TSPAN4

Summary

TSPAN4 (tetraspanin 4, HGNC:11859) is a protein-coding gene on chromosome 11p15.5, encoding Tetraspanin-4 (O14817). Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Source: NCBI Gene 7106 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_003271

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11859
Approved symbol	TSPAN4
Name	tetraspanin 4
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	NAG-2, TSPAN-4, TETRASPAN
Ensembl gene	ENSG00000214063
Ensembl biotype	protein_coding
OMIM	602644
Entrez	7106

Gene structure

Transcript identifiers

Ensembl transcripts: 76 — 70 protein_coding, 6 retained_intron

ENST00000346501, ENST00000397396, ENST00000397397, ENST00000397404, ENST00000397406, ENST00000397408, ENST00000397411, ENST00000409531, ENST00000409543, ENST00000464987, ENST00000468468, ENST00000494815, ENST00000524895, ENST00000525201, ENST00000525334, ENST00000526055, ENST00000527644, ENST00000529566, ENST00000530404, ENST00000532375, ENST00000894461, ENST00000894462, ENST00000894463, ENST00000894464, ENST00000894465, ENST00000894466, ENST00000894467, ENST00000894468, ENST00000894469, ENST00000894470, ENST00000894471, ENST00000894472, ENST00000894473, ENST00000894474, ENST00000894475, ENST00000894476, ENST00000894477, ENST00000894478, ENST00000894479, ENST00000894480, ENST00000894481, ENST00000894482, ENST00000894483, ENST00000894484, ENST00000894485, ENST00000894486, ENST00000894487, ENST00000894488, ENST00000894489, ENST00000912168, ENST00000912169, ENST00000912170, ENST00000912171, ENST00000912172, ENST00000912173, ENST00000912174, ENST00000912175, ENST00000912176, ENST00000912177, ENST00000912178, ENST00000912179, ENST00000971873, ENST00000971874, ENST00000971875, ENST00000971876, ENST00000971877, ENST00000971878, ENST00000971879, ENST00000971880, ENST00000971881, ENST00000971882, ENST00000971883, ENST00000971884, ENST00000971885, ENST00000971886, ENST00000971887

RefSeq mRNA: 7 — MANE Select: NM_003271 NM_001025234, NM_001025235, NM_001025236, NM_001025237, NM_001025238, NM_001025239, NM_003271

CCDS: CCDS41589, CCDS7721

Canonical transcript exons

ENST00000397397 — 9 exons

Exon	Start	End
ENSE00001301323	847201	847300
ENSE00002189838	842852	842915
ENSE00003537950	864437	864511
ENSE00003545594	865694	865825
ENSE00003548838	866562	867111
ENSE00003566913	865918	866001
ENSE00003585196	865513	865614
ENSE00003640300	850288	850367
ENSE00003787171	862550	862741

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 98.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 61.0147 / max 579.0660, expressed in 1804 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112322	27.2501	1782
112325	18.8587	1418
112324	7.1223	1431
112326	2.6097	1013
112323	2.5145	1124
112329	1.7509	559
112321	0.5401	312
112328	0.3683	188

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	98.88	gold quality
right lung	UBERON:0002167	97.92	gold quality
omental fat pad	UBERON:0010414	97.77	gold quality
peritoneum	UBERON:0002358	97.71	gold quality
adipose tissue of abdominal region	UBERON:0007808	97.51	gold quality
left uterine tube	UBERON:0001303	97.40	gold quality
right ovary	UBERON:0002118	97.38	gold quality
endocervix	UBERON:0000458	97.36	gold quality
left ovary	UBERON:0002119	97.35	gold quality
body of uterus	UBERON:0009853	97.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	97.28	gold quality
upper lobe of left lung	UBERON:0008952	97.20	gold quality
tibial nerve	UBERON:0001323	97.06	gold quality
right lobe of thyroid gland	UBERON:0001119	97.03	gold quality
left lobe of thyroid gland	UBERON:0001120	96.95	gold quality
mucosa of stomach	UBERON:0001199	96.92	gold quality
right coronary artery	UBERON:0001625	96.86	gold quality
upper lobe of lung	UBERON:0008948	96.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.28	gold quality
adipose tissue	UBERON:0001013	96.27	gold quality
thyroid gland	UBERON:0002046	96.25	gold quality
metanephros cortex	UBERON:0010533	96.23	gold quality
lower esophagus	UBERON:0013473	96.22	gold quality
spleen	UBERON:0002106	96.05	gold quality
connective tissue	UBERON:0002384	95.73	gold quality
ectocervix	UBERON:0012249	95.69	gold quality
apex of heart	UBERON:0002098	95.53	gold quality
coronary artery	UBERON:0001621	95.29	gold quality
left coronary artery	UBERON:0001626	95.25	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	59.01
E-MTAB-8410	yes	56.94
E-ANND-3	yes	19.01
E-HCAD-1	yes	17.11
E-CURD-112	yes	13.99
E-HCAD-13	yes	11.65
E-MTAB-6678	yes	11.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TSPAN4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-182-5P	99.87	74.03	2589
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-12131	99.48	68.72	1673
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-1178-3P	98.57	67.09	890
HSA-MIR-216B-3P	98.55	67.19	1223
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-342-3P	96.44	67.48	1344

Literature-anchored findings (GeneRIF, showing 4)

• TM4SF4/il-TMP has the potential to be biomarker in a hepatocellular carcinoma and plays a crucial role in promotion of cancer cell proliferation (PMID:22236579)
• Exome sequencing of child-parent trios with bladder exstrophy: Findings in 26 children. (PMID:34355505)
• Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor. (PMID:34439793)
• TSPAN4 and migrasomes in atherosclerosis regression correlated to myocardial infarction and pan-cancer progression. (PMID:36513632)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan4a	ENSDARG00000089354
mus_musculus	Tspan4	ENSMUSG00000025511
rattus_norvegicus	Tspan4	ENSRNOG00000029810

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN9 (ENSG00000011105), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), TSPAN15 (ENSG00000099282), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), TSPAN14 (ENSG00000108219), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN33 (ENSG00000158457), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN10 (ENSG00000182612), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-4 — O14817 (reviewed: O14817)

Alternative names: Novel antigen 2, Transmembrane 4 superfamily member 7

All UniProt accessions (8): A8MVV6, E9PMX4, E9PN41, E9PPX8, E9PSH3, O14817, J3KNL1, J3KQ42

UniProt curated annotations — full annotation on UniProt →

Function. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells. Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells. Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis. May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling.

Subunit / interactions. Forms a complex with integrins. Interacts with HRH4.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets.

Similarity. Belongs to the tetraspanin (TM4SF) family.

RefSeq proteins (7): NP_001020405, NP_001020406, NP_001020407, NP_001020408, NP_001020409, NP_001020410, NP_003262* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000301	Tetraspanin_animals	Family
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family
IPR018503	Tetraspanin_CS	Conserved_site

Pfam: PF00335

UniProt features (13 total): topological domain 5, transmembrane region 4, glycosylation site 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14817-F1	89.95	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 152, 161

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 217 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN, MODULE_64, FOXO4_01, GGGTGGRR_PAX4_03, USF_C, YU_MYC_TARGETS_UP, UEDA_PERIFERAL_CLOCK, ACATTCC_MIR1_MIR206, TGACATY_UNKNOWN, ABBUD_LIF_SIGNALING_1_UP, GOMF_SIGNALING_RECEPTOR_BINDING, ZAMORA_NOS2_TARGETS_DN, FOXO4_02

GO Biological Process (1): protein-containing complex assembly (GO:0065003)

GO Molecular Function (3): antigen binding (GO:0003823), integrin binding (GO:0005178), protein binding (GO:0005515)

GO Cellular Component (4): plasma membrane (GO:0005886), focal adhesion (GO:0005925), vesicle (GO:0031982), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular component assembly	1
protein-containing complex organization	1
signaling receptor binding	1
protein-containing complex binding	1
cell adhesion molecule binding	1
membrane	1
cell periphery	1
cell-substrate junction	1
membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

756 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN4	GDF15	P78360	880
TSPAN4	CHD7	Q9P2D1	649
TSPAN4	SERPINA7	P05543	643
TSPAN4	ADCY10	Q96PN6	637
TSPAN4	NISCH	Q9Y2I1	573
TSPAN4	CD81	P18582	571
TSPAN4	TMEM8B	A6NDV4	571
TSPAN4	ITGB1	P05556	508
TSPAN4	CCDC136	Q96JN2	507
TSPAN4	ASPDH	A6ND91	488
TSPAN4	CD9	P21926	487
TSPAN4	ITGA6	P23229	441
TSPAN4	TSPAN31	Q12999	439
TSPAN4	CTIF	O43310	425
TSPAN4	B4E171	B4E171	416

IntAct

128 interactions, top by confidence:

A	B	Type	Score
NOTCH2NLA	TSPAN4	psi-mi:“MI:0915”(physical association)	0.670
TSPAN4	NOTCH2NLA	psi-mi:“MI:0915”(physical association)	0.670
CYSRT1	TSPAN4	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	MDFI	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	NOTCH2NLC	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	NR4A3	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	LCE2D	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	CREB5	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	CLEC2D	psi-mi:“MI:0915”(physical association)	0.560
FCHO1	TSPAN4	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	LCE3A	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	CATSPER1	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	LCE3D	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	LCE4A	psi-mi:“MI:0915”(physical association)	0.560
	TSPAN4	psi-mi:“MI:0915”(physical association)	0.560
PHLDA1	TSPAN4	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	GNE	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	LCE3C	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	KRTAP9-2	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	HOXA1	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	KRTAP9-3	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	GRN	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	GUCD1	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	CHRD	psi-mi:“MI:0915”(physical association)	0.560
TSPAN4	FRS3	psi-mi:“MI:0915”(physical association)	0.560
VGLL3	TSPAN4	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (58): NOTCH2NL (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Affinity Capture-RNA), TSPAN4 (Affinity Capture-RNA), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid), TSPAN4 (Two-hybrid)

ESM2 similar proteins: B0BM39, B3VSC2, B5X3I6, F7BWT7, O14494, O14817, O35566, O42602, O42603, O43688, O60636, O62772, O75954, O88956, O95857, O95858, P35353, P47866, P48509, P60588, Q01453, Q06AA5, Q13324, Q3SYV5, Q3ZBV0, Q4L208, Q5RAP3, Q5RAZ3, Q5ZJ75, Q60748, Q6DCQ3, Q6GMK6, Q6WL85, Q86UF1, Q8BJU2, Q8K593, Q8R3S2, Q8R4D1, Q90812, Q91ZH7

Diamond homologs: A0A8M2B5N2, A0A8V0ZLT4, B0BM39, B3VSC2, B5X3I6, O14817, O60635, O75954, O97703, P11049, P60033, P60034, Q06AA5, Q11098, Q26499, Q3T0S3, Q4R7W6, Q4V8E0, Q58CY8, Q5RAP3, Q5RC27, Q61470, Q6AYR9, Q6DCQ3, Q6GMK6, Q80WR1, Q8BJU2, Q922J6, Q96SJ8, Q99J59, Q9DCK3, O60636, P19397, P24485, P30932, P35762, P40240, P62079, P62080, Q17QJ5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 40 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Keratinization	13	25.9×	2e-14
Formation of the cornified envelope	7	22.0×	3e-07

GO biological processes:

GO term	Partners	Fold	FDR
keratinization	8	52.0×	4e-10

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1977 predictions. Top by Δscore:

Variant	Effect	Δscore
11:842412:AC:A	donor_gain	1.0000
11:842412:ACC:A	donor_gain	1.0000
11:842413:CC:C	donor_gain	1.0000
11:842413:CCC:C	donor_gain	1.0000
11:842413:CCCCT:C	donor_gain	1.0000
11:850366:GG:G	donor_gain	1.0000
11:850367:GG:G	donor_gain	1.0000
11:862537:T:TA	acceptor_gain	1.0000
11:862540:T:A	acceptor_gain	1.0000
11:862548:AGCTG:A	acceptor_gain	1.0000
11:862549:GCTGG:G	acceptor_gain	1.0000
11:862641:C:A	acceptor_gain	1.0000
11:862741:TG:T	donor_loss	1.0000
11:862742:G:GG	donor_gain	1.0000
11:862742:GTGA:G	donor_loss	1.0000
11:864434:CA:C	acceptor_loss	1.0000
11:864435:A:AG	acceptor_gain	1.0000
11:864435:AGTTC:A	acceptor_loss	1.0000
11:864436:G:GA	acceptor_gain	1.0000
11:864436:GTT:G	acceptor_gain	1.0000
11:864509:AAGG:A	donor_loss	1.0000
11:864510:AGGT:A	donor_loss	1.0000
11:864511:GGTA:G	donor_loss	1.0000
11:865511:A:AG	acceptor_gain	1.0000
11:865511:AGATT:A	acceptor_gain	1.0000
11:865512:G:GA	acceptor_gain	1.0000
11:865512:GA:G	acceptor_gain	1.0000
11:865512:GAT:G	acceptor_gain	1.0000
11:865512:GATT:G	acceptor_gain	1.0000
11:865512:GATTG:G	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000141388 (11:852064 G>A,T), RS1000218968 (11:845084 C>G,T), RS1000285576 (11:861438 C>T), RS1000390673 (11:847480 G>A,T), RS1000441734 (11:843285 G>T), RS1000639494 (11:863458 C>A,T), RS1000695966 (11:844245 G>A), RS1000920457 (11:852944 G>A,C), RS1000934032 (11:855855 C>T), RS1000977106 (11:861181 A>C), RS1000987371 (11:844421 C>G), RS1000994924 (11:857638 C>G,T), RS1001029418 (11:860949 C>T), RS1001167936 (11:862519 T>C), RS1001175730 (11:846884 C>T)

Disease associations

OMIM: gene MIM:602644 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90012857_13	Falling risk	2.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	6
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	4
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, decreases expression	4
Tobacco Smoke Pollution	decreases expression, increases methylation	3
Tretinoin	decreases expression, increases expression	3
Particulate Matter	decreases reaction, increases abundance, decreases expression	3
Arsenic	increases abundance, increases expression, affects cotreatment, decreases expression	2
Phenylmercuric Acetate	increases expression, affects cotreatment	2
Smoke	increases expression, decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	decreases methylation	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
entinostat	increases expression	1
monomethylarsonous acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
dorsomorphin	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Arsenic Trioxide	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acetaminophen	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_XU79	HAP1 TSPAN4 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.