TSC22D4

Summary

TSC22D4 (TSC22 domain family member 4, HGNC:21696) is a protein-coding gene on chromosome 7q22.1, encoding TSC22 domain family protein 4 (Q9Y3Q8). Binds DNA and acts as a transcriptional repressor.

TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators (see TSC22D3; MIM 300506) (Kester et al., 1999 [PubMed 10488076]; Fiorenza et al., 2001 [PubMed 11707329]).

Source: NCBI Gene 81628 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 79 total
• MANE Select transcript: NM_030935

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21696
Approved symbol	TSC22D4
Name	TSC22 domain family member 4
Location	7q22.1
Locus type	gene with protein product
Status	Approved
Aliases	THG-1, TILZ2
Ensembl gene	ENSG00000166925
Ensembl biotype	protein_coding
OMIM	611914
Entrez	81628

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 retained_intron

ENST00000300181, ENST00000393991, ENST00000423266, ENST00000456330, ENST00000493217

RefSeq mRNA: 2 — MANE Select: NM_030935 NM_001303043, NM_030935

CCDS: CCDS5695

Canonical transcript exons

ENST00000300181 — 5 exons

Exon	Start	End
ENSE00001107839	100466519	100467168
ENSE00001107845	100478794	100479214
ENSE00003503628	100467552	100467600
ENSE00003504362	100474274	100474440
ENSE00003562321	100477277	100478307

Expression profiles

Bgee: expression breadth ubiquitous, 264 present calls, max score 99.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 56.4034 / max 2293.2010, expressed in 1817 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
85206	29.9163	1815
85201	24.7422	236
85204	0.8047	501
85207	0.2656	86
85203	0.2469	103
85205	0.2217	65
85202	0.2059	56

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	99.54	gold quality
spinal cord	UBERON:0002240	99.07	gold quality
amygdala	UBERON:0001876	98.89	gold quality
peripheral nervous system	UBERON:0000010	98.81	gold quality
nerve	UBERON:0001021	98.81	gold quality
tibial nerve	UBERON:0001323	98.81	gold quality
right frontal lobe	UBERON:0002810	98.76	gold quality
nucleus accumbens	UBERON:0001882	98.69	gold quality
putamen	UBERON:0001874	98.41	gold quality
cingulate cortex	UBERON:0003027	98.38	gold quality
anterior cingulate cortex	UBERON:0009835	98.35	gold quality
granulocyte	CL:0000094	98.25	gold quality
caudate nucleus	UBERON:0001873	98.25	gold quality
middle frontal gyrus	UBERON:0002702	98.18	gold quality
lower esophagus mucosa	UBERON:0035834	98.13	gold quality
hypothalamus	UBERON:0001898	97.72	gold quality
prefrontal cortex	UBERON:0000451	97.66	gold quality
Brodmann (1909) area 10	UBERON:0013541	97.26	gold quality
Brodmann (1909) area 9	UBERON:0013540	97.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.05	gold quality
lateral globus pallidus	UBERON:0002476	96.69	gold quality
corpus callosum	UBERON:0002336	96.56	gold quality
inferior vagus X ganglion	UBERON:0005363	96.55	gold quality
substantia nigra	UBERON:0002038	96.44	gold quality
midbrain	UBERON:0001891	96.35	gold quality
cerebellar hemisphere	UBERON:0002245	96.32	gold quality
olfactory bulb	UBERON:0002264	96.32	silver quality
cerebellar cortex	UBERON:0002129	96.27	gold quality
ventral tegmental area	UBERON:0002691	96.05	gold quality
subthalamic nucleus	UBERON:0001906	96.02	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-MTAB-7316	yes	1298.91
E-GEOD-84465	yes	791.55
E-MTAB-11121	yes	633.88
E-GEOD-137537	yes	37.16
E-ANND-3	yes	5.10

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting TSC22D4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-320A-3P	99.77	69.73	2107
HSA-MIR-320B	99.77	69.73	2107
HSA-MIR-320C	99.77	69.73	2107
HSA-MIR-320D	99.77	69.73	2107
HSA-MIR-4429	99.77	69.62	2111
HSA-MIR-3140-5P	99.39	69.04	1136
HSA-MIR-5582-5P	99.27	71.42	1879
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-4784	99.15	67.41	1733
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-3150B-3P	98.81	67.21	1728
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-8089	97.74	66.21	1698
HSA-MIR-4667-5P	97.61	66.67	1683
HSA-MIR-4689	96.97	65.79	1209
HSA-MIR-6858-5P	96.05	64.59	1020
HSA-MIR-6822-5P	93.94	66.34	812

Literature-anchored findings (GeneRIF, showing 8)

• Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. (PMID:20149264)
• tRNA(His) guanylyltransferase (THG1), a unique 3’-5’ nucleotidyl transferase, shares unexpected structural homology with canonical 5’-3’ DNA polymerases. (PMID:21059936)
• Data suggest transcription factor TSC22D4 inhibition as an insulin sensitizing option in diabetes therapy. (PMID:27827363)
• Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB. (PMID:31806366)
• THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. (PMID:31864704)
• Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. (PMID:35378329)
• TSC22D4 promotes TGFbeta1-induced activation of hepatic stellate cells. (PMID:35714570)
• Promotion of squamous cell carcinoma tumorigenesis by oncogene-mediated THG-1/TSC22D4 phosphorylation. (PMID:37607779)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm57848	ENSMUSG00000144222
mus_musculus	Tsc22d4	ENSMUSG00000144223
rattus_norvegicus	Tsc22d4	ENSRNOG00000050805
drosophila_melanogaster	bun	FBGN0259176
caenorhabditis_elegans		WBGENE00011824
caenorhabditis_elegans		WBGENE00012994

Paralogs (3): TSC22D1 (ENSG00000102804), TSC22D3 (ENSG00000157514), TSC22D2 (ENSG00000196428)

Protein

Protein identifiers

TSC22 domain family protein 4 — Q9Y3Q8 (reviewed: Q9Y3Q8)

Alternative names: TSC22-related-inducible leucine zipper protein 2

All UniProt accessions (3): Q9Y3Q8, H7BZ77, H7C0M8

UniProt curated annotations — full annotation on UniProt →

Function. Binds DNA and acts as a transcriptional repressor. Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13. Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release. May play a role in neurite elongation and survival.

Subunit / interactions. Forms a homodimer or heterodimer. Forms a heterodimer with TSC22D1 isoforms 1 and 2. Interacts with NRBP1.

Subcellular location. Nucleus. Cytoplasm. Cell projection. Dendrite. Synapse.

Tissue specificity. Expressed in the liver.

Similarity. Belongs to the TSC-22/Dip/Bun family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y3Q8-1	1	yes
Q9Y3Q8-2	2

RefSeq proteins (2): NP_001289972, NP_112197* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000580	TSC22/Bun	Family
IPR042553	TSC22D4	Family
IPR047862	TSC22/BUN_CS	Conserved_site

Pfam: PF01166

UniProt features (24 total): modified residue 14, region of interest 4, compositionally biased region 2, chain 1, splice variant 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3Q8-F1	57.99	0.13

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (14): 165, 187, 189, 190, 211, 225, 229, 260, 264, 279, 370, 49, 57, 62

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 207 (showing top): TAATAAT_MIR126, GOBP_NEURON_PROJECTION_EXTENSION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_GROWTH, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, GOBP_NEUROGENESIS, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, CAGCTG_AP4_Q5, GTGCCTT_MIR506, BROWNE_HCMV_INFECTION_24HR_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, ZIC1_01, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), response to osmotic stress (GO:0006970), glucose homeostasis (GO:0042593), negative regulation of DNA-templated transcription (GO:0045892), neuron cellular homeostasis (GO:0070050), neuron projection extension (GO:1990138), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): nucleus (GO:0005634), cytoplasm (GO:0005737), dendrite (GO:0030425), synapse (GO:0045202), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transcription by RNA polymerase II	2
regulation of DNA-templated transcription	2
cellular anatomical structure	2
regulation of transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
response to stress	1
response to abiotic stimulus	1
carbohydrate homeostasis	1
DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
cellular homeostasis	1
developmental cell growth	1
neuron projection morphogenesis	1
developmental growth involved in morphogenesis	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
neuron projection	1
dendritic tree	1
cell junction	1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSC22D4	LHX4	Q969G2	650
TSC22D4	LHX3	Q9UBR4	588
TSC22D4	SLCO6A1	Q86UG4	490
TSC22D4	NYAP1	Q6ZVC0	450
TSC22D4	SPACDR	Q8IZ16	448
TSC22D4	Q5T8A5	Q5T8A5	434
TSC22D4	ZC2HC1B	Q5TFG8	419
TSC22D4	CTNNA1	P35221	400
TSC22D4	GIGYF1	O75420	393
TSC22D4	WDR53	Q7Z5U6	389
TSC22D4	TGFB1	P01137	385
TSC22D4	TSC22D1	Q15714	383
TSC22D4	ZCWPW1	Q9H0M4	377
TSC22D4	FAM117B	Q6P1L5	366
TSC22D4	PPP1R35	Q8TAP8	360

IntAct

208 interactions, top by confidence:

A	B	Type	Score
NRBP1	TSC22D4	psi-mi:“MI:0915”(physical association)	0.930
TSC22D4	NRBP1	psi-mi:“MI:0915”(physical association)	0.930
NRBP2	TSC22D4	psi-mi:“MI:0915”(physical association)	0.840
MAD2L1	TSC22D4	psi-mi:“MI:0915”(physical association)	0.800
TSC22D4	MAD2L1	psi-mi:“MI:0915”(physical association)	0.800
TSC22D4	PIN1	psi-mi:“MI:0915”(physical association)	0.780
PIN1	TSC22D4	psi-mi:“MI:0915”(physical association)	0.780
TSC22D4	KEAP1	psi-mi:“MI:0915”(physical association)	0.760
TSC22D4	KEAP1	psi-mi:“MI:0403”(colocalization)	0.760
NRBP1	TSC22D2	psi-mi:“MI:0914”(association)	0.730
TSC22D4	POLR1C	psi-mi:“MI:0915”(physical association)	0.720
ZBTB24	TSC22D4	psi-mi:“MI:0915”(physical association)	0.720
TSC22D4	ZBTB24	psi-mi:“MI:0915”(physical association)	0.720
POLR1C	TSC22D4	psi-mi:“MI:0915”(physical association)	0.720
TSC22D4	ZMYND10	psi-mi:“MI:0915”(physical association)	0.700

BioGRID (212): TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid), TSC22D4 (Two-hybrid)

ESM2 similar proteins: A2A7S8, A5D7K1, A5PK23, B1AXH1, F1QGH6, O94885, O95402, Q08495, Q08DM1, Q3T044, Q499V8, Q5HYW2, Q5PQP4, Q5R4B6, Q5R8Q8, Q5SYE7, Q5T0Z8, Q5U2R6, Q6PDH0, Q6PFX7, Q6PGN9, Q6ZVC0, Q7TT28, Q80U35, Q80VC9, Q80Z38, Q86UU1, Q86WR7, Q8BI29, Q8C5R2, Q8CAF4, Q8JZX9, Q8K4J6, Q8N1G1, Q8TF72, Q91Z58, Q969V6, Q96A73, Q9BW04, Q9D0P7

Diamond homologs: E9Q7M2, O75157, P62500, P62501, P80220, Q22544, Q24522, Q24523, Q27I66, Q3B8N7, Q3MHL6, Q5R4H1, Q5RED5, Q99576, Q9EQN3, Q9EQZ1, Q9Y3Q8, Q9Z2S7, Q15714, Q4R4H5, Q91012

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 101 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-1-host interactions	6	17.9×	2e-04
SARS-CoV-1 Infection	6	14.5×	4e-04
G2/M Checkpoints	5	11.4×	3e-03
TP53 Regulates Metabolic Genes	5	11.0×	3e-03
SARS-CoV Infections	8	7.5×	8e-04
Cell Cycle Checkpoints	5	7.5×	9e-03
Transcriptional Regulation by TP53	7	7.4×	2e-03
Viral Infection Pathways	10	5.2×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

728 predictions. Top by Δscore:

Variant	Effect	Δscore
7:100467139:C:CT	acceptor_gain	1.0000
7:100467599:CA:C	acceptor_gain	1.0000
7:100467601:C:CC	acceptor_gain	1.0000
7:100474270:CTA:C	donor_loss	1.0000
7:100474272:A:AC	donor_gain	1.0000
7:100474273:C:CC	donor_gain	1.0000
7:100474273:CCTA:C	donor_loss	1.0000
7:100474466:CACA:C	acceptor_gain	1.0000
7:100474469:A:C	acceptor_gain	1.0000
7:100467166:GTCC:G	acceptor_loss	0.9900
7:100467167:TC:T	acceptor_gain	0.9900
7:100467168:CC:C	acceptor_gain	0.9900
7:100467179:C:T	acceptor_gain	0.9900
7:100467548:TTACC:T	donor_loss	0.9900
7:100467550:A:AC	donor_gain	0.9900
7:100467550:A:AT	donor_loss	0.9900
7:100467551:C:CC	donor_gain	0.9900
7:100467597:GCCA:G	acceptor_gain	0.9900
7:100467598:CCA:C	acceptor_gain	0.9900
7:100467598:CCAC:C	acceptor_gain	0.9900
7:100467599:CAC:C	acceptor_gain	0.9900
7:100474273:CCTAT:C	donor_gain	0.9900
7:100474438:CAC:C	acceptor_gain	0.9900
7:100474441:CTGGA:C	acceptor_loss	0.9900
7:100474442:T:C	acceptor_loss	0.9900
7:100474449:G:T	acceptor_gain	0.9900
7:100467164:AAGTC:A	acceptor_gain	0.9800
7:100467166:GTC:G	acceptor_gain	0.9800
7:100467169:C:CC	acceptor_gain	0.9800
7:100467179:C:CT	acceptor_gain	0.9800

AlphaMissense

2501 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:100467116:A:G	L344P	1.000
7:100467137:A:T	V337D	1.000
7:100467149:A:G	L333P	1.000
7:100467149:A:T	L333H	1.000
7:100467153:G:C	H332D	1.000
7:100467156:A:G	S331P	1.000
7:100467157:C:A	K330N	1.000
7:100467157:C:G	K330N	1.000
7:100467557:C:G	A325P	1.000
7:100467565:A:C	I322S	1.000
7:100467565:A:T	I322N	1.000
7:100477769:C:A	W90C	1.000
7:100477769:C:G	W90C	1.000
7:100477771:A:G	W90R	1.000
7:100477771:A:T	W90R	1.000
7:100477823:G:C	F72L	1.000
7:100477823:G:T	F72L	1.000
7:100477824:A:G	F72S	1.000
7:100477825:A:G	F72L	1.000
7:100478004:A:G	I12T	1.000
7:100467053:A:G	L365P	0.999
7:100467074:A:G	L358P	0.999
7:100467104:A:G	I348T	0.999
7:100467134:C:G	R338P	0.999
7:100467141:C:G	A336P	0.999
7:100467150:G:A	L333F	0.999
7:100467151:G:C	H332Q	0.999
7:100467151:G:T	H332Q	0.999
7:100467158:T:A	K330M	0.999
7:100467159:T:C	K330E	0.999

dbSNP variants (sampled 300 via entrez): RS1000076772 (7:100468996 C>A,T), RS1000131233 (7:100474997 C>G,T), RS1000423470 (7:100474864 C>A), RS1000500983 (7:100477085 G>C), RS1000875952 (7:100467440 G>A,C), RS1001036218 (7:100479780 G>C), RS1001053067 (7:100470387 G>A), RS1001136562 (7:100476680 G>A), RS1001461507 (7:100473173 C>T), RS1001504587 (7:100478335 G>C), RS1002043366 (7:100478118 G>C), RS1002068328 (7:100472100 G>A), RS1002133679 (7:100467475 A>G,T), RS1002435006 (7:100472064 C>T), RS1002591435 (7:100473204 G>A,C)

Disease associations

OMIM: gene MIM:611914 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST004603_40	Platelet count	6.000000e-15
GCST010002_259	Refractive error	3.000000e-16
GCST010702_48	Subcortical volume (MOSTest)	6.000000e-10
GCST010703_289	Brain morphology (MOSTest)	6.000000e-15

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004309	platelet count
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, affects expression	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
beta-lapachone	increases expression	1
coumarin	affects phosphorylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
perfluoro-n-nonanoic acid	decreases expression	1
ICG 001	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Arsenic	affects methylation	1
Caffeine	decreases phosphorylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Selenomethionine	affects expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_AW46	K562 eGFP-TSC22D4	Cancer cell line	Female
CVCL_B2JT	Abcam HeLa TSC22D4 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.