TTN-AS1

Summary

TTN-AS1 (TTN antisense RNA 1, HGNC:44124) is a long non-coding RNA gene on chromosome 2q31.2.

This gene encodes a non-coding RNA transcribed from the opposite strand to the titin gene.

Source: NCBI Gene 100506866 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44124
Approved symbol	TTN-AS1
Name	TTN antisense RNA 1
Location	2q31.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237298
Ensembl biotype	lncRNA
Entrez	100506866
RNAcentral	URS000075ABF2 — lncRNA, 4607 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 93 — 93 lncRNA

ENST00000415561, ENST00000418062, ENST00000419746, ENST00000431259, ENST00000431752, ENST00000438095, ENST00000442329, ENST00000450692, ENST00000456053, ENST00000578746, ENST00000582038, ENST00000582847, ENST00000584485, ENST00000585358, ENST00000585451, ENST00000585487, ENST00000585625, ENST00000586452, ENST00000586707, ENST00000586831, ENST00000587568, ENST00000587576, ENST00000587944, ENST00000588244, ENST00000588257, ENST00000588716, ENST00000588804, ENST00000589234, ENST00000589355, ENST00000589391, ENST00000589434, ENST00000589487, ENST00000589830, ENST00000589842, ENST00000589907, ENST00000590040, ENST00000590743, ENST00000590773, ENST00000590807, ENST00000590932, ENST00000591332, ENST00000591466, ENST00000591867, ENST00000592161, ENST00000592182, ENST00000592600, ENST00000592630, ENST00000592689, ENST00000592750, ENST00000592836, ENST00000604571, ENST00000604956, ENST00000610005, ENST00000610290, ENST00000614124, ENST00000620591, ENST00000625480, ENST00000625536, ENST00000626117, ENST00000626138, ENST00000626517, ENST00000626954, ENST00000627527, ENST00000627564, ENST00000627661, ENST00000628296, ENST00000628826, ENST00000629094, ENST00000629117, ENST00000630096, ENST00000631319, ENST00000653807, ENST00000657023, ENST00000657210, ENST00000657818, ENST00000659121, ENST00000663178, ENST00000664161, ENST00000664776, ENST00000671355, ENST00000702938, ENST00000768381, ENST00000768382, ENST00000768383, ENST00000768384, ENST00000768385, ENST00000768386, ENST00000768387, ENST00000768388, ENST00000768389, ENST00000768390, ENST00000768391, ENST00000768392

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415561 — 3 exons

Exon	Start	End
ENSE00001617738	178537604	178537691
ENSE00001665285	178537387	178537530
ENSE00004128648	178538698	178538904

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 99.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.7820 / max 198.8834, expressed in 1718 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23939	10.9496	1705
23938	0.7710	461
23940	0.0614	21

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	99.84	gold quality
gastrocnemius	UBERON:0001388	99.60	gold quality
right atrium auricular region	UBERON:0006631	99.56	gold quality
apex of heart	UBERON:0002098	99.55	gold quality
muscle of leg	UBERON:0001383	99.23	gold quality
bone marrow cell	CL:0002092	96.74	gold quality
cardiac atrium	UBERON:0002081	96.13	gold quality
heart left ventricle	UBERON:0002084	96.00	gold quality
cardiac ventricle	UBERON:0002082	94.48	gold quality
heart	UBERON:0000948	93.02	gold quality
calcaneal tendon	UBERON:0003701	92.80	gold quality
adrenal tissue	UBERON:0018303	92.52	gold quality
colonic epithelium	UBERON:0000397	90.64	gold quality
left lobe of thyroid gland	UBERON:0001120	90.17	gold quality
adenohypophysis	UBERON:0002196	89.91	gold quality
right lobe of thyroid gland	UBERON:0001119	89.83	gold quality
sural nerve	UBERON:0015488	89.78	gold quality
right uterine tube	UBERON:0001302	89.77	gold quality
left ovary	UBERON:0002119	89.76	gold quality
minor salivary gland	UBERON:0001830	89.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.44	gold quality
bone marrow	UBERON:0002371	89.39	gold quality
mucosa of stomach	UBERON:0001199	89.37	gold quality
right ovary	UBERON:0002118	89.26	gold quality
thyroid gland	UBERON:0002046	89.19	gold quality
body of pancreas	UBERON:0001150	89.18	gold quality
right lung	UBERON:0002167	88.97	gold quality
tendon	UBERON:0000043	88.43	gold quality
descending thoracic aorta	UBERON:0002345	88.04	gold quality
upper lobe of left lung	UBERON:0008952	87.94	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-11268	yes	1443.29
E-ANND-3	yes	7.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• our results show that CD31 plays an important biological role in human angiosarcoma by regulating endothelial cell function and redox status via the Hippo signaling pathway member YAP (PMID:29101304)
• lncRNA TTN-AS1 was involved in the progression of CC cells by regulation of miR-573-E2F3 axis (PMID:30135013)
• The findings obtained in the present study indicate that TTN-AS1 facilitated PTC progression by regulating the miR-153-3p/ZNRF2 axis and activating the PI3K/Akt/mTOR pathway. (PMID:30811764)
• miR-376b-3p and KLF12 are involved in TTN-AS1-mediated gastric cancer progression (PMID:30943745)
• TTN-AS1 plays a carcinogenic part in the lung adenocarcinoma progression through destabilizing PTEN protein so as to activate PI3K/AKT pathway.TTN-AS1 is highly expressed in lung adenocarcinoma. (PMID:31027732)
• ur study revealed that TTN-AS1 played an important role in lung adenocarcinoma (LUAD) progression. TTN-AS1/miR-142-5p/CDK5 regulatory axis may serve as a novel therapeutic target in the treatment of LUAD. (PMID:31363080)
• Long non-coding RNA TTN-AS1 promotes cell proliferation and inhibits cell apoptosis in prostatic cancer by sponging miR-193a-5p. (PMID:31599406)
• LncRNA TTN-AS1 acts as sponge for miR-15b-5p to regulate FBXW7 expression in ovarian cancer. (PMID:32049388)
• LncRNA TTN-AS1/miR-134-5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK-3beta/beta-catenin pathway. (PMID:32749739)
• LncRNA TTN-AS1 promotes the progression of cholangiocarcinoma via the miR-320a/neuropilin-1 axis. (PMID:32801339)
• Long noncoding RNA TTN-AS1 facilitates tumorigenesis and metastasis by maintaining TTN expression in skin cutaneous melanoma. (PMID:32820147)
• Long noncoding RNA TTNAS1 regulates the proliferation, invasion and migration of triplenegative breast cancer by targeting miR2115p. (PMID:33179096)
• Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis. (PMID:33517826)
• LncRNA TTN-AS1 acts as a tumor promoter in gallbladder carcinoma by regulating miR-107/HMGA1 axis. (PMID:34090483)
• Long non-coding RNA TTN-AS1/microRNA-199a-3p/runt-related transcription factor 1 gene axis regulates the progression of oral squamous cell carcinoma. (PMID:34606420)
• Long non-coding RNA titin-antisense RNA1 contributes to growth and metastasis of cholangiocarcinoma by suppressing microRNA-513a-5p to upregulate stratifin. (PMID:34903127)
• SQLE facilitates the pancreatic cancer progression via the lncRNA-TTN-AS1/miR-133b/SQLE axis. (PMID:35638462)
• Prognostic significance of long noncoding RNA TTN-AS1 in various malignancies. (PMID:37528740)
• Circulating tumor cell-derived exosome-transmitted long non-coding RNA TTN-AS1 can promote the proliferation and migration of cholangiocarcinoma cells. (PMID:38637832)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.