TSPAN10

Summary

TSPAN10 (tetraspanin 10, HGNC:29942) is a protein-coding gene on chromosome 17q25.3, encoding Tetraspanin-10 (Q9H1Z9). Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10.

Enables enzyme binding activity. Involved in establishment of protein localization to organelle. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 83882 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_001290212

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29942
Approved symbol	TSPAN10
Name	tetraspanin 10
Location	17q25.3
Locus type	gene with protein product
Status	Approved
Aliases	OCSP
Ensembl gene	ENSG00000182612
Ensembl biotype	protein_coding
Entrez	83882

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000571707, ENST00000571914, ENST00000611590, ENST00000621293, ENST00000696047, ENST00000696048, ENST00000869738, ENST00000869739, ENST00000869740

RefSeq mRNA: 2 — MANE Select: NM_001290212 NM_001290212, NM_031945

CCDS: CCDS58608

Canonical transcript exons

ENST00000611590 — 4 exons

Exon	Start	End
ENSE00003653175	81644992	81645629
ENSE00003714871	81647901	81648749
ENSE00003749738	81642307	81642448
ENSE00003965890	81637196	81637406

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 98.95.

FANTOM5 (CAGE): breadth broad, TPM avg 6.1663 / max 410.9174, expressed in 571 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163345	3.2422	370
163344	2.9241	468

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pigmented layer of retina	UBERON:0001782	98.95	gold quality
kidney epithelium	UBERON:0004819	94.48	gold quality
cardiac muscle of right atrium	UBERON:0003379	91.55	gold quality
left ventricle myocardium	UBERON:0006566	91.50	gold quality
myocardium	UBERON:0002349	88.09	gold quality
upper arm skin	UBERON:0004263	87.65	gold quality
vena cava	UBERON:0004087	86.35	gold quality
epithelial cell of pancreas	CL:0000083	85.93	gold quality
gingival epithelium	UBERON:0001949	82.42	silver quality
gingiva	UBERON:0001828	81.90	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	81.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.78	gold quality
nasal cavity epithelium	UBERON:0005384	79.28	gold quality
vastus lateralis	UBERON:0001379	78.67	gold quality
pericardium	UBERON:0002407	77.87	gold quality
pharyngeal mucosa	UBERON:0000355	77.83	gold quality
quadriceps femoris	UBERON:0001377	77.46	gold quality
subthalamic nucleus	UBERON:0001906	77.28	gold quality
cardia of stomach	UBERON:0001162	77.08	gold quality
saphenous vein	UBERON:0007318	77.01	gold quality
dorsal plus ventral thalamus	UBERON:0001897	76.82	gold quality
pons	UBERON:0000988	76.78	gold quality
inferior vagus X ganglion	UBERON:0005363	76.75	gold quality
layer of synovial tissue	UBERON:0007616	76.71	gold quality
buccal mucosa cell	CL:0002336	76.61	silver quality
trachea	UBERON:0003126	76.22	gold quality
nipple	UBERON:0002030	76.21	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	76.16	gold quality
pylorus	UBERON:0001166	76.08	gold quality
substantia nigra pars reticulata	UBERON:0001966	76.07	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-135	yes	1199.42
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

11 targeting TSPAN10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-3960	99.41	66.11	96
HSA-MIR-4651	99.06	67.57	2002
HSA-MIR-608	98.93	67.83	2013
HSA-MIR-6846-5P	98.81	65.86	1121
HSA-MIR-6848-5P	98.81	65.49	1126
HSA-MIR-8072	98.27	66.24	83
HSA-MIR-10400-5P	96.91	66.00	56
HSA-MIR-4467	96.51	64.44	69
HSA-MIR-10392-3P	88.79	61.83	122

Literature-anchored findings (GeneRIF, showing 1)

• Genetic variant within the TSPAN10 gene is associated with strabismus. (PMID:31073882)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan10	ENSDARG00000044767
mus_musculus	Tspan10	ENSMUSG00000039691
rattus_norvegicus	Tspan10	ENSRNOG00000046076

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN9 (ENSG00000011105), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), TSPAN15 (ENSG00000099282), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), TSPAN14 (ENSG00000108219), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN33 (ENSG00000158457), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN4 (ENSG00000214063), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-10 — Q9H1Z9 (reviewed: Q9H1Z9)

Alternative names: Oculospanin

All UniProt accessions (2): A0A087X235, Q6PJ65

UniProt curated annotations — full annotation on UniProt →

Function. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates.

Subunit / interactions. Interacts with ADAM10.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).

Similarity. Belongs to the tetraspanin (TM4SF) family.

RefSeq proteins (2): NP_001277141, NP_114151 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family
IPR018503	Tetraspanin_CS	Conserved_site

Pfam: PF00335

UniProt features (25 total): topological domain 5, sequence conflict 5, disulfide bond 4, transmembrane region 4, region of interest 2, sequence variant 2, chain 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9HV7	X-RAY DIFFRACTION	1.55

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H1Z9-F1	77.71	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 212–279, 213–243, 229–237, 244–258

Glycosylation sites (1): 228

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 39 (showing top): GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, CEBPZ_TARGET_GENES, CIITA_TARGET_GENES, GLI4_TARGET_GENES, KAT2A_TARGET_GENES, ZFP3_TARGET_GENES, ZNF146_TARGET_GENES, ZNF7_TARGET_GENES, ZNF711_TARGET_GENES, ZNF85_TARGET_GENES, ZSCAN30_TARGET_GENES, GSE17721_CTRL_VS_POLYIC_8H_BMDC_DN, HU_FETAL_RETINA_RPE, DESCARTES_MAIN_FETAL_RETINAL_PIGMENT_CELLS

GO Biological Process (1): establishment of protein localization to organelle (GO:0072594)

GO Molecular Function (1): enzyme binding (GO:0019899)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
establishment of protein localization	1
protein binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

756 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN10	NPLOC4	Q8TAT6	699
TSPAN10	RAD51B	O15315	524
TSPAN10	LRIT1	Q9P2V4	494
TSPAN10	FIZ1	Q96SL8	482
TSPAN10	CD81	P18582	474
TSPAN10	CD9	P21926	473
TSPAN10	RD3L	P0DJH9	467
TSPAN10	TSPAN14	Q8NG11	434
TSPAN10	B3GLCT	Q6Y288	431
TSPAN10	PILRB	Q9UKJ0	431
TSPAN10	ADAM10	O14672	425
TSPAN10	ARMS2	P0C7Q2	419
TSPAN10	TSPAN32	Q96QS1	413
TSPAN10	TSPAN9	O75954	408
TSPAN10	TSPAN12	O95859	408

IntAct

16 interactions, top by confidence:

A	B	Type	Score
HSD17B13	TSPAN10	psi-mi:“MI:0915”(physical association)	0.590
ADGRG5	KLRG2	psi-mi:“MI:0914”(association)	0.530
ADAM10	TSPAN10	psi-mi:“MI:0915”(physical association)	0.400
LHFPL1	TSPAN10	psi-mi:“MI:0915”(physical association)	0.400
PNLDC1	C1QL1	psi-mi:“MI:0914”(association)	0.350
TSPAN10	KLRG2	psi-mi:“MI:0914”(association)	0.350
OR6T1	PSMD11	psi-mi:“MI:0914”(association)	0.350
SLC26A6	SLC25A17	psi-mi:“MI:0914”(association)	0.350
OR52B2	PCCA	psi-mi:“MI:0914”(association)	0.350
PTX3	OFD1	psi-mi:“MI:0914”(association)	0.350
SLC12A9	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC44A1	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
TP53	PPM1G	psi-mi:“MI:0914”(association)	0.350

BioGRID (77): ADAM10 (Affinity Capture-Western), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-RNA), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TSPAN10 (Proximity Label-MS), TSPAN10 (Affinity Capture-MS), FITM2 (Affinity Capture-MS), FAM134C (Affinity Capture-MS)

ESM2 similar proteins: A6NGC4, A6NKX4, A6NM10, F1NZP5, O96011, P0C242, P27544, P27545, Q0VCY6, Q2TBI8, Q3SYU3, Q4V8E5, Q5F2F2, Q5JZQ7, Q5RFI0, Q5U2T1, Q5U419, Q6AYM9, Q6GQT6, Q6PIS1, Q6TCG5, Q6UXD7, Q6UXT9, Q71RH2, Q7TNV1, Q7Z403, Q80ZE4, Q863Y8, Q86WI3, Q8BMT9, Q8CHK3, Q8IU68, Q8IXF9, Q8N9H8, Q8TBR7, Q8VC26, Q8WUG5, Q96N66, Q99640, Q99JT6

Diamond homologs: A0A8M2B5N2, A0A8V0ZLT4, A1L157, B5X3I6, O43657, O60635, O60636, O70352, O95859, O97703, P19075, P19397, P21926, P24485, P27701, P28648, P30409, P30932, P31053, P35762, P40237, P40239, P40240, P40241, P41731, P60033, P60034, P61170, P61171, P62079, P62080, Q17QJ5, Q29RH7, Q2KHY8, Q2KIS9, Q3SYV5, Q3T0S3, Q3ZBH3, Q3ZCD0, Q4R7W6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

658 predictions. Top by Δscore:

Variant	Effect	Δscore
17:81637301:G:GT	donor_gain	0.9900
17:81637403:ACAGG:A	donor_loss	0.9900
17:81637407:G:GA	donor_loss	0.9900
17:81637407:G:GG	donor_gain	0.9900
17:81645627:CCT:C	donor_gain	0.9900
17:81645630:G:GG	donor_gain	0.9900
17:81637404:CAG:C	donor_gain	0.9800
17:81645182:TC:T	donor_gain	0.9800
17:81645625:AACCT:A	donor_gain	0.9800
17:81645626:ACCT:A	donor_gain	0.9800
17:81637405:AG:A	donor_gain	0.9700
17:81637406:GG:G	donor_gain	0.9700
17:81637408:T:G	donor_loss	0.9700
17:81645281:G:T	donor_gain	0.9700
17:81645626:ACCTG:A	donor_loss	0.9700
17:81645627:CCTGT:C	donor_loss	0.9700
17:81645628:CT:C	donor_gain	0.9700
17:81645628:CTG:C	donor_loss	0.9700
17:81645629:TGTGA:T	donor_loss	0.9700
17:81645630:GT:G	donor_loss	0.9700
17:81645631:T:A	donor_loss	0.9700
17:81645632:G:GC	donor_loss	0.9700
17:81637288:A:T	donor_gain	0.9600
17:81645121:GCCT:G	donor_gain	0.9600
17:81645281:G:GT	donor_gain	0.9600
17:81645613:G:GT	donor_gain	0.9600
17:81645633:A:AT	donor_loss	0.9600
17:81645634:G:C	donor_loss	0.9600
17:81647896:TGCA:T	acceptor_loss	0.9600
17:81647897:GCA:G	acceptor_loss	0.9600

AlphaMissense

2235 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000126252 (17:81645382 C>T), RS1000202766 (17:81637097 G>A), RS1000327775 (17:81645694 C>T), RS1000803042 (17:81637984 T>C), RS1000867415 (17:81639185 G>A), RS1000915233 (17:81636480 T>C), RS1000944261 (17:81644229 C>G,T), RS1001079004 (17:81640867 T>C), RS1001173218 (17:81638251 A>G), RS1001430225 (17:81641110 A>T), RS1001671386 (17:81640252 G>A), RS1001782775 (17:81635212 G>A), RS1001981653 (17:81635404 G>A), RS1002450586 (17:81644668 G>A), RS1002575476 (17:81644878 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST003219_14	Advanced age-related macular degeneration	2.000000e-11
GCST003997_35	Myopia	2.000000e-18
GCST005580_29	Intraocular pressure	2.000000e-13
GCST006291_89	Spherical equivalent or myopia (age of diagnosis)	3.000000e-09
GCST006976_1	Macular thickness	1.000000e-118
GCST006986_12	Red vs. brown/black hair color	3.000000e-21
GCST006989_54	Brown vs. black hair color	8.000000e-70
GCST007157_9	Corneal astigmatism	8.000000e-09
GCST007159_31	Corneal astigmatism	2.000000e-13
GCST007486_24	Hair morphology traits	2.000000e-09
GCST007486_4	Hair morphology traits	1.000000e-08
GCST009474_2	Central retinal vein equivalent	4.000000e-09
GCST010002_133	Refractive error	2.000000e-50

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:1001492	atrophic macular degeneration
EFO:0004695	intraocular pressure measurement
EFO:0004847	age at onset
EFO:0003924	hair color
EFO:1002040	Corneal astigmatism
EFO:0010554	retinal vasculature measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects cotreatment, increases expression	2
Valproic Acid	affects cotreatment, increases expression, increases methylation	2
Particulate Matter	decreases expression, increases expression	2
afuresertib	increases expression	1
FR900359	affects phosphorylation	1
propionaldehyde	increases expression	1
sodium arsenate	decreases expression, increases abundance	1
o,p’-DDT	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
benzo(e)pyrene	decreases methylation	1
ferrous chloride	decreases expression	1
CGP 52608	increases reaction, affects binding	1
AM 251	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
jinfukang	increases expression, affects cotreatment	1
Arsenic	increases abundance, decreases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation	1
Dactinomycin	affects cotreatment, increases expression	1
Estradiol	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Methapyrilene	decreases methylation	1
Mustard Gas	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Zearalenone	decreases expression	1
Cadmium Chloride	increases expression	1
beta-Naphthoflavone	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.