TTTY2

Summary

TTTY2 (testis expressed transcript, Y-linked 2, HGNC:14023) is a long non-coding RNA gene on chromosome Yp11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14023
Approved symbol	TTTY2
Name	testis expressed transcript, Y-linked 2
Location	Yp11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TTY2, lINC00109
Ensembl gene	ENSG00000212855
Ensembl biotype	lncRNA
Entrez	60439
RNAcentral	URS000075C4F8 — lncRNA, 1642 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000417072, ENST00000757459, ENST00000757460, ENST00000757461, ENST00000757462, ENST00000757463, ENST00000757464, ENST00000757465, ENST00000757466, ENST00000757467, ENST00000757468, ENST00000757469, ENST00000757470, ENST00000757471, ENST00000757472

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417072 — 7 exons

Exon	Start	End
ENSE00001625965	9756177	9756255
ENSE00001626669	9740584	9742401
ENSE00001628061	9744878	9744964
ENSE00001637388	9756376	9756573
ENSE00001647627	9757797	9758476
ENSE00001654045	9752349	9752497
ENSE00001742514	9753190	9753346

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 71.60.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gall bladder	UBERON:0002110	71.60	gold quality
rectum	UBERON:0001052	55.27	gold quality
transverse colon	UBERON:0001157	51.93	gold quality
colon	UBERON:0001155	51.70	gold quality
muscle layer of sigmoid colon	UBERON:0035805	49.08	gold quality
minor salivary gland	UBERON:0001830	47.37	gold quality
small intestine	UBERON:0002108	47.36	gold quality
small intestine Peyer’s patch	UBERON:0003454	47.17	gold quality
right lobe of liver	UBERON:0001114	46.87	silver quality
islet of Langerhans	UBERON:0000006	46.13	silver quality
tibial nerve	UBERON:0001323	45.60	silver quality
left testis	UBERON:0004533	45.21	gold quality
Ammon’s horn	UBERON:0001954	44.79	silver quality
testis	UBERON:0000473	44.48	gold quality
body of pancreas	UBERON:0001150	44.25	silver quality
right adrenal gland	UBERON:0001233	42.82	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	42.74	gold quality
skin of leg	UBERON:0001511	42.62	gold quality
stomach	UBERON:0000945	42.55	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.09	gold quality
hypothalamus	UBERON:0001898	42.04	silver quality
skin of abdomen	UBERON:0001416	41.85	gold quality
right testis	UBERON:0004534	41.39	gold quality
amygdala	UBERON:0001876	41.10	silver quality
left adrenal gland	UBERON:0001234	39.49	silver quality
lower esophagus muscularis layer	UBERON:0035833	39.39	silver quality
pituitary gland	UBERON:0000007	39.01	silver quality
mucosa of transverse colon	UBERON:0004991	38.74	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Results indicate that the TTTY2 gene family may play a significant role in spermatogenesis and suggest a possible mechanism of nonhomologous recombinational events that may cause genomic instability and ultimately lead to male infertility. (PMID:24919818)
• Data suggest that TTY2 gene family TTY2L2A and TTY2L12A deletions can be considered as one of the genetic risk factors for non-obstructive azoospermia. (PMID:28364784)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.