TRUB1

Summary

TRUB1 (TruB pseudouridine synthase family member 1, HGNC:16060) is a protein-coding gene on chromosome 10q25.3, encoding Pseudouridylate synthase TRUB1 (Q8WWH5). Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs.

Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).

Source: NCBI Gene 142940 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_139169

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16060
Approved symbol	TRUB1
Name	TruB pseudouridine synthase family member 1
Location	10q25.3
Locus type	gene with protein product
Status	Approved
Aliases	PUS4
Ensembl gene	ENSG00000165832
Ensembl biotype	protein_coding
OMIM	610726
Entrez	142940

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000298746, ENST00000485065, ENST00000900221, ENST00000900222, ENST00000900223, ENST00000922143, ENST00000948779

RefSeq mRNA: 1 — MANE Select: NM_139169 NM_139169

CCDS: CCDS7591

Canonical transcript exons

ENST00000298746 — 8 exons

Exon	Start	End
ENSE00001097026	114959726	114959807
ENSE00001097091	114970368	114970440
ENSE00001131261	114974329	114974385
ENSE00001131265	114972135	114972274
ENSE00001194052	114975123	114977676
ENSE00001194057	114938195	114938539
ENSE00003485263	114942645	114942743
ENSE00003679685	114951094	114951149

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 95.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.9191 / max 172.2434, expressed in 1792 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107169	16.9191	1792

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	95.88	gold quality
left ventricle myocardium	UBERON:0006566	95.80	gold quality
cardiac muscle of right atrium	UBERON:0003379	94.79	silver quality
myocardium	UBERON:0002349	93.16	gold quality
Brodmann (1909) area 46	UBERON:0006483	90.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.72	gold quality
kidney epithelium	UBERON:0004819	89.18	silver quality
calcaneal tendon	UBERON:0003701	89.07	gold quality
right adrenal gland cortex	UBERON:0035827	88.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.65	gold quality
ileal mucosa	UBERON:0000331	88.62	gold quality
adrenal gland	UBERON:0002369	88.59	gold quality
heart right ventricle	UBERON:0002080	88.50	gold quality
islet of Langerhans	UBERON:0000006	88.48	gold quality
left adrenal gland	UBERON:0001234	88.43	gold quality
mucosa of sigmoid colon	UBERON:0004993	88.22	gold quality
superior frontal gyrus	UBERON:0002661	88.00	gold quality
adrenal cortex	UBERON:0001235	87.96	gold quality
right adrenal gland	UBERON:0001233	87.88	gold quality
left adrenal gland cortex	UBERON:0035825	87.73	gold quality
pigmented layer of retina	UBERON:0001782	87.66	gold quality
retina	UBERON:0000966	87.64	gold quality
postcentral gyrus	UBERON:0002581	87.30	gold quality
cauda epididymis	UBERON:0004360	87.23	gold quality
colonic mucosa	UBERON:0000317	87.21	gold quality
prefrontal cortex	UBERON:0000451	86.99	gold quality
Brodmann (1909) area 23	UBERON:0013554	86.42	gold quality
oocyte	CL:0000023	86.41	gold quality
entorhinal cortex	UBERON:0002728	86.38	gold quality
caput epididymis	UBERON:0004358	86.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

166 targeting TRUB1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-590-3P	99.96	74.34	6478

Literature-anchored findings (GeneRIF, showing 6)

• TRUB1 gene encodes a 349-amino acid product, with a VFAVHKPKGPTSA box in positions 71-83 corresponding to motif I of the TruB family (PMID:12736709)
• The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA. (PMID:32926445)
• Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. (PMID:33023933)
• Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Psi55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro. (PMID:36018806)
• Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution. (PMID:36302989)
• Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1. (PMID:38776834)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	trub1	ENSDARG00000053805
mus_musculus	Trub1	ENSMUSG00000025086
rattus_norvegicus	Trub1	ENSRNOG00000017321

Protein

Protein identifiers

Pseudouridylate synthase TRUB1 — Q8WWH5 (reviewed: Q8WWH5)

Alternative names: TruB pseudouridine synthase homolog 1, tRNA pseudouridine 55 synthase TRUB1

All UniProt accessions (1): Q8WWH5

UniProt curated annotations — full annotation on UniProt →

Function. Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5’-GUUCNANNC-3’, harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation.

Subcellular location. Nucleus. Cytoplasm. Cytosol.

Tissue specificity. Highly expressed in heart, skeletal muscle and liver. Expressed at lower levels in lung, small intestine, kidney and spleen.

Similarity. Belongs to the pseudouridine synthase TruB family.

RefSeq proteins (1): NP_631908* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002501	PsdUridine_synth_N	Domain
IPR014780	tRNA_psdUridine_synth_TruB	Family
IPR020103	PsdUridine_synth_cat_dom_sf	Homologous_superfamily

Pfam: PF01509

Catalyzed reactions (Rhea), 3 shown:

• uridine(55) in tRNA = pseudouridine(55) in tRNA (RHEA:42532)
• a uridine in tRNA = a pseudouridine in tRNA (RHEA:54572)
• a uridine in mRNA = a pseudouridine in mRNA (RHEA:56644)

UniProt features (11 total): mutagenesis site 3, modified residue 2, sequence variant 2, initiator methionine 1, chain 1, sequence conflict 1, active site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8JFX	X-RAY DIFFRACTION	2.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WWH5-F1	81.45	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 121 (nucleophile)

Post-translational modifications (2): 2, 11

Mutagenesis-validated functional residues (3):

Position	Phenotype
121	abolished pseudouridine synthase activity without affecting ability to promote processing of let-7 mirnas; when associat
147	abolished rna-binding and ability to promote processing of let-7 mirnas.
163	abolished pseudouridine synthase activity without affecting ability to promote processing of let-7 mirnas; when associat

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 168 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_TRNA_METABOLIC_PROCESS, GGAMTNNNNNTCCY_UNKNOWN, GOBP_MRNA_MODIFICATION, GOBP_PSEUDOURIDINE_SYNTHESIS, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_RNA_MODIFICATION, DODD_NASOPHARYNGEAL_CARCINOMA_UP, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, SENESE_HDAC1_TARGETS_UP, GOBP_PRE_MIRNA_PROCESSING, GOBP_TRNA_PROCESSING, DURCHDEWALD_SKIN_CARCINOGENESIS_UP, GOBP_TRNA_MODIFICATION

GO Biological Process (9): mRNA processing (GO:0006397), tRNA modification (GO:0006400), tRNA pseudouridine synthesis (GO:0031119), mRNA pseudouridine synthesis (GO:1990481), positive regulation of pre-miRNA processing (GO:2000633), pseudouridine synthesis (GO:0001522), RNA processing (GO:0006396), tRNA processing (GO:0008033), RNA modification (GO:0009451)

GO Molecular Function (7): pseudouridine synthase activity (GO:0009982), pre-miRNA binding (GO:0070883), tRNA pseudouridine(55) synthase activity (GO:0160148), RNA binding (GO:0003723), protein binding (GO:0005515), isomerase activity (GO:0016853), tRNA pseudouridine synthase activity (GO:0106029)

GO Cellular Component (4): nucleus (GO:0005634), mitochondrion (GO:0005739), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
RNA modification	2
pseudouridine synthesis	2
intracellular membrane-bounded organelle	2
cytoplasm	2
cellular anatomical structure	2
mRNA metabolic process	1
tRNA processing	1
tRNA modification	1
mRNA modification	1
pre-miRNA processing	1
positive regulation of miRNA processing	1
regulation of pre-miRNA processing	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
tRNA metabolic process	1
RNA metabolic process	1
macromolecule modification	1
intramolecular transferase activity	1
RNA binding	1
tRNA pseudouridine synthase activity	1
nucleic acid binding	1
binding	1
catalytic activity	1
pseudouridine synthase activity	1
catalytic activity, acting on a tRNA	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2624 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRUB1	PUS1	Q9Y606	876
TRUB1	PUS7	Q96PZ0	873
TRUB1	PUS3	Q9BZE2	838
TRUB1	PUS10	Q3MIT2	833
TRUB1	RPUSD2	Q8IZ73	811
TRUB1	PUS7L	Q9H0K6	781
TRUB1	TRMT1	Q9NXH9	766
TRUB1	RPUSD3	Q6P087	724
TRUB1	RPUSD4	Q96CM3	716
TRUB1	TARBP1	Q13395	689
TRUB1	TRMT6	Q9UJA5	676
TRUB1	METTL1	Q9UBP6	665
TRUB1	RPUSD1	Q9UJJ7	654
TRUB1	PUSL1	Q8N0Z8	648
TRUB1	WDR4	P57081	645
TRUB1	NOP10	Q9NPE3	645

IntAct

33 interactions, top by confidence:

A	B	Type	Score
TRAF2	HTRA2	psi-mi:“MI:0914”(association)	0.750
SETMAR	HSPA8	psi-mi:“MI:0914”(association)	0.530
TRUB1	CAPG	psi-mi:“MI:0914”(association)	0.500
TRUB1	CAPG	psi-mi:“MI:0915”(physical association)	0.500
	TRUB1	psi-mi:“MI:0407”(direct interaction)	0.440
TRUB1	SRPK2	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
CD72	TRUB1	psi-mi:“MI:0915”(physical association)	0.400
TRUB1	E2	psi-mi:“MI:0915”(physical association)	0.370
TRUB1	E7	psi-mi:“MI:0915”(physical association)	0.370
S100A9	TRUB1	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
CAND1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
SLC2A2	APOB	psi-mi:“MI:0914”(association)	0.350
TRUB1	USP11	psi-mi:“MI:0914”(association)	0.350
PKM	PAWR	psi-mi:“MI:0914”(association)	0.350
SSB	RPS3A	psi-mi:“MI:0914”(association)	0.350
PRPS2	SMCHD1	psi-mi:“MI:0914”(association)	0.350
SLC2A2	CAPG	psi-mi:“MI:0914”(association)	0.350
NUDT9	WDR5B	psi-mi:“MI:0914”(association)	0.350
FECH	GTPBP10	psi-mi:“MI:0914”(association)	0.350
SNW1		psi-mi:“MI:0914”(association)	0.350
CDC5L		psi-mi:“MI:0914”(association)	0.350
TRUB1	E2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (47): TRUB1 (Co-fractionation), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), MTFMT (Affinity Capture-MS), USP11 (Affinity Capture-MS), TCEAL1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), TRUB1 (Affinity Capture-MS), MTFMT (Affinity Capture-MS)

ESM2 similar proteins: A2ADA5, A4PCD4, A6H611, D3ZDM7, F6PHZ6, O75344, P04053, P09838, P17256, P36195, P47823, P55345, Q01992, Q03426, Q08602, Q0V8R7, Q13144, Q1L8I0, Q3MIT2, Q4KM92, Q4QQT0, Q5CZL1, Q5E9Z1, Q5I0L3, Q5M7T9, Q5M934, Q5RFE6, Q5XGM5, Q64350, Q6GQ53, Q7L3T8, Q80W22, Q86YJ6, Q8BYL4, Q8C0D0, Q8CHW4, Q8N0Z8, Q8WWH5, Q91XW8, Q92089

Diamond homologs: A6LLV6, O59721, O95900, Q5M934, Q5XFW2, Q5XGG2, Q8C0D0, Q8WWH5, Q91WG3, A0AIC9, A0JUU8, A0Q0Q4, A0Q7W5, A1R520, A1S464, A1ST47, A1U5Z8, A3MJW6, A3N007, A3NUL2, A4IWL0, A4QEY6, A4VPN8, A4XYD8, A5FQR4, A5IIS7, A5N845, A5UBU2, A5UF28, A5W985, A6LEL7, A6VCJ9, A6VNE2, A7GG03, A7GRE0, A7NAR1, A8FDD4, B0JJJ5, B0KHX6, B0TXH9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1052 predictions. Top by Δscore:

Variant	Effect	Δscore
10:114938518:TTG:T	donor_gain	1.0000
10:114938537:C:T	donor_gain	1.0000
10:114938537:CAGG:C	donor_loss	1.0000
10:114938539:GG:G	donor_loss	1.0000
10:114938540:G:C	donor_loss	1.0000
10:114938541:T:G	donor_loss	1.0000
10:114951088:TTGTA:T	acceptor_loss	1.0000
10:114951089:TGTA:T	acceptor_loss	1.0000
10:114951090:GTAGT:G	acceptor_loss	1.0000
10:114951091:TA:T	acceptor_loss	1.0000
10:114951092:A:AG	acceptor_gain	1.0000
10:114951092:A:G	acceptor_loss	1.0000
10:114951092:AGTT:A	acceptor_gain	1.0000
10:114951093:G:GG	acceptor_gain	1.0000
10:114951093:GT:G	acceptor_gain	1.0000
10:114951093:GTT:G	acceptor_gain	1.0000
10:114951093:GTTG:G	acceptor_gain	1.0000
10:114970441:G:GG	donor_gain	1.0000
10:114972111:T:G	acceptor_gain	1.0000
10:114972125:A:AG	acceptor_gain	1.0000
10:114972126:T:G	acceptor_gain	1.0000
10:114972130:A:AG	acceptor_gain	1.0000
10:114972131:C:G	acceptor_gain	1.0000
10:114972132:A:AG	acceptor_gain	1.0000
10:114972133:A:G	acceptor_gain	1.0000
10:114972272:TAGGT:T	donor_loss	1.0000
10:114972273:AGG:A	donor_loss	1.0000
10:114972274:GGTAA:G	donor_loss	1.0000
10:114972275:G:GC	donor_loss	1.0000
10:114972276:T:A	donor_loss	1.0000

AlphaMissense

2228 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:114942702:G:A	G115E	0.997
10:114942734:G:A	G126R	0.996
10:114942734:G:C	G126R	0.996
10:114951100:G:A	G131E	0.996
10:114951149:G:C	K147N	0.996
10:114951149:G:T	K147N	0.996
10:114974339:T:G	C249W	0.996
10:114974368:T:A	V259D	0.996
10:114938481:G:C	K76N	0.995
10:114938481:G:T	K76N	0.995
10:114942704:C:G	H116D	0.995
10:114942708:G:A	G117E	0.995
10:114942735:G:A	G126E	0.995
10:114959742:G:A	G153E	0.995
10:114975153:T:C	L275P	0.995
10:114975212:T:A	W295R	0.995
10:114975212:T:C	W295R	0.995
10:114942741:T:C	L128P	0.994
10:114975138:C:A	A270D	0.994
10:114959729:T:C	Y149H	0.993
10:114974359:G:C	R256T	0.993
10:114974380:G:A	G263E	0.993
10:114938479:A:G	K76E	0.992
10:114942721:C:A	D121E	0.992
10:114942721:C:G	D121E	0.992
10:114942738:T:A	V127D	0.992
10:114951097:T:A	V130D	0.992
10:114974337:T:C	C249R	0.992
10:114974359:G:T	R256I	0.992
10:114938519:T:C	L89S	0.991

dbSNP variants (sampled 300 via entrez): RS1000069781 (10:114943894 T>C), RS1000188759 (10:114961102 T>A,C), RS1000491323 (10:114967699 T>C), RS1000696970 (10:114961081 G>A), RS1000702805 (10:114954076 T>A,C), RS1000752470 (10:114953785 T>A,C,G), RS1000826824 (10:114972666 G>T), RS1000900460 (10:114973049 A>C), RS1000961749 (10:114948541 G>A,T), RS1001051388 (10:114960701 A>C), RS1001069800 (10:114942286 A>G), RS1001103945 (10:114942614 T>A,C), RS1001249814 (10:114955375 A>G), RS1001285459 (10:114950626 T>C), RS1001295534 (10:114950936 A>G)

Disease associations

OMIM: gene MIM:610726 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_226	Refractive error	2.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	2
Acetaminophen	decreases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
trichostatin A	decreases expression	1
arsenite	affects binding, decreases reaction	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
coumarin	increases phosphorylation	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
1-nitropyrene	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
corosolic acid	increases expression	1
jinfukang	decreases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Vorinostat	increases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Formaldehyde	increases expression	1
Gold	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Testosterone	decreases expression	1
Tretinoin	decreases expression	1
Tunicamycin	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0SC	Ubigene HeLa TRUB1 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.