TTTY4

Summary

TTTY4 (testis expressed transcript, Y-linked 4, HGNC:16481) is a long non-coding RNA gene on chromosome Yq11.223.

There are three copies of this gene on chromosome Y. This record represents the most centromeric copy.

Source: NCBI Gene 114761 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16481
Approved symbol	TTTY4
Name	testis expressed transcript, Y-linked 4
Location	Yq11.223
Locus type	RNA, long non-coding
Status	Approved
Aliases	TTY4, TTTY4A, LINC00123
Ensembl gene	ENSG00000226906
Ensembl biotype	lncRNA
OMIM	400037
Entrez	114761
RNAcentral	URS000075A070 — lncRNA, 1370 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000436568

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436568 — 4 exons

Exon	Start	End
ENSE00001687747	22963628	22963703
ENSE00001713773	22972284	22973284
ENSE00001760629	22936455	22936615
ENSE00001806588	22965508	22965615

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 89.10.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.10	gold quality
adult mammalian kidney	UBERON:0000082	55.29	gold quality
kidney	UBERON:0002113	54.42	gold quality
liver	UBERON:0002107	50.73	silver quality
gall bladder	UBERON:0002110	49.85	gold quality
right lobe of liver	UBERON:0001114	49.56	silver quality
cortex of kidney	UBERON:0001225	47.85	gold quality
islet of Langerhans	UBERON:0000006	46.78	gold quality
body of pancreas	UBERON:0001150	43.23	silver quality
metanephros cortex	UBERON:0010533	40.17	silver quality
left testis	UBERON:0004533	24.74	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The rs3749893 A allele of TSPYL-4 was associated with a protective effect against the deterioration of pulmonary function. (PMID:22736055)

Cross-species orthologs

0 orthologs

Paralogs (2): TTTY4C (ENSG00000228296), TTTY4B (ENSG00000235412)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.