TTTY6B

Summary

TTTY6B (testis expressed transcript, Y-linked 6B, HGNC:31887) is a long non-coding RNA gene on chromosome Yq11.223.

There are two copies of this locus in the P3 palindrome on chromosome Y. This record represents the more centromeric copy.

Source: NCBI Gene 441543 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31887
Approved symbol	TTTY6B
Name	testis expressed transcript, Y-linked 6B
Location	Yq11.223
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00128
Ensembl gene	ENSG00000131548
Ensembl biotype	lncRNA
Entrez	441543
RNAcentral	URS000075A904 — lncRNA, 473 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000253848, ENST00000774327, ENST00000774328

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000253848 — 7 exons

Exon	Start	End
ENSE00001917099	22144966	22145079
ENSE00003687937	22145298	22145435
ENSE00004140217	22131944	22131998
ENSE00004140218	22146593	22146831
ENSE00004140219	22139194	22139355
ENSE00004140222	22134379	22134452
ENSE00004140223	22141638	22141798

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 58.13.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	58.13	gold quality
Ammon’s horn	UBERON:0001954	55.73	gold quality
kidney	UBERON:0002113	55.19	silver quality
islet of Langerhans	UBERON:0000006	54.94	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.03	gold quality
duodenum	UBERON:0002114	51.38	gold quality
transverse colon	UBERON:0001157	50.39	gold quality
body of pancreas	UBERON:0001150	49.58	gold quality
adult mammalian kidney	UBERON:0000082	49.34	gold quality
colon	UBERON:0001155	49.24	gold quality
body of stomach	UBERON:0001161	48.07	gold quality
muscle layer of sigmoid colon	UBERON:0035805	47.74	gold quality
right atrium auricular region	UBERON:0006631	46.56	gold quality
rectum	UBERON:0001052	46.23	gold quality
right lobe of liver	UBERON:0001114	44.88	silver quality
lower esophagus muscularis layer	UBERON:0035833	44.62	gold quality
putamen	UBERON:0001874	44.16	gold quality
right frontal lobe	UBERON:0002810	44.03	gold quality
skin of leg	UBERON:0001511	43.96	silver quality
multicellular organism	UBERON:0000468	43.75	gold quality
heart left ventricle	UBERON:0002084	42.24	silver quality
minor salivary gland	UBERON:0001830	42.12	gold quality
brain	UBERON:0000955	42.07	gold quality
prostate gland	UBERON:0002367	41.52	gold quality
skin of abdomen	UBERON:0001416	40.29	silver quality
right testis	UBERON:0004534	40.23	gold quality
nucleus accumbens	UBERON:0001882	39.50	silver quality
caudate nucleus	UBERON:0001873	38.50	silver quality
left testis	UBERON:0004533	38.31	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	38.21	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (1): TTTY6 (ENSG00000131538)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.