TTTY15

Summary

TTTY15 (testis expressed transcript, Y-linked 15, HGNC:18567) is a long non-coding RNA gene on chromosome Yq11.221.

At a glance

• Clinical variants (ClinVar): 6 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18567
Approved symbol	TTTY15
Name	testis expressed transcript, Y-linked 15
Location	Yq11.221
Locus type	RNA, long non-coding
Status	Approved
Aliases	DKFZP434I143, NCRNA00138
OMIM	400051
Entrez	64595
RNAcentral	URS00022AE7F3 — lncRNA, 5266 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• This is the first research investigating the utility of TTTY15-USP9Y in prostate cancer detection (PMID:26008593)
• We found that TTTY15 levels were frequently elevated in prostate cancer (PCa) tissues compared with those in paracancerous normal tissues in a large group of PCa patients, and we observed a tumour suppressive effect after TTTY15 knockout using CRISPR/Cas9. These results may have therapeutic implications for PCa patients (PMID:30527798)
• Suppression of long noncoding RNA TTTY15 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-455-5p. (PMID:30898696)
• LncRNA TTTY15 regulates hypoxia-induced vascular endothelial cell injury via targeting miR-186-5p in cardiovascular disease. (PMID:32271447)
• Long noncoding RNA TTTY15 promotes growth and metastasis of esophageal squamous cell carcinoma by sponging microRNA-337-3p to upregulate the expression of JAK2. (PMID:32868648)
• LncRNA TTTY15 knockdown alleviates H2O2-stimulated myocardial cell injury by regulating the miR-98-5p/CRP pathway. (PMID:32888161)
• Silencing TTTY15 mitigates hypoxia-induced mitochondrial energy metabolism dysfunction and cardiomyocytes apoptosis via TTTY15/let-7i-5p and TLR3/NF-kappaB pathways. (PMID:32926961)
• LncRNA testis-specific transcript, Y-linked 15 (TTTY15) promotes proliferation, migration and invasion of colorectal cancer cells via regulating miR-29a-3p/DVL3 axis. (PMID:33016900)
• Circulating long non-coding RNA TTTY15 and HULC serve as potential novel biomarkers for predicting acute myocardial infarction. (PMID:35246050)
• Long non-coding RNA TTTY15 silencing inhibits gastric cancer progression by sponging microRNA-98-5p to down-regulate cyclin D2 expression. (PMID:35266852)
• Male-specific long non-coding RNA testis-specific transcript, Y-linked 15 promotes gastric cancer cell growth by regulating Wnt family member 1/beta-catenin signaling by sponging microRNA let-7a-5p. (PMID:35287556)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000278344 (Y:12689106 G>A), RS1001020411 (Y:12662753 T>C), RS1001513757 (Y:12664247 G>T), RS1002044144 (Y:12691422 G>A), RS1004193799 (Y:12674891 A>T), RS1004553990 (Y:12681073 C>G), RS1004926513 (Y:12681987 T>C), RS1005149166 (Y:12667364 A>G), RS1005247379 (Y:12669223 C>T), RS1007586749 (Y:12661961 A>G), RS1008364696 (Y:12677459 C>T), RS1008797991 (Y:12686911 T>C), RS1008875959 (Y:12678646 A>G), RS1009373551 (Y:12688791 C>T), RS1009412697 (Y:12687452 T>G)

Disease associations

OMIM: gene MIM:400051 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects expression, affects methylation	2
incobotulinumtoxinA	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Smoke	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.