TTC4

Summary

TTC4 (tetratricopeptide repeat domain 4, HGNC:12394) is a protein-coding gene on chromosome 1p32.3, encoding Hsp70/Hsp90 co-chaperone CNS1 homolog (O95801). Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins. It is a selective cancer dependency (DepMap: 81.2% of cell lines).

This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene.

Source: NCBI Gene 7268 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total
• Cancer dependency (DepMap): dependent in 81.2% of screened cell lines
• MANE Select transcript: NM_004623

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12394
Approved symbol	TTC4
Name	tetratricopeptide repeat domain 4
Location	1p32.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC5097, FLJ41930, CNS1
Ensembl gene	ENSG00000243725
Ensembl biotype	protein_coding
OMIM	606753
Entrez	7268

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 7 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000371281, ENST00000371284, ENST00000486091, ENST00000486621, ENST00000876949, ENST00000876950, ENST00000934475, ENST00000934476, ENST00000970583, ENST00000970584

RefSeq mRNA: 2 — MANE Select: NM_004623 NM_001291333, NM_004623

CCDS: CCDS596

Canonical transcript exons

ENST00000371281 — 10 exons

Exon	Start	End
ENSE00001916259	54715861	54716019
ENSE00001950635	54741411	54742657
ENSE00003475759	54733629	54733710
ENSE00003476538	54737582	54737664
ENSE00003486312	54722675	54722799
ENSE00003492944	54721163	54721240
ENSE00003533561	54717492	54717653
ENSE00003589511	54728346	54728432
ENSE00003598202	54731486	54731700
ENSE00003680510	54716600	54716717

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 91.43.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.7301 / max 265.9175, expressed in 1819 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2962	27.6503	1818
2961	1.0797	682

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	91.43	gold quality
muscle of leg	UBERON:0001383	91.02	gold quality
islet of Langerhans	UBERON:0000006	90.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.72	gold quality
skeletal muscle tissue	UBERON:0001134	89.34	gold quality
muscle tissue	UBERON:0002385	88.77	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.70	gold quality
pituitary gland	UBERON:0000007	88.45	gold quality
adenohypophysis	UBERON:0002196	88.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.42	gold quality
ventricular zone	UBERON:0003053	87.41	gold quality
apex of heart	UBERON:0002098	87.34	gold quality
heart left ventricle	UBERON:0002084	86.88	gold quality
hypothalamus	UBERON:0001898	86.78	gold quality
right frontal lobe	UBERON:0002810	86.65	gold quality
caudate nucleus	UBERON:0001873	86.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.08	gold quality
smooth muscle tissue	UBERON:0001135	86.04	gold quality
lower esophagus muscularis layer	UBERON:0035833	85.99	gold quality
lower esophagus	UBERON:0013473	85.98	gold quality
heart	UBERON:0000948	85.95	gold quality
nucleus accumbens	UBERON:0001882	85.94	gold quality
endometrium	UBERON:0001295	85.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	85.87	gold quality
brain	UBERON:0000955	85.80	gold quality
amygdala	UBERON:0001876	85.79	gold quality
pancreas	UBERON:0001264	85.78	gold quality
skin of leg	UBERON:0001511	85.77	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.74	gold quality
putamen	UBERON:0001874	85.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.86

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting TTC4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-4530	99.69	66.47	1509
HSA-MIR-586	99.65	70.40	2051
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-5009-3P	99.45	69.43	1341
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-183-5P	99.31	72.27	1164
HSA-MIR-3678-3P	99.31	67.10	1432
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-143-5P	98.98	68.87	946
HSA-MIR-3194-3P	98.83	66.22	1167
HSA-MIR-5006-5P	98.79	66.92	1246
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-9500	98.62	66.54	1845
HSA-MIR-147A	98.33	66.40	795
HSA-MIR-3166	98.24	66.63	1223
HSA-MIR-6787-3P	97.75	66.17	1233
HSA-MIR-3928-3P	97.61	66.53	1096
HSA-MIR-6818-5P	97.50	67.10	1167
HSA-MIR-1289	97.46	65.37	655

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 81.2% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• TTC4 is highly expressed in malignant melanoma (PMID:18320024)
• Studies identi fi ed a novel signal of nuclear localization (NLS) in all MSL1 protein isoforms and found that the combination of both NLS allows for its intra-nuclear focal accumulation and nuclear transport of TTC4 while all MSL1 isoforms affect H4K16Ac. (PMID:24913909)
• Study identified TTC4 as a TBK1 interactor and positive regulator of Sendai virus-induced innate immunity. (PMID:29251827)
• Promoting TTC4 and HSP70 interaction and translocation of annexin A7 to lysosome inhibits apoptosis in vascular endothelial cells. (PMID:33000523)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ttc4	ENSDARG00000044405
mus_musculus	Ttc4	ENSMUSG00000025413
rattus_norvegicus	Ttc4	ENSRNOG00000042467
drosophila_melanogaster	Dpit47	FBGN0266518
caenorhabditis_elegans		WBGENE00015916

Paralogs (18): RPAP3 (ENSG00000005175), TOMM34 (ENSG00000025772), ST13 (ENSG00000100380), STUB1 (ENSG00000103266), SPAG1 (ENSG00000104450), SGTA (ENSG00000104969), TTC1 (ENSG00000113312), TTC31 (ENSG00000115282), UNC45A (ENSG00000140553), UNC45B (ENSG00000141161), SPATA16 (ENSG00000144962), TTC12 (ENSG00000149292), TOMM70 (ENSG00000154174), SUGT1 (ENSG00000165416), STIP1 (ENSG00000168439), TTC32 (ENSG00000183891), SGTB (ENSG00000197860), DNAAF4 (ENSG00000256061)

Protein

Protein identifiers

Hsp70/Hsp90 co-chaperone CNS1 homolog — O95801 (reviewed: O95801)

Alternative names: Tetratricopeptide repeat protein 4

All UniProt accessions (1): O95801

UniProt curated annotations — full annotation on UniProt →

Function. Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins. Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. Promotes Sendai virus (SeV)-induced host cell innate immune responses.

Subunit / interactions. Interacts (via TPR repeats) with HSP90AB1. Interacts with HSPA8 and CDC6. Interacts with TBK1. Interacts with MSL1.

Subcellular location. Nucleus. Nucleoplasm. Cytoplasm.

Tissue specificity. Highly expressed in proliferating tissue and tumor cell lines but not in normal cell lines.

Similarity. Belongs to the TTC4 family.

RefSeq proteins (2): NP_001278262, NP_004614* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR044059	Csn1/TTC4_wheel	Domain

Pfam: PF18972

UniProt features (37 total): strand 7, mutagenesis site 6, helix 6, modified residue 4, turn 4, site 4, repeat 3, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6HFO	X-RAY DIFFRACTION	1.65

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95801-F1	87.31	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (4): 77 (essential for interaction with cdc6); 152 (essential for interaction with hspa8); 156 (essential for interaction with hspa8); 217 (essential for interaction with cdc6)

Post-translational modifications (4): 51, 243, 1, 47

Mutagenesis-validated functional residues (6):

Position	Phenotype
42	no effect on interaction with hspa8, hsp90ab1 and cdc6.
67	no effect on interaction with hspa8, hsp90ab1 and cdc6.
77	no effect on interaction with hspa8 and hsp90ab1. loss of interaction with cdc6.
152	loss of interaction with hspa8.
156	loss of interaction with hspa8.
217	no effect on interaction with hspa8 and hsp90ab1. loss of interaction with cdc6.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 120 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, GOBP_PROTEIN_MATURATION, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_PROTEIN_FOLDING, GOBP_DEFENSE_RESPONSE_TO_VIRUS, DANG_BOUND_BY_MYC, GOBP_RESPONSE_TO_VIRUS, GOCC_INTERMEDIATE_FILAMENT_CYTOSKELETON, BENPORATH_MYC_MAX_TARGETS, GOMF_HEAT_SHOCK_PROTEIN_BINDING, GOMF_HSP90_PROTEIN_BINDING, GOMF_PROTEIN_FOLDING_CHAPERONE_BINDING, GOMF_HSP70_PROTEIN_BINDING, ALKBH3_TARGET_GENES, DIDO1_TARGET_GENES

GO Biological Process (4): protein folding (GO:0006457), innate immune response (GO:0045087), defense response to virus (GO:0051607), immune system process (GO:0002376)

GO Molecular Function (3): Hsp70 protein binding (GO:0030544), Hsp90 protein binding (GO:0051879), protein binding (GO:0005515)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
heat shock protein binding	2
cellular anatomical structure	2
cellular process	1
protein maturation	1
immune response	1
defense response to symbiont	1
defense response	1
response to virus	1
biological_process	1
protein-folding chaperone binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2882 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TTC4	SMAD3	P84022	771
TTC4	CDC37	Q16543	677
TTC4	RAX	Q9Y2V3	665
TTC4	PPID	Q08752	658
TTC4	FOXP3	Q9BZS1	608
TTC4	GATA3	P23771	602
TTC4	SATB1	Q01826	599
TTC4	CBFB	Q13951	596
TTC4	IL4	P05112	589
TTC4	TNFRSF18	Q9Y5U5	586
TTC4	TTC9C	Q8N5M4	573
TTC4	HSP90AA1	P07900	573
TTC4	TBX21	Q9UL17	567
TTC4	HSP90AB1	P08238	566
TTC4	GPS1	Q13098	565

IntAct

82 interactions, top by confidence:

A	B	Type	Score
TTC4	HGH1	psi-mi:“MI:0915”(physical association)	0.770
TTC4	HSP90AB1	psi-mi:“MI:0915”(physical association)	0.750
TTC4	HSP90AB1	psi-mi:“MI:0407”(direct interaction)	0.750
TTC4	HSP90AB1	psi-mi:“MI:0914”(association)	0.750
TTC4	EDRF1	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
HSP90AA1	CHUK	psi-mi:“MI:0914”(association)	0.670
SLC27A6	TTC4	psi-mi:“MI:0914”(association)	0.640
TTC4	SNAPC3	psi-mi:“MI:0915”(physical association)	0.560
TBK1	TTC4	psi-mi:“MI:0914”(association)	0.540
TBK1	TTC4	psi-mi:“MI:0915”(physical association)	0.540
TBK1	TTC4	psi-mi:“MI:0403”(colocalization)	0.540
HSP90AA1	USP19	psi-mi:“MI:0914”(association)	0.530
SERPINB13	TTC4	psi-mi:“MI:0914”(association)	0.530
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.530
TTC4	HSPA8	psi-mi:“MI:0915”(physical association)	0.480
TTC4	CDC6	psi-mi:“MI:0915”(physical association)	0.480
TUBA1A	TUBAL3	psi-mi:“MI:2364”(proximity)	0.420
MTRF1L	TTC4	psi-mi:“MI:0915”(physical association)	0.400
TTC4		psi-mi:“MI:0915”(physical association)	0.400
	TTC4	psi-mi:“MI:0915”(physical association)	0.400
TTC4	RXFP4	psi-mi:“MI:0915”(physical association)	0.370
	TTC4	psi-mi:“MI:0915”(physical association)	0.370
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
TBK1	FMNL1	psi-mi:“MI:0914”(association)	0.350

BioGRID (190): HSP90AB3P (Affinity Capture-MS), GCC2 (Affinity Capture-MS), EDRF1 (Affinity Capture-MS), HGH1 (Affinity Capture-MS), TTC4 (Affinity Capture-MS), CTPS1 (Co-fractionation), HAT1 (Co-fractionation), PCID2 (Co-fractionation), SAC3D1 (Co-fractionation), TLN2 (Co-fractionation), TTC4 (Co-fractionation), TTC4 (Co-fractionation), TTC4 (Co-fractionation), TTC4 (Co-fractionation), TTC4 (Co-fractionation)

ESM2 similar proteins: A0A1L8G016, A1A5Q0, B3DH20, D3Z8X7, D4A1F2, E1BTG2, F1MF74, F1RA39, O14730, O60308, O88978, O94851, O95801, P51432, P70566, Q1RMR5, Q1RMT7, Q28FY0, Q2YDM7, Q3UHZ5, Q3UM18, Q4KLT3, Q4R3F0, Q4R8L2, Q5BJT6, Q5EA11, Q5ZJD3, Q6AZN0, Q6P5Q4, Q7Z569, Q80V31, Q863A4, Q863A5, Q863A6, Q863A7, Q86X45, Q8BML1, Q8CCP0, Q8R368, Q8R3H9

Diamond homologs: A1Z6M6, O95801, Q28IV3, Q5EA11, Q6NU95, Q8R3H9, A4K2V0, A6HD62, A6ZRW3, D7REX8, F1RBN2, F4IRM4, F4JTI1, F4K487, F4KCL7, O13754, O14217, O16259, O35814, O48802, O54981, O94826, P07213, P23231, P25638, P31948, P33313, P38825, P53041, P53042, Q07617, Q12118, Q13451, Q15785, Q32PZ3, Q3KRD5, Q3ZBR5, Q43207, Q4R8N7, Q5PPS5

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 73 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	8	27.2×	2e-07
Autophagy	5	13.0×	2e-03
Macroautophagy	5	10.1×	3e-03
SARS-CoV-2 activates/modulates innate and adaptive immune responses	5	7.8×	8e-03

GO biological processes:

GO term	Partners	Fold	FDR
protein folding	9	13.5×	1e-05
protein stabilization	8	7.8×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1476 predictions. Top by Δscore:

Variant	Effect	Δscore
1:54716005:G:GT	donor_gain	1.0000
1:54716015:AGAAG:A	donor_loss	1.0000
1:54716017:AAG:A	donor_loss	1.0000
1:54716018:AGG:A	donor_loss	1.0000
1:54716019:GG:G	donor_loss	1.0000
1:54716020:G:GA	donor_loss	1.0000
1:54717488:GCA:G	acceptor_loss	1.0000
1:54717490:A:AG	acceptor_gain	1.0000
1:54717491:G:GA	acceptor_gain	1.0000
1:54717491:GA:G	acceptor_gain	1.0000
1:54717491:GAA:G	acceptor_gain	1.0000
1:54717491:GAAC:G	acceptor_gain	1.0000
1:54717491:GAACA:G	acceptor_gain	1.0000
1:54717638:GCACA:G	donor_gain	1.0000
1:54717643:G:GG	donor_gain	1.0000
1:54717650:CTGG:C	donor_loss	1.0000
1:54717651:TGGGT:T	donor_loss	1.0000
1:54717652:GG:G	donor_gain	1.0000
1:54717653:GG:G	donor_gain	1.0000
1:54717655:T:A	donor_loss	1.0000
1:54721146:AAAC:A	acceptor_gain	1.0000
1:54721149:C:CA	acceptor_gain	1.0000
1:54728345:GC:G	acceptor_gain	1.0000
1:54731485:GGCTA:G	acceptor_gain	1.0000
1:54733706:TGGAG:T	donor_loss	1.0000
1:54733709:AGG:A	donor_loss	1.0000
1:54733709:AGGTA:A	donor_loss	1.0000
1:54733710:GG:G	donor_loss	1.0000
1:54733711:G:A	donor_loss	1.0000
1:54733711:GTAAG:G	donor_loss	1.0000

AlphaMissense

2558 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:54717630:G:C	R123P	0.997
1:54717511:A:C	K83N	0.993
1:54717511:A:T	K83N	0.993
1:54717554:G:C	A98P	0.992
1:54717632:G:C	A124P	0.992
1:54731630:T:A	W276R	0.992
1:54731630:T:C	W276R	0.992
1:54717518:G:C	G86R	0.991
1:54717519:G:A	G86D	0.991
1:54722675:G:A	G157D	0.991
1:54717555:C:A	A98D	0.990
1:54717633:C:A	A124E	0.990
1:54717575:G:C	G105R	0.989
1:54722683:T:C	C160R	0.989
1:54722685:C:G	C160W	0.989
1:54722725:T:C	C174R	0.988
1:54722734:G:A	G177R	0.988
1:54722734:G:C	G177R	0.988
1:54722785:G:C	A194P	0.988
1:54717519:G:T	G86V	0.987
1:54716621:T:C	F45L	0.986
1:54716623:T:A	F45L	0.986
1:54716623:T:G	F45L	0.986
1:54721199:C:A	A143D	0.986
1:54733672:T:A	W314R	0.986
1:54733672:T:C	W314R	0.986
1:54722713:G:C	A170P	0.985
1:54717576:G:A	G105D	0.984
1:54717638:G:C	A126P	0.984
1:54721198:G:C	A143P	0.982

dbSNP variants (sampled 300 via entrez): RS1000162021 (1:54730026 A>G), RS1000189006 (1:54719220 G>A), RS1000235241 (1:54732455 T>C,G), RS1000291350 (1:54726390 A>C), RS1000363913 (1:54726040 A>C), RS1000889200 (1:54737433 C>T), RS1000976834 (1:54718566 A>G), RS1001163720 (1:54731784 T>G), RS1001278133 (1:54732022 G>A), RS1001391709 (1:54724742 T>G), RS1001597126 (1:54718086 A>C,G), RS1001941720 (1:54736049 C>T), RS1002109186 (1:54737800 C>T), RS1002169926 (1:54738245 C>A,T), RS1002213250 (1:54733160 A>AAT)

Disease associations

OMIM: gene MIM:606753 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, increases expression	2
beta-lapachone	increases expression	1
benzo(e)pyrene	decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
Acetaminophen	affects expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Methapyrilene	decreases methylation	1
Ozone	affects expression, increases abundance	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases methylation	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	increases expression	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.