TRPC5OS

Summary

TRPC5OS (TRPC5 opposite strand, HGNC:40593) is a protein-coding gene on chromosome Xq23, encoding Putative uncharacterized protein TRPC5OS (A6NMA1).

At a glance

• MANE Select transcript: NM_001195578

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40593
Approved symbol	TRPC5OS
Name	TRPC5 opposite strand
Location	Xq23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000204025
Ensembl biotype	protein_coding
Entrez	100329135

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000371970, ENST00000612026, ENST00000635763

RefSeq mRNA: 3 — MANE Select: NM_001195578 NM_001195576, NM_001195577, NM_001195578

CCDS: CCDS83485

Canonical transcript exons

ENST00000635763 — 4 exons

Exon	Start	End
ENSE00001456582	111896407	111896495
ENSE00001456583	111895951	111896096
ENSE00003798940	111901540	111903990
ENSE00003800603	111876181	111876273

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 82.87.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0588 / max 50.0704, expressed in 4 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
197306	0.0306	3
197305	0.0102	3
197303	0.0078	3
197307	0.0065	4
197304	0.0037	2

Top tissues by expression

211 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	82.87	gold quality
testis	UBERON:0000473	81.35	gold quality
left testis	UBERON:0004533	81.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.52	gold quality
adult organism	UBERON:0007023	69.76	gold quality
kidney epithelium	UBERON:0004819	66.67	gold quality
sperm	CL:0000019	62.99	gold quality
left ventricle myocardium	UBERON:0006566	56.55	gold quality
epithelial cell of pancreas	CL:0000083	54.99	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.94	gold quality
corpus epididymis	UBERON:0004359	54.26	silver quality
upper arm skin	UBERON:0004263	53.52	gold quality
nasal cavity epithelium	UBERON:0005384	52.13	gold quality
myocardium	UBERON:0002349	51.58	gold quality
tibialis anterior	UBERON:0001385	49.68	silver quality
deltoid	UBERON:0001476	48.57	gold quality
oviduct epithelium	UBERON:0004804	48.12	silver quality
pancreatic ductal cell	CL:0002079	47.84	silver quality
lower lobe of lung	UBERON:0008949	47.28	silver quality
ileal mucosa	UBERON:0000331	46.85	silver quality
quadriceps femoris	UBERON:0001377	46.63	gold quality
tibia	UBERON:0000979	46.06	gold quality
vastus lateralis	UBERON:0001379	45.55	gold quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
right uterine tube	UBERON:0001302	43.35	silver quality
mucosa of stomach	UBERON:0001199	43.27	silver quality
fallopian tube	UBERON:0003889	42.88	gold quality
gall bladder	UBERON:0002110	42.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.77

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

111 targeting TRPC5OS, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Trpc5os	ENSMUSG00000072934
rattus_norvegicus	Trpc5os	ENSRNOG00000064383

Protein

Protein identifiers

Putative uncharacterized protein TRPC5OS — A6NMA1 (reviewed: A6NMA1)

Alternative names: TRPC5 opposite strand protein, TRPC5-antisense RNA 1

All UniProt accessions (1): A6NMA1

UniProt curated annotations — full annotation on UniProt →

RefSeq proteins (3): NP_001182505, NP_001182506, NP_001182507* (*=MANE)

Domains & families (InterPro)

UniProt features (3 total): chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NMA1-F1	72.63	0.25

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 34 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, chrXq23, MIR607, MIR570_3P, MIR95_5P, MIR3529_3P, MIR627_3P, MIR137_3P, MIR196A_1_3P, MIR664A_3P, MIR6873_3P, MIR1185_1_3P_MIR1185_2_3P, LET_7F_2_3P, MIR6507_5P, MIR130A_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

2 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRPC5OS	ETAA1	Q9NY74	0

IntAct

0 interactions, top by confidence:

BioGRID (1): TRPC5OS (Synthetic Lethality)

ESM2 similar proteins: A0L486, A1A0T8, A1L3P1, A4VVZ9, A4W2A7, A5VPI8, A6NMA1, A6U7A2, A6X296, A7HX41, A7IM18, A9MA26, B0CKX7, B2IIA1, B2SAC9, B6IN07, B7GUQ0, B8DTW7, C0HK64, C0RHZ3, F5HGI9, K4JY29, O13619, O94688, P08804, P16792, P85800, Q17684, Q2RT88, Q2W519, Q2YN12, Q32PD7, Q3U898, Q55GR4, Q57E91, Q5RDL6, Q6DDA3, Q6FM20, Q6G465, Q6NVV0

Diamond homologs: A6NMA1, Q3UHV4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

98 predictions. Top by Δscore:

Variant	Effect	Δscore
X:111878995:C:A	donor_gain	0.9600
X:111878101:T:TA	donor_gain	0.9100
X:111878994:T:TA	donor_gain	0.8900
X:111894545:G:A	donor_gain	0.8900
X:111894629:A:C	donor_gain	0.8500
X:111878054:G:C	donor_gain	0.7500
X:111878053:AGATT:A	donor_gain	0.7100
X:111876176:C:T	donor_gain	0.6900
X:111901122:T:C	donor_gain	0.6500
X:111876177:T:G	donor_gain	0.6400
X:111876174:T:A	donor_gain	0.6100
X:111878097:AGCCT:A	donor_gain	0.6000
X:111887782:A:AC	donor_gain	0.5900
X:111887783:C:CC	donor_gain	0.5900
X:111887779:T:C	donor_gain	0.5700
X:111876178:A:T	donor_gain	0.5500
X:111894595:C:A	donor_gain	0.5500
X:111876156:C:T	donor_gain	0.5400
X:111876261:CCT:C	acceptor_gain	0.5300
X:111878053:A:AC	donor_gain	0.5300
X:111879517:GTCC:G	acceptor_gain	0.5300
X:111878991:ACTTC:A	donor_gain	0.5200
X:111878992:CTTCC:C	donor_gain	0.5200
X:111879516:AGTCC:A	acceptor_gain	0.5200
X:111894286:ATTG:A	donor_gain	0.5200
X:111876296:TA:T	acceptor_gain	0.5100
X:111878060:T:C	donor_gain	0.5100
X:111888347:T:TA	donor_gain	0.5000
X:111876177:T:TT	donor_gain	0.4900
X:111876181:A:T	donor_gain	0.4900

AlphaMissense

725 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:111901919:G:C	A24P	0.950
X:111901929:T:C	L27P	0.931
X:111901908:T:C	L20S	0.929
X:111901920:C:A	A24D	0.911
X:111902067:T:A	I73K	0.906
X:111901895:T:C	C16R	0.884
X:111901897:T:G	C16W	0.868
X:111902058:T:C	L70S	0.867
X:111902067:T:C	I73T	0.857
X:111901887:T:A	L13H	0.853
X:111902067:T:G	I73R	0.845
X:111902070:T:A	L74H	0.831
X:111901887:T:C	L13P	0.811
X:111901896:G:A	C16Y	0.799
X:111901901:G:C	A18P	0.797
X:111901929:T:A	L27H	0.796
X:111901887:T:G	L13R	0.792
X:111902070:T:C	L74P	0.781
X:111901917:T:A	I23K	0.778
X:111901917:T:G	I23R	0.759
X:111901929:T:G	L27R	0.745
X:111901899:T:A	V17E	0.730
X:111901932:T:C	L28S	0.718
X:111902070:T:G	L74R	0.688
X:111901905:A:C	Q19P	0.674
X:111902040:T:A	L64H	0.665
X:111902109:A:T	D87V	0.649
X:111902040:T:G	L64R	0.622
X:111902040:T:C	L64P	0.610
X:111901875:T:A	L9H	0.606

dbSNP variants (sampled 300 via entrez): RS1000094580 (X:111884205 C>T), RS1000213364 (X:111889341 A>G), RS1000263578 (X:111876682 A>T), RS1000309725 (X:111888794 C>A), RS1000331530 (X:111888443 G>A), RS1000441977 (X:111900789 T>C), RS1000487111 (X:111876483 A>G), RS1000564298 (X:111878695 A>G), RS1000755772 (X:111896536 G>A), RS1000785638 (X:111887937 G>A), RS1000822892 (X:111899004 T>C), RS1001052966 (X:111876004 A>G), RS1001066019 (X:111885746 T>G), RS1001253376 (X:111896138 C>T), RS1001761365 (X:111890166 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, decreases expression	1
Lipopolysaccharides	decreases expression, decreases reaction	1
Malathion	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.