TTC21B-AS1

Summary

TTC21B-AS1 (TTC21B antisense RNA 1, HGNC:41115) is a long non-coding RNA gene on chromosome 2q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41115
Approved symbol	TTC21B-AS1
Name	TTC21B antisense RNA 1
Location	2q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224490
Ensembl biotype	lncRNA
Entrez	100506134
RNAcentral	URS000075DF74 — lncRNA, 746 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 lncRNA, 1 retained_intron

ENST00000440322, ENST00000443032, ENST00000446624, ENST00000773695

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440322 — 4 exons

Exon	Start	End
ENSE00001628014	165933857	165934076
ENSE00001653540	165948035	165949891
ENSE00001687666	165947197	165947341
ENSE00001786713	165947888	165947925

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 82.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0511 / max 61.2675, expressed in 7 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23441	0.0236	6
23442	0.0155	5
23440	0.0080	1
202460	0.0040	1

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.64	gold quality
bone marrow cell	CL:0002092	69.46	silver quality
skeletal muscle tissue	UBERON:0001134	69.35	silver quality
sural nerve	UBERON:0015488	68.49	gold quality
calcaneal tendon	UBERON:0003701	66.57	gold quality
bone marrow	UBERON:0002371	65.04	gold quality
corpus callosum	UBERON:0002336	64.86	gold quality
vermiform appendix	UBERON:0001154	63.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.14	gold quality
adrenal tissue	UBERON:0018303	59.52	gold quality
monocyte	CL:0000576	58.45	gold quality
leukocyte	CL:0000738	58.42	gold quality
uterine cervix	UBERON:0000002	57.86	silver quality
liver	UBERON:0002107	57.84	gold quality
tonsil	UBERON:0002372	56.97	gold quality
duodenum	UBERON:0002114	56.46	gold quality
blood	UBERON:0000178	56.13	gold quality
stromal cell of endometrium	CL:0002255	55.32	silver quality
lymph node	UBERON:0000029	55.05	gold quality
gall bladder	UBERON:0002110	55.03	gold quality
endometrium	UBERON:0001295	54.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.02	gold quality
islet of Langerhans	UBERON:0000006	52.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	52.18	gold quality
kidney	UBERON:0002113	52.02	gold quality
right lobe of liver	UBERON:0001114	52.01	gold quality
cortex of kidney	UBERON:0001225	51.81	gold quality
placenta	UBERON:0001987	50.96	gold quality
superior frontal gyrus	UBERON:0002661	50.13	gold quality
lung	UBERON:0002048	50.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.77

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.