TSBP1-AS1

Summary

TSBP1-AS1 (TSBP1 and BTNL2 antisense RNA 1, HGNC:39756) is a long non-coding RNA gene on chromosome 6p21.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39756
Approved symbol	TSBP1-AS1
Name	TSBP1 and BTNL2 antisense RNA 1
Location	6p21.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	XXbac-BPG154L12.4
Ensembl gene	ENSG00000225914
Ensembl biotype	lncRNA
Entrez	101929163
RNAcentral	URS0000A77003 — lncRNA, 2020 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 50 — 50 lncRNA

ENST00000425033, ENST00000426643, ENST00000611838, ENST00000642577, ENST00000644884, ENST00000645134, ENST00000645167, ENST00000645563, ENST00000646176, ENST00000646550, ENST00000646628, ENST00000647036, ENST00000653107, ENST00000653523, ENST00000653922, ENST00000685706, ENST00000690046, ENST00000700993, ENST00000732381, ENST00000732382, ENST00000732383, ENST00000732384, ENST00000732385, ENST00000732386, ENST00000732387, ENST00000732388, ENST00000732389, ENST00000732390, ENST00000732391, ENST00000732392, ENST00000732393, ENST00000732394, ENST00000732395, ENST00000732396, ENST00000732397, ENST00000732398, ENST00000732399, ENST00000732400, ENST00000732401, ENST00000732402, ENST00000732403, ENST00000732404, ENST00000732405, ENST00000732406, ENST00000732407, ENST00000732408, ENST00000732409, ENST00000732410, ENST00000732411, ENST00000732412

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000425033 — 2 exons

Exon	Start	End
ENSE00001680220	32255711	32255941
ENSE00001712130	32262612	32265838

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 93.77.

FANTOM5 (CAGE): breadth broad, TPM avg 0.3890 / max 23.9007, expressed in 188 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67134	0.3890	188

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar vermis	UBERON:0004720	93.77	gold quality
quadriceps femoris	UBERON:0001377	89.92	gold quality
thymus	UBERON:0002370	85.78	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.66	gold quality
ganglionic eminence	UBERON:0004023	83.97	gold quality
ventricular zone	UBERON:0003053	83.60	gold quality
cortical plate	UBERON:0005343	82.76	gold quality
spinal cord	UBERON:0002240	82.75	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.75	gold quality
hypothalamus	UBERON:0001898	80.22	gold quality
Ammon’s horn	UBERON:0001954	78.34	gold quality
amygdala	UBERON:0001876	78.15	gold quality
temporal lobe	UBERON:0001871	78.06	gold quality
anterior cingulate cortex	UBERON:0009835	77.78	gold quality
substantia nigra	UBERON:0002038	77.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.01	gold quality
nucleus accumbens	UBERON:0001882	76.74	gold quality
ovary	UBERON:0000992	75.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	75.39	gold quality
right ovary	UBERON:0002118	75.31	gold quality
left ovary	UBERON:0002119	75.05	gold quality
superior frontal gyrus	UBERON:0002661	74.84	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.74	gold quality
sural nerve	UBERON:0015488	74.65	gold quality
caudate nucleus	UBERON:0001873	73.55	gold quality
corpus callosum	UBERON:0002336	73.28	gold quality
putamen	UBERON:0001874	72.79	gold quality
cerebral cortex	UBERON:0000956	72.77	gold quality
uterine cervix	UBERON:0000002	72.74	gold quality
colonic epithelium	UBERON:0000397	72.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Our findings suggest that CpG-single nucleotide polymorphisms at the C6orf10/LOC101929163 locus might modify age of onset in C9orf72 carriers belonging to the entire amyotrophic lateral sclerosis-frontotemporal dementia spectrum by controlling DNA methylation and gene expression (PMID:30252044)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.