TSNAX

Summary

TSNAX (translin associated factor X, HGNC:12380) is a protein-coding gene on chromosome 1q42.2, encoding Translin-associated protein X (Q99598). Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC).

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.

Source: NCBI Gene 7257 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 30 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_005999

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12380
Approved symbol	TSNAX
Name	translin associated factor X
Location	1q42.2
Locus type	gene with protein product
Status	Approved
Aliases	TRAX, C3PO
Ensembl gene	ENSG00000116918
Ensembl biotype	protein_coding
OMIM	602964
Entrez	7257

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000366639, ENST00000413309, ENST00000475168, ENST00000476913, ENST00000602825, ENST00000903833, ENST00000903834, ENST00000947977, ENST00000947978, ENST00000947979

RefSeq mRNA: 1 — MANE Select: NM_005999 NM_005999

CCDS: CCDS1596

Canonical transcript exons

ENST00000366639 — 6 exons

Exon	Start	End
ENSE00003468705	231564528	231566524
ENSE00003480362	231528669	231528826
ENSE00003498044	231529255	231529359
ENSE00003535238	231537213	231537327
ENSE00003655702	231561128	231561255
ENSE00003682497	231542481	231542611

Expression profiles

Bgee: expression breadth ubiquitous, 293 present calls, max score 96.36.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 41.3865 / max 753.4331, expressed in 1816 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9052	41.3865	1816

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	96.36	gold quality
choroid plexus epithelium	UBERON:0003911	95.38	gold quality
parietal pleura	UBERON:0002400	95.27	gold quality
secondary oocyte	CL:0000655	95.24	gold quality
buccal mucosa cell	CL:0002336	95.22	gold quality
pleura	UBERON:0000977	94.98	gold quality
islet of Langerhans	UBERON:0000006	94.63	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	94.59	gold quality
germinal epithelium of ovary	UBERON:0001304	94.56	gold quality
visceral pleura	UBERON:0002401	94.56	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.34	gold quality
biceps brachii	UBERON:0001507	94.30	gold quality
monocyte	CL:0000576	94.24	gold quality
calcaneal tendon	UBERON:0003701	94.19	gold quality
penis	UBERON:0000989	94.17	gold quality
mononuclear cell	CL:0000842	94.13	gold quality
pigmented layer of retina	UBERON:0001782	94.11	gold quality
lateral nuclear group of thalamus	UBERON:0002736	94.10	gold quality
seminal vesicle	UBERON:0000998	94.02	gold quality
vastus lateralis	UBERON:0001379	94.00	gold quality
mucosa of paranasal sinus	UBERON:0005030	93.99	gold quality
palpebral conjunctiva	UBERON:0001812	93.94	gold quality
epithelium of nasopharynx	UBERON:0001951	93.94	gold quality
leukocyte	CL:0000738	93.86	gold quality
corpus epididymis	UBERON:0004359	93.86	gold quality
substantia nigra pars compacta	UBERON:0001965	93.58	gold quality
tendon	UBERON:0000043	93.44	gold quality
quadriceps femoris	UBERON:0001377	93.41	gold quality
gastrocnemius	UBERON:0001388	93.24	gold quality
lateral globus pallidus	UBERON:0002476	93.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F4

miRNA regulators (miRDB)

130 targeting TSNAX, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-433-3P	99.98	69.37	1203
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-3910	99.95	71.13	2227

Literature-anchored findings (GeneRIF, showing 16)

• TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation (PMID:14711818)
• One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. (PMID:15838535)
• Translin “chaperones” Trax and forms heteromeric complex that is DNA binding competent (PMID:15919079)
• The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. (PMID:19255581)
• Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. (PMID:19760522)
• C3PO endonuclease is an asymmetric octamer barrel consisting of six translin and two TRAX subunits which activates RISC by degrading the Ago2-nicked passenger strand of siRNA. (PMID:21552258)
• TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. (PMID:22427937)
• Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder (PMID:22673686)
• Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. (PMID:22889834)
• LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. (PMID:24928020)
• TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. (PMID:25043320)
• High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. (PMID:25239642)
• Translin and Trax control telomere-associated transcript levels in human cells in a telomere-specific fashion. (PMID:27183912)
• TRAX Provides Neuroprotection for Huntington’s Disease Via Modulating a Novel Subset of MicroRNAs. (PMID:35997316)
• Conformational alteration in glycan induces phospholipase Cbeta1 activation and angiogenesis. (PMID:36517806)
• The associations between cognitive functions and TSNAX genetic variations in patients with schizophrenia. (PMID:37030547)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tsnax	ENSDARG00000115282
mus_musculus	Tsnax	ENSMUSG00000056820
rattus_norvegicus	Tsnax	ENSRNOG00000049784
drosophila_melanogaster	Trax	FBGN0038327

Paralogs (1): TSN (ENSG00000211460)

Protein

Protein identifiers

Translin-associated protein X — Q99598 (reviewed: Q99598)

Alternative names: Translin-associated factor X

All UniProt accessions (2): Q99598, Q5VVQ1

UniProt curated annotations — full annotation on UniProt →

Function. Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.

Subunit / interactions. Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner.

Subcellular location. Cytoplasm. Perinuclear region. Golgi apparatus. Nucleus.

Post-translational modifications. Sumoylated with SUMO1.

Similarity. Belongs to the translin family.

RefSeq proteins (1): NP_005990* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002848	Translin_fam	Family
IPR016068	Translin_N	Homologous_superfamily
IPR016069	Translin_C	Homologous_superfamily
IPR036081	Translin_sf	Homologous_superfamily

Pfam: PF01997

UniProt features (18 total): helix 9, region of interest 2, binding site 2, chain 1, turn 1, compositionally biased region 1, cross-link 1, strand 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
3QB5	X-RAY DIFFRACTION	2.95
3PJA	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99598-F1	83.08	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 129; 197

Post-translational modifications (1): 279

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-426486	Small interfering RNA (siRNA) biogenesis

MSigDB gene sets: 187 (showing top): GCM_MAP4K4, HORIUCHI_WTAP_TARGETS_DN, GOMF_ENDONUCLEASE_ACTIVITY, GOMF_RNA_NUCLEASE_ACTIVITY, GOMF_NUCLEASE_ACTIVITY, GOBP_MALE_GAMETE_GENERATION, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOMF_RNA_ENDONUCLEASE_ACTIVITY, OCT1_06, SCHLOSSER_SERUM_RESPONSE_DN, GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GCM_NF2, GOMF_SIGNALING_RECEPTOR_BINDING, ACEVEDO_LIVER_CANCER_UP

GO Biological Process (4): spermatogenesis (GO:0007283), cell differentiation (GO:0030154), siRNA processing (GO:0030422), regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194)

GO Molecular Function (9): DNA binding (GO:0003677), single-stranded DNA binding (GO:0003697), RNA binding (GO:0003723), RNA endonuclease activity (GO:0004521), A2A adenosine receptor binding (GO:0031687), sequence-specific DNA binding (GO:0043565), protein-containing complex binding (GO:0044877), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), cytosol (GO:0005829), perinuclear region of cytoplasm (GO:0048471), endoribonuclease complex (GO:1902555)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Gene Silencing by RNA	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	3
nucleic acid binding	2
DNA binding	2
binding	2
intracellular membrane-bounded organelle	2
developmental process involved in reproduction	1
male gamete generation	1
cellular developmental process	1
regulatory ncRNA processing	1
post-transcriptional gene silencing	1
regulatory ncRNA-mediated gene silencing	1
endonuclease activity	1
RNA nuclease activity	1
adenosine receptor binding	1
cation binding	1
nuclear lumen	1
intracellular anatomical structure	1
endomembrane system	1
endonuclease complex	1

Protein interactions and networks

STRING

1458 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSNAX	TSN	Q15631	992
TSNAX	DISC1	Q9NRI5	904
TSNAX	TSNAXIP1	Q2TAA8	878
TSNAX	AGO2	Q9UKV8	770
TSNAX	PTGER3	P43115	737
TSNAX	GOLGA3	Q08378	704
TSNAX	DICER1	Q9UPY3	658
TSNAX	PLCB1	Q9NQ66	641
TSNAX	SUN1	O94901	621
TSNAX	C1D	Q13901	612
TSNAX	MRFAP1L1	Q96HT8	596
TSNAX	ADORA2A	P29274	580
TSNAX	GAP43	P17677	558
TSNAX	SYNE2	Q8WXH0	553
TSNAX	SUN2	Q9UH99	549

IntAct

232 interactions, top by confidence:

A	B	Type	Score
TSN	TSNAX	psi-mi:“MI:0915”(physical association)	0.920
TSN	TSNAX	psi-mi:“MI:0407”(direct interaction)	0.920
C1QTNF9	C1QTNF9B	psi-mi:“MI:0914”(association)	0.780
BLOC1S5	TSNAX	psi-mi:“MI:0915”(physical association)	0.720
TSNAX	BLOC1S5	psi-mi:“MI:0915”(physical association)	0.720
TSNAX	KLC3	psi-mi:“MI:0915”(physical association)	0.670
KLC3	TSNAX	psi-mi:“MI:0915”(physical association)	0.670
LDB2	TSNAX	psi-mi:“MI:0915”(physical association)	0.670
GADD45G	TSNAX	psi-mi:“MI:0915”(physical association)	0.670
PMF1	TSNAX	psi-mi:“MI:0915”(physical association)	0.670
KLC3	TSNAX	psi-mi:“MI:0915”(physical association)	0.630
	TSNAX	psi-mi:“MI:0915”(physical association)	0.560
TSNAX	AIMP1	psi-mi:“MI:0915”(physical association)	0.560
TCF12	TSNAX	psi-mi:“MI:0915”(physical association)	0.560
TSNAX	LZTS2	psi-mi:“MI:0915”(physical association)	0.560
CARD9	TSNAX	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (251): TSNAX (Two-hybrid), TSNAX (Two-hybrid), AIMP1 (Two-hybrid), BLOC1S5 (Two-hybrid), CARD9 (Two-hybrid), LZTS2 (Two-hybrid), KLC3 (Two-hybrid), TSNAX (Biochemical Activity), SOGA1 (Affinity Capture-MS), GOLGA3 (Affinity Capture-MS), CEP128 (Affinity Capture-MS), KIF2A (Affinity Capture-MS), RGPD8 (Affinity Capture-MS), RGPD5 (Affinity Capture-MS), PCNT (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q1LSX9, A2APV2, A2VE39, A7YY45, A9UMG5, D2HRF1, F4IDS7, O55091, P10687, P10894, Q28E61, Q2T9V5, Q32L27, Q3MHI7, Q4R599, Q5GFD8, Q5GFD9, Q5M8G6, Q5R558, Q5R981, Q5RC21, Q5U2Z5, Q5ZLV4, Q5ZMG1, Q642J4, Q7YQJ9, Q7Z569, Q8CCJ3, Q8CE96, Q8K2Z8, Q8K394, Q8K4M9, Q8N1G2, Q8VZM1, Q8WVN8, Q91XL9, Q96DT6, Q96FJ0, Q96PY5, Q99598

Diamond homologs: O74955, Q4R599, Q5RC21, Q99598, Q9JHB5, Q9QZE7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 68 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Cell Cycle Checkpoints	6	12.3×	2e-03
Cell Cycle	8	6.7×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	25
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1123 predictions. Top by Δscore:

Variant	Effect	Δscore
1:231528869:G:T	donor_gain	1.0000
1:231536006:G:GT	donor_gain	1.0000
1:231542479:A:AG	acceptor_gain	1.0000
1:231542479:AGT:A	acceptor_gain	1.0000
1:231542480:G:GG	acceptor_gain	1.0000
1:231542480:GT:G	acceptor_gain	1.0000
1:231542480:GTG:G	acceptor_gain	1.0000
1:231542609:CAGG:C	donor_loss	1.0000
1:231542611:GGTA:G	donor_loss	1.0000
1:231542612:GT:G	donor_loss	1.0000
1:231542613:TAA:T	donor_loss	1.0000
1:231561123:TTCA:T	acceptor_loss	1.0000
1:231561126:A:AG	acceptor_gain	1.0000
1:231561127:G:GA	acceptor_gain	1.0000
1:231561241:A:T	donor_gain	1.0000
1:231561254:CT:C	donor_gain	1.0000
1:231561256:G:GG	donor_gain	1.0000
1:231528824:A:T	donor_gain	0.9900
1:231528848:G:T	donor_gain	0.9900
1:231528848:GGCGT:G	donor_gain	0.9900
1:231528869:G:GT	donor_gain	0.9900
1:231529360:G:GG	donor_gain	0.9900
1:231536007:A:T	donor_gain	0.9900
1:231537212:GC:G	acceptor_gain	0.9900
1:231537212:GCA:G	acceptor_gain	0.9900
1:231537323:ACAAG:A	donor_loss	0.9900
1:231537325:AAG:A	donor_loss	0.9900
1:231537327:GGT:G	donor_loss	0.9900
1:231537328:G:A	donor_loss	0.9900
1:231537329:TGA:T	donor_loss	0.9900

AlphaMissense

1930 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:231537273:G:C	R61P	1.000
1:231537294:A:T	K68I	1.000
1:231537295:A:C	K68N	1.000
1:231537295:A:T	K68N	1.000
1:231561148:G:C	A130P	1.000
1:231564600:G:A	G190R	1.000
1:231564600:G:C	G190R	1.000
1:231564629:G:A	M199I	1.000
1:231564629:G:C	M199I	1.000
1:231564629:G:T	M199I	1.000
1:231537228:T:C	L46P	0.999
1:231537258:T:C	L56P	0.999
1:231537269:A:C	S60R	0.999
1:231537271:T:A	S60R	0.999
1:231537271:T:G	S60R	0.999
1:231537290:A:C	S67R	0.999
1:231537292:T:A	S67R	0.999
1:231537292:T:G	S67R	0.999
1:231537293:A:G	K68E	0.999
1:231537294:A:C	K68T	0.999
1:231537305:T:C	F72L	0.999
1:231537307:T:A	F72L	0.999
1:231537307:T:G	F72L	0.999
1:231561135:G:C	Q125H	0.999
1:231561135:G:T	Q125H	0.999
1:231561147:A:C	E129D	0.999
1:231561147:A:T	E129D	0.999
1:231564601:G:A	G190E	0.999
1:231564601:G:T	G190V	0.999
1:231564606:G:C	A192P	0.999

dbSNP variants (sampled 300 via entrez): RS1000025103 (1:231531179 G>C), RS1000110509 (1:231552485 A>G), RS1000226260 (1:231553860 A>G), RS1000263996 (1:231534395 A>G), RS1000278509 (1:231553698 T>TC), RS1000480502 (1:231559604 A>G), RS1000520511 (1:231535677 A>G), RS1000546486 (1:231529687 G>A), RS1000599770 (1:231535926 A>G), RS1000614912 (1:231528544 G>C), RS1000630559 (1:231542255 C>A,G,T), RS1000653786 (1:231535591 A>G), RS1000872698 (1:231563894 ACT>A), RS1000904030 (1:231558665 A>G), RS1000975997 (1:231535485 A>C)

Disease associations

OMIM: gene MIM:602964 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003744_1	Chronic periodontitis (mean interproximal clinical attachment level)	8.000000e-09
GCST009391_507	Metabolite levels	2.000000e-06
GCST009391_9	Metabolite levels	2.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007780	periodontal measurement
EFO:0010527	pyridoxate measurement
EFO:0007813	cotinine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4524025 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 23,148 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL6246	ELLAGIC ACID	2	23,148

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.46	IC50	3500	nM	ELLAGIC ACID

PubChem BioAssay actives

1 with measured affinity, of 21 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione	1316798: Inhibition of wild type His-tagged translin/trax E126A mutant (unknown origin) coexpressed in Escherichia coli BL21 cells assessed as reduction in pre-miRNA degradation by gel electrophoresis assay	ic50	3.5000	uM

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	increases expression, affects cotreatment, increases methylation	2
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
tetrahydropalmatine	decreases expression	1
sodium arsenite	increases expression, affects cotreatment, increases abundance	1
butyraldehyde	increases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
ochratoxin A	decreases acetylation, decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
ICG 001	decreases expression	1
bisphenol S	increases expression	1
LDN 193189	increases expression, affects cotreatment	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Aspirin	increases expression	1
Cadmium	increases abundance, increases expression	1
Copper	affects binding, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	increases expression, affects cotreatment	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Nickel	decreases expression	1
Ribonucleotides	affects binding	1
Sulindac	decreases expression	1
Thiosemicarbazones	affects binding, increases expression	1
Tobacco Smoke Pollution	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	decreases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3855682	Binding	Inhibition of wild type His-tagged translin/trax E126A mutant (unknown origin) coexpressed in Escherichia coli BL21 cells using RNase Alert as substrate at 30 uM incubated for 10 mins prior to substrate addition monitored over 60 mins by fl	A druggable target for rescuing microRNA defects. — Bioorg Med Chem Lett

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.