TSGA10

Summary

TSGA10 (testis specific 10, HGNC:14927) is a protein-coding gene on chromosome 2q11.2, encoding Testis-specific gene 10 protein (Q9BZW7). Plays a role in spermatogenesis.

Predicted to enable structural molecule activity. Predicted to be involved in spermatogenesis. Predicted to act upstream of or within cell projection assembly. Predicted to be located in neuron projection; sperm fibrous sheath; and sperm principal piece. Predicted to be active in motile cilium. Implicated in spermatogenic failure 26.

Source: NCBI Gene 80705 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spermatogenic failure 26 (Limited, GenCC)
• GWAS associations: 6
• Clinical variants (ClinVar): 116 total — 1 pathogenic
• Phenotypes (HPO): 4
• MANE Select transcript: NM_025244

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14927
Approved symbol	TSGA10
Name	testis specific 10
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Aliases	CEP4L, CT79
Ensembl gene	ENSG00000135951
Ensembl biotype	protein_coding
OMIM	607166
Entrez	80705

Gene structure

Transcript identifiers

Ensembl transcripts: 45 — 32 protein_coding, 11 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000355053, ENST00000393482, ENST00000393483, ENST00000409564, ENST00000410001, ENST00000462782, ENST00000464459, ENST00000465216, ENST00000471174, ENST00000476849, ENST00000478090, ENST00000483914, ENST00000488960, ENST00000489348, ENST00000489546, ENST00000489926, ENST00000494483, ENST00000498097, ENST00000674128, ENST00000851767, ENST00000851768, ENST00000851769, ENST00000851770, ENST00000851771, ENST00000851772, ENST00000851773, ENST00000851774, ENST00000851775, ENST00000851776, ENST00000851777, ENST00000851778, ENST00000851779, ENST00000851780, ENST00000917866, ENST00000917867, ENST00000917868, ENST00000970974, ENST00000970975, ENST00000970976, ENST00000970977, ENST00000970978, ENST00000970979, ENST00000970980, ENST00000970981, ENST00000970982

RefSeq mRNA: 5 — MANE Select: NM_025244 NM_001349012, NM_001349013, NM_001349014, NM_025244, NM_182911

CCDS: CCDS2037

Canonical transcript exons

ENST00000393483 — 21 exons

Exon	Start	End
ENSE00000921822	99020280	99020482
ENSE00001200168	99109389	99109512
ENSE00001372701	99118551	99118686
ENSE00001381394	99110850	99110915
ENSE00001384554	99127048	99127176
ENSE00001390858	99117544	99117759
ENSE00001515447	98997261	98998221
ENSE00001871956	99154693	99154942
ENSE00003485382	99073018	99073073
ENSE00003536451	99064939	99065124
ENSE00003545025	99103967	99104118
ENSE00003576451	99035230	99035439
ENSE00003582893	99068888	99068998
ENSE00003585997	99108833	99108991
ENSE00003606020	99105359	99105436
ENSE00003606612	99071706	99071874
ENSE00003610547	99105527	99105697
ENSE00003633909	99018536	99018640
ENSE00003666833	99081282	99081397
ENSE00003680765	99078659	99078813
ENSE00003787176	99018200	99018349

Expression profiles

Bgee: expression breadth ubiquitous, 193 present calls, max score 98.37.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.8417 / max 108.5483, expressed in 1466 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29870	1.5894	809
29875	1.1080	636
29874	1.1003	585
29869	0.9121	489
29876	0.8305	459
29873	0.1479	61
29872	0.1054	41
29871	0.0481	20

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.37	gold quality
right uterine tube	UBERON:0001302	96.27	gold quality
male germ cell	CL:0000015	96.17	gold quality
bronchial epithelial cell	CL:0002328	94.77	gold quality
left testis	UBERON:0004533	94.62	gold quality
right testis	UBERON:0004534	94.04	gold quality
epithelium of bronchus	UBERON:0002031	93.54	gold quality
testis	UBERON:0000473	93.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.65	gold quality
bronchus	UBERON:0002185	92.05	gold quality
buccal mucosa cell	CL:0002336	89.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.75	gold quality
adenohypophysis	UBERON:0002196	86.39	gold quality
mucosa of paranasal sinus	UBERON:0005030	85.63	gold quality
pituitary gland	UBERON:0000007	84.47	gold quality
left lobe of thyroid gland	UBERON:0001120	83.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.82	gold quality
right lobe of thyroid gland	UBERON:0001119	83.61	gold quality
thyroid gland	UBERON:0002046	83.35	gold quality
secondary oocyte	CL:0000655	83.24	gold quality
calcaneal tendon	UBERON:0003701	82.85	gold quality
islet of Langerhans	UBERON:0000006	82.36	gold quality
metanephros cortex	UBERON:0010533	82.16	gold quality
corpus callosum	UBERON:0002336	81.97	gold quality
body of pancreas	UBERON:0001150	80.78	gold quality
cerebellar hemisphere	UBERON:0002245	80.70	gold quality
cerebellar cortex	UBERON:0002129	80.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.49	gold quality
spinal cord	UBERON:0002240	79.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.31

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

80 targeting TSGA10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-548AG	99.77	69.25	1492
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-200A-5P	99.76	69.10	949
HSA-MIR-200B-5P	99.76	69.05	948
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-548AI	99.69	69.24	1494
HSA-MIR-570-5P	99.69	69.24	1494
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459

Literature-anchored findings (GeneRIF, showing 18)

• over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers (PMID:15107545)
• The RT-PCR of TSGA10 expression may help in detection of residual clonal cells leading to early diagnosis and better prognostic qualification of the acute lymphoblastic leukemia. (PMID:16406020)
• TSGA10 is target of immune reactions in Autoimmune polyendocrine syndrome type 1 (APS1). (PMID:18000009)
• TSGA10 could influence the function of antigen presenting cells via its interaction with cytoskeletal proteins such as vimentin (PMID:20797700)
• TSGA10 should be considered as an autoantigen in a subset of autoimmune polyendocrine syndrome type 1 patients and also in a minority of systemic lupus erythematosus patients (PMID:21198756)
• Report role for mir-577/TSGA10 axis in regulation esophageal squamous cell carcinoma progression. (PMID:24294352)
• Overexpression of TSGA10 would induce disruption of HIF-1alpha axis and exert potent inhibitory effects on tumor angiogenesis and metastasis. (PMID:26573430)
• TSGA10 tends to express variants with shorter 5’UTR. (PMID:28739310)
• we speculate that the presence of rare sequence variants within TSGA10 may be associated with acephalic spermatozoa in humans (PMID:28905369)
• Results show that TSGA10 is directly regulated by mir-23a which targeted the 3’UTR of mir-23a to regulate angiogenesis. (PMID:29520105)
• This study showed the role of Lactobacilli in down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes. Such expression change might be involved in the anticancer effects of these Lactobacilli. The underlying mechanisms of these observations are not clear but epigenetic modulatory mechanisms may participate in this process. (PMID:30545223)
• the current study showed that TSGA10 could be considered as a tumor suppressor in acute myeloid leukemia (PMID:30638859)
• Overexpression of TSGA10, as a tumor suppressor gene, in endothelial cells resulted in decreased proliferation, migration and therefore, angiogenic activity of HUVECs and may involved HIF2a binding. (PMID:31704243)
• Hypoxia-induced microRNA-10b-3p promotes esophageal squamous cell carcinoma growth and metastasis by targeting TSGA10. (PMID:31772141)
• TSGA10 overexpression could decrease the metastatic and metabolic activity of cancer cells through its inhibitory effect on HIF-1 activity. Therefore, TSGA10 could be considered in the research for therapeutic candidates in cancer. (PMID:32086108)
• Novel mutations in PMFBP1, TSGA10 and SUN5: Expanding the spectrum of mutations that may cause acephalic spermatozoa. (PMID:32285443)
• TSGA10 as a Potential Key Factor in the Process of Spermatid Differentiation/Maturation: Deciphering Its Association with Autophagy Pathway. (PMID:34232471)
• Pathogenesis of acephalic spermatozoa syndrome caused by splicing mutation and de novo deletion in TSGA10. (PMID:34409526)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tsga10	ENSDARG00000052512
mus_musculus	Tsga10	ENSMUSG00000060771
rattus_norvegicus	Tsga10	ENSRNOG00000058681

Paralogs (4): CROCC (ENSG00000058453), CEP250 (ENSG00000126001), CEP135 (ENSG00000174799), CROCC2 (ENSG00000226321)

Protein

Protein identifiers

Testis-specific gene 10 protein — Q9BZW7 (reviewed: Q9BZW7)

Alternative names: Testis development protein NYD-SP7

All UniProt accessions (5): A0A218MIY9, Q9BZW7, A0A669KBL0, B8ZZZ9, F8WA32

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A.

Subunit / interactions. Interacts with HIF1A.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole.

Tissue specificity. Expressed in the testis, in spermatozoa (at protein level). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach.

Post-translational modifications. Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.

Disease relevance. Spermatogenic failure 26 (SPGF26) [MIM:617961] An autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the CEP135/TSGA10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BZW7-1	1	yes
Q9BZW7-2	2

RefSeq proteins (5): NP_001335941, NP_001335942, NP_001335943, NP_079520, NP_878915 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR051877	Centriole_BasalBody_StrucProt	Family

UniProt features (13 total): sequence conflict 4, region of interest 2, compositionally biased region 2, modified residue 2, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZW7-F1	81.70	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 163, 688

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 166 (showing top): GOBP_MALE_GAMETE_GENERATION, GOCC_MICROTUBULE_ORGANIZING_CENTER, KIM_RESPONSE_TO_TSA_AND_DECITABINE_UP, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, WEBER_METHYLATED_LCP_IN_FIBROBLAST_DN, NKX22_01, GFI1_01, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOCC_NEURON_PROJECTION, CONRAD_GERMLINE_STEM_CELL, RFX1_02, CDPCR3HD_01, GOBP_CELL_PROJECTION_ORGANIZATION, WALLACE_PROSTATE_CANCER_RACE_DN, TGGAAA_NFAT_Q4_01

GO Biological Process (2): spermatogenesis (GO:0007283), cell projection assembly (GO:0030031)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (7): cytoplasm (GO:0005737), centriole (GO:0005814), motile cilium (GO:0031514), sperm fibrous sheath (GO:0035686), neuron projection (GO:0043005), sperm principal piece (GO:0097228), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular membraneless organelle	2
sperm flagellum	2
developmental process involved in reproduction	1
male gamete generation	1
cellular component assembly	1
cell projection organization	1
binding	1
intracellular anatomical structure	1
microtubule organizing center	1
cilium	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

1201 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSGA10	PMFBP1	Q8TBY8	711
TSGA10	SUN5	Q8TC36	691
TSGA10	BRDT	Q58F21	601
TSGA10	CEP112	Q8N8E3	582
TSGA10	ODF4	Q2M2E3	553
TSGA10	AKAP3	O75969	535
TSGA10	HMGN5	P82970	522
TSGA10	HOOK1	Q9UJC3	491
TSGA10	SPATC1L	Q9H0A9	489
TSGA10	ACTG1	P02571	484
TSGA10	CABYR	O75952	478
TSGA10	SPA17	Q15506	477
TSGA10	ROPN1	Q9HAT0	466
TSGA10	SOX30	O94993	466
TSGA10	AKAP4	Q5JQC9	451

IntAct

259 interactions, top by confidence:

A	B	Type	Score
PRPF31	TSGA10	psi-mi:“MI:0915”(physical association)	0.720
TSGA10	CDC73	psi-mi:“MI:0915”(physical association)	0.720
CDC73	TSGA10	psi-mi:“MI:0915”(physical association)	0.720
TSGA10	CCHCR1	psi-mi:“MI:0915”(physical association)	0.720
TSGA10	CEP44	psi-mi:“MI:0915”(physical association)	0.720
TSGA10	PRPF31	psi-mi:“MI:0915”(physical association)	0.720
CCHCR1	TSGA10	psi-mi:“MI:0915”(physical association)	0.720
TSGA10	BIRC2	psi-mi:“MI:0915”(physical association)	0.670
BIRC2	TSGA10	psi-mi:“MI:0915”(physical association)	0.670
TSGA10	BCL6B	psi-mi:“MI:0915”(physical association)	0.560
FLJ38668	TSGA10	psi-mi:“MI:0915”(physical association)	0.560
ZBTB24	TSGA10	psi-mi:“MI:0915”(physical association)	0.560
SCEL	TSGA10	psi-mi:“MI:0915”(physical association)	0.560
CREB5	TSGA10	psi-mi:“MI:0915”(physical association)	0.560
TSGA10	CDK18	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (108): TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid), TSGA10 (Two-hybrid)

ESM2 similar proteins: A0A2R8QCI3, A3KGV1, A3KNA5, A7MD70, B1WB65, B8JK76, F6ZDS4, G5E861, O35550, O35551, P55937, P85001, Q08DR9, Q15276, Q2T9U2, Q4R6W3, Q4R703, Q4R8C3, Q502I3, Q5BJF6, Q5M9N0, Q5PQ23, Q5PR68, Q5R829, Q5RG45, Q5ZKK5, Q66GS9, Q66KE8, Q6AYX5, Q6NRC9, Q6NRW2, Q6NY15, Q6P5D4, Q6ZU80, Q80UF4, Q811U3, Q86SQ7, Q8BI22, Q8CDI6, Q8CDI7

Diamond homologs: Q4R6W3, Q5RG45, Q66GS9, Q6NY15, Q6P5D4, Q9BZW7, Q9Z220, A8ID55

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	84
Likely benign	8
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
523232	NM_182911.4(TSGA10):c.211del	Pathogenic

SpliceAI

4652 predictions. Top by Δscore:

Variant	Effect	Δscore
2:99018198:A:AC	donor_gain	1.0000
2:99018199:C:CC	donor_gain	1.0000
2:99018199:CT:C	donor_gain	1.0000
2:99018531:CTTA:C	donor_loss	1.0000
2:99018532:TTA:T	donor_loss	1.0000
2:99018533:TA:T	donor_loss	1.0000
2:99018534:A:AC	donor_gain	1.0000
2:99018534:A:T	donor_loss	1.0000
2:99018534:AC:A	donor_gain	1.0000
2:99018535:C:CT	donor_gain	1.0000
2:99018535:CC:C	donor_gain	1.0000
2:99018535:CCT:C	donor_gain	1.0000
2:99018535:CCTT:C	donor_gain	1.0000
2:99018535:CCTTT:C	donor_gain	1.0000
2:99018636:TGGCC:T	acceptor_gain	1.0000
2:99018637:GGCC:G	acceptor_gain	1.0000
2:99018638:GCC:G	acceptor_gain	1.0000
2:99018638:GCCC:G	acceptor_loss	1.0000
2:99018639:CC:C	acceptor_gain	1.0000
2:99018639:CCC:C	acceptor_gain	1.0000
2:99018640:CC:C	acceptor_gain	1.0000
2:99018641:C:CA	acceptor_loss	1.0000
2:99018641:C:CC	acceptor_gain	1.0000
2:99020278:A:AC	donor_gain	1.0000
2:99020279:C:CC	donor_gain	1.0000
2:99035226:ATAC:A	donor_loss	1.0000
2:99035227:TA:T	donor_loss	1.0000
2:99035228:ACCAT:A	donor_loss	1.0000
2:99035229:C:CG	donor_loss	1.0000
2:99064932:AACTT:A	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000034167 (2:99082569 T>C,G), RS1000051205 (2:99039072 A>T), RS1000091457 (2:99028241 A>G), RS1000093847 (2:99027412 T>C), RS1000146043 (2:99027690 C>G,T), RS1000237097 (2:99112491 G>C), RS1000299197 (2:99098747 T>G), RS1000302937 (2:99079469 T>C), RS1000326766 (2:99021338 C>A), RS1000335725 (2:99079881 A>C), RS1000344653 (2:99123638 AT>A,ATT), RS1000392154 (2:99138276 A>G), RS1000417546 (2:99025281 A>T), RS1000503307 (2:99032758 G>C), RS1000536203 (2:99086230 G>A,C)

Disease associations

OMIM: gene MIM:607166 | disease phenotypes: MIM:617961

GenCC curated gene-disease

Disease	Classification	Inheritance
spermatogenic failure 26	Limited	Unknown

Mondo (1): spermatogenic failure 26 (MONDO:0054730)

Orphanet (0):

HPO phenotypes

4 total (4 of 4 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0003251	Male infertility
HP:0011462	Young adult onset
HP:0012869	Acephalic spermatozoa

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001241_13	Bipolar disorder	3.000000e-06
GCST005316_286	Intelligence (MTAG)	1.000000e-08
GCST90002385_136	High light scatter reticulocyte count	4.000000e-17
GCST90002386_252	High light scatter reticulocyte percentage of red cells	4.000000e-18
GCST90002405_132	Reticulocyte count	5.000000e-13
GCST90002406_25	Reticulocyte fraction of red cells	3.000000e-14

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	increases expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Valproic Acid	decreases methylation, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
tungsten carbide	affects cotreatment, increases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt	affects cotreatment, increases expression	1
sodium arsenite	increases expression	1
manganese chloride	increases expression	1
benzo(e)pyrene	decreases methylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	affects expression	1
Amiodarone	increases expression	1
Chenodeoxycholic Acid	affects cotreatment, increases expression	1
Cobalt	affects cotreatment, increases expression	1
Demecolcine	increases expression	1
Deoxycholic Acid	affects cotreatment, increases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Glycochenodeoxycholic Acid	affects cotreatment, increases expression	1
Glycocholic Acid	affects cotreatment, increases expression	1
Glycodeoxycholic Acid	affects cotreatment, increases expression	1
Manganese	increases expression	1
Methapyrilene	decreases methylation	1
Methyl Methanesulfonate	increases expression	1
Quercetin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.