TUSC8

Summary

TUSC8 (tumor suppressor candidate 8, HGNC:49111) is a long non-coding RNA gene on chromosome 13q14.11.

Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing.

Source: NCBI Gene 400128 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49111
Approved symbol	TUSC8
Name	tumor suppressor candidate 8
Location	13q14.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	XLOC_010588
Ensembl gene	ENSG00000237361
Ensembl biotype	lncRNA
Entrez	400128
RNAcentral	URS000075BBEF — lncRNA, 1098 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000432701, ENST00000607312, ENST00000660135, ENST00000700923, ENST00000701079, ENST00000781292, ENST00000781293, ENST00000781294, ENST00000781295, ENST00000781296, ENST00000781297, ENST00000781298, ENST00000781299, ENST00000781300, ENST00000781301, ENST00000781302, ENST00000781303

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432701 — 2 exons

Exon	Start	End
ENSE00004153297	44405614	44405967
ENSE00004153305	44399996	44400955

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 81.82.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0481 / max 10.3552, expressed in 22 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137043	0.0481	22

Top tissues by expression

202 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	81.82	gold quality
minor salivary gland	UBERON:0001830	79.43	gold quality
saliva-secreting gland	UBERON:0001044	76.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.63	gold quality
mouth mucosa	UBERON:0003729	75.91	gold quality
liver	UBERON:0002107	74.94	gold quality
body of stomach	UBERON:0001161	74.04	gold quality
superficial temporal artery	UBERON:0001614	73.58	gold quality
right uterine tube	UBERON:0001302	71.93	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	70.99	silver quality
stomach	UBERON:0000945	70.98	gold quality
fundus of stomach	UBERON:0001160	70.56	gold quality
mucosa of transverse colon	UBERON:0004991	70.20	gold quality
rectum	UBERON:0001052	69.95	gold quality
tonsil	UBERON:0002372	68.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.58	gold quality
prostate gland	UBERON:0002367	67.91	gold quality
cortical plate	UBERON:0005343	67.87	gold quality
secondary oocyte	CL:0000655	67.79	gold quality
bone marrow cell	CL:0002092	67.79	silver quality
transverse colon	UBERON:0001157	66.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.02	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	65.34	gold quality
endocervix	UBERON:0000458	64.89	gold quality
nasal cavity epithelium	UBERON:0005384	64.75	gold quality
mammary duct	UBERON:0001765	63.87	silver quality
corpus epididymis	UBERON:0004359	63.49	gold quality
thoracic mammary gland	UBERON:0005200	63.38	gold quality
mammary gland	UBERON:0001911	63.34	gold quality
lower lobe of lung	UBERON:0008949	63.19	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Results suggested that XLOC_010588 plays a pivotal role in cervical cancer cell proliferation via decreasing c-Myc expression. (PMID:24667250)
• These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of cervical cancer cells by upregulating PTEN via miR-641. (PMID:31033083)
• TUSC8 inhibits the development of osteosarcoma by sponging miR1973p and targeting EHD2. (PMID:32945345)
• TUSC8 enhances cisplatin sensitivity of NSCLC cells through regulating VEGFA. (PMID:34076977)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.