TSPAN9

Summary

TSPAN9 (tetraspanin 9, HGNC:21640) is a protein-coding gene on chromosome 12p13.33-p13.32, encoding Tetraspanin-9 (O75954).

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified.

Source: NCBI Gene 10867 — RefSeq curated summary.

At a glance

• GWAS associations: 35
• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_006675

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21640
Approved symbol	TSPAN9
Name	tetraspanin 9
Location	12p13.33-p13.32
Locus type	gene with protein product
Status	Approved
Aliases	NET-5
Ensembl gene	ENSG00000011105
Ensembl biotype	protein_coding
OMIM	613137
Entrez	10867

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 27 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000011898, ENST00000407263, ENST00000431374, ENST00000444315, ENST00000492305, ENST00000537971, ENST00000539631, ENST00000640568, ENST00000649909, ENST00000865933, ENST00000865934, ENST00000865935, ENST00000865936, ENST00000865937, ENST00000865938, ENST00000865939, ENST00000865940, ENST00000865941, ENST00000865942, ENST00000865943, ENST00000865944, ENST00000865945, ENST00000865946, ENST00000865947, ENST00000865948, ENST00000865949, ENST00000865950, ENST00000865951, ENST00000865952, ENST00000971277, ENST00000971278

RefSeq mRNA: 2 — MANE Select: NM_006675 NM_001168320, NM_006675

CCDS: CCDS8520

Canonical transcript exons

ENST00000011898 — 9 exons

Exon	Start	End
ENSE00000713721	3281198	3281329
ENSE00000713723	3281734	3281817
ENSE00001158633	3201177	3201256
ENSE00001265639	3083653	3083719
ENSE00002214365	3283045	3286559
ENSE00003464188	3278421	3278612
ENSE00003506448	3278992	3279066
ENSE00003602209	3280382	3280483
ENSE00003848960	3077379	3077453

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 97.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.9020 / max 382.7136, expressed in 1523 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123476	10.0469	1500
123477	1.7911	827
123479	1.5378	453
123486	0.3960	242
123483	0.1185	79
123482	0.0118	4

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	97.53	gold quality
cerebellar hemisphere	UBERON:0002245	97.51	gold quality
cerebellar cortex	UBERON:0002129	97.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.25	gold quality
cerebellum	UBERON:0002037	96.63	gold quality
right atrium auricular region	UBERON:0006631	95.90	gold quality
heart left ventricle	UBERON:0002084	95.82	gold quality
cardiac ventricle	UBERON:0002082	95.72	gold quality
cardiac atrium	UBERON:0002081	95.34	gold quality
heart	UBERON:0000948	94.67	gold quality
right lung	UBERON:0002167	93.91	gold quality
right lobe of liver	UBERON:0001114	93.85	gold quality
stromal cell of endometrium	CL:0002255	93.65	gold quality
vena cava	UBERON:0004087	93.24	gold quality
gall bladder	UBERON:0002110	92.98	gold quality
metanephros cortex	UBERON:0010533	91.94	gold quality
heart right ventricle	UBERON:0002080	91.70	gold quality
adult mammalian kidney	UBERON:0000082	91.57	gold quality
body of uterus	UBERON:0009853	91.25	gold quality
right ovary	UBERON:0002118	91.17	gold quality
left ovary	UBERON:0002119	91.06	gold quality
liver	UBERON:0002107	91.02	gold quality
upper lobe of left lung	UBERON:0008952	90.59	gold quality
upper lobe of lung	UBERON:0008948	90.31	gold quality
endocervix	UBERON:0000458	89.88	gold quality
right coronary artery	UBERON:0001625	89.70	gold quality
myocardium	UBERON:0002349	89.68	gold quality
renal medulla	UBERON:0000362	89.57	gold quality
left uterine tube	UBERON:0001303	89.50	gold quality
tibial artery	UBERON:0007610	89.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.13

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXO3

miRNA regulators (miRDB)

152 targeting TSPAN9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-652-5P	99.91	67.49	505

Literature-anchored findings (GeneRIF, showing 5)

• Findings suggest a role for Tspan9 in regulating platelet function in concert with other platelet tetraspanins and their associated proteins. (PMID:18795891)
• tetraspanin CD9 has a role in determining vascular smooth muscle cell injury phenotypes (PMID:18799160)
• TSPAN9 is an endosomal tetraspanin whose depletion has a pronounced effect on the entry of several viruses that fuse in the early endosome. (PMID:26865714)
• The proliferation, migration and invasion of human gastric cancer SGC7901 cells were significantly inhibited by overexpression of Tspan9. (PMID:27177197)
• expression of the membrane protein TSPAN9 regulates gastric cancer cell migration and invasion by inhibiting the FAK-RAS-ERK1/2 signaling pathway. The extracellular secretory protein EMILIN1 can increase this tumor suppressive effect by promoting the expression of TSPAN9. (PMID:31242895)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tspan9a	ENSDARG00000025299
danio_rerio	tspan9b	ENSDARG00000045706
mus_musculus	Tspan9	ENSMUSG00000030352
rattus_norvegicus	Tspan9	ENSRNOG00000051620

Paralogs (32): TSPAN6 (ENSG00000000003), CD9 (ENSG00000010278), TSPAN17 (ENSG00000048140), TSPAN32 (ENSG00000064201), CD82 (ENSG00000085117), TSPAN15 (ENSG00000099282), CD37 (ENSG00000104894), UPK1A (ENSG00000105668), TSPAN12 (ENSG00000106025), TSPAN13 (ENSG00000106537), TSPAN14 (ENSG00000108219), CD81 (ENSG00000110651), TSPAN11 (ENSG00000110900), PRPH2 (ENSG00000112619), UPK1B (ENSG00000114638), TSPAN1 (ENSG00000117472), TSPAN8 (ENSG00000127324), TSPAN16 (ENSG00000130167), TSPAN2 (ENSG00000134198), CD63 (ENSG00000135404), TSPAN31 (ENSG00000135452), TSPAN3 (ENSG00000140391), CD53 (ENSG00000143119), ROM1 (ENSG00000149489), TSPAN7 (ENSG00000156298), TSPAN18 (ENSG00000157570), TSPAN33 (ENSG00000158457), TSPAN5 (ENSG00000168785), CD151 (ENSG00000177697), TSPAN10 (ENSG00000182612), TSPAN4 (ENSG00000214063), TSPAN19 (ENSG00000231738)

Protein

Protein identifiers

Tetraspanin-9 — O75954 (reviewed: O75954)

Alternative names: Tetraspan NET-5

All UniProt accessions (5): O75954, A0A1W2PQ04, A0A3B3IST1, B5MD23, E9PHL0

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Found in a complex with GP6.

Subcellular location. Membrane.

Tissue specificity. Expressed in megakaryocytes and platelets (at protein level).

Post-translational modifications. Glycosylated.

Similarity. Belongs to the tetraspanin (TM4SF) family.

RefSeq proteins (2): NP_001161792, NP_006666* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000301	Tetraspanin_animals	Family
IPR008952	Tetraspanin_EC2_sf	Homologous_superfamily
IPR018499	Tetraspanin/Peripherin	Family
IPR018503	Tetraspanin_CS	Conserved_site

Pfam: PF00335

UniProt features (12 total): topological domain 5, transmembrane region 4, chain 1, glycosylation site 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75954-F1	89.65	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 180

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 212 (showing top): GOBP_MYELOID_CELL_HOMEOSTASIS, TGCACTT_MIR519C_MIR519B_MIR519A, GCANCTGNY_MYOD_Q6, GOBP_PLATELET_ACTIVATION, TERAMOTO_OPN_TARGETS_CLUSTER_6, GOBP_WOUND_HEALING, GOBP_CELL_CELL_ADHESION, BROWNE_HCMV_INFECTION_24HR_UP, ACATTCC_MIR1_MIR206, AACTTT_UNKNOWN, GOBP_REGULATION_OF_MITOCHONDRIAL_MEMBRANE_POTENTIAL, GOBP_MULTICELLULAR_ORGANISMAL_LEVEL_HOMEOSTASIS, GOBP_HOMOTYPIC_CELL_CELL_ADHESION, GOBP_HEMOSTASIS, AML1_01

GO Biological Process (6): neutrophil homeostasis (GO:0001780), collagen-activated tyrosine kinase receptor signaling pathway (GO:0038063), regulation of mitochondrial membrane potential (GO:0051881), platelet aggregation (GO:0070527), receptor diffusion trapping (GO:0098953), mitocytosis (GO:0160040)

GO Molecular Function (1): signaling receptor binding (GO:0005102)

GO Cellular Component (6): plasma membrane (GO:0005886), focal adhesion (GO:0005925), extracellular matrix (GO:0031012), tetraspanin-enriched microdomain (GO:0097197), migrasome (GO:0140494), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
plasma membrane	2
cellular anatomical structure	2
leukocyte homeostasis	1
myeloid cell homeostasis	1
cell surface receptor protein tyrosine kinase signaling pathway	1
collagen-activated signaling pathway	1
regulation of membrane potential	1
platelet activation	1
homotypic cell-cell adhesion	1
localization within membrane	1
mitochondrion distribution	1
establishment of mitochondrion localization	1
migracytosis	1
protein binding	1
membrane	1
cell periphery	1
cell-substrate junction	1
external encapsulating structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

944 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSPAN9	TSPAN32	Q96QS1	715
TSPAN9	ITGB1	P05556	595
TSPAN9	GP6	Q9HCN6	555
TSPAN9	CD63	P08962	515
TSPAN9	CD151	P48509	499
TSPAN9	CD9	P21926	492
TSPAN9	VWCE	Q96DN2	428
TSPAN9	B4E171	B4E171	418
TSPAN9	TSPAN14	Q8NG11	418
TSPAN9	NRIP2	Q9BQI9	414
TSPAN9	TSPAN2	O60636	410
TSPAN9	PRMT8	Q9NR22	409
TSPAN9	TSPAN10	Q9H1Z9	408
TSPAN9	RIPOR2	Q9Y4F9	403
TSPAN9	CRACR2A	Q9BSW2	401

IntAct

13 interactions, top by confidence:

A	B	Type	Score
TSPAN15	ADAM10	psi-mi:“MI:0914”(association)	0.840
TSPAN5	ADAM10	psi-mi:“MI:0914”(association)	0.800
CD9	ADAM10	psi-mi:“MI:0914”(association)	0.750
EVA1B	NRP1	psi-mi:“MI:0914”(association)	0.530
ADAM10	TSPAN9	psi-mi:“MI:0914”(association)	0.350
EVA1B	TMEM131L	psi-mi:“MI:0914”(association)	0.350
TSC22D3	VPS37C	psi-mi:“MI:0914”(association)	0.350
SYT2	SMAP	psi-mi:“MI:0914”(association)	0.350
VSIG1	RIMOC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (9): TSPAN9 (Affinity Capture-RNA), TSPAN9 (Affinity Capture-MS), TSPAN9 (Affinity Capture-RNA), TSPAN9 (Affinity Capture-RNA), TSPAN9 (Affinity Capture-MS), TSPAN9 (Affinity Capture-MS), TSPAN9 (Affinity Capture-MS), TSPAN9 (Affinity Capture-RNA), TSPAN9 (Affinity Capture-RNA)

ESM2 similar proteins: B0BM39, B3VSC2, B5X3I6, F7BWT7, O14494, O14817, O35566, O42602, O42603, O43688, O60636, O62772, O75954, O88956, O95857, O95858, P35353, P47866, P48509, P60588, Q01453, Q06AA5, Q13324, Q3SYV5, Q3ZBV0, Q4L208, Q5RAP3, Q5RAZ3, Q5ZJ75, Q60748, Q6DCQ3, Q6GMK6, Q6WL85, Q86UF1, Q8BJU2, Q8K593, Q8R3S2, Q8R4D1, Q90812, Q91ZH7

Diamond homologs: A0A8M2B5N2, A0A8V0ZLT4, B0BM39, B3VSC2, B5X3I6, O14817, O60635, O75954, O97703, P11049, P60033, P60034, Q06AA5, Q11098, Q26499, Q3T0S3, Q4R7W6, Q4V8E0, Q58CY8, Q5RAP3, Q5RC27, Q61470, Q6AYR9, Q6DCQ3, Q6GMK6, Q80WR1, Q8BJU2, Q922J6, Q96SJ8, Q99J59, Q9DCK3, O60636, P19397, P24485, P30932, P35762, P40240, P62079, P62080, Q17QJ5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	35
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3797 predictions. Top by Δscore:

Variant	Effect	Δscore
12:3077449:GCGCG:G	donor_gain	1.0000
12:3077452:CGG:C	donor_loss	1.0000
12:3077454:G:GG	donor_gain	1.0000
12:3077455:T:A	donor_loss	1.0000
12:3278609:CAGC:C	donor_gain	1.0000
12:3278611:GC:G	donor_gain	1.0000
12:3278613:G:GG	donor_gain	1.0000
12:3278990:A:AG	acceptor_gain	1.0000
12:3278991:G:GA	acceptor_gain	1.0000
12:3279063:CAAGG:C	donor_loss	1.0000
12:3279064:AAGGT:A	donor_loss	1.0000
12:3279066:GGT:G	donor_loss	1.0000
12:3279067:GTAAG:G	donor_loss	1.0000
12:3279068:T:G	donor_loss	1.0000
12:3280372:C:CA	acceptor_gain	1.0000
12:3280376:T:TA	acceptor_gain	1.0000
12:3280378:GCAGG:G	acceptor_loss	1.0000
12:3280379:CA:C	acceptor_loss	1.0000
12:3280380:A:AG	acceptor_gain	1.0000
12:3280380:AG:A	acceptor_gain	1.0000
12:3280380:AGGT:A	acceptor_gain	1.0000
12:3280380:AGGTG:A	acceptor_loss	1.0000
12:3280381:G:GC	acceptor_gain	1.0000
12:3280381:GG:G	acceptor_gain	1.0000
12:3280381:GGT:G	acceptor_gain	1.0000
12:3280381:GGTG:G	acceptor_gain	1.0000
12:3280381:GGTGA:G	acceptor_gain	1.0000
12:3280478:GC:G	donor_gain	1.0000
12:3280479:C:G	donor_gain	1.0000
12:3280482:AGG:A	donor_loss	1.0000

AlphaMissense

1588 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:3281233:G:C	W156C	0.999
12:3281233:G:T	W156C	0.999
12:3280407:T:C	L119P	0.998
12:3281210:G:T	G149C	0.998
12:3281231:T:A	W156R	0.998
12:3281231:T:C	W156R	0.998
12:3280463:T:A	W138R	0.997
12:3280463:T:C	W138R	0.997
12:3281204:T:C	C147R	0.997
12:3278428:G:A	G24D	0.996
12:3278442:G:A	G29R	0.996
12:3278442:G:C	G29R	0.996
12:3278448:G:C	G31R	0.996
12:3278538:G:C	G61R	0.996
12:3278539:G:A	G61D	0.996
12:3278559:G:C	G68R	0.996
12:3278578:G:A	G74E	0.996
12:3280465:G:C	W138C	0.996
12:3280465:G:T	W138C	0.996
12:3281204:T:A	C147S	0.996
12:3281205:G:C	C147S	0.996
12:3281207:T:A	C148S	0.996
12:3281208:G:A	C148Y	0.996
12:3281208:G:C	C148S	0.996
12:3281211:G:A	G149D	0.996
12:3281211:G:T	G149V	0.996
12:3278449:G:A	G31D	0.995
12:3278458:T:C	L34P	0.995
12:3278560:G:A	G68D	0.995
12:3278568:G:C	G71R	0.995

dbSNP variants (sampled 300 via entrez): RS1000025806 (12:3083828 G>A), RS1000032889 (12:3147285 C>T), RS1000034161 (12:3212229 C>T), RS1000044296 (12:3180968 G>A,T), RS1000100527 (12:3190262 A>G), RS1000101937 (12:3217809 C>T), RS1000116956 (12:3080632 G>A), RS1000119236 (12:3157240 C>G,T), RS1000132034 (12:3105943 C>T), RS1000154416 (12:3190016 A>G), RS1000175498 (12:3265925 G>A), RS1000184924 (12:3141906 A>G), RS1000185946 (12:3175644 C>A,T), RS1000203157 (12:3116327 C>T), RS1000204843 (12:3085680 A>C)

Disease associations

OMIM: gene MIM:613137 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

35 associations (top):

Study	Trait	p-value
GCST002029_1	Temporomandibular joint disorder	8.000000e-06
GCST002337_62	Amyotrophic lateral sclerosis (sporadic)	3.000000e-06
GCST003210_6	Low vWF levels	1.000000e-07
GCST003372_36	Glomerular filtration rate (creatinine)	5.000000e-14
GCST004292_4	Glomerular filtration rate (creatinine)	2.000000e-09
GCST004616_90	Platelet distribution width	1.000000e-18
GCST005196_60	Coronary artery disease	1.000000e-06
GCST005984_36	Glomerular filtration rate	7.000000e-10
GCST005985_36	Creatinine levels	7.000000e-11
GCST006479_80	Diverticular disease	1.000000e-06
GCST006979_881	Heel bone mineral density	6.000000e-16
GCST007344_94	Estimated glomerular filtration rate	4.000000e-09
GCST007876_94	Estimated glomerular filtration rate	5.000000e-20
GCST008058_55	Estimated glomerular filtration rate	8.000000e-29
GCST008059_59	Estimated glomerular filtration rate	1.000000e-24
GCST008060_27	Estimated glomerular filtration rate	9.000000e-06
GCST008506_9	Stress sensitivity (neuroticism score x major depressive disorder status interaction)	8.000000e-06
GCST008747_73	Estimated glomerular filtration rate	2.000000e-19
GCST008790_44	Urinary albumin-to-creatinine ratio	2.000000e-08
GCST009462_113	Optic disc size	5.000000e-15
GCST011739_6	Cutaneous leishmaniasis	2.000000e-06
GCST012228_545	Waist-hip index	2.000000e-11
GCST012230_38	Waist-to-hip ratio adjusted for BMI	2.000000e-11
GCST012231_106	A body shape index	1.000000e-08
GCST90000025_1013	Appendicular lean mass	7.000000e-22
GCST90000025_1014	Appendicular lean mass	8.000000e-60
GCST90000025_1015	Appendicular lean mass	2.000000e-55
GCST90002398_136	Neutrophil count	8.000000e-12
GCST90002401_227	Platelet distribution width	4.000000e-46
GCST90002401_228	Platelet distribution width	5.000000e-10

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0007984	platelet component distribution width
EFO:0009959	diverticular disease
EFO:0009270	heel bone mineral density
EFO:0007660	neuroticism measurement
EFO:0007778	urinary albumin to creatinine ratio
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0007789	BMI-adjusted waist circumference
EFO:0004980	appendicular lean mass
EFO:0004833	neutrophil count
EFO:0004305	erythrocyte count
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	4
Estradiol	decreases expression	3
bisphenol A	decreases expression, decreases methylation, increases expression	2
Silicon Dioxide	decreases expression, decreases methylation	2
Valproic Acid	increases methylation, increases expression	2
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation, increases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment	2
aristolochic acid I	decreases expression	1
2,4,6-tribromophenol	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
perfluorooctanoic acid	decreases expression	1
benzo(e)pyrene	affects methylation, increases methylation	1
potassium chromate(VI)	increases expression	1
aflatoxin B2	increases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	increases expression	1
abrine	increases expression	1
bisphenol S	decreases methylation	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cisplatin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.