TRT-AGT7-1

Summary

TRT-AGT7-1 (tRNA-Thr (AGT) 7-1, HGNC:12352) is a gene on chromosome 17q24.1.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12352
Approved symbol	TRT-AGT7-1
Name	tRNA-Thr (AGT) 7-1
Location	17q24.1
Locus type	RNA, transfer
Status	Approved
Aliases	tRNA-Thr-AGT-7-1
Entrez	7238
RNAcentral	URS00006E1AD1 — tRNA, 74 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• results show that LK6 binds to ERK and is activated by ERK signalling and it is responsible for phosphorylating eIF4E in Drosophila (PMID:15487973)
• our results suggest that the level of eIF4E protein is regulated by Diap1, and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein. (PMID:18182863)
• These results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3’ splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs. (PMID:18671938)
• data are consistent with the idea that Parkin and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events. (PMID:20869429)
• eIF4E regulates the sex-specific expression of the master switch gene Sxl. (PMID:21829374)
• Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function. (PMID:22507384)
• Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. (PMID:22833128)
• eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. (PMID:25179781)
• Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding. (PMID:25702871)
• Both eIF4E-1 and eIF4E-3 are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages. (PMID:25849588)
• The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation. (PMID:27773676)
• Drosophila Me31B is a Dual eIF4E-Interacting Protein. (PMID:36638908)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.