TTC28-AS1

Summary

TTC28-AS1 (TTC28 antisense RNA 1, HGNC:29336) is a long non-coding RNA gene on chromosome 22q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29336
Approved symbol	TTC28-AS1
Name	TTC28 antisense RNA 1
Location	22q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	KIAA1648
Ensembl gene	ENSG00000235954
Ensembl biotype	lncRNA
Entrez	284900
RNAcentral	URS000075C14D — lncRNA, 963 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 54 lncRNA, 2 retained_intron

ENST00000417381, ENST00000417497, ENST00000419253, ENST00000424161, ENST00000425112, ENST00000428584, ENST00000428818, ENST00000428858, ENST00000430853, ENST00000433317, ENST00000434221, ENST00000435348, ENST00000436996, ENST00000437713, ENST00000452612, ENST00000453632, ENST00000454741, ENST00000454996, ENST00000540665, ENST00000654312, ENST00000654553, ENST00000654619, ENST00000655196, ENST00000655332, ENST00000659843, ENST00000662329, ENST00000662424, ENST00000662682, ENST00000663167, ENST00000664946, ENST00000665376, ENST00000665505, ENST00000665529, ENST00000669227, ENST00000670585, ENST00000670661, ENST00000688200, ENST00000690710, ENST00000702093, ENST00000723558, ENST00000723559, ENST00000723560, ENST00000723561, ENST00000723562, ENST00000723563, ENST00000723564, ENST00000723565, ENST00000723566, ENST00000723567, ENST00000723568, ENST00000723569, ENST00000723570, ENST00000723571, ENST00000723572, ENST00000723573, ENST00000723574

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417381 — 2 exons

Exon	Start	End
ENSE00004045348	27919437	27919966
ENSE00004045365	27922018	27923011

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 92.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.9976 / max 348.0970, expressed in 1726 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191561	12.5544	1717
209439	0.4431	236

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.35	gold quality
ganglionic eminence	UBERON:0004023	89.77	gold quality
cortical plate	UBERON:0005343	89.44	gold quality
ventricular zone	UBERON:0003053	89.40	gold quality
left ovary	UBERON:0002119	88.75	gold quality
oviduct epithelium	UBERON:0004804	88.71	gold quality
right lobe of liver	UBERON:0001114	88.52	gold quality
right hemisphere of cerebellum	UBERON:0014890	88.51	gold quality
cerebellar hemisphere	UBERON:0002245	88.50	gold quality
right uterine tube	UBERON:0001302	88.42	gold quality
cerebellar cortex	UBERON:0002129	88.34	gold quality
monocyte	CL:0000576	88.12	gold quality
leukocyte	CL:0000738	87.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.36	gold quality
lower esophagus mucosa	UBERON:0035834	87.23	gold quality
right ovary	UBERON:0002118	87.22	gold quality
ovary	UBERON:0000992	86.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	86.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.72	gold quality
lower esophagus	UBERON:0013473	86.71	gold quality
cerebellum	UBERON:0002037	86.61	gold quality
granulocyte	CL:0000094	86.30	gold quality
body of uterus	UBERON:0009853	85.98	gold quality
body of pancreas	UBERON:0001150	85.86	gold quality
endocervix	UBERON:0000458	85.61	gold quality
colonic epithelium	UBERON:0000397	85.57	gold quality
mucosa of stomach	UBERON:0001199	85.47	gold quality
adenohypophysis	UBERON:0002196	85.47	gold quality
right lung	UBERON:0002167	85.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• TTC28-AS1 expression is positively correlated with low-density lipoprotein cholesterol in type 2 diabetes mellitus. (PMID:31509021)
• Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis. (PMID:34623609)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.