TSPOAP1-AS1

Summary

TSPOAP1-AS1 (TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1, HGNC:44148) is a long non-coding RNA gene on chromosome 17q22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44148
Approved symbol	TSPOAP1-AS1
Name	TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1
Location	17q22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000265148
Ensembl biotype	lncRNA
Entrez	100506779
RNAcentral	URS000075DAE9 — lncRNA, 2500 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000578025, ENST00000578334, ENST00000579527, ENST00000579859, ENST00000580022, ENST00000580515, ENST00000580633, ENST00000582348, ENST00000583826, ENST00000583841, ENST00000585236, ENST00000656608, ENST00000667382, ENST00000690694, ENST00000700895, ENST00000790336, ENST00000790337, ENST00000790338, ENST00000790339, ENST00000790340

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578025 — 4 exons

Exon	Start	End
ENSE00002698474	58337215	58337310
ENSE00002709897	58337448	58337679
ENSE00002731860	58351735	58351914
ENSE00002734950	58351999	58353719

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 91.73.

FANTOM5 (CAGE): breadth broad, TPM avg 4.9000 / max 174.1171, expressed in 448 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161918	1.9685	265
161915	1.2340	230
161914	0.7715	184
161917	0.4920	208
161916	0.2744	137
161911	0.1034	50
161910	0.0563	22

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	91.73	gold quality
leukocyte	CL:0000738	88.16	gold quality
monocyte	CL:0000576	87.90	gold quality
blood	UBERON:0000178	87.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.54	gold quality
lymph node	UBERON:0000029	82.43	gold quality
vermiform appendix	UBERON:0001154	82.29	gold quality
right uterine tube	UBERON:0001302	81.87	gold quality
endothelial cell	CL:0000115	81.35	gold quality
bone marrow cell	CL:0002092	80.43	gold quality
thymus	UBERON:0002370	78.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.02	gold quality
bone marrow	UBERON:0002371	77.95	gold quality
cerebellar hemisphere	UBERON:0002245	77.60	gold quality
cerebellar cortex	UBERON:0002129	77.43	gold quality
ileal mucosa	UBERON:0000331	77.17	gold quality
cortical plate	UBERON:0005343	76.98	gold quality
spleen	UBERON:0002106	76.18	gold quality
cerebellum	UBERON:0002037	75.85	gold quality
caecum	UBERON:0001153	73.30	gold quality
right frontal lobe	UBERON:0002810	73.12	gold quality
prefrontal cortex	UBERON:0000451	72.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	72.77	gold quality
anterior cingulate cortex	UBERON:0009835	72.65	gold quality
mucosa of transverse colon	UBERON:0004991	72.55	gold quality
tonsil	UBERON:0002372	72.50	gold quality
colonic epithelium	UBERON:0000397	71.94	gold quality
left uterine tube	UBERON:0001303	71.91	gold quality
rectum	UBERON:0001052	71.51	gold quality
gall bladder	UBERON:0002110	71.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA BZRAP1-AS1 silencing suppresses tumor angiogenesis in hepatocellular carcinoma by mediating THBS1 methylation. (PMID:31847842)
• Hypermethylation of the TSPOAP1-AS1 Promoter May Be Associated with Obesity in Overweight/Obese Korean Subjects. (PMID:32392798)
• Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock. (PMID:33344646)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.