,G), RS1000199297 (2:28862415 C>T), RS1000263038 (2:28865939 C>T), RS1000507133 (2:28853097 A>G), RS1000573364 (2:28870446 T>C), RS1000700670 (2:28870356 G>A,T), RS1000763048 (2:28851812 G>A,C,T), RS1000839018 (2:28864606 G>A), RS1000962675 (2:28857998 A>G), RS1001312311 (2:28864872 G>T), RS1001730242 (2:28869365 G>C), RS1001896877 (2:28871431 T>C), RS1001915421 (2:28863337 G>A), RS1001979806 (2:28858012 G>C)

Disease associations

OMIM: gene MIM:619404 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005580_106	Intraocular pressure	5.000000e-08
GCST007656_7	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy)	9.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, increases expression	2
Benzo(a)pyrene	affects methylation, decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
bisphenol A	decreases expression	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
manganese chloride	increases abundance, increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Manganese	increases expression, increases abundance	1
Phthalic Acids	increases methylation	1
Plant Extracts	affects cotreatment, increases expression	1
Quercetin	decreases expression	1
Ribonucleotides	affects binding	1
Selenium	decreases expression	1
Smoke	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
Cyclosporine	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.