TSPEAR-AS1

Summary

TSPEAR-AS1 (TSPEAR antisense RNA 1, HGNC:1271) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1271
Approved symbol	TSPEAR-AS1
Name	TSPEAR antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235890
Ensembl biotype	lncRNA
Entrez	54082
RNAcentral	URS000075E4C3 — lncRNA, 2553 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000330490, ENST00000354333, ENST00000430181, ENST00000451035, ENST00000465978, ENST00000715809, ENST00000789496, ENST00000789497

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000330490 — 3 exons

Exon	Start	End
ENSE00001310393	44518259	44518332
ENSE00001327329	44517216	44517835
ENSE00001623177	44518628	44518756

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 83.46.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5904 / max 30.5981, expressed in 206 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189491	0.2989	104
189490	0.1714	77
189489	0.1201	66

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.46	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.46	gold quality
spleen	UBERON:0002106	78.32	gold quality
right lobe of liver	UBERON:0001114	77.03	gold quality
mucosa of stomach	UBERON:0001199	72.84	gold quality
pituitary gland	UBERON:0000007	71.65	gold quality
apex of heart	UBERON:0002098	70.91	gold quality
left uterine tube	UBERON:0001303	70.89	gold quality
liver	UBERON:0002107	70.44	gold quality
body of uterus	UBERON:0009853	69.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.85	gold quality
right testis	UBERON:0004534	68.50	gold quality
left testis	UBERON:0004533	68.46	gold quality
heart left ventricle	UBERON:0002084	68.36	gold quality
right atrium auricular region	UBERON:0006631	68.21	gold quality
right lobe of thyroid gland	UBERON:0001119	68.03	gold quality
thyroid gland	UBERON:0002046	67.98	gold quality
endocervix	UBERON:0000458	67.66	gold quality
myometrium	UBERON:0001296	67.64	gold quality
testis	UBERON:0000473	67.55	gold quality
left lobe of thyroid gland	UBERON:0001120	67.51	gold quality
adenohypophysis	UBERON:0002196	66.82	gold quality
ectocervix	UBERON:0012249	66.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.77	gold quality
heart	UBERON:0000948	66.71	gold quality
cortical plate	UBERON:0005343	66.53	gold quality
bone marrow cell	CL:0002092	66.33	silver quality
upper lobe of left lung	UBERON:0008952	66.18	gold quality
lower esophagus	UBERON:0013473	64.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p. (PMID:35477008)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.