TSPAN33

Summary

TSPAN33 (tetraspanin 33, HGNC:28743) is a protein-coding gene on chromosome 7q32.1, encoding Tetraspanin-33 (Q86UF1). Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10.

Enables enzyme binding activity. Involved in pore complex assembly; protein localization to plasma membrane; and protein maturation. Located in plasma membrane. Part of pore complex.

Source: NCBI Gene 340348 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 33 total
• MANE Select transcript: NM_178562

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28743
Approved symbol	TSPAN33
Name	tetraspanin 33
Location	7q32.1
Locus type	gene with protein product
Status	Approved
Aliases	MGC50844, Penumbra
Ensembl gene	ENSG00000158457
Ensembl biotype	protein_coding
OMIM	610120
Entrez	340348

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000486685, ENST00000496963, ENST00000498745, ENST00000614309, ENST00000903575, ENST00000903576, ENST00000935290, ENST00000935291, ENST00000935292, ENST00000940895

RefSeq mRNA: 1 — MANE Select: NM_178562 NM_178562

CCDS: CCDS5810

Canonical transcript exons

ENST00000486685 — 8 exons

Exon	Start	End
ENSE00003694296	129167399	129167560
ENSE00003717721	129166778	129166906
ENSE00003728682	129167773	129169699
ENSE00003728821	129162833	129162907
ENSE00003732312	129162394	129162521
ENSE00003740423	129144707	129145082
ENSE00003744277	129164474	129164569
ENSE00003751992	129161679	129161736

Expression profiles

Bgee: expression breadth ubiquitous, 243 present calls, max score 98.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.6630 / max 209.6333, expressed in 1101 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
204691	9.2075	1092
204692	0.2463	112
204693	0.2093	107

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	98.84	gold quality
adult mammalian kidney	UBERON:0000082	97.18	gold quality
renal medulla	UBERON:0000362	96.62	gold quality
metanephros cortex	UBERON:0010533	95.48	gold quality
kidney	UBERON:0002113	95.00	gold quality
cortex of kidney	UBERON:0001225	94.87	gold quality
parotid gland	UBERON:0001831	93.86	gold quality
monocyte	CL:0000576	93.84	gold quality
leukocyte	CL:0000738	93.54	gold quality
lymph node	UBERON:0000029	92.55	gold quality
caput epididymis	UBERON:0004358	91.76	gold quality
corpus epididymis	UBERON:0004359	91.57	gold quality
metanephros	UBERON:0000081	91.39	gold quality
vermiform appendix	UBERON:0001154	91.03	gold quality
right lobe of liver	UBERON:0001114	91.00	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.44	silver quality
medial globus pallidus	UBERON:0002477	90.18	gold quality
caecum	UBERON:0001153	89.98	gold quality
upper arm skin	UBERON:0004263	89.71	silver quality
liver	UBERON:0002107	89.61	gold quality
globus pallidus	UBERON:0001875	88.82	gold quality
body of pancreas	UBERON:0001150	88.77	gold quality
tonsil	UBERON:0002372	88.67	gold quality
hypothalamus	UBERON:0001898	88.58	gold quality
adenohypophysis	UBERON:0002196	88.53	gold quality
pituitary gland	UBERON:0000007	88.35	gold quality
epithelium of nasopharynx	UBERON:0001951	87.70	gold quality
adult organism	UBERON:0007023	87.61	gold quality
spleen	UBERON:0002106	87.60	gold quality
pancreas	UBERON:0001264	87.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting TSPAN33, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-5002-5P	99.76	70.84	1763

Literature-anchored findings (GeneRIF, showing 5)

• TSPAN33 is overexpressed in activated and malignant B cells. (PMID:24211713)
• The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target. (PMID:27574297)
• Data show that tetraspanin 33 (tspan33) is an early activation marker, and that disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) protein expression does not correlate with Tspan33 expression in B cells. (PMID:28449222)
• Tetraspanin 33 (TSPAN33) regulates endocytosis and migration of human B lymphocytes by affecting the tension of the plasma membrane. (PMID:31958362)
• Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33. (PMID:32371390)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan33a	ENSDARG00000004497
mus_musculus	Tspan33	ENSMUSG00000001763
rattus_norvegicus	Tspan33	ENSRNOG00000007900

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN9 (ENSG00000011105), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), TSPAN15 (ENSG00000099282), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), TSPAN14 (ENSG00000108219), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN10 (ENSG00000182612), TSPAN4 (ENSG00000214063), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-33 — Q86UF1 (reviewed: Q86UF1)

Alternative names: Penumbra, Proerythroblast new membrane

All UniProt accessions (1): Q86UF1

UniProt curated annotations — full annotation on UniProt →

Function. Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.

Subunit / interactions. Homodimer; disulfide-linked. Interacts (via extracellular domain) with ADAM10 (via extracellular domain). Interacts (via cytoplasmic domain) with PLEKHA7 (via WW domains); the interaction is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens.

Subcellular location. Cell membrane. Cell junction. Adherens junction. Cytoplasm.

Tissue specificity. Predominantly expressed in erythroblasts.

Similarity. Belongs to the tetraspanin (TM4SF) family.

RefSeq proteins (1): NP_848657* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000301	Tetraspanin_animals	Family
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family

Pfam: PF00335

UniProt features (15 total): topological domain 5, disulfide bond 4, transmembrane region 4, chain 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86UF1-F1	89.41	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 156–224, 157–189, 173–183, 190–203

Glycosylation sites (1): 172

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-977225	Amyloid fiber formation

MSigDB gene sets: 162 (showing top): CCAWYNNGAAR_UNKNOWN, AREB6_03, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOCC_CELL_SURFACE, CAGCTG_AP4_Q5, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_PROTEIN_MATURATION, MYOD_01, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, chr7q32

GO Biological Process (3): pore complex assembly (GO:0046931), protein maturation (GO:0051604), protein localization to plasma membrane (GO:0072659)

GO Molecular Function (2): enzyme binding (GO:0019899), protein binding (GO:0005515)

GO Cellular Component (9): endoplasmic reticulum lumen (GO:0005788), plasma membrane (GO:0005886), adherens junction (GO:0005912), cell surface (GO:0009986), pore complex (GO:0046930), tetraspanin-enriched microdomain (GO:0097197), cytoplasm (GO:0005737), membrane (GO:0016020), anchoring junction (GO:0070161)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
protein-containing complex assembly	1
gene expression	1
protein metabolic process	1
protein localization to membrane	1
protein localization to cell periphery	1
protein binding	1
binding	1
endoplasmic reticulum	1
intracellular organelle lumen	1
membrane	1
cell periphery	1
cell-cell junction	1
membrane protein complex	1
plasma membrane	1
intracellular anatomical structure	1
cell junction	1

Protein interactions and networks

STRING

476 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN33	ADAM10	O14672	907
TSPAN33	PDZD11	Q5EBL8	665
TSPAN33	PLPPR3	Q6T4P5	529
TSPAN33	TSPAN32	Q96QS1	475
TSPAN33	TSPAN3	O60637	459
TSPAN33	NT5M	Q9NPB1	451
TSPAN33	TM6SF1	Q9BZW5	447
TSPAN33	PLEKHA7	Q6IQ23	446
TSPAN33	TSPAN31	Q12999	397
TSPAN33	CD9	P21926	377
TSPAN33	EGFL7	Q9UHF1	376
TSPAN33	H2BC21	Q16778	374
TSPAN33	TSPAN13	O95857	369
TSPAN33	SLC5A6	Q9Y289	365
TSPAN33	TMEM182	Q6ZP80	362

IntAct

91 interactions, top by confidence:

A	B	Type	Score
ADAM10	TSPAN33	psi-mi:“MI:0915”(physical association)	0.620
TSPAN33	ADAM10	psi-mi:“MI:0915”(physical association)	0.620
ADAM10	TSPAN33	psi-mi:“MI:0403”(colocalization)	0.620
TSPAN33	TMEM106C	psi-mi:“MI:0915”(physical association)	0.600
TSPAN33	LHFPL5	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	DARS2	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	MTIF3	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	MFF	psi-mi:“MI:0915”(physical association)	0.560
FAM209A	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	TMEM45B	psi-mi:“MI:0915”(physical association)	0.560
NEMP1	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	GPX8	psi-mi:“MI:0915”(physical association)	0.560
GAD2	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
GORAB	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
CLDN7	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	SIT1	psi-mi:“MI:0915”(physical association)	0.560
MGST3	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
COQ9	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
SPINT1	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
GJA8	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
PLEKHO1	TSPAN33	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	GPR152	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	RELL2	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	SLC35C2	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	CISD2	psi-mi:“MI:0915”(physical association)	0.560
TSPAN33	SHISA4	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (71): ADAM10 (Affinity Capture-Western), MSN (Affinity Capture-MS), PDZD11 (Affinity Capture-MS), PLEKHA7 (Affinity Capture-MS), PLEKHA7 (Affinity Capture-MS), PDZD11 (Affinity Capture-MS), EZR (Affinity Capture-MS), MSN (Affinity Capture-MS), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid), TSPAN33 (Two-hybrid)

ESM2 similar proteins: B0BM39, B3VSC2, B5X3I6, F7BWT7, O14494, O14817, O35566, O42602, O42603, O43688, O60636, O62772, O75954, O88956, O95857, O95858, P35353, P47866, P48509, P60588, Q01453, Q06AA5, Q13324, Q3SYV5, Q3ZBV0, Q4L208, Q5RAP3, Q5RAZ3, Q5ZJ75, Q60748, Q6DCQ3, Q6GMK6, Q6WL85, Q86UF1, Q8BJU2, Q8K593, Q8R3S2, Q8R4D1, Q90812, Q91ZH7

Diamond homologs: F7BWT7, O95858, P62079, P62080, Q0VC33, Q17QJ5, Q1JQA4, Q3SYV5, Q4V8E0, Q58DN3, Q5RH71, Q68VK5, Q6GQF5, Q86UF1, Q8NG11, Q8QZY6, Q8R3S2, Q96FV3, Q9D7W4, A0A8M2B5N2, A0A8V0ZLT4, A1L157, B5X3I6, O43657, O60635, O60636, O70352, O95859, O97703, P19075, P19397, P21926, P24485, P27701, P28648, P30409, P30932, P31053, P35762, P40237

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
PLEKHA7	“up-regulates activity”	TSPAN33	binding
TSPAN33	“up-regulates activity”	ADAM10	binding
PDZD11	“up-regulates activity”	TSPAN33	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

33 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1235 predictions. Top by Δscore:

Variant	Effect	Δscore
7:129145078:TCTGG:T	donor_gain	1.0000
7:129145080:TGG:T	donor_gain	1.0000
7:129145081:GG:G	donor_gain	1.0000
7:129145081:GGG:G	donor_gain	1.0000
7:129145082:GG:G	donor_gain	1.0000
7:129145082:GGTG:G	donor_loss	1.0000
7:129145083:G:GG	donor_gain	1.0000
7:129145084:T:A	donor_loss	1.0000
7:129161677:AGGT:A	acceptor_gain	1.0000
7:129161678:GGTG:G	acceptor_gain	1.0000
7:129161733:GCAG:G	donor_gain	1.0000
7:129161736:GGTG:G	donor_loss	1.0000
7:129161737:G:GG	donor_gain	1.0000
7:129161737:GTG:G	donor_loss	1.0000
7:129161738:T:A	donor_loss	1.0000
7:129162392:A:AG	acceptor_gain	1.0000
7:129162393:G:GT	acceptor_gain	1.0000
7:129162393:GAA:G	acceptor_gain	1.0000
7:129162518:GACG:G	donor_gain	1.0000
7:129162520:CGGT:C	donor_loss	1.0000
7:129162522:G:C	donor_loss	1.0000
7:129162522:G:GG	donor_gain	1.0000
7:129162523:T:G	donor_loss	1.0000
7:129164462:T:G	acceptor_gain	1.0000
7:129164462:T:TA	acceptor_gain	1.0000
7:129164468:C:CA	acceptor_gain	1.0000
7:129164472:AG:A	acceptor_gain	1.0000
7:129164473:GG:G	acceptor_gain	1.0000
7:129164473:GGCTC:G	acceptor_gain	1.0000
7:129164567:AAGG:A	donor_loss	1.0000

AlphaMissense

1856 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:129166813:G:C	W165C	1.000
7:129166813:G:T	W165C	1.000
7:129166811:T:A	W165R	0.999
7:129166811:T:C	W165R	0.999
7:129166788:G:A	C157Y	0.998
7:129166829:T:C	F171L	0.998
7:129166831:C:A	F171L	0.998
7:129166831:C:G	F171L	0.998
7:129166884:G:A	C189Y	0.998
7:129166886:T:A	C190S	0.998
7:129166887:G:C	C190S	0.998
7:129162487:G:A	G85E	0.997
7:129162496:G:C	R88P	0.997
7:129166785:G:A	C156Y	0.997
7:129166787:T:A	C157S	0.997
7:129166788:G:C	C157S	0.997
7:129166789:T:G	C157W	0.997
7:129166791:G:A	G158E	0.997
7:129166822:C:A	N168K	0.997
7:129166822:C:G	N168K	0.997
7:129166883:T:C	C189R	0.997
7:129166885:T:G	C189W	0.997
7:129166888:C:G	C190W	0.997
7:129167417:T:A	C203S	0.997
7:129167418:G:C	C203S	0.997
7:129162486:G:T	G85W	0.996
7:129164547:T:C	L146P	0.996
7:129166784:T:A	C156S	0.996
7:129166784:T:C	C156R	0.996
7:129166785:G:C	C156S	0.996

dbSNP variants (sampled 300 via entrez): RS1000094104 (7:129165418 T>C), RS1000308064 (7:129155077 A>C,T), RS1000423534 (7:129165761 T>G), RS1000943825 (7:129146528 C>T), RS1001009703 (7:129146216 T>C), RS1001110429 (7:129144366 G>A,T), RS1001447617 (7:129145687 G>A,C,T), RS1001478121 (7:129145465 G>A,T), RS1001613944 (7:129149429 A>G), RS1001730102 (7:129149174 T>C), RS1001916118 (7:129163579 A>G), RS1002013264 (7:129147758 G>A,C), RS1002124815 (7:129153717 G>A), RS1002152013 (7:129155366 A>G), RS1002212093 (7:129160331 A>C,G)

Disease associations

OMIM: gene MIM:610120 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST001728_11	Ulcerative colitis	4.000000e-14
GCST007876_104	Estimated glomerular filtration rate	8.000000e-10

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	5
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	4
trichostatin A	affects cotreatment, decreases expression	3
Aflatoxin B1	increases expression, increases methylation, affects expression	3
Cisplatin	increases expression, affects cotreatment	2
Tretinoin	decreases expression	2
bisphenol F	affects cotreatment, decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
butyraldehyde	increases expression	1
nickel sulfate	increases expression	1
pentanal	increases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
incobotulinumtoxinA	decreases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Aldehydes	increases expression	1
Benzene	decreases expression	1
Cadmium	increases expression	1
Carbamazepine	affects expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Dichloroacetic Acid	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Ethyl Methanesulfonate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.