TSACC

Summary

TSACC (TSSK6 activating cochaperone, HGNC:30636) is a protein-coding gene on chromosome 1q22, encoding TSSK6-activating co-chaperone protein (Q96A04). Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Enables protein-folding chaperone binding activity. Predicted to be active in cytoplasm.

Source: NCBI Gene 128229 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 24 total
• MANE Select transcript: NM_001304817

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30636
Approved symbol	TSACC
Name	TSSK6 activating cochaperone
Location	1q22
Locus type	gene with protein product
Status	Approved
Aliases	SSTK-IP, SIP
Ensembl gene	ENSG00000163467
Ensembl biotype	protein_coding
OMIM	619679
Entrez	128229

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 protein_coding

ENST00000368251, ENST00000368252, ENST00000368253, ENST00000368254, ENST00000368255, ENST00000466306, ENST00000470342, ENST00000481479, ENST00000902464, ENST00000922497, ENST00000922498

RefSeq mRNA: 11 — MANE Select: NM_001304817 NM_001304817, NM_001304818, NM_001304819, NM_001304820, NM_001304821, NM_001304822, NM_001304823, NM_001304824, NM_001304825, NM_001304826, NM_144627

CCDS: CCDS1141, CCDS76223

Canonical transcript exons

ENST00000368254 — 4 exons

Exon	Start	End
ENSE00001446696	156338526	156338605
ENSE00001446697	156346768	156346995
ENSE00003710024	156344580	156344708
ENSE00003710997	156339634	156339791

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 99.64.

FANTOM5 (CAGE): breadth broad, TPM avg 4.0558 / max 2791.3139, expressed in 692 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5716	3.8980	670
5717	0.0564	10
5719	0.0452	4
5714	0.0180	4
5715	0.0176	4
5722	0.0089	1
5713	0.0048	4
5721	0.0040	2
5720	0.0029	2

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	99.64	gold quality
right testis	UBERON:0004534	99.62	gold quality
left testis	UBERON:0004533	99.48	gold quality
adult organism	UBERON:0007023	99.13	gold quality
testis	UBERON:0000473	97.03	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.30	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.64	gold quality
cardiac muscle of right atrium	UBERON:0003379	80.90	gold quality
left ventricle myocardium	UBERON:0006566	80.61	gold quality
kidney epithelium	UBERON:0004819	75.96	gold quality
epithelial cell of pancreas	CL:0000083	74.93	gold quality
mucosa of paranasal sinus	UBERON:0005030	74.14	gold quality
nasal cavity epithelium	UBERON:0005384	72.44	gold quality
superficial temporal artery	UBERON:0001614	72.14	gold quality
upper arm skin	UBERON:0004263	69.80	gold quality
right adrenal gland	UBERON:0001233	69.33	gold quality
deltoid	UBERON:0001476	69.27	gold quality
epithelium of nasopharynx	UBERON:0001951	68.07	gold quality
right adrenal gland cortex	UBERON:0035827	67.70	gold quality
left adrenal gland	UBERON:0001234	67.69	gold quality
left adrenal gland cortex	UBERON:0035825	67.58	gold quality
right lobe of liver	UBERON:0001114	66.82	gold quality
cauda epididymis	UBERON:0004360	66.57	gold quality
adrenal cortex	UBERON:0001235	66.44	gold quality
tibialis anterior	UBERON:0001385	66.31	silver quality
adrenal gland	UBERON:0002369	65.71	gold quality
quadriceps femoris	UBERON:0001377	65.57	gold quality
adrenal tissue	UBERON:0018303	64.43	gold quality
gingival epithelium	UBERON:0001949	64.41	gold quality
myocardium	UBERON:0002349	64.37	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	5800.81
E-GEOD-124263	yes	2249.98
E-ANND-3	no	2.54

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tsacc	ENSMUSG00000010538
rattus_norvegicus	Tsacc	ENSRNOG00000037552

Protein

Protein identifiers

TSSK6-activating co-chaperone protein — Q96A04 (reviewed: Q96A04)

Alternative names: SSTK-interacting protein

All UniProt accessions (2): Q96A04, V9GYT6

UniProt curated annotations — full annotation on UniProt →

Function. Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Subunit / interactions. Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.

Tissue specificity. Expressed in testis but is absent from mature sperm.

Similarity. Belongs to the TSACC family.

RefSeq proteins (11): NP_001291746, NP_001291747, NP_001291748, NP_001291749, NP_001291750, NP_001291751, NP_001291752, NP_001291753, NP_001291754, NP_001291755, NP_653228 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031679	SSTK-IP	Family

Pfam: PF15836

UniProt features (6 total): region of interest 2, compositionally biased region 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96A04-F1	67.99	0.23

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 58 (showing top): TGCGCANK_UNKNOWN, chr1q22, GOMF_PROTEIN_FOLDING_CHAPERONE_BINDING, HSF2_01, HSF1_01, KOYAMA_SEMA3B_TARGETS_DN, NRF1_Q6, ASH1L_TARGET_GENES, BARX1_TARGET_GENES, FOXE1_TARGET_GENES, FOXG1_TARGET_GENES, ID2_TARGET_GENES, PITX1_TARGET_GENES, PPARGC1A_TARGET_GENES, PRKDC_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (2): protein-folding chaperone binding (GO:0051087), protein binding (GO:0005515)

GO Cellular Component (1): cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein binding	1
binding	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

294 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSACC	C22orf23	Q9BZE7	661
TSACC	CATSPERG	Q6ZRH7	587
TSACC	ODAD4	Q96NG3	580
TSACC	CATSPERT	Q53TS8	569
TSACC	ARMH4	Q86TY3	547
TSACC	GKAP1	Q5VSY0	522
TSACC	ACTRT2	Q8TDY3	507
TSACC	TSSK6	Q9BXA6	507
TSACC	SPATA16	Q9BXB7	494
TSACC	GARIN1B	Q96KD3	465
TSACC	NUPR2	A6NF83	457
TSACC	CCDC54	Q8NEL0	456
TSACC	TM4SF18	Q96CE8	450
TSACC	TCEAL4	Q96EI5	449
TSACC	ANKRD7	Q92527	448
TSACC	ADAM32	Q8TC27	448

IntAct

27 interactions, top by confidence:

A	B	Type	Score
TSACC	FOXP2	psi-mi:“MI:0915”(physical association)	0.720
FOXP2	TSACC	psi-mi:“MI:0915”(physical association)	0.720
TSACC	LIX1	psi-mi:“MI:0915”(physical association)	0.560
LIX1	TSACC	psi-mi:“MI:0915”(physical association)	0.560
CRYAA	TSACC	psi-mi:“MI:0915”(physical association)	0.560
TSACC	ATN1	psi-mi:“MI:0915”(physical association)	0.560
TSACC	PAK1	psi-mi:“MI:0915”(physical association)	0.560
KLF11	TSACC	psi-mi:“MI:0915”(physical association)	0.560
TSACC	NUP58	psi-mi:“MI:0915”(physical association)	0.560
DTNB	TSACC	psi-mi:“MI:0915”(physical association)	0.370
TSACC	KDM1A	psi-mi:“MI:0915”(physical association)	0.370
TSACC	FOXP2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): TSACC (Two-hybrid), TSACC (Two-hybrid), TSACC (Two-hybrid), TSACC (Two-hybrid), TSACC (Affinity Capture-RNA), TSACC (Cross-Linking-MS (XL-MS)), TSACC (Affinity Capture-RNA), KDM1A (Two-hybrid)

ESM2 similar proteins: A6QL29, A7WNB2, B3NDY8, B4H957, B4IG10, B4J184, B4KZN6, B4MHR1, B4MXH8, B4QQE2, B5DRT7, B7Z073, O82286, P09513, P0C766, P13622, P14289, P14976, P17926, P19722, P29046, P29047, P33483, P36713, P68948, P68949, P68962, P68963, P75266, P80250, P97863, Q01047, Q09SZ8, Q0R5R0, Q1PD56, Q3E744, Q3SZX7, Q4R7E8, Q65YU9, Q6UY65

Diamond homologs: Q3T016, Q4R7E8, Q96A04, Q9DA44

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

943 predictions. Top by Δscore:

Variant	Effect	Δscore
1:156346740:T:TA	acceptor_gain	1.0000
1:156346743:A:AG	acceptor_gain	1.0000
1:156338152:A:AC	donor_gain	0.9900
1:156338153:C:CC	donor_gain	0.9900
1:156338153:CTGAG:C	donor_gain	0.9900
1:156346744:C:G	acceptor_gain	0.9900
1:156346748:C:A	acceptor_gain	0.9900
1:156346751:T:A	acceptor_gain	0.9900
1:156346763:T:TA	acceptor_gain	0.9900
1:156346764:G:A	acceptor_gain	0.9800
1:156338024:T:TA	donor_gain	0.9600
1:156338132:T:TA	donor_gain	0.9600
1:156344578:A:T	acceptor_gain	0.9600
1:156346769:T:A	acceptor_gain	0.9600
1:156338290:TAC:T	donor_gain	0.9500
1:156338291:ACA:A	donor_gain	0.9500
1:156338292:CAC:C	donor_gain	0.9500
1:156344579:G:T	acceptor_gain	0.9500
1:156346732:T:TA	acceptor_gain	0.9500
1:156338153:CT:C	donor_gain	0.9400
1:156338153:CTG:C	donor_gain	0.9400
1:156338296:TCA:T	donor_gain	0.9400
1:156338310:T:A	donor_gain	0.9400
1:156344577:TA:T	acceptor_gain	0.9400
1:156344578:A:AG	acceptor_gain	0.9400
1:156344579:G:GG	acceptor_gain	0.9400
1:156346766:AGTT:A	acceptor_gain	0.9300
1:156346767:GT:G	acceptor_gain	0.9300
1:156346767:GTT:G	acceptor_gain	0.9300
1:156346767:GTTG:G	acceptor_gain	0.9300

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000011592 (1:156343958 T>C), RS1000311668 (1:156344330 T>C), RS1000509068 (1:156344289 A>G), RS1000662458 (1:156343928 C>T), RS1000712347 (1:156338433 A>G), RS1000743269 (1:156338555 G>A,T), RS1001111989 (1:156342802 G>A,T), RS1001305265 (1:156336850 T>C), RS1001597568 (1:156338620 C>T), RS1002018688 (1:156340978 T>C), RS1002101043 (1:156344956 T>C), RS1002246123 (1:156341441 T>C), RS1002714337 (1:156335651 G>A), RS1002896083 (1:156346408 G>A), RS1003140286 (1:156339891 T>G)

Disease associations

OMIM: gene MIM:619679 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000582_7	Mean corpuscular hemoglobin concentration	3.000000e-09
GCST001521_7	Subcutaneous adipose tissue	9.000000e-06
GCST90000047_18	Age at first sexual intercourse	8.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
jinfukang	increases expression	1
Benzo(a)pyrene	affects expression	1
Cisplatin	increases expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.