TTC9-DT

Summary

TTC9-DT (TTC9 divergent transcript, HGNC:53243) is a long non-coding RNA gene on chromosome 14q24.2.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 101928075 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53243
Approved symbol	TTC9-DT
Name	TTC9 divergent transcript
Location	14q24.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245466
Ensembl biotype	lncRNA
Entrez	101928075
RNAcentral	URS00003D0DA0 — lncRNA, 2941 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000500016

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500016 — 3 exons

Exon	Start	End
ENSE00001965431	70641008	70641298
ENSE00001980392	70608798	70611350
ENSE00003620176	70633762	70633858

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 69.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0108 / max 3.2962, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
143920	0.0108	3

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	69.10	gold quality
lower esophagus mucosa	UBERON:0035834	65.87	gold quality
right uterine tube	UBERON:0001302	59.99	gold quality
cortical plate	UBERON:0005343	59.27	gold quality
ganglionic eminence	UBERON:0004023	59.14	gold quality
ventricular zone	UBERON:0003053	59.00	silver quality
skeletal muscle tissue	UBERON:0001134	58.64	gold quality
muscle of leg	UBERON:0001383	56.95	gold quality
gastrocnemius	UBERON:0001388	56.54	gold quality
esophagus	UBERON:0001043	55.21	gold quality
esophagus mucosa	UBERON:0002469	55.02	gold quality
adult mammalian kidney	UBERON:0000082	54.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	53.63	silver quality
lymph node	UBERON:0000029	52.94	gold quality
spleen	UBERON:0002106	52.48	gold quality
tonsil	UBERON:0002372	52.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	52.21	gold quality
blood	UBERON:0000178	51.65	gold quality
fallopian tube	UBERON:0003889	50.84	gold quality
prefrontal cortex	UBERON:0000451	50.26	silver quality
right lobe of thyroid gland	UBERON:0001119	49.78	silver quality
superior frontal gyrus	UBERON:0002661	49.52	gold quality
small intestine Peyer’s patch	UBERON:0003454	49.40	gold quality
multicellular organism	UBERON:0000468	49.26	gold quality
islet of Langerhans	UBERON:0000006	48.41	gold quality
uterine cervix	UBERON:0000002	47.99	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	47.69	gold quality
vagina	UBERON:0000996	47.68	gold quality
vermiform appendix	UBERON:0001154	46.75	silver quality
lung	UBERON:0002048	46.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.