TYMSOS

Summary

TYMSOS (TYMS opposite strand RNA, HGNC:29553) is a long non-coding RNA gene on chromosome 18p11.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29553
Approved symbol	TYMSOS
Name	TYMS opposite strand RNA
Location	18p11.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000176912
Ensembl biotype	lncRNA
Entrez	494514
RNAcentral	URS00021231D4 — lncRNA, 795 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000323813, ENST00000585033, ENST00000664942, ENST00000688530, ENST00000688642, ENST00000701410

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000323813 — 2 exons

Exon	Start	End
ENSE00003938205	649473	649964
ENSE00004105405	657842	658352

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 93.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.3904 / max 54.1666, expressed in 1191 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170944	3.3904	1191

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	93.23	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	78.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.44	gold quality
mucosa of transverse colon	UBERON:0004991	76.82	gold quality
putamen	UBERON:0001874	76.72	gold quality
spinal cord	UBERON:0002240	75.49	gold quality
ventricular zone	UBERON:0003053	74.38	gold quality
amygdala	UBERON:0001876	74.19	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	72.11	silver quality
substantia nigra	UBERON:0002038	71.86	gold quality
Ammon’s horn	UBERON:0001954	71.36	gold quality
ganglionic eminence	UBERON:0004023	70.88	gold quality
hypothalamus	UBERON:0001898	70.12	gold quality
prefrontal cortex	UBERON:0000451	70.08	gold quality
caudate nucleus	UBERON:0001873	70.07	gold quality
midbrain	UBERON:0001891	69.66	gold quality
colonic epithelium	UBERON:0000397	69.64	silver quality
stromal cell of endometrium	CL:0002255	68.28	gold quality
bone marrow cell	CL:0002092	67.17	silver quality
corpus callosum	UBERON:0002336	66.82	gold quality
temporal lobe	UBERON:0001871	66.78	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.62	gold quality
tibialis anterior	UBERON:0001385	66.60	silver quality
frontal cortex	UBERON:0001870	66.33	gold quality
right frontal lobe	UBERON:0002810	66.31	gold quality
cerebral cortex	UBERON:0000956	65.84	gold quality
nucleus accumbens	UBERON:0001882	65.58	gold quality
neocortex	UBERON:0001950	65.56	gold quality
forebrain	UBERON:0001890	65.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth. (PMID:33608498)
• Construction of lncRNA TYMSOS/hsa-miR-101-3p/CEP55 and TYMSOS/hsa-miR-195-5p/CHEK1 Axis in Non-small Cell Lung Cancer. (PMID:36352081)
• IncRNA TYMSOS Promotes Epithelial-Mesenchymal Transition and Metastasis in Thyroid Carcinoma through Regulating MARCKSL1 and Activating the PI3K/Akt Signaling Pathway. (PMID:36374807)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.