TTTY6

Summary

TTTY6 (testis expressed transcript, Y-linked 6, HGNC:16483) is a long non-coding RNA gene on chromosome Yq11.223.

There are two copies of this locus in the P3 palindrome on chromosome Y. This record represents the more telomeric copy.

Source: NCBI Gene 84672 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16483
Approved symbol	TTTY6
Name	testis expressed transcript, Y-linked 6
Location	Yq11.223
Locus type	RNA, long non-coding
Status	Approved
Aliases	TTY6, TTTY6A, LINC00127
Ensembl gene	ENSG00000131538
Ensembl biotype	lncRNA
OMIM	400039
Entrez	84672
RNAcentral	URS000075C246 — lncRNA, 512 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000253838, ENST00000769610

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000253838 — 7 exons

Exon	Start	End
ENSE00001785382	22441345	22441458
ENSE00003499302	22440989	22441126
ENSE00004130878	22444624	22444784
ENSE00004130879	22439593	22439831
ENSE00004130881	22447067	22447228
ENSE00004130883	22454418	22454472
ENSE00004130884	22451969	22452042

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 57.11.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	57.11	gold quality
right lobe of liver	UBERON:0001114	56.39	gold quality
substantia nigra	UBERON:0002038	52.96	gold quality
adult mammalian kidney	UBERON:0000082	51.95	gold quality
blood	UBERON:0000178	51.84	silver quality
kidney	UBERON:0002113	51.29	gold quality
thyroid gland	UBERON:0002046	49.28	gold quality
duodenum	UBERON:0002114	49.27	gold quality
body of pancreas	UBERON:0001150	49.22	gold quality
rectum	UBERON:0001052	46.23	gold quality
heart left ventricle	UBERON:0002084	45.50	silver quality
transverse colon	UBERON:0001157	45.21	gold quality
stomach	UBERON:0000945	44.75	gold quality
colon	UBERON:0001155	44.44	gold quality
minor salivary gland	UBERON:0001830	43.98	gold quality
spleen	UBERON:0002106	43.94	silver quality
small intestine	UBERON:0002108	43.94	gold quality
prefrontal cortex	UBERON:0000451	43.87	silver quality
cortex of kidney	UBERON:0001225	43.78	gold quality
upper lobe of left lung	UBERON:0008952	42.84	gold quality
body of stomach	UBERON:0001161	42.51	silver quality
mucosa of transverse colon	UBERON:0004991	42.51	silver quality
anterior cingulate cortex	UBERON:0009835	42.20	silver quality
lower esophagus muscularis layer	UBERON:0035833	42.07	silver quality
Brodmann (1909) area 9	UBERON:0013540	41.84	silver quality
muscle layer of sigmoid colon	UBERON:0035805	41.24	silver quality
amygdala	UBERON:0001876	40.95	gold quality
prostate gland	UBERON:0002367	40.74	gold quality
nucleus accumbens	UBERON:0001882	40.63	silver quality
cerebral cortex	UBERON:0000956	40.54	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): TTTY6B (ENSG00000131548)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.