TTC39A-AS1

Summary

TTC39A-AS1 (TTC39A antisense RNA 1, HGNC:40851) is a long non-coding RNA gene on chromosome 1p32.3.

Predicted to enable chromatin binding activity; ribonucleoprotein complex binding activity; and transcription cis-regulatory region binding activity. Predicted to act upstream of or within with a negative effect on inflammatory response and transcription by RNA polymerase II. Predicted to act upstream of or within gene expression; nucleosome organization; and response to lipopolysaccharide.

Source: NCBI Gene 102724097 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40851
Approved symbol	TTC39A-AS1
Name	TTC39A antisense RNA 1
Location	1p32.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	lincRNA-EPS
Ensembl gene	ENSG00000261664
Ensembl biotype	lncRNA
Entrez	102724097
RNAcentral	URS000075B0C0 — lncRNA, 650 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000564479, ENST00000568425, ENST00000723822, ENST00000723823

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000564479 — 3 exons

Exon	Start	End
ENSE00002598814	51334753	51335324
ENSE00002601637	51330130	51330213
ENSE00002625047	51329654	51329809

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 80.25.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	80.25	gold quality
right uterine tube	UBERON:0001302	74.06	gold quality
fallopian tube	UBERON:0003889	71.32	gold quality
pituitary gland	UBERON:0000007	69.92	gold quality
rectum	UBERON:0001052	69.39	gold quality
adenohypophysis	UBERON:0002196	68.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.77	gold quality
pancreas	UBERON:0001264	66.24	gold quality
mucosa of transverse colon	UBERON:0004991	63.69	gold quality
gall bladder	UBERON:0002110	63.33	gold quality
skeletal muscle tissue	UBERON:0001134	61.75	silver quality
body of stomach	UBERON:0001161	60.59	gold quality
prostate gland	UBERON:0002367	60.41	gold quality
duodenum	UBERON:0002114	60.21	gold quality
primary visual cortex	UBERON:0002436	60.21	gold quality
stomach	UBERON:0000945	59.77	gold quality
heart left ventricle	UBERON:0002084	59.58	gold quality
transverse colon	UBERON:0001157	59.23	gold quality
body of pancreas	UBERON:0001150	58.12	gold quality
heart	UBERON:0000948	57.85	gold quality
colon	UBERON:0001155	57.78	gold quality
lung	UBERON:0002048	57.30	gold quality
upper lobe of left lung	UBERON:0008952	57.26	gold quality
thoracic mammary gland	UBERON:0005200	56.94	gold quality
apex of heart	UBERON:0002098	56.91	gold quality
metanephros cortex	UBERON:0010533	56.55	gold quality
leukocyte	CL:0000738	56.51	gold quality
intestine	UBERON:0000160	56.30	gold quality
cortex of kidney	UBERON:0001225	55.96	gold quality
prefrontal cortex	UBERON:0000451	55.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.75

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Study found that lincRNA-EPS expression was down-regulated in the monocytes from patients with active pulmonary tuberculosis compared with healthy individuals, accompanied by significant attenuated monocyte apoptosis and enhanced autophagy. (PMID:31669366)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.