TTTY14

Summary

TTTY14 (testis expressed transcript, Y-linked 14, HGNC:18495) is a long non-coding RNA gene on chromosome Yq11.222.

Predicted to enable pre-mRNA 5’-splice site binding activity. Predicted to be involved in mRNA 5’-splice site recognition. Predicted to be part of U1 snRNP.

Source: NCBI Gene 83869 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18495
Approved symbol	TTTY14
Name	testis expressed transcript, Y-linked 14
Location	Yq11.222
Locus type	RNA, long non-coding
Status	Approved
Aliases	TTY14, NCRNA00137, PRO2834
Ensembl gene	ENSG00000176728
Ensembl biotype	lncRNA
Entrez	83869
RNAcentral	URS0000BC43AC — lncRNA, 901 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 56 — 56 lncRNA

ENST00000324446, ENST00000331787, ENST00000447937, ENST00000452584, ENST00000454875, ENST00000505047, ENST00000610801, ENST00000650897, ENST00000650923, ENST00000651032, ENST00000651286, ENST00000651355, ENST00000651396, ENST00000651734, ENST00000651886, ENST00000652153, ENST00000652348, ENST00000652699, ENST00000656768, ENST00000657901, ENST00000658318, ENST00000660026, ENST00000663061, ENST00000664804, ENST00000667260, ENST00000667262, ENST00000667450, ENST00000667617, ENST00000667640, ENST00000669716, ENST00000669869, ENST00000670243, ENST00000670354, ENST00000805060, ENST00000850201, ENST00000850202, ENST00000850203, ENST00000850204, ENST00000850205, ENST00000850206, ENST00000850207, ENST00000850208, ENST00000850209, ENST00000850210, ENST00000850211, ENST00000850212, ENST00000850213, ENST00000850214, ENST00000850215, ENST00000850216, ENST00000850217, ENST00000850218, ENST00000850219, ENST00000850220, ENST00000850221, ENST00000850222

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000324446 — 2 exons

Exon	Start	End
ENSE00001285919	18877068	18878228
ENSE00001702356	18872501	18872834

Expression profiles

Bgee: expression breadth ubiquitous, 207 present calls, max score 93.04.

FANTOM5 (CAGE): breadth broad, TPM avg 2.1260 / max 56.8238, expressed in 697 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201270	1.4423	624
201271	0.4427	205
201272	0.2411	127

Top tissues by expression

264 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	93.04	gold quality
sural nerve	UBERON:0015488	90.72	gold quality
apex of heart	UBERON:0002098	88.96	gold quality
colonic epithelium	UBERON:0000397	87.60	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.19	gold quality
cerebellar cortex	UBERON:0002129	86.86	gold quality
cerebellar hemisphere	UBERON:0002245	86.81	gold quality
cerebellum	UBERON:0002037	85.47	gold quality
prostate gland	UBERON:0002367	82.43	gold quality
metanephros cortex	UBERON:0010533	81.32	gold quality
mucosa of transverse colon	UBERON:0004991	81.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	80.36	gold quality
adrenal tissue	UBERON:0018303	80.22	gold quality
corpus callosum	UBERON:0002336	80.14	gold quality
pituitary gland	UBERON:0000007	79.89	gold quality
calcaneal tendon	UBERON:0003701	79.81	gold quality
heart left ventricle	UBERON:0002084	79.72	gold quality
cardiac ventricle	UBERON:0002082	79.62	gold quality
adenohypophysis	UBERON:0002196	78.98	gold quality
nucleus accumbens	UBERON:0001882	78.97	gold quality
right frontal lobe	UBERON:0002810	78.50	gold quality
right lobe of liver	UBERON:0001114	78.19	gold quality
heart right ventricle	UBERON:0002080	77.80	silver quality
descending thoracic aorta	UBERON:0002345	77.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.45	gold quality
right lung	UBERON:0002167	77.42	gold quality
gluteal muscle	UBERON:0002000	77.26	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	77.21	gold quality
parotid gland	UBERON:0001831	77.18	silver quality
anterior cingulate cortex	UBERON:0009835	77.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.70

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.