TRPM2-AS

Summary

TRPM2-AS (TRPM2 antisense RNA, HGNC:50758) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50758
Approved symbol	TRPM2-AS
Name	TRPM2 antisense RNA
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	TRPM2-AS1
Ensembl gene	ENSG00000230061
Ensembl biotype	lncRNA
Entrez	101928607
RNAcentral	URS0000759FE8 — lncRNA, 875 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000423310, ENST00000456880

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423310 — 3 exons

Exon	Start	End
ENSE00001659958	44414588	44414944
ENSE00001670662	44423376	44423481
ENSE00001678346	44425150	44425272

Expression profiles

Bgee: expression breadth ubiquitous, 149 present calls, max score 95.92.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1133 / max 7.8450, expressed in 51 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190751	0.1133	51

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.92	gold quality
myocardium	UBERON:0002349	80.48	gold quality
buccal mucosa cell	CL:0002336	78.03	gold quality
tendon of biceps brachii	UBERON:0008188	75.24	gold quality
spleen	UBERON:0002106	71.14	gold quality
oocyte	CL:0000023	69.25	gold quality
granulocyte	CL:0000094	69.20	gold quality
bone marrow cell	CL:0002092	68.91	silver quality
right frontal lobe	UBERON:0002810	68.58	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.29	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.60	gold quality
cerebellar hemisphere	UBERON:0002245	66.73	gold quality
cerebellar cortex	UBERON:0002129	66.60	gold quality
cerebellum	UBERON:0002037	64.65	gold quality
monocyte	CL:0000576	64.47	gold quality
nucleus accumbens	UBERON:0001882	64.22	gold quality
caudate nucleus	UBERON:0001873	64.18	gold quality
blood	UBERON:0000178	63.66	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.63	gold quality
putamen	UBERON:0001874	63.48	gold quality
prefrontal cortex	UBERON:0000451	63.45	gold quality
anterior cingulate cortex	UBERON:0009835	62.49	gold quality
sural nerve	UBERON:0015488	62.11	gold quality
smooth muscle tissue	UBERON:0001135	61.81	gold quality
secondary oocyte	CL:0000655	60.77	gold quality
endocervix	UBERON:0000458	60.71	gold quality
hypothalamus	UBERON:0001898	60.57	gold quality
neocortex	UBERON:0001950	60.43	gold quality
frontal cortex	UBERON:0001870	60.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• TRPM2-AS inhibits the growth, migration, and invasion of gliomas through JNK, c-Jun, and RGS4. (PMID:31637708)
• TRPM2-AS promotes cancer cell proliferation through control of TAF15. (PMID:31887411)
• Associations Between Genomic Variants in lncRNA-TRPM2-AS and lncRNA-HNF1A-AS1 Genes and Risk of Multiple Sclerosis. (PMID:32100228)
• Long non-coding RNA TRPM2-AS regulates microRNA miR-138-5p and PLAU (Plasminogen Activator, Urokinase) to promote the progression of gastric adenocarcinoma. (PMID:34696681)
• TRPM2-AS promotes the malignancy of osteosarcoma cells by targeting miR-15b-5p/PPM1D axis. (PMID:35100080)
• Long non-coding RNA TRPM2 antisense RNA as a potential therapeutic target promotes tumorigenesis and metastasis in esophageal cancer. (PMID:35156509)
• TRPM2-AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR-497-5p. (PMID:35238054)
• Contribution and underlying mechanisms of lncRNA TRPM2-AS in the development and progression of human cancers. (PMID:37871443)
• PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway. (PMID:38097564)
• Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway. (PMID:38532427)
• Long non-coding TRPM2-AS regulates fracture healing by targeting miR-545-3p/Bmp2. (PMID:39118176)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.