TTC28

Summary

TTC28 (tetratricopeptide repeat domain 28, HGNC:29179) is a protein-coding gene on chromosome 22q12.1, encoding Tetratricopeptide repeat protein 28 (Q96AY4). During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.

Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody.

Source: NCBI Gene 23331 — RefSeq curated summary.

At a glance

• GWAS associations: 26
• Clinical variants (ClinVar): 413 total
• MANE Select transcript: NM_001145418

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29179
Approved symbol	TTC28
Name	tetratricopeptide repeat domain 28
Location	22q12.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1043
Ensembl gene	ENSG00000100154
Ensembl biotype	protein_coding
OMIM	615098
Entrez	23331

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000397906, ENST00000431039, ENST00000442232, ENST00000468807, ENST00000469670, ENST00000480563, ENST00000490475, ENST00000612946

RefSeq mRNA: 4 — MANE Select: NM_001145418 NM_001145418, NM_001393403, NM_001393404, NM_001393405

CCDS: CCDS46678

Canonical transcript exons

ENST00000397906 — 23 exons

Exon	Start	End
ENSE00000651944	27989878	27990007
ENSE00000651945	27992587	27992663
ENSE00000651947	27996135	27996259
ENSE00000651948	27998540	27999260
ENSE00000651949	28001374	28001553
ENSE00000651956	28094080	28094245
ENSE00000879679	28014248	28014392
ENSE00000879682	28105279	28105802
ENSE00001173052	28098915	28099044
ENSE00001173060	28101171	28101280
ENSE00001173076	28096190	28096408
ENSE00001231767	28107062	28108403
ENSE00001297696	28030226	28030366
ENSE00001321146	27990789	27990812
ENSE00001492787	28163092	28163599
ENSE00001492788	28296198	28296328
ENSE00001551541	28629552	28629830
ENSE00001556591	28679622	28679840
ENSE00001559219	27978014	27983851
ENSE00003492820	28297580	28297852
ENSE00003566454	27985249	27985356
ENSE00003640178	28306496	28306643
ENSE00003685416	27993287	27993518

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 93.50.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1231 / max 6.7852, expressed in 59 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193483	0.1231	59

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	93.50	gold quality
corpus epididymis	UBERON:0004359	91.63	gold quality
cortical plate	UBERON:0005343	91.61	gold quality
embryo	UBERON:0000922	90.94	gold quality
synovial joint	UBERON:0002217	89.97	gold quality
tibia	UBERON:0000979	89.68	gold quality
secondary oocyte	CL:0000655	89.53	gold quality
urethra	UBERON:0000057	89.05	gold quality
germinal epithelium of ovary	UBERON:0001304	88.80	gold quality
parietal pleura	UBERON:0002400	88.72	gold quality
pleura	UBERON:0000977	88.60	gold quality
visceral pleura	UBERON:0002401	88.36	gold quality
parotid gland	UBERON:0001831	88.35	gold quality
saphenous vein	UBERON:0007318	88.01	gold quality
lower lobe of lung	UBERON:0008949	87.88	gold quality
sural nerve	UBERON:0015488	87.46	gold quality
sperm	CL:0000019	86.94	gold quality
pericardium	UBERON:0002407	86.52	gold quality
mucosa of paranasal sinus	UBERON:0005030	86.31	gold quality
caput epididymis	UBERON:0004358	86.11	gold quality
left ovary	UBERON:0002119	85.74	gold quality
adrenal tissue	UBERON:0018303	85.69	gold quality
cauda epididymis	UBERON:0004360	85.61	gold quality
ovary	UBERON:0000992	85.31	gold quality
male germ cell	CL:0000015	85.29	gold quality
tendon of biceps brachii	UBERON:0008188	85.10	silver quality
right ovary	UBERON:0002118	85.07	gold quality
penis	UBERON:0000989	84.92	gold quality
blood vessel layer	UBERON:0004797	84.65	gold quality
colonic epithelium	UBERON:0000397	84.64	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	23.56
E-ANND-3	yes	11.50

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

245 targeting TTC28, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4425	100.00	67.59	1049
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819

Literature-anchored findings (GeneRIF, showing 1)

• observations indicated that a novel big protein TPRBK is essential for the formation and integrity of the midbody, hence we postulated that TPRBK plays a critical role in the progress of mitosis and cytokinesis during mammalian cell cycle (PMID:23036704)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	TTC28	ENSDARG00000114920
mus_musculus	Ttc28	ENSMUSG00000033209
rattus_norvegicus	Ttc28	ENSRNOG00000032590
drosophila_melanogaster	CG43163	FBGN0262719

Paralogs (6): GPSM2 (ENSG00000121957), TTC29 (ENSG00000137473), GPSM1 (ENSG00000160360), RAPSN (ENSG00000165917), TTC24 (ENSG00000187862), GPSM3 (ENSG00000213654)

Protein

Protein identifiers

Tetratricopeptide repeat protein 28 — Q96AY4 (reviewed: Q96AY4)

Alternative names: TPR repeat-containing big gene cloned at Keio

All UniProt accessions (4): Q96AY4, A0A087WW06, B0QYP4, B0QYP5

UniProt curated annotations — full annotation on UniProt →

Function. During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.

Subunit / interactions. Interacts with AURKB.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle. Spindle pole. Midbody.

Tissue specificity. Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.

RefSeq proteins (4): NP_001138890, NP_001380332, NP_001380333, NP_001380334 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR024983	CHAT_dom	Domain
IPR058900	TTC28_C	Domain

Pfam: PF12770, PF13176, PF13424, PF26117

UniProt features (50 total): repeat 28, compositionally biased region 8, modified residue 8, region of interest 5, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96AY4-F1	69.05	0.21

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 1, 28, 1590, 2104, 2224, 2251, 2393, 2398

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 202 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOCC_MICROTUBULE_ORGANIZING_CENTER, ONKEN_UVEAL_MELANOMA_UP, CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN, GOBP_REGULATION_OF_CELL_CYCLE, GOCC_CENTROSOME, GOBP_MITOTIC_CELL_CYCLE, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, NFE2_01, GOCC_SPINDLE

GO Biological Process (2): regulation of mitotic cell cycle (GO:0007346), cell division (GO:0051301)

GO Molecular Function (2): kinase binding (GO:0019900), protein binding (GO:0005515)

GO Cellular Component (6): spindle pole (GO:0000922), centrosome (GO:0005813), midbody (GO:0030496), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular membraneless organelle	2
mitotic cell cycle	1
regulation of cell cycle	1
cellular process	1
enzyme binding	1
binding	1
spindle	1
centriole	1
microtubule organizing center	1
intracellular anatomical structure	1
microtubule cytoskeleton	1

Protein interactions and networks

STRING

1847 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TTC28	BRCA1	P38398	620
TTC28	DLK2	Q6UY11	576
TTC28	KTN1	Q86UP2	534
TTC28	IAH1	Q2TAA2	499
TTC28	MACROD2	A1Z1Q3	439
TTC28	CHEK2	O96017	418
TTC28	PITPNB	P48739	418
TTC28	NLE1	Q9NVX2	377
TTC28	EIF1AX	P47813	364
TTC28	TMEM229B	Q8NBD8	361
TTC28	PLCH2	O75038	355
TTC28	CFTR	P13569	353
TTC28	PIGW	Q7Z7B1	353
TTC28	F13B	P05160	347
TTC28	OSGEP	Q9NPF4	341

IntAct

90 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
NCK2	SH3PXD2B	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
CD79A	METTL15	psi-mi:“MI:0914”(association)	0.530
TSPYL6	NME4	psi-mi:“MI:0914”(association)	0.530
SDF4	GTPBP6	psi-mi:“MI:0914”(association)	0.530
NCK1	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
LAMP3	METTL15	psi-mi:“MI:0914”(association)	0.530
PCDHGB1	FAM171A2	psi-mi:“MI:0914”(association)	0.530
MYCBPAP	CHSY3	psi-mi:“MI:0914”(association)	0.530
TOMM70	TTC28	psi-mi:“MI:0915”(physical association)	0.400
TTC28	PDCD11	psi-mi:“MI:0915”(physical association)	0.400
ZNF862	TTC28	psi-mi:“MI:0915”(physical association)	0.370
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
APP	RTL1	psi-mi:“MI:0914”(association)	0.350
PRMT2	KRBA1	psi-mi:“MI:0914”(association)	0.350
BSG	METTL15	psi-mi:“MI:0914”(association)	0.350
P4HA2	CCDC85C	psi-mi:“MI:0914”(association)	0.350
ICAM1	RTL8C	psi-mi:“MI:0914”(association)	0.350
PCDHGB1	FAM171A2	psi-mi:“MI:0914”(association)	0.350
HLA-B		psi-mi:“MI:0914”(association)	0.350
DOCK5	DPYSL4	psi-mi:“MI:0914”(association)	0.350

BioGRID (141): TTC28 (Affinity Capture-MS), TTC28 (Affinity Capture-MS), TTC28 (Affinity Capture-MS), TTC28 (Affinity Capture-MS), TTC28 (Affinity Capture-MS), TTC28 (Affinity Capture-MS), TTC28 (Synthetic Growth Defect), TTC28 (Proximity Label-MS), TTC28 (Affinity Capture-MS), TTC28 (Proximity Label-MS), TTC28 (Proximity Label-MS), TTC28 (Proximity Label-MS), TTC28 (Proximity Label-MS), TTC28 (Proximity Label-MS), TTC28 (Affinity Capture-MS)

ESM2 similar proteins: A0MQH0, A2AWA9, A7Y521, B1H1Z8, B4ZIX8, B5KFI0, O88544, O94826, P70188, Q0P5I8, Q13042, Q13098, Q148V7, Q25BN1, Q3SZA0, Q3T0V3, Q3ZBE1, Q4R5E6, Q5F415, Q5R648, Q5R8I6, Q5RAN1, Q5ZIL9, Q6NRT5, Q6P4Z9, Q6TUI4, Q75Q39, Q7L5D6, Q80XJ3, Q8BPU7, Q8C1Z7, Q8K0F1, Q8R349, Q8VBV7, Q92556, Q92845, Q96AY4, Q96RK4, Q9BT78, Q9CZW5

Diamond homologs: A0A3L6DPG1, A5WWA0, A6HD62, D3ZSP7, F1QB30, G3X9R7, O13797, O16259, O35814, O54981, O88196, P31948, P53041, P53042, P53804, Q06003, Q0JL44, Q14B02, Q29RU0, Q2TA44, Q388N2, Q3U2C5, Q3ZBZ8, Q496Y0, Q4R8N7, Q54DA8, Q566M8, Q5DTZ6, Q5QLR5, Q5R8D8, Q5RF74, Q5SPX3, Q5XEP2, Q5Z880, Q5ZHY5, Q60676, Q60864, Q6AY01, Q6DGE9, Q6NPT7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 117 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	6	58.6×	9e-08
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	51.7×	1e-07
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	51.7×	1e-07
Activation of BH3-only proteins	6	38.2×	7e-07
RHO GTPases activate PKNs	6	24.4×	8e-06
Intrinsic Pathway for Apoptosis	6	22.5×	1e-05
G2/M Checkpoints	8	13.8×	7e-06
SARS-CoV-1-host interactions	6	13.5×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
intracellular protein localization	9	8.9×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

413 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	342
Likely benign	38
Benign	12

Top pathogenic / likely-pathogenic (0)

SpliceAI

5744 predictions. Top by Δscore:

Variant	Effect	Δscore
22:27985243:TCTTA:T	donor_loss	1.0000
22:27985244:CTTA:C	donor_loss	1.0000
22:27985245:TTA:T	donor_loss	1.0000
22:27985246:TA:T	donor_loss	1.0000
22:27985247:A:AC	donor_gain	1.0000
22:27985247:A:T	donor_loss	1.0000
22:27985248:C:CC	donor_gain	1.0000
22:27985248:C:CT	donor_loss	1.0000
22:27985248:CCAAA:C	donor_gain	1.0000
22:27985356:CCTA:C	acceptor_loss	1.0000
22:27985357:C:CC	acceptor_gain	1.0000
22:27985357:C:CG	acceptor_loss	1.0000
22:27989876:A:AC	donor_gain	1.0000
22:27989877:C:CC	donor_gain	1.0000
22:27989877:C:G	donor_loss	1.0000
22:27990006:AG:A	acceptor_gain	1.0000
22:27990008:C:CC	acceptor_gain	1.0000
22:27990827:T:TC	acceptor_gain	1.0000
22:27992580:GACTT:G	donor_loss	1.0000
22:27992581:ACTTA:A	donor_loss	1.0000
22:27992582:CTT:C	donor_loss	1.0000
22:27992583:TTAC:T	donor_loss	1.0000
22:27992584:TACCC:T	donor_loss	1.0000
22:27992585:A:AC	donor_gain	1.0000
22:27992585:AC:A	donor_gain	1.0000
22:27992586:C:CA	donor_loss	1.0000
22:27992586:C:CC	donor_gain	1.0000
22:27992586:CC:C	donor_gain	1.0000
22:27992586:CCCGG:C	donor_gain	1.0000
22:27992659:CAGAC:C	acceptor_gain	1.0000

AlphaMissense

16171 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:27985317:A:G	L1916P	1.000
22:27989915:C:A	W1890C	1.000
22:27989915:C:G	W1890C	1.000
22:27989917:A:G	W1890R	1.000
22:27989917:A:T	W1890R	1.000
22:27993355:A:T	V1803D	1.000
22:27993422:A:G	W1781R	1.000
22:27993422:A:T	W1781R	1.000
22:27993511:T:A	K1751I	1.000
22:27996136:A:G	L1748P	1.000
22:27996140:G:C	H1747D	1.000
22:28096211:A:G	W1249R	1.000
22:28096211:A:T	W1249R	1.000
22:28105335:C:T	G1084E	1.000
22:28105336:C:G	G1084R	1.000
22:28105336:C:T	G1084R	1.000
22:28107324:C:G	G841R	1.000
22:28107564:C:G	G761R	1.000
22:28107683:C:T	G721D	1.000
22:28107800:A:G	L682P	1.000
22:28107803:C:T	G681D	1.000
22:28107804:C:G	G681R	1.000
22:28107863:A:G	L661P	1.000
22:28107923:C:T	G641D	1.000
22:28107924:C:G	G641R	1.000
22:28107926:A:G	L640P	1.000
22:28108043:C:T	G601D	1.000
22:28108044:C:G	G601R	1.000
22:28108046:A:G	L600P	1.000
22:28108048:G:C	N599K	1.000

dbSNP variants (sampled 300 via entrez): RS1000000457 (22:28246113 C>T), RS1000004215 (22:28282752 C>G), RS1000007429 (22:28166004 A>T), RS1000007601 (22:28576458 G>A), RS1000008280 (22:28530348 C>G), RS1000010962 (22:28335575 T>C), RS1000013825 (22:28034371 C>T), RS1000015179 (22:28432577 A>T), RS1000022764 (22:28156324 C>A,T), RS1000022806 (22:28419264 T>C), RS1000025749 (22:28063548 G>A), RS1000026393 (22:28381442 C>T), RS1000029988 (22:28081789 G>C), RS1000030823 (22:28224395 G>A), RS1000031804 (22:28671656 T>G)

Disease associations

OMIM: gene MIM:615098 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

26 associations (top):

Study	Trait	p-value
GCST002553_2	Pancreatic cancer	1.000000e-08
GCST003070_6	Cerebrospinal T-tau levels	1.000000e-06
GCST003071_1	Cerebrospinal P-tau181p levels	3.000000e-07
GCST003078_4	Cerebrospinal fluid p-Tau181p:AB1-42 ratio	6.000000e-06
GCST004610_102	White blood cell count	3.000000e-11
GCST004627_114	Lymphocyte count	3.000000e-09
GCST005652_6	Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction)	9.000000e-06
GCST006085_104	Prostate cancer	2.000000e-08
GCST006628_46	Systolic blood pressure	6.000000e-10
GCST007576_115	Chronotype	1.000000e-08
GCST008158_116	Body mass index	3.000000e-06
GCST009597_21	Multiple sclerosis	1.000000e-07
GCST009724_103	Vertical cup-disc ratio (multi-trait analysis)	1.000000e-17
GCST010083_317	Hemoglobin levels	3.000000e-08
GCST010244_195	Triglyceride levels	3.000000e-08
GCST012490_160	Femur bone mineral density x serum urate levels interaction	3.000000e-11
GCST90002388_263	Lymphocyte count	1.000000e-12
GCST90002388_264	Lymphocyte count	6.000000e-25
GCST90002389_436	Lymphocyte percentage of white cells	1.000000e-09
GCST90002400_501	Plateletcrit	8.000000e-17
GCST90002400_502	Plateletcrit	3.000000e-13
GCST90002404_589	Red cell distribution width	7.000000e-09
GCST90011899_61	Aspartate aminotransferase levels	2.000000e-08
GCST90013421_5	Left-handedness	4.000000e-09
GCST90044902_7	Polycystic ovary syndrome (adjusted for age)	2.000000e-16
GCST90044903_5	Polycystic ovary syndrome (adjusted for age and BMI)	5.000000e-14

EFO canonical traits (18, from GWAS)

EFO ID	Trait name
EFO:0004760	t-tau measurement
EFO:0004763	p-tau measurement
EFO:0007709	p-tau:beta-amyloid 1-42 ratio measurement
EFO:0004587	lymphocyte count
EFO:0003959	cleft lip
EFO:0009116	vitamin supplement exposure measurement
EFO:0006335	systolic blood pressure
EFO:0008328	chronotype measurement
EFO:0004340	body mass index
EFO:0006939	cup-to-disc ratio measurement
EFO:0004509	hemoglobin measurement
EFO:0004530	triglyceride measurement
EFO:0004531	urate measurement
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007985	platelet crit
EFO:0009188	Red cell distribution width
EFO:0004736	aspartate aminotransferase measurement
EFO:0009902	handedness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	7
Valproic Acid	affects cotreatment, decreases expression, increases methylation	4
Aflatoxin B1	decreases expression, increases methylation	3
Tobacco Smoke Pollution	decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
bisphenol F	decreases expression, affects cotreatment	1
dicrotophos	increases expression	1
methylmercuric chloride	decreases expression	1
methyleugenol	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, decreases methylation	1
arsenite	affects binding, decreases reaction	1
butyraldehyde	decreases expression	1
manganese chloride	decreases expression, increases abundance	1
benzo(e)pyrene	decreases methylation	1
potassium chromate(VI)	decreases expression	1
aflatoxin B2	decreases methylation	1
coumarin	affects phosphorylation	1
perfluorooctane sulfonic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
clothianidin	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases methylation	1
jinfukang	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.