TSPAN14

Summary

TSPAN14 (tetraspanin 14, HGNC:23303) is a protein-coding gene on chromosome 10q23.1, encoding Tetraspanin-14 (Q8NG11). Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10.

Enables enzyme binding activity. Involved in positive regulation of Notch signaling pathway; protein localization to plasma membrane; and protein maturation. Located in plasma membrane.

Source: NCBI Gene 81619 — RefSeq curated summary.

At a glance

• GWAS associations: 31
• Clinical variants (ClinVar): 46 total
• MANE Select transcript: NM_030927

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23303
Approved symbol	TSPAN14
Name	tetraspanin 14
Location	10q23.1
Locus type	gene with protein product
Status	Approved
Aliases	DC-TM4F2, MGC11352
Ensembl gene	ENSG00000108219
Ensembl biotype	protein_coding
Entrez	81619

Gene structure

Transcript identifiers

Ensembl transcripts: 69 — 67 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000265450, ENST00000341863, ENST00000372156, ENST00000372157, ENST00000372158, ENST00000372164, ENST00000429989, ENST00000469149, ENST00000481124, ENST00000714437, ENST00000714438, ENST00000714439, ENST00000714440, ENST00000714441, ENST00000714442, ENST00000714443, ENST00000714444, ENST00000714445, ENST00000910475, ENST00000910476, ENST00000910477, ENST00000910478, ENST00000910479, ENST00000910480, ENST00000910481, ENST00000910482, ENST00000910483, ENST00000910484, ENST00000910485, ENST00000910486, ENST00000910487, ENST00000910488, ENST00000910489, ENST00000910490, ENST00000910491, ENST00000910492, ENST00000910493, ENST00000910494, ENST00000910495, ENST00000910496, ENST00000910497, ENST00000910498, ENST00000910499, ENST00000910500, ENST00000910501, ENST00000910502, ENST00000910503, ENST00000910504, ENST00000910505, ENST00000910506, ENST00000910507, ENST00000910508, ENST00000910509, ENST00000910510, ENST00000910511, ENST00000940593, ENST00000940594, ENST00000940595, ENST00000940596, ENST00000940597, ENST00000964935, ENST00000964936, ENST00000964937, ENST00000964938, ENST00000964939, ENST00000964940, ENST00000964941, ENST00000964942, ENST00000964943

RefSeq mRNA: 9 — MANE Select: NM_030927 NM_001128309, NM_001351266, NM_001351267, NM_001351268, NM_001351269, NM_001351270, NM_001351271, NM_001351272, NM_030927

CCDS: CCDS44448, CCDS7369

Canonical transcript exons

ENST00000429989 — 9 exons

Exon	Start	End
ENSE00000986156	80509301	80509471
ENSE00000986157	80512144	80512269
ENSE00000986158	80514019	80514063
ENSE00000986159	80516204	80516323
ENSE00003484216	80504728	80504778
ENSE00003554777	80507228	80507374
ENSE00003597471	80489217	80489314
ENSE00004024000	80454310	80454371
ENSE00004024006	80517905	80522631

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 97.67.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 51.8725 / max 325.8575, expressed in 1822 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105869	41.2285	1819
105867	4.4116	1639
105882	2.1226	1065
105866	0.7848	490
105868	0.6635	409
105864	0.5619	156
105865	0.5046	257
105871	0.4441	167
105875	0.3135	130
105873	0.2646	95

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	97.67	gold quality
right lung	UBERON:0002167	97.58	gold quality
lower esophagus mucosa	UBERON:0035834	96.91	gold quality
granulocyte	CL:0000094	96.86	gold quality
tibial nerve	UBERON:0001323	96.74	gold quality
omental fat pad	UBERON:0010414	96.42	gold quality
peritoneum	UBERON:0002358	96.39	gold quality
esophagus mucosa	UBERON:0002469	96.31	gold quality
upper lobe of left lung	UBERON:0008952	96.31	gold quality
monocyte	CL:0000576	96.27	gold quality
leukocyte	CL:0000738	96.27	gold quality
mononuclear cell	CL:0000842	96.16	gold quality
adipose tissue of abdominal region	UBERON:0007808	96.14	gold quality
subcutaneous adipose tissue	UBERON:0002190	96.12	gold quality
skin of leg	UBERON:0001511	95.94	gold quality
upper lobe of lung	UBERON:0008948	95.85	gold quality
skin of abdomen	UBERON:0001416	95.33	gold quality
apex of heart	UBERON:0002098	95.15	gold quality
ganglionic eminence	UBERON:0004023	95.10	gold quality
ectocervix	UBERON:0012249	95.09	gold quality
pericardium	UBERON:0002407	95.03	gold quality
blood	UBERON:0000178	94.90	gold quality
lymph node	UBERON:0000029	94.78	gold quality
endocervix	UBERON:0000458	94.68	gold quality
stromal cell of endometrium	CL:0002255	94.65	gold quality
right lobe of thyroid gland	UBERON:0001119	94.54	gold quality
minor salivary gland	UBERON:0001830	94.45	gold quality
adipose tissue	UBERON:0001013	94.44	gold quality
pharyngeal mucosa	UBERON:0000355	94.43	gold quality
zone of skin	UBERON:0000014	94.19	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-135922	yes	23.87
E-HCAD-9	yes	15.75
E-MTAB-9067	yes	13.01
E-MTAB-2983	no	239.61
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

117 targeting TSPAN14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-3120-5P	100.00	65.56	965
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-3065-3P	99.87	70.25	1407
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-139-5P	99.80	69.50	1399

Literature-anchored findings (GeneRIF, showing 2)

• genetic alterations of TSPAN14, SLC2A13 and PHF20 could play a role in non-small-cell lung cancer promotion (PMID:19473719)
• Data suggest that large extracellular loop of Tspan14 mediates interaction with ADAM10, promotes ADAM10 maturation/trafficking to cell surface, and affects ADAM10 substrate specificity; ADAM10/Tspan14 interact in platelets/vascular endothelial cells. (PMID:26668317)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan14	ENSDARG00000055938
mus_musculus	Tspan14	ENSMUSG00000037824
rattus_norvegicus	Tspan14	ENSRNOG00000010813

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN9 (ENSG00000011105), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), TSPAN15 (ENSG00000099282), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN33 (ENSG00000158457), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN10 (ENSG00000182612), TSPAN4 (ENSG00000214063), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-14 — Q8NG11 (reviewed: Q8NG11)

Alternative names: DC-TM4F2, Transmembrane 4 superfamily member 14

All UniProt accessions (5): Q8NG11, A0AAQ5BI32, A0AAQ5BI33, A6NEP9, H7BXY6

UniProt curated annotations — full annotation on UniProt →

Function. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Negatively regulates ADAM10-mediated cleavage of GP6. Promotes ADAM10-mediated cleavage of CDH5.

Subunit / interactions. Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression.

Subcellular location. Cell membrane.

Similarity. Belongs to the tetraspanin (TM4SF) family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8NG11-1	1	yes
Q8NG11-2	2
Q8NG11-3	3

RefSeq proteins (9): NP_001121781, NP_001338195, NP_001338196, NP_001338197, NP_001338198, NP_001338199, NP_001338200, NP_001338201, NP_112189* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000301	Tetraspanin_animals	Family
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family
IPR018503	Tetraspanin_CS	Conserved_site

Pfam: PF00335

UniProt features (20 total): topological domain 5, disulfide bond 4, transmembrane region 4, splice variant 2, sequence conflict 2, chain 1, region of interest 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG11-F1	87.89	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 153–221, 154–186, 170–180, 187–200

Glycosylation sites (1): 169

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-977225	Amyloid fiber formation

MSigDB gene sets: 207 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GOBP_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY, GOCC_CELL_SURFACE, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, RICKMAN_METASTASIS_DN, GOBP_PROTEIN_MATURATION, GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY, CCCAGAG_MIR326, MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN, GOBP_LOCALIZATION_WITHIN_MEMBRANE, ACEVEDO_LIVER_CANCER_UP, CTAWWWATA_RSRFC4_Q2, AGCATTA_MIR155

GO Biological Process (4): positive regulation of Notch signaling pathway (GO:0045747), protein maturation (GO:0051604), protein localization to plasma membrane (GO:0072659), intracellular protein localization (GO:0008104)

GO Molecular Function (2): enzyme binding (GO:0019899), protein binding (GO:0005515)

GO Cellular Component (7): endoplasmic reticulum lumen (GO:0005788), plasma membrane (GO:0005886), cell surface (GO:0009986), specific granule membrane (GO:0035579), tertiary granule membrane (GO:0070821), tetraspanin-enriched microdomain (GO:0097197), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
secretory granule membrane	2
Notch signaling pathway	1
regulation of Notch signaling pathway	1
positive regulation of signal transduction	1
gene expression	1
protein metabolic process	1
protein localization to membrane	1
protein localization to cell periphery	1
macromolecule localization	1
protein binding	1
binding	1
endoplasmic reticulum	1
intracellular organelle lumen	1
membrane	1
cell periphery	1
specific granule	1
tertiary granule	1
plasma membrane	1

Protein interactions and networks

STRING

730 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN14	ADAM10	O14672	906
TSPAN14	DYDC1	Q8WWB3	634
TSPAN14	DYDC2	Q96IM9	611
TSPAN14	SH2D4B	Q5SQS7	583
TSPAN14	PTK2B	Q14289	539
TSPAN14	CD81	P18582	517
TSPAN14	SERPINA1	P01009	494
TSPAN14	CD9	P21926	492
TSPAN14	SHC1	P29353	488
TSPAN14	SOS1	Q07889	482
TSPAN14	SQSTM1	Q13501	468
TSPAN14	TSC2	P49815	465
TSPAN14	CCSER2	Q9H7U1	457
TSPAN14	RICTOR	Q6R327	455
TSPAN14	SMIM15	Q7Z3B0	447

IntAct

29 interactions, top by confidence:

A	B	Type	Score
TSPAN15	ADAM10	psi-mi:“MI:0914”(association)	0.840
TSPAN5	ADAM10	psi-mi:“MI:0914”(association)	0.800
CD9	ADAM10	psi-mi:“MI:0914”(association)	0.750
TSPAN14	ADAM10	psi-mi:“MI:0914”(association)	0.740
ADAM10	TSPAN14	psi-mi:“MI:0915”(physical association)	0.740
TSPAN14	ADAM10	psi-mi:“MI:0915”(physical association)	0.740
ADAM10	TSPAN14	psi-mi:“MI:0403”(colocalization)	0.740
CD151	ADAM10	psi-mi:“MI:0914”(association)	0.530
ADAM10	TSPAN14	psi-mi:“MI:0915”(physical association)	0.400
ATP13A2	TSPAN14	psi-mi:“MI:0915”(physical association)	0.370
ADAM10	TSPAN9	psi-mi:“MI:0914”(association)	0.350
ITGA3	ADAM10	psi-mi:“MI:0914”(association)	0.350
CD81	STX3	psi-mi:“MI:0914”(association)	0.350
CD81	PVR	psi-mi:“MI:0914”(association)	0.350
CD81	CD276	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
CANX	HLA-A	psi-mi:“MI:0914”(association)	0.350
ATP2B2	ESYT2	psi-mi:“MI:0914”(association)	0.350
TSC22D3	VPS37C	psi-mi:“MI:0914”(association)	0.350
CSDE1	VPS37C	psi-mi:“MI:0914”(association)	0.350

BioGRID (16): ADAM10 (Affinity Capture-Western), TSPAN14 (Affinity Capture-MS), TSPAN14 (Affinity Capture-MS), TSPAN14 (Proximity Label-MS), TSPAN14 (Affinity Capture-MS), TSPAN14 (Affinity Capture-MS), TSPAN14 (Proximity Label-MS), TSPAN14 (Affinity Capture-MS), TSPAN14 (Co-fractionation), TSPAN14 (Co-fractionation), TSPAN14 (Co-fractionation), TSPAN14 (Co-fractionation), UFL1 (Co-fractionation), TSPAN14 (Affinity Capture-RNA), TSPAN14 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1B0GVX0, A2ADU8, A2ADU9, A2Y075, A6QP72, O82232, P34655, P55017, P55018, P56508, P59158, P68178, P68179, Q0DKW8, Q0VBW2, Q22701, Q3ZCB2, Q53GD3, Q54RZ2, Q5REK4, Q5RJI2, Q5TYP8, Q66I68, Q6DK93, Q6DK99, Q6E1M8, Q6E213, Q6GMG8, Q6GZQ0, Q6NUC1, Q6P828, Q6PCW6, Q6ZPD8, Q8H5T6, Q8NG11, Q8QZY6, Q8S5M8, Q91VA1, Q9ARD5, Q9BYD5

Diamond homologs: F7BWT7, O95858, P62079, P62080, Q0VC33, Q17QJ5, Q1JQA4, Q3SYV5, Q4V8E0, Q58DN3, Q5RH71, Q68VK5, Q6GQF5, Q86UF1, Q8NG11, Q8QZY6, Q8R3S2, Q96FV3, Q9D7W4, A0A8V0ZLT4, A1L157, B0BM39, B3VSC2, O35566, O60636, O70352, O75954, O95859, O97703, P19075, P21926, P30409, P30932, P31053, P35762, P40237, P40239, P40240, P40241, P48509

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1929 predictions. Top by Δscore:

Variant	Effect	Δscore
10:80507370:ACTTT:A	donor_gain	1.0000
10:80507371:CTTT:C	donor_gain	1.0000
10:80507372:TTT:T	donor_gain	1.0000
10:80507372:TTTGT:T	donor_loss	1.0000
10:80507373:TT:T	donor_gain	1.0000
10:80507373:TTGTG:T	donor_loss	1.0000
10:80507374:TGTG:T	donor_loss	1.0000
10:80507375:G:GG	donor_gain	1.0000
10:80507375:GTGA:G	donor_loss	1.0000
10:80507376:T:A	donor_loss	1.0000
10:80507377:G:GG	donor_loss	1.0000
10:80509299:A:AG	acceptor_gain	1.0000
10:80509299:A:C	acceptor_loss	1.0000
10:80509300:G:GA	acceptor_gain	1.0000
10:80509300:GT:G	acceptor_gain	1.0000
10:80509300:GTT:G	acceptor_gain	1.0000
10:80509300:GTTC:G	acceptor_gain	1.0000
10:80509300:GTTCT:G	acceptor_gain	1.0000
10:80509467:AAGCT:A	donor_gain	1.0000
10:80509468:AGCT:A	donor_gain	1.0000
10:80509468:AGCTG:A	donor_loss	1.0000
10:80509469:GCT:G	donor_gain	1.0000
10:80509469:GCTG:G	donor_gain	1.0000
10:80509470:CT:C	donor_gain	1.0000
10:80509471:TG:T	donor_loss	1.0000
10:80509472:G:GG	donor_gain	1.0000
10:80509472:GTAA:G	donor_loss	1.0000
10:80509473:T:G	donor_loss	1.0000
10:80512135:T:TA	acceptor_gain	1.0000
10:80512136:G:A	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000022393 (10:80470866 A>C), RS1000055194 (10:80492040 G>C,T), RS1000098560 (10:80508899 C>T), RS1000109061 (10:80469498 G>A), RS1000123744 (10:80511339 T>A), RS1000131243 (10:80508711 C>G,T), RS1000144160 (10:80452409 C>T), RS1000183987 (10:80490332 A>G), RS1000189517 (10:80499878 C>A,T), RS1000307851 (10:80494828 C>T), RS1000317445 (10:80496800 C>T), RS1000347922 (10:80457733 C>T), RS1000392614 (10:80482223 A>G), RS1000487144 (10:80453939 A>C,G), RS1000504808 (10:80453107 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

31 associations (top):

Study	Trait	p-value
GCST001725_5	Inflammatory bowel disease	9.000000e-16
GCST003262_100	Post bronchodilator FEV1	5.000000e-06
GCST003262_1012	Post bronchodilator FEV1	3.000000e-06
GCST003262_122	Post bronchodilator FEV1	4.000000e-07
GCST003262_49	Post bronchodilator FEV1	8.000000e-07
GCST003262_58	Post bronchodilator FEV1	4.000000e-06
GCST003262_668	Post bronchodilator FEV1	2.000000e-06
GCST003262_682	Post bronchodilator FEV1	6.000000e-07
GCST003262_88	Post bronchodilator FEV1	2.000000e-06
GCST004131_69	Inflammatory bowel disease	5.000000e-08
GCST004132_36	Crohn’s disease	7.000000e-08
GCST005194_134	Coronary artery disease	2.000000e-11
GCST005195_92	Coronary artery disease	2.000000e-11
GCST005196_34	Coronary artery disease	2.000000e-10
GCST005537_191	Chronic inflammatory diseases (ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy)	1.000000e-13
GCST005542_5	Sarcoidosis (non-Lofgren’s syndrome without extrapulmonary manifestations)	4.000000e-06
GCST006629_29	Pulse pressure	1.000000e-14
GCST007692_28	Chronic obstructive pulmonary disease	4.000000e-08
GCST008017_8	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome	8.000000e-06
GCST008058_221	Estimated glomerular filtration rate	4.000000e-12
GCST008059_148	Estimated glomerular filtration rate	1.000000e-11
GCST008362_118	Birth weight	2.000000e-08
GCST010726_40	Periventricular white matter hyperintensities	1.000000e-08
GCST010866_144	Coronary artery disease	3.000000e-06
GCST011365_103	Myocardial infarction	1.000000e-07
GCST011564_2	Severe coronary stenosis (young age of onset interaction)	4.000000e-07
GCST012214_8	Alzheimer’s disease	4.000000e-06
GCST90002388_567	Lymphocyte count	4.000000e-11
GCST90002393_359	Monocyte count	4.000000e-13
GCST90002407_302	White blood cell count	3.000000e-13

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0004314	forced expiratory volume
EFO:0005763	pulse pressure measurement
EFO:0004344	birth weight
EFO:0005665	white matter hyperintensity measurement
EFO:0004847	age at onset
EFO:0004587	lymphocyte count
EFO:0005091	monocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tretinoin	increases expression	2
Valproic Acid	increases methylation, affects expression, decreases expression	2
Cyclosporine	decreases expression	2
dicrotophos	increases expression	1
propionaldehyde	increases expression	1
bisphenol A	affects expression	1
quercitrin	decreases expression	1
mono-(2-ethylhexyl)phthalate	increases expression	1
sulforaphane	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
aflatoxin B2	decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression, affects response to substance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
Arsenic Trioxide	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Caffeine	decreases phosphorylation	1
Dexamethasone	increases expression	1
Doxorubicin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ethyl Methanesulfonate	increases expression	1
Folic Acid	decreases expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Selenium	affects cotreatment, increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.