TSPAN15

Summary

TSPAN15 (tetraspanin 15, HGNC:23298) is a protein-coding gene on chromosome 10q22.1, encoding Tetraspanin-15 (O95858). Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene.

Source: NCBI Gene 23555 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_012339

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23298
Approved symbol	TSPAN15
Name	tetraspanin 15
Location	10q22.1
Locus type	gene with protein product
Status	Approved
Aliases	NET-7
Ensembl gene	ENSG00000099282
Ensembl biotype	protein_coding
OMIM	613140
Entrez	23555

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 14 protein_coding, 3 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000373290, ENST00000452130, ENST00000459981, ENST00000470508, ENST00000475069, ENST00000478112, ENST00000486093, ENST00000490083, ENST00000858299, ENST00000858300, ENST00000858301, ENST00000858302, ENST00000858303, ENST00000858304, ENST00000954128, ENST00000954129, ENST00000954130, ENST00000954131, ENST00000954132, ENST00000954133

RefSeq mRNA: 2 — MANE Select: NM_012339 NM_001351263, NM_012339

CCDS: CCDS7294

Canonical transcript exons

ENST00000373290 — 8 exons

Exon	Start	End
ENSE00000638708	69483691	69483876
ENSE00001186450	69506829	69507666
ENSE00001886704	69451465	69451690
ENSE00003500682	69485141	69485215
ENSE00003526702	69506124	69506240
ENSE00003579638	69504438	69504485
ENSE00003679864	69495594	69495689
ENSE00003685116	69498280	69498396

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 96.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 22.2448 / max 298.1186, expressed in 1343 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105348	21.0821	1342
105349	1.0767	402
105350	0.0859	49

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	96.89	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.73	gold quality
mucosa of stomach	UBERON:0001199	96.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.36	gold quality
mucosa of transverse colon	UBERON:0004991	96.31	gold quality
rectum	UBERON:0001052	96.24	gold quality
spinal cord	UBERON:0002240	95.91	gold quality
transverse colon	UBERON:0001157	95.87	gold quality
body of stomach	UBERON:0001161	95.75	gold quality
trigeminal ganglion	UBERON:0001675	95.17	gold quality
inferior vagus X ganglion	UBERON:0005363	94.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	94.55	gold quality
stomach	UBERON:0000945	94.46	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.43	gold quality
cerebellar hemisphere	UBERON:0002245	94.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.35	gold quality
cerebellar cortex	UBERON:0002129	94.27	gold quality
lower esophagus	UBERON:0013473	94.27	gold quality
corpus callosum	UBERON:0002336	94.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	93.97	gold quality
omental fat pad	UBERON:0010414	93.93	gold quality
fundus of stomach	UBERON:0001160	93.91	gold quality
peritoneum	UBERON:0002358	93.90	gold quality
dorsal root ganglion	UBERON:0000044	93.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.69	gold quality
adipose tissue of abdominal region	UBERON:0007808	93.61	gold quality
colon	UBERON:0001155	93.60	gold quality
gall bladder	UBERON:0002110	93.45	gold quality
sural nerve	UBERON:0015488	93.39	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.24	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-11	yes	26.97
E-MTAB-5061	yes	26.24
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): F2RL1

miRNA regulators (miRDB)

20 targeting TSPAN15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-31-5P	98.58	68.35	1239
HSA-MIR-4665-5P	97.91	67.69	1536
HSA-MIR-558	97.50	67.16	977
HSA-MIR-6890-3P	97.50	65.71	997
HSA-MIR-6857-3P	96.70	65.43	915
HSA-MIR-4296	96.35	63.55	1233
HSA-MIR-4749-5P	92.16	62.26	179
HSA-MIR-4706	89.76	60.23	156

Literature-anchored findings (GeneRIF, showing 6)

• Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. (PMID:25772935)
• TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-kappaB signaling. (PMID:29650964)
• Tspan15 is a new stemness-related marker in hepatocellular carcinoma which exhibits high potential of tumor growth and recurrence. (PMID:31390680)
• Overexpression of Tspan15 positively regulates development of OSCC. (PMID:31518558)
• The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex. (PMID:32111735)
• Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. (PMID:34739841)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan15	ENSDARG00000039455
mus_musculus	Tspan15	ENSMUSG00000037031
rattus_norvegicus	Tspan15	ENSRNOG00000046204

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN9 (ENSG00000011105), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), TSPAN14 (ENSG00000108219), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN33 (ENSG00000158457), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN10 (ENSG00000182612), TSPAN4 (ENSG00000214063), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-15 — O95858 (reviewed: O95858)

Alternative names: Tetraspan NET-7, Transmembrane 4 superfamily member 15

All UniProt accessions (2): O95858, H7C285

UniProt curated annotations — full annotation on UniProt →

Function. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.

Subunit / interactions. Interacts with ADAM10; the interaction influences ADAM10 substrate specificity, endocytosis and turnover.

Subcellular location. Cell membrane. Late endosome membrane.

Post-translational modifications. Palmitoylated.

Similarity. Belongs to the tetraspanin (TM4SF) family.

RefSeq proteins (2): NP_001338192, NP_036471* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000301	Tetraspanin_animals	Family
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family

Pfam: PF00335

UniProt features (41 total): helix 10, topological domain 5, turn 5, disulfide bond 4, mutagenesis site 4, transmembrane region 4, strand 4, glycosylation site 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7RDB	X-RAY DIFFRACTION	2.52
8ESV	ELECTRON MICROSCOPY	3.3
7RD5	X-RAY DIFFRACTION	3.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95858-F1	88.14	0.75

Antibody-complex structures (SAbDab): 2 — 7RD5, 8ESV

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 154–219, 155–185, 171–179, 186–198

Glycosylation sites (3): 118, 189, 230

Mutagenesis-validated functional residues (4):

Position	Phenotype
166–169	alsmost abolishes interaction with adam10. decreases maturation of adam10 and cdh2/n-cadherin cleavage.
193–196	no effect on interaction with adam10. decreases maturation of adam10. no effect on cdh2/n-cadherin cleavage.
204–206	no effect on interaction with adam10. no effect on maturation of adam10. no effect on cdh2/n-cadherin cleavage.
288–291	strongly reduces palmitoylation levels.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-977225	Amyloid fiber formation

MSigDB gene sets: 122 (showing top): GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOCC_CELL_SURFACE, CHANDRAN_METASTASIS_DN, GOBP_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_PROTEIN_MATURATION, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_REGULATION_OF_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS, GOBP_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS, GOBP_REGULATION_OF_NOTCH_SIGNALING_PATHWAY, GOBP_MEMBRANE_PROTEIN_ECTODOMAIN_PROTEOLYSIS, AIGNER_ZEB1_TARGETS, GOBP_MEMBRANE_PROTEIN_PROTEOLYSIS

GO Biological Process (4): negative regulation of Notch signaling pathway (GO:0045746), regulation of membrane protein ectodomain proteolysis (GO:0051043), protein maturation (GO:0051604), protein localization to plasma membrane (GO:0072659)

GO Molecular Function (2): enzyme binding (GO:0019899), protein binding (GO:0005515)

GO Cellular Component (10): endoplasmic reticulum lumen (GO:0005788), cytosol (GO:0005829), plasma membrane (GO:0005886), cell surface (GO:0009986), nuclear body (GO:0016604), cell junction (GO:0030054), late endosome membrane (GO:0031902), tetraspanin-enriched microdomain (GO:0097197), endosome (GO:0005768), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
Notch signaling pathway	1
regulation of Notch signaling pathway	1
negative regulation of signal transduction	1
membrane protein ectodomain proteolysis	1
regulation of proteolysis	1
regulation of protein catabolic process	1
gene expression	1
protein metabolic process	1
protein localization to membrane	1
protein localization to cell periphery	1
protein binding	1
binding	1
endoplasmic reticulum	1
intracellular organelle lumen	1
cytoplasm	1
membrane	1
cell periphery	1
nucleoplasm	1
intracellular membraneless organelle	1
late endosome	1
endosome membrane	1
plasma membrane	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

576 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN15	ADAM10	O14672	802
TSPAN15	SLC44A2	Q8IWA5	662
TSPAN15	TSPAN12	O95859	615
TSPAN15	PTGFRN	Q9P2B2	596
TSPAN15	CD9	P21926	592
TSPAN15	ITGB1	P05556	553
TSPAN15	BTRC	Q9Y297	511
TSPAN15	TSPAN13	O95857	500
TSPAN15	FGG	P02679	492
TSPAN15	CD44	P16070	474
TSPAN15	B3GNT3	Q9Y2A9	465
TSPAN15	TSPAN31	Q12999	443
TSPAN15	GP6	Q9HCN6	407
TSPAN15	PROCR	Q9UNN8	395
TSPAN15	CD81	P18582	395

IntAct

90 interactions, top by confidence:

A	B	Type	Score
TSPAN15	ADAM10	psi-mi:“MI:0914”(association)	0.840
ADAM10	TSPAN15	psi-mi:“MI:0915”(physical association)	0.840
TSPAN15	ADAM10	psi-mi:“MI:0915”(physical association)	0.840
ADAM10	TSPAN15	psi-mi:“MI:0403”(colocalization)	0.840
CD9	ADAM10	psi-mi:“MI:0914”(association)	0.750
SYNE4	TSPAN15	psi-mi:“MI:0915”(physical association)	0.560
TSPAN15	GYPC	psi-mi:“MI:0915”(physical association)	0.560
TSPAN15	STRIT1	psi-mi:“MI:0915”(physical association)	0.560
SLC7A1	TMEM223	psi-mi:“MI:0914”(association)	0.530
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
C3AR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
GYPB	TCAF2	psi-mi:“MI:0914”(association)	0.530
FZD10	NRP1	psi-mi:“MI:0914”(association)	0.530
TSPAN2	TSPAN3	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
EMC6	EMC8	psi-mi:“MI:0914”(association)	0.530
TSPAN5	SC5D	psi-mi:“MI:0914”(association)	0.530

BioGRID (302): SYNE4 (Two-hybrid), ADAM10 (Affinity Capture-Western), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Synthetic Lethality), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS), TSPAN15 (Affinity Capture-MS)

ESM2 similar proteins: A0A8M2B5N2, A0A8V0ZLT4, A1L157, F7BWT7, O35566, O60636, O60637, O75841, O95858, P11049, P20274, P21926, P30413, P30932, P31053, P38573, P40239, P40240, P40241, P48509, P54825, P55344, P56563, P61170, P61171, Q1JQA4, Q2KHY8, Q3SZR9, Q3ZBH3, Q566D0, Q58CY8, Q5RE11, Q61470, Q6GQF5, Q6GR34, Q6IP19, Q6PBE5, Q6PFT6, Q7SZ07, Q80WR1

Diamond homologs: F7BWT7, O95858, P62079, P62080, Q0VC33, Q17QJ5, Q1JQA4, Q3SYV5, Q4V8E0, Q58DN3, Q5RH71, Q68VK5, Q6GQF5, Q86UF1, Q8NG11, Q8QZY6, Q8R3S2, Q96FV3, Q9D7W4, O42281, O42282, O42581, O42582, O42583, P15499, P17438, P17810, P23942, P32958, P35906, P48509, P52204, P52205, P61170, P61171, Q03395, Q3ZBH3, Q5PPM7, Q9QZA6, A0A8V0ZLT4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
F2RL1	“down-regulates quantity by repression”	TSPAN15	“transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 97 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Class A/1 (Rhodopsin-like receptors)	8	10.4×	7e-05
GPCR ligand binding	9	10.1×	5e-05
G alpha (q) signalling events	9	9.1×	6e-05
Signaling by GPCR	9	6.3×	6e-04
GPCR downstream signalling	7	5.3×	1e-02

GO biological processes:

GO term	Partners	Fold	FDR
phospholipase C-activating G protein-coupled receptor signaling pathway	7	11.0×	1e-03
adenylate cyclase-activating G protein-coupled receptor signaling pathway	7	9.4×	2e-03
G protein-coupled receptor signaling pathway	12	5.2×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	43
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1874 predictions. Top by Δscore:

Variant	Effect	Δscore
10:69451689:GG:G	donor_gain	1.0000
10:69451690:GG:G	donor_gain	1.0000
10:69483683:T:TA	acceptor_gain	1.0000
10:69483686:T:A	acceptor_gain	1.0000
10:69483686:TGCA:T	acceptor_loss	1.0000
10:69483687:GCA:G	acceptor_loss	1.0000
10:69483688:CAG:C	acceptor_loss	1.0000
10:69483689:A:AC	acceptor_loss	1.0000
10:69483689:A:AG	acceptor_gain	1.0000
10:69483689:AGCT:A	acceptor_gain	1.0000
10:69483690:G:GA	acceptor_gain	1.0000
10:69483690:GC:G	acceptor_gain	1.0000
10:69483690:GCT:G	acceptor_gain	1.0000
10:69483690:GCTG:G	acceptor_gain	1.0000
10:69483690:GCTGA:G	acceptor_gain	1.0000
10:69483872:AAGCA:A	donor_gain	1.0000
10:69483873:AGCA:A	donor_gain	1.0000
10:69483874:GCA:G	donor_gain	1.0000
10:69483874:GCAG:G	donor_gain	1.0000
10:69483876:AGT:A	donor_loss	1.0000
10:69483877:G:GG	donor_gain	1.0000
10:69483877:GT:G	donor_loss	1.0000
10:69485139:A:AG	acceptor_gain	1.0000
10:69485140:G:GG	acceptor_gain	1.0000
10:69495593:GACC:G	acceptor_gain	1.0000
10:69495686:AAAGG:A	donor_loss	1.0000
10:69495687:AAGG:A	donor_loss	1.0000
10:69495688:AGG:A	donor_loss	1.0000
10:69495690:G:C	donor_loss	1.0000
10:69504436:A:AG	acceptor_gain	1.0000

AlphaMissense

1929 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:69498315:G:C	W163C	1.000
10:69498315:G:T	W163C	1.000
10:69498286:T:C	C154R	0.999
10:69498290:G:A	C155Y	0.999
10:69498313:T:A	W163R	0.999
10:69498313:T:C	W163R	0.999
10:69506160:T:C	C219R	0.999
10:69506161:G:A	C219Y	0.999
10:69483802:G:C	G70R	0.998
10:69498286:T:A	C154S	0.998
10:69498287:G:C	C154S	0.998
10:69498288:C:G	C154W	0.998
10:69498289:T:A	C155S	0.998
10:69498289:T:C	C155R	0.998
10:69498290:G:C	C155S	0.998
10:69498291:T:G	C155W	0.998
10:69498324:T:A	N166K	0.998
10:69498324:T:G	N166K	0.998
10:69498379:T:C	C185R	0.998
10:69498380:G:A	C185Y	0.998
10:69498381:C:G	C185W	0.998
10:69498382:T:A	C186S	0.998
10:69498383:G:C	C186S	0.998
10:69504459:T:A	C198S	0.998
10:69504460:G:C	C198S	0.998
10:69506157:G:T	G218C	0.998
10:69506160:T:A	C219S	0.998
10:69506161:G:C	C219S	0.998
10:69506162:C:G	C219W	0.998
10:69483718:G:C	G42R	0.997

dbSNP variants (sampled 300 via entrez): RS1000039404 (10:69536795 A>G), RS1000043368 (10:69493103 A>G), RS1000052664 (10:69548368 A>G), RS1000108204 (10:69542406 A>G), RS1000111684 (10:69453780 C>T), RS1000123409 (10:69454103 A>G), RS1000154766 (10:69496056 G>A,C), RS1000164709 (10:69541918 T>G), RS1000210393 (10:69508396 A>C,T), RS1000212100 (10:69459909 A>G), RS1000214459 (10:69542089 G>A), RS1000283941 (10:69547794 C>T), RS1000290173 (10:69465476 T>A,G), RS1000290393 (10:69463729 G>C), RS1000329910 (10:69503794 C>T)

Disease associations

OMIM: gene MIM:613140 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST001694_6	Response to taxane treatment (paclitaxel)	6.000000e-07
GCST002808_2	Venous thromboembolism	2.000000e-16
GCST003390_9	Thrombosis	3.000000e-07
GCST004256_9	Venous thromboembolism	2.000000e-07
GCST008839_343	Height	8.000000e-09
GCST009030_14	Venous thromboembolism	3.000000e-30
GCST009097_6	Venous thromboembolism	2.000000e-55
GCST010118_183	Type 2 diabetes	2.000000e-11
GCST010396_218	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-06
GCST90002385_482	High light scatter reticulocyte count	1.000000e-17
GCST90002386_403	High light scatter reticulocyte percentage of red cells	6.000000e-18
GCST90002387_359	Immature fraction of reticulocytes	1.000000e-12
GCST90002405_262	Reticulocyte count	5.000000e-15
GCST90002406_301	Reticulocyte fraction of red cells	1.000000e-15

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0003907	deep vein thrombosis
EFO:0007874	gut microbiome measurement
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	3
potassium chromate(VI)	affects cotreatment, decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Valproic Acid	affects expression, increases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
lasiocarpine	increases expression	1
methyleugenol	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation	1
tris(2-butoxyethyl) phosphate	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	decreases expression	1
nickel sulfate	increases expression	1
2,3,4,5-tetrachlorophenate	affects response to substance	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
chromium hexavalent ion	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
entinostat	increases expression	1
ICG 001	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	increases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Sunitinib	decreases expression	1
Zoledronic Acid	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Cadmium	increases abundance, increases expression	1
Catechin	affects cotreatment, increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Ketoconazole	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.