TSR1

Summary

TSR1 (TSR1 ribosome maturation factor, HGNC:25542) is a protein-coding gene on chromosome 17p13.3, encoding Pre-rRNA-processing protein TSR1 homolog (Q2NL82). Required during maturation of the 40S ribosomal subunit in the nucleolus. It is a common-essential gene (DepMap: required in 100.0% of cancer cell lines).

Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus.

Source: NCBI Gene 55720 — RefSeq curated summary.

At a glance

• Gene–disease (curated): idiopathic spontaneous coronary artery dissection (Limited, GenCC)
• GWAS associations: 6
• Clinical variants (ClinVar): 140 total
• Cancer dependency (DepMap): dependent in 100.0% of screened cell lines (common-essential)
• MANE Select transcript: NM_018128

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25542
Approved symbol	TSR1
Name	TSR1 ribosome maturation factor
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10534
Ensembl gene	ENSG00000167721
Ensembl biotype	protein_coding
OMIM	611214
Entrez	55720

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000301364, ENST00000571806, ENST00000575049, ENST00000576112, ENST00000576202, ENST00000909712, ENST00000915542, ENST00000915543, ENST00000915544, ENST00000915545, ENST00000947905, ENST00000947906

RefSeq mRNA: 1 — MANE Select: NM_018128 NM_018128

CCDS: CCDS32525

Canonical transcript exons

ENST00000301364 — 15 exons

Exon	Start	End
ENSE00001116104	2324504	2324578
ENSE00001116105	2330515	2330625
ENSE00001116106	2334472	2334896
ENSE00001116107	2329343	2329475
ENSE00001116108	2324689	2324829
ENSE00001116110	2332169	2332359
ENSE00001116113	2330947	2331109
ENSE00001116114	2333557	2333716
ENSE00001116116	2332961	2333124
ENSE00001116117	2336037	2336140
ENSE00001434347	2322396	2324374
ENSE00002683031	2336331	2336457
ENSE00003525447	2325304	2325420
ENSE00003562245	2335260	2335394
ENSE00003639590	2335511	2335730

Expression profiles

Bgee: expression breadth ubiquitous, 300 present calls, max score 98.87.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.5427 / max 296.1890, expressed in 1816 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163820	39.5427	1816

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cervix squamous epithelium	UBERON:0006922	98.87	gold quality
nipple	UBERON:0002030	98.21	gold quality
mucosa of paranasal sinus	UBERON:0005030	98.19	gold quality
buccal mucosa cell	CL:0002336	98.16	gold quality
renal medulla	UBERON:0000362	97.96	gold quality
male germ cell	CL:0000015	97.80	gold quality
sperm	CL:0000019	97.79	gold quality
cardia of stomach	UBERON:0001162	97.78	gold quality
ventral tegmental area	UBERON:0002691	97.78	gold quality
superficial temporal artery	UBERON:0001614	97.71	gold quality
lateral globus pallidus	UBERON:0002476	97.65	gold quality
olfactory bulb	UBERON:0002264	97.59	gold quality
superior surface of tongue	UBERON:0007371	97.56	gold quality
blood vessel layer	UBERON:0004797	97.41	gold quality
pylorus	UBERON:0001166	97.35	gold quality
pericardium	UBERON:0002407	97.27	gold quality
subthalamic nucleus	UBERON:0001906	97.17	gold quality
inferior vagus X ganglion	UBERON:0005363	97.10	gold quality
lateral nuclear group of thalamus	UBERON:0002736	97.05	gold quality
periodontal ligament	UBERON:0008266	97.03	gold quality
trigeminal ganglion	UBERON:0001675	97.02	gold quality
medulla oblongata	UBERON:0001896	96.91	gold quality
pharyngeal mucosa	UBERON:0000355	96.89	gold quality
saphenous vein	UBERON:0007318	96.88	gold quality
type B pancreatic cell	CL:0000169	96.76	gold quality
superior vestibular nucleus	UBERON:0007227	96.73	gold quality
tongue	UBERON:0001723	96.70	gold quality
substantia nigra pars compacta	UBERON:0001965	96.68	gold quality
body of tongue	UBERON:0011876	96.66	gold quality
vena cava	UBERON:0004087	96.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

107 targeting TSR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-10401-5P	99.99	65.79	948
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-7978	99.86	66.90	856
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-5093	99.67	69.26	2291
HSA-MIR-6762-3P	99.66	66.94	1188
HSA-MIR-7157-5P	99.66	69.33	1829
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-3679-3P	99.64	69.88	1599
HSA-MIR-4743-3P	99.62	68.12	2095
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-105-5P	99.54	69.24	2060
HSA-MIR-7853-5P	99.54	69.30	2055
HSA-MIR-103A-1-5P	99.39	67.78	1545
HSA-MIR-103A-2-5P	99.39	67.72	1577

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 100.0% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 3)

• hTsr1 is involved downstream in nuclear export of the pre-40S particles. (PMID:20805244)
• This study describes the clinical characteristics of the Chinese Han population with Spontaneous Coronary Artery Dissection and identified TSR1 as a potential causal gene, which might bring about a further progress in diagnosis and treatment of the disorder. (PMID:31296287)
• a novel congenital cataract candidate gene TSR1 was identified by whole genome sequencing and Sanger sequencing in a Chinese congenital cataract family (PMID:32102773)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tsr1	ENSDARG00000007744
mus_musculus	Tsr1	ENSMUSG00000038335
rattus_norvegicus	Tsr1	ENSRNOG00000002980
drosophila_melanogaster	Tsr1	FBGN0037073
caenorhabditis_elegans		WBGENE00006497

Paralogs (1): BMS1 (ENSG00000165733)

Protein

Protein identifiers

Pre-rRNA-processing protein TSR1 homolog — Q2NL82 (reviewed: Q2NL82)

All UniProt accessions (4): Q2NL82, I3L1Q5, I3L4E8, I3L4T0

UniProt curated annotations — full annotation on UniProt →

Function. Required during maturation of the 40S ribosomal subunit in the nucleolus.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.

RefSeq proteins (1): NP_060598* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007034	BMS1_TSR1_C	Domain
IPR012948	AARP2CN	Domain
IPR030387	G_Bms1/Tsr1_dom	Domain
IPR039761	Bms1/Tsr1	Family

Pfam: PF04950, PF08142, PF22298

UniProt features (85 total): strand 48, helix 14, turn 12, sequence variant 4, sequence conflict 2, compositionally biased region 2, chain 1, domain 1, region of interest 1

Structure

Experimental structures (PDB)

17 structures.

PDB	Method	Resolution (Å)
6ZMT	ELECTRON MICROSCOPY	3
7WTU	ELECTRON MICROSCOPY	3
7WTZ	ELECTRON MICROSCOPY	3
7WTT	ELECTRON MICROSCOPY	3.1
7WTX	ELECTRON MICROSCOPY	3.1
6ZN5	ELECTRON MICROSCOPY	3.2
7WTS	ELECTRON MICROSCOPY	3.2
7WTW	ELECTRON MICROSCOPY	3.2
7WU0	ELECTRON MICROSCOPY	3.3
7WTV	ELECTRON MICROSCOPY	3.5
6G18	ELECTRON MICROSCOPY	3.6
8ZDD	ELECTRON MICROSCOPY	3.7
8ZDC	ELECTRON MICROSCOPY	3.8
6G4S	ELECTRON MICROSCOPY	4
6G51	ELECTRON MICROSCOPY	4.1
6G4W	ELECTRON MICROSCOPY	4.5
6G53	ELECTRON MICROSCOPY	4.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q2NL82-F1	80.62	0.48

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 209 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GSE45365_NK_CELL_VS_BCELL_UP, RNGTGGGC_UNKNOWN, GOBP_RIBOSOME_BIOGENESIS, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_MATURATION_OF_SSU_RRNA, CACCAGC_MIR138, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, PUJANA_CHEK2_PCC_NETWORK, AP1_Q4_01, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GOBP_MATURATION_OF_SSU_RRNA_FROM_TRICISTRONIC_RRNA_TRANSCRIPT_SSU_RRNA_5_8S_RRNA_LSU_RRNA, GROSS_HYPOXIA_VIA_HIF1A_UP, TGANTCA_AP1_C

GO Biological Process (3): maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000462), endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000479), ribosome biogenesis (GO:0042254)

GO Molecular Function (5): RNA binding (GO:0003723), GTPase activity (GO:0003924), GTP binding (GO:0005525), U3 snoRNA binding (GO:0034511), protein binding (GO:0005515)

GO Cellular Component (4): nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear lumen	2
cellular anatomical structure	2
maturation of SSU-rRNA	1
rRNA processing	1
ribonucleoprotein complex biogenesis	1
nucleic acid binding	1
ribonucleoside triphosphate phosphatase activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
snoRNA binding	1
binding	1
intracellular membraneless organelle	1
cytoplasm	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2538 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TSR1	BYSL	Q13895	963
TSR1	LTV1	Q96GA3	943
TSR1	RIOK2	Q9BVS4	937
TSR1	TSR2	Q969E8	902
TSR1	RCL1	Q9Y2P8	892
TSR1	PNO1	Q9NRX1	883
TSR1	NOB1	Q9ULX3	877
TSR1	TSR3	Q9UJK0	810
TSR1	RIOK1	Q9BRS2	805
TSR1	RRP12	Q5JTH9	744
TSR1	POLR2B	P30876	674
TSR1	MCM7	P33993	667
TSR1	WDR12	Q9GZL7	665
TSR1	RPS3	P23396	664
TSR1	TXNL4B	Q9NX01	655

IntAct

146 interactions, top by confidence:

A	B	Type	Score
XPC	CETN3	psi-mi:“MI:0914”(association)	0.730
PTK2	TGFB1I1	psi-mi:“MI:0914”(association)	0.680
TSR1	RPS3	psi-mi:“MI:0914”(association)	0.640
BYSL	PARN	psi-mi:“MI:0914”(association)	0.640
TSR1	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
TSR1	RHBDD2	psi-mi:“MI:0915”(physical association)	0.560
ZBTB48	ZBTB24	psi-mi:“MI:0914”(association)	0.530
TSR1	PARN	psi-mi:“MI:0914”(association)	0.530
ABCE1	EIF3H	psi-mi:“MI:0914”(association)	0.530
KPNB1	POM121C	psi-mi:“MI:0914”(association)	0.530
RIOK2	BYSL	psi-mi:“MI:0914”(association)	0.530
TSR1	RPSA	psi-mi:“MI:0914”(association)	0.530
LIN28B	ELAVL2	psi-mi:“MI:0914”(association)	0.530
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
TSR1	H1-5	psi-mi:“MI:0915”(physical association)	0.400
Csnk1e		psi-mi:“MI:0915”(physical association)	0.400
SDC1	ILVBL	psi-mi:“MI:0915”(physical association)	0.400
TSR1	YWHAZ	psi-mi:“MI:0915”(physical association)	0.400
PCNA	TSR1	psi-mi:“MI:0915”(physical association)	0.370
Rpl35	RPS6	psi-mi:“MI:0914”(association)	0.350
Eif3a	RPSA	psi-mi:“MI:0914”(association)	0.350
Cep78	ING5	psi-mi:“MI:0914”(association)	0.350
RPL10	RPS6	psi-mi:“MI:0914”(association)	0.350
Srp72		psi-mi:“MI:0914”(association)	0.350
CDK2AP1	MTA3	psi-mi:“MI:0914”(association)	0.350
Rrbp1	PIPSL	psi-mi:“MI:0914”(association)	0.350
NOP56	C12orf43	psi-mi:“MI:0914”(association)	0.350
IBTK	POP7	psi-mi:“MI:0914”(association)	0.350
HNRNPU		psi-mi:“MI:0914”(association)	0.350

BioGRID (446): TSR1 (Affinity Capture-MS), TSR1 (Affinity Capture-MS), TSR1 (Affinity Capture-MS), TSR1 (Affinity Capture-MS), TSR1 (Affinity Capture-MS), HSP90B1 (Co-fractionation), LTV1 (Co-fractionation), MRPL2 (Co-fractionation), POLR1C (Co-fractionation), POLR1D (Co-fractionation), RPS7 (Co-fractionation), TSR1 (Co-fractionation), TSR1 (Co-fractionation), TSR1 (Co-fractionation), TSR1 (Co-fractionation)

ESM2 similar proteins: A3GFS1, A3LXF0, A5DBG1, A6ZMA9, A7TTC4, O13956, O74774, O74945, O94653, P09880, P14906, P23615, P25038, P32769, P33755, P36048, P41814, P53893, Q04660, Q07381, Q08965, Q09915, Q19329, Q2NL82, Q3MNT0, Q54JN0, Q54YA7, Q5A6Q4, Q5R434, Q5SWD9, Q5XGY1, Q61WR2, Q6BKK7, Q6BRG6, Q6BRJ9, Q6BVE1, Q6C7B9, Q6CF35, Q6CIH3, Q6CLF6

Diamond homologs: O13956, Q07381, Q2NL82, Q5R434, Q5SWD9, Q5XGY1, Q9VP47, Q19329, Q54YA7, Q61WR2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 183 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Eukaryotic Translation Initiation	9	22.1×	9e-09
Cap-dependent Translation Initiation	9	22.1×	9e-09
SARS-CoV-1 modulates host translation machinery	9	22.1×	9e-09
Eukaryotic Translation Elongation	9	19.9×	2e-08
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	9	19.4×	2e-08
Formation of the ternary complex, and subsequently, the 43S complex	11	18.8×	1e-09
Influenza Infection	13	18.1×	6e-11
Influenza Viral RNA Transcription and Replication	10	17.1×	1e-08

GO biological processes:

GO term	Partners	Fold	FDR
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	6	25.3×	2e-05
NLS-bearing protein import into nucleus	5	25.1×	2e-04
ribosomal small subunit biogenesis	15	21.4×	3e-13
ribosomal large subunit biogenesis	6	16.6×	2e-04
cytoplasmic translation	14	16.2×	8e-11
negative regulation of innate immune response	5	16.0×	1e-03
rRNA processing	14	12.4×	2e-09
translational initiation	5	11.2×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

140 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	111
Likely benign	6
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

1887 predictions. Top by Δscore:

Variant	Effect	Δscore
17:2323133:CAG:C	acceptor_loss	1.0000
17:2323134:A:C	acceptor_loss	1.0000
17:2324371:GTAC:G	acceptor_gain	1.0000
17:2324372:TAC:T	acceptor_gain	1.0000
17:2324372:TACC:T	acceptor_loss	1.0000
17:2324374:CCTAG:C	acceptor_loss	1.0000
17:2324375:C:CA	acceptor_loss	1.0000
17:2324375:C:CC	acceptor_gain	1.0000
17:2324576:CCTCT:C	acceptor_gain	1.0000
17:2324580:T:C	acceptor_gain	1.0000
17:2324580:T:TC	acceptor_gain	1.0000
17:2324587:C:CT	acceptor_gain	1.0000
17:2324594:A:C	acceptor_gain	1.0000
17:2324712:A:AC	donor_gain	1.0000
17:2324713:C:CC	donor_gain	1.0000
17:2324713:CTA:C	donor_gain	1.0000
17:2324825:CATTC:C	acceptor_gain	1.0000
17:2324827:TTC:T	acceptor_gain	1.0000
17:2324828:TCCTA:T	acceptor_loss	1.0000
17:2324830:C:CC	acceptor_gain	1.0000
17:2324830:C:CG	acceptor_loss	1.0000
17:2324831:T:G	acceptor_loss	1.0000
17:2325297:AACTT:A	donor_loss	1.0000
17:2325298:ACTTA:A	donor_loss	1.0000
17:2325301:TA:T	donor_loss	1.0000
17:2325302:A:AT	donor_loss	1.0000
17:2325425:CA:C	acceptor_gain	1.0000
17:2325426:A:AC	acceptor_gain	1.0000
17:2325432:G:C	acceptor_gain	1.0000
17:2325432:G:GC	acceptor_gain	1.0000

AlphaMissense

5327 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:2324365:C:T	G749D	0.999
17:2324524:C:T	G739E	0.999
17:2324748:C:T	G701D	0.999
17:2331066:A:G	W514R	0.999
17:2331066:A:T	W514R	0.999
17:2324324:C:G	D763H	0.998
17:2324352:G:C	C753W	0.998
17:2324525:C:G	G739R	0.998
17:2324525:C:T	G739R	0.998
17:2324548:A:G	L731P	0.998
17:2324709:C:G	R714P	0.998
17:2324323:T:A	D763V	0.997
17:2324323:T:G	D763A	0.997
17:2324354:A:G	C753R	0.997
17:2324365:C:A	G749V	0.997
17:2324562:A:C	F726L	0.997
17:2324562:A:T	F726L	0.997
17:2324564:A:G	F726L	0.997
17:2324576:C:G	D722H	0.997
17:2324700:A:G	F717S	0.997
17:2324749:C:G	G701R	0.997
17:2324750:A:C	S700R	0.997
17:2324750:A:T	S700R	0.997
17:2324752:T:G	S700R	0.997
17:2332178:G:T	A496D	0.997
17:2332213:A:C	F484L	0.997
17:2332213:A:T	F484L	0.997
17:2332215:A:G	F484L	0.997
17:2324305:A:G	L769P	0.996
17:2324317:A:T	V765E	0.996

dbSNP variants (sampled 300 via entrez): RS1000210601 (17:2322271 G>GT), RS1000493871 (17:2325983 A>G), RS1000566864 (17:2325696 T>A), RS1000579269 (17:2322655 C>T), RS1000724567 (17:2331763 T>C), RS1000822271 (17:2328000 C>T), RS1000840496 (17:2335114 T>C), RS1000856020 (17:2337391 C>G), RS1001062259 (17:2328342 T>C), RS1001158695 (17:2326830 C>T), RS1001377510 (17:2326977 C>T), RS1001388705 (17:2329057 C>T), RS1001529402 (17:2334739 G>A), RS1001723141 (17:2333596 G>A), RS1002005500 (17:2338237 G>A,C)

Disease associations

OMIM: gene MIM:611214 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
idiopathic spontaneous coronary artery dissection	Limited	Autosomal dominant

Mondo (1): idiopathic spontaneous coronary artery dissection (MONDO:0007385)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST000442_1	Aortic root size	2.000000e-11
GCST002539_85	Schizophrenia	3.000000e-10
GCST004521_272	Autism spectrum disorder or schizophrenia	7.000000e-10
GCST006803_64	Schizophrenia	5.000000e-10
GCST010703_278	Brain morphology (MOSTest)	2.000000e-15
GCST90000025_116	Appendicular lean mass	4.000000e-16

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004980	appendicular lean mass

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C565153	Coronary Artery Dissection, Spontaneous (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	3
Tretinoin	decreases expression	3
sodium arsenite	decreases expression	2
potassium chromate(VI)	affects cotreatment, increases expression	2
Nickel	increases expression	2
Valproic Acid	increases expression, affects expression	2
Cyclosporine	increases expression	2
Aflatoxin B1	increases expression, increases methylation	2
TAK-243	increases sumoylation	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
sodium arsenate	decreases expression	1
perfluorooctanoic acid	increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
chromium hexavalent ion	increases expression	1
4-phenylbutyric acid	decreases expression	1
cylindrospermopsin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Doxorubicin	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.