TTTY3B

Summary

TTTY3B (testis expressed transcript, Y-linked 3B, HGNC:31888) is a long non-coding RNA gene on chromosome Yq11.23.

There are two copies of this gene within the P1 palindrome on chromosome Y. This record represents the more centromeric copy.

Source: NCBI Gene 474148 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31888
Approved symbol	TTTY3B
Name	testis expressed transcript, Y-linked 3B
Location	Yq11.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	LNCRNA00122
Ensembl gene	ENSG00000280961
Ensembl biotype	lncRNA
Entrez	474148
RNAcentral	URS00001D8277 — lncRNA, 344 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000631331

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000631331 — 3 exons

Exon	Start	End
ENSE00003765656	23941519	23941622
ENSE00003768854	23936727	23936831
ENSE00003773969	23939186	23939320

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 94.03.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.03	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.64	gold quality
substantia nigra	UBERON:0002038	61.62	gold quality
gastrocnemius	UBERON:0001388	60.73	gold quality
small intestine Peyer’s patch	UBERON:0003454	44.66	gold quality
tibial artery	UBERON:0007610	44.17	silver quality
lung	UBERON:0002048	42.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	42.80	silver quality
esophagus mucosa	UBERON:0002469	42.42	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	42.42	gold quality
hypothalamus	UBERON:0001898	41.02	gold quality
anterior cingulate cortex	UBERON:0009835	40.65	silver quality
caudate nucleus	UBERON:0001873	40.54	gold quality
nucleus accumbens	UBERON:0001882	40.35	silver quality
putamen	UBERON:0001874	39.91	gold quality
ascending aorta	UBERON:0001496	39.86	silver quality
skin of leg	UBERON:0001511	38.78	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	38.67	silver quality
left testis	UBERON:0004533	34.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): TTTY3 (ENSG00000231141)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.