TUSC7

Summary

TUSC7 (tumor suppressor candidate 7, HGNC:27701) is a long non-coding RNA gene on chromosome 3q13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27701
Approved symbol	TUSC7
Name	tumor suppressor candidate 7
Location	3q13.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00902, LOC285194
Ensembl gene	ENSG00000243197
Ensembl biotype	lncRNA
OMIM	616057
Entrez	285194
RNAcentral	URS00026A1F84 — lncRNA, 2107 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000466156, ENST00000466856, ENST00000477539, ENST00000477805, ENST00000496154, ENST00000496242, ENST00000609361, ENST00000660554, ENST00000665622

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000466156 — 4 exons

Exon	Start	End
ENSE00001862911	116712355	116712599
ENSE00001895289	116716188	116716431
ENSE00001929387	116714039	116714150
ENSE00001941677	116709969	116710421

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 85.17.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	85.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.68	gold quality
left testis	UBERON:0004533	81.18	gold quality
testis	UBERON:0000473	81.08	gold quality
right testis	UBERON:0004534	79.80	gold quality
adrenal tissue	UBERON:0018303	75.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	74.34	gold quality
sural nerve	UBERON:0015488	61.42	silver quality
stomach	UBERON:0000945	59.52	gold quality
urinary bladder	UBERON:0001255	59.34	silver quality
uterine cervix	UBERON:0000002	59.28	gold quality
blood	UBERON:0000178	56.28	gold quality
multicellular organism	UBERON:0000468	55.72	gold quality
monocyte	CL:0000576	54.52	gold quality
calcaneal tendon	UBERON:0003701	54.11	gold quality
superior frontal gyrus	UBERON:0002661	53.83	gold quality
prefrontal cortex	UBERON:0000451	53.51	gold quality
lung	UBERON:0002048	52.92	gold quality
adrenal gland	UBERON:0002369	52.58	gold quality
endometrium	UBERON:0001295	52.48	silver quality
kidney	UBERON:0002113	52.46	gold quality
primary visual cortex	UBERON:0002436	52.41	gold quality
intestine	UBERON:0000160	51.98	gold quality
cortex of kidney	UBERON:0001225	50.94	silver quality
pancreas	UBERON:0001264	50.24	silver quality
heart	UBERON:0000948	50.09	gold quality
liver	UBERON:0002107	49.46	silver quality
prostate gland	UBERON:0002367	49.15	gold quality
tibial nerve	UBERON:0001323	49.04	gold quality
gastrocnemius	UBERON:0001388	48.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 25)

• The results suggest that loc285194 is a p53-regulated tumor suppressor, which acts in part through repression of miR-211. (PMID:23558749)
• LOC285194 might be a novel prognostic indicator in colorectal cancer. (PMID:23680400)
• Decreased expression of LOC285194 could serve as a molecular marker to predict the clinical outcome of Esophageal squamous cell carcinoma patients after surgery, and select patients who would benefit from preoperative Chemoradiotherapy. (PMID:25169763)
• Low expression of TUSC7 is associated with osteosarcoma. (PMID:26781978)
• A three-lncRNA signature (LOC285194, RP11-462C24.1 and Nbla12061) identified via stepwise regression analysis showed potential as a diagnostic marker for colorectal cancer. (PMID:27683121)
• Ectopic expression of TUSC7 in HCT116 and SW480 cells significantly inhibited cell proliferation rate. There were 2 binding sites of miR-211-3p within the sequence of TUSC7 and TUSC7 expression level was negatively correlated with miR-211-3p. (PMID:28214867)
• long non-coding RNA TUSC7 was underexpressed in endometrial carcinoma, especially in endometrial carcinoma chemotherapy-resistant tissues and cell lines and acted as a potential tumor suppressor gene to inhibit cell growth as well as advance the chemotherapy sensitivity through targeted silencing of miR-23b, which might provide a new therapeutic target to endometrial carcinoma (PMID:28653877)
• TUSC7 was an independent prognostic indicator for overall survival and disease free survival. (PMID:28925483)
• Low expression of TUSC7 is associated with temozolomide resistance in glioblastoma. (PMID:29397407)
• These findings suggested TUSC7 suppressed chemotherapy resistance of ESCC by downregulating miR-224 to modulate DESC1/EGFR/AKT pathway. (PMID:29530057)
• Study results revealed that the expression of LOC285194 was significantly lower in non-small cell lung cancer (NSCLC) tumor tissues when compared with the corresponding non-tumor tissues. Its expression was correlated with the tumor size, disease-free survival, and overall survival rates. RNA protein interaction analysis revealed that p53 was the direct binding target of LOC285194 in NSCLC. (PMID:30542733)
• overexpression of TUSC7 inhibited Colorectal cancer (CRC) cell proliferation, metastasis, invasion and epithelialmesenchymal transition These findings indicated that TUSC7 is involved in CRC development. (PMID:31002365)
• This study demonstrated that decreased level of lncRNA loc285194 was associated with poor clinical outcomes for patients with different types of cancer, supporting a promising potential biomarker for prognosis and metastasis in human cancers.[systematic review and meta-analysis] (PMID:31054796)
• TUSC7 was downexpressed in EC tissues and cell lines, and TUSC7 upregulation could remarkably inhibit cell proliferation, cycle progression and metastasis in EC cells. (PMID:31200002)
• TUSC-7 was proved to be one strong suppressive lnc-RNA in lung adenocarcinoma stem cells, functioning through inactivating NOTCH signaling, and the turbulence on division modes precisely pointed to the key mechanisms of stem cells’ renewal. (PMID:31279783)
• Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy. (PMID:31494574)
• Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211. (PMID:31652435)
• Long non-coding RNA LOC285194 in cancer. (PMID:31837299)
• LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/beta-catenin signaling pathway. (PMID:31991056)
• LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway. (PMID:32439362)
• Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3beta pathway in ovarian cancer. (PMID:32706063)
• [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion]. (PMID:32897196)
• Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis. (PMID:33370523)
• lncRNA TUSC7 inhibits osteosarcoma progression through the miR181a/RASSF6 axis. (PMID:33416181)
• A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer. (PMID:35296964)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.